JP2014513528A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513528A5 JP2014513528A5 JP2014506501A JP2014506501A JP2014513528A5 JP 2014513528 A5 JP2014513528 A5 JP 2014513528A5 JP 2014506501 A JP2014506501 A JP 2014506501A JP 2014506501 A JP2014506501 A JP 2014506501A JP 2014513528 A5 JP2014513528 A5 JP 2014513528A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- mirna
- ratio
- subject
- mci
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476591P | 2011-04-18 | 2011-04-18 | |
| US61/476,591 | 2011-04-18 | ||
| US201161478766P | 2011-04-25 | 2011-04-25 | |
| US61/478,766 | 2011-04-25 | ||
| US201161546431P | 2011-10-12 | 2011-10-12 | |
| US61/546,431 | 2011-10-12 | ||
| PCT/US2012/034025 WO2012145363A1 (en) | 2011-04-18 | 2012-04-18 | METHODS OF USING miRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513528A JP2014513528A (ja) | 2014-06-05 |
| JP2014513528A5 true JP2014513528A5 (enExample) | 2015-06-18 |
| JP6021893B2 JP6021893B2 (ja) | 2016-11-09 |
Family
ID=47041896
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506501A Active JP6021893B2 (ja) | 2011-04-18 | 2012-04-18 | 軽度認知機能障害（ＭＣＩ）およびアルツハイマー病（ＡＤ）の早期検出ならびにモニタリングのために体液からのｍｉＲＮＡを使用する方法 |
| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9556487B2 (enExample) |
| EP (4) | EP2699666B1 (enExample) |
| JP (3) | JP6021893B2 (enExample) |
| CN (3) | CN105861712B (enExample) |
| AU (2) | AU2012245628B2 (enExample) |
| CA (2) | CA2833389C (enExample) |
| ES (1) | ES2630602T3 (enExample) |
| RU (1) | RU2626540C2 (enExample) |
| WO (2) | WO2012145363A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2699666B1 (en) | 2011-04-18 | 2016-10-05 | DiamiR, LLC | miRNA-BASED UNIVERSAL SCREENING TEST (UST) |
| US20160289762A1 (en) | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| US20140087964A1 (en) * | 2012-09-24 | 2014-03-27 | University Of Virginia Patent Foundation | Compositions and methods for detecting aberrant regulation, expression, and levels of hgh |
| US20140100124A1 (en) * | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
| EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
| EP2733220B1 (en) | 2012-11-16 | 2017-10-18 | Siemens Aktiengesellschaft | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
| CN104903468B (zh) | 2012-11-16 | 2019-04-23 | 萨尔大学 | 用于帕金森氏病的新诊断MiRNA标志物 |
| JP2014128249A (ja) * | 2012-12-28 | 2014-07-10 | Hokkaido Univ | 神経変性疾患の検査と治療に対するｍｉＲＮＡ又はその標的遺伝子の利用 |
| CN103805693B (zh) * | 2013-10-29 | 2017-01-11 | 宁夏医科大学 | 微小分子RNA-508-5p作为抗肿瘤标志物的用途 |
| JP6930832B2 (ja) * | 2013-11-18 | 2021-09-01 | ディアミール, エルエルシーDiamir, Llc | パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法 |
| CA2939343A1 (en) * | 2014-02-18 | 2015-08-27 | Baylor Research Institute | Mir-320e and colorectal cancer |
| KR102505827B1 (ko) * | 2014-04-10 | 2023-03-03 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 이식거부 및 면억억제 요법의 내성을 진단하기 위한 마이크로 리보핵산(miRNA)의 용도 |
| CN103937888B (zh) * | 2014-04-14 | 2016-08-17 | 上海交通大学 | 鉴别胃癌的血浆microRNA标志物的筛选与应用 |
| WO2015164431A2 (en) * | 2014-04-22 | 2015-10-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers |
| WO2015181825A1 (en) * | 2014-05-28 | 2015-12-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of glucocorticoid therapy and determining responsiveness thereof |
| CA3224457A1 (en) * | 2014-06-18 | 2015-12-23 | Toray Industries, Inc. | Esophageal cancer detection kit or device, and detection method |
| US10487324B2 (en) | 2015-02-25 | 2019-11-26 | Washington University | Methods to detect motor neuron disease comprising micro-RNAs |
| HK1249182A1 (zh) * | 2015-05-28 | 2018-10-26 | Immunexpress Pty Ltd | 验证生物标志物测量 |
| WO2016197024A2 (en) | 2015-06-05 | 2016-12-08 | MiRagen Therapeutics, Inc. | Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl) |
| CN104940954B (zh) * | 2015-06-23 | 2017-12-26 | 同济大学 | MicroRNA‑7在制备抗胶质化药物中的应用 |
| US20180355346A1 (en) * | 2015-09-11 | 2018-12-13 | Corning Incorporated | Compositions and methods for nucleic acid purification from blood samples |
| ES2734678T3 (es) * | 2015-12-22 | 2019-12-11 | Siemens Ag | Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos |
| WO2017120285A1 (en) * | 2016-01-05 | 2017-07-13 | Diamir, Llc | METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| CN109716129B (zh) | 2016-09-16 | 2023-10-03 | 武田药品工业株式会社 | 用于遗传性血管性水肿的rna生物标记 |
| GB201616691D0 (en) | 2016-09-30 | 2016-11-16 | King S College London | Assay |
| CN106544435A (zh) * | 2016-09-30 | 2017-03-29 | 河北医科大学第医院 | 检测miR‑206所需逆转录引物对在制备预测试剂盒中的应用 |
| SG10201709799SA (en) * | 2016-11-29 | 2018-06-28 | Helios Bioelectronics Inc | Method for quantitatively profiling nucleic acids |
| JP7107477B2 (ja) * | 2016-12-28 | 2022-07-27 | 国立大学法人 熊本大学 | ミトコンドリアｔＲＮＡ修飾の検出法 |
| WO2018139759A1 (ko) * | 2017-01-26 | 2018-08-02 | 주식회사 바이오오케스트라 | 마이크로 rna를 이용한 알츠하이머병 진단방법 |
| AU2018300159A1 (en) * | 2017-07-12 | 2020-02-06 | Texas Tech University System | MicroRNA-455-3p as a peripheral biomarker for Alzheimer's disease |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| KR101830583B1 (ko) * | 2017-08-11 | 2018-02-20 | 주식회사 인피니트헬스케어 | Ｗｓｉ 스트리밍 방법 |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| CN107811609B (zh) * | 2017-09-22 | 2020-06-09 | 中国医学科学院北京协和医院 | 一种脑老化评估系统 |
| CA3083140A1 (en) * | 2017-11-30 | 2019-06-06 | Provincial Health Services Authority | Methods for evaluating head and neck cancers |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| EP4697021A3 (en) | 2018-02-13 | 2026-05-20 | Toray Industries | DEMENTIA DETECTION KIT OR DEVICE AND METHOD |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| RU2677280C1 (ru) * | 2018-05-17 | 2019-01-16 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики многососудистого атеросклеротического поражения коронарных артерий у больных ишемической болезнью сердца при абдоминальном ожирении |
| US11332789B2 (en) | 2018-05-21 | 2022-05-17 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods for diagnosing and treating hyperlipidemia-related diseases |
| EP3807422B1 (en) | 2018-06-15 | 2025-12-03 | Universitat Autònoma de Barcelona | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease |
| CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的系统和方法 |
| CN109055541B (zh) * | 2018-09-26 | 2020-08-28 | 上海市精神卫生中心（上海市心理咨询培训中心） | Ad所致mci诊断标志物及其应用 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
| KR20220024160A (ko) * | 2019-06-17 | 2022-03-03 | 주식회사 바이오오케스트라 | 마이크로rna를 이용하여 알츠하이머 질환 동물 모델을 준비하기 위한 조성물 및 방법 |
| WO2021024331A1 (ja) | 2019-08-02 | 2021-02-11 | 株式会社 東芝 | 分析方法及びキット |
| KR20230014705A (ko) * | 2020-04-23 | 2023-01-30 | 주식회사 바이오오케스트라 | Mir-485-3p 발현을 사용하는 진단 방법 |
| US20220073992A1 (en) * | 2020-11-24 | 2022-03-10 | Hossein Abdul Tehrani Abdul Tehrani | Diagnosis of chronic kidney disease (ckd) and its subgroups |
| CN112562867A (zh) * | 2021-02-22 | 2021-03-26 | 天津迈德新医药科技有限公司 | 一种预测极早期hiv感染风险的装置、存储介质和电子装置 |
| CN112980954B (zh) * | 2021-03-03 | 2022-02-25 | 首都医科大学宣武医院 | 一种预测神经退行性疾病风险的试剂盒及其用途 |
| CN115976194A (zh) * | 2022-12-12 | 2023-04-18 | 天津市肿瘤医院空港医院 | 一种基于外泌体微小rna的神经系统疾病诊断方法 |
| WO2025089057A1 (ja) * | 2023-10-24 | 2025-05-01 | アークレイ株式会社 | スモールｒｎａ測定用血液試料の調製方法及び保存方法、スモールｒｎａの発現量の測定方法、疾患の判定方法、検査方法、モデルの生成方法、検査装置、検査システム、検査プログラム、並びに記録媒体 |
| WO2026094719A1 (ja) * | 2024-10-28 | 2026-05-07 | アークレイ株式会社 | 標準物質及び品質保証方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US743A (en) | 1838-05-17 | Improvement in plows | ||
| US5071A (en) | 1847-04-17 | George page | ||
| FR2552909B1 (fr) | 1983-09-30 | 1985-11-08 | Thomson Csf | Appareil indicateur cartographique de relief et son u tilisation pour la navigation aerienne |
| US4829304A (en) | 1986-05-20 | 1989-05-09 | Harris Corp. | Map-aided navigation system employing TERCOM-SITAN signal processing |
| KR940002799B1 (ko) | 1986-07-28 | 1994-04-02 | 가부시끼가이샤 도요다지도오쇽기 세이사꾸쇼 | 보텀 드래프트 로울러의 청소장치 |
| US4939663A (en) | 1988-04-04 | 1990-07-03 | Harris Corporation | Elevation map-referenced mechanism for updating vehicle navigation system estimates |
| EP0381178A1 (en) | 1989-02-02 | 1990-08-08 | Honeywell Inc. | Method and apparatus for aircraft navigation |
| US5071743A (en) | 1989-10-27 | 1991-12-10 | Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada | Process for conducting site-directed mutagenesis |
| JP3442774B2 (ja) | 1991-07-01 | 2003-09-02 | バーレックス ラボラトリーズ，インコーポレイティド | 新規な突然変異誘発法および組成物 |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| US6242222B1 (en) | 1996-06-07 | 2001-06-05 | Massachusetts Institute Of Technology | Programmed sequential mutagenesis |
| US5780270A (en) | 1996-07-17 | 1998-07-14 | Promega Corporation | Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity |
| EP2290073A3 (en) | 2004-05-28 | 2011-08-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| CA2857878A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP1966390A1 (en) | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| EP2484782B1 (en) * | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| US7799531B2 (en) | 2006-02-28 | 2010-09-21 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2008036765A2 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| WO2008045505A2 (en) | 2006-10-10 | 2008-04-17 | Xenomics, Inc. | Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media |
| AU2007347449A1 (en) * | 2007-02-16 | 2008-08-28 | The Johns Hopkins University | The microRNAome |
| WO2008153692A2 (en) | 2007-05-22 | 2008-12-18 | The Brigham And Women's Hospital, Inc. | Microrna expression profiling of cerebrospinal fluid |
| US20090004668A1 (en) | 2007-06-22 | 2009-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Pre-miRNA loop-modulated target regulation |
| WO2009009457A1 (en) | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| KR20100049079A (ko) | 2007-07-18 | 2010-05-11 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 인간의 정상 심장과 기능부진 심장에서 마이크로 ｒｎａ의 차등 발현 |
| EP2613149B1 (en) | 2007-07-25 | 2014-09-17 | University Of Louisville Research Foundation, Inc. | Exosome-associated microRNA as a diagnostic marker |
| ES2660785T3 (es) | 2007-08-22 | 2018-03-26 | Trovagene, Inc. | Métodos de uso de ARNmi para la detección de la muerte de células in vivo |
| US7653509B2 (en) | 2007-08-29 | 2010-01-26 | Verity Software House | Probability state models |
| US7993831B2 (en) | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| EP2610342B1 (en) * | 2007-09-14 | 2016-05-04 | The Ohio State University Research Foundation | MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof |
| CN101918594A (zh) | 2007-11-30 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 肺癌中外周血中的微rna表达特征谱和靶向 |
| ES2936256T3 (es) | 2008-02-01 | 2023-03-15 | Massachusetts Gen Hospital | Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas |
| CA2716906A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer |
| RU2367959C1 (ru) * | 2008-03-05 | 2009-09-20 | Государственное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" | Способ лабораторной диагностики заболеваний ротовой полости по элементному составу слюны |
| WO2009114681A2 (en) | 2008-03-13 | 2009-09-17 | Dharmacon, Inc. | Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy |
| WO2009120877A2 (en) | 2008-03-26 | 2009-10-01 | The Johns Hopkins University | Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases |
| EP2271931A4 (en) | 2008-04-25 | 2011-10-12 | Merck Sharp & Dohme | MICRO-RNA BIOMARKERS FOR TISSUE INJURIES |
| EP2281903B1 (en) | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| WO2009143379A2 (en) * | 2008-05-21 | 2009-11-26 | Fred Hutchinson Cancer Research Center | Use of extracellular rna to measure disease |
| US20100167937A1 (en) | 2008-07-08 | 2010-07-01 | Power3 Medical Products, Inc. | Multiple forms of Alzheimer's disease based on differences in concentrations of protein biomarkers in blood serum |
| EP3211098B1 (en) | 2008-11-10 | 2023-03-15 | Battelle Memorial Institute | Method utilizing microrna to determine physiological conditions |
| CA2743211A1 (en) | 2008-11-12 | 2010-05-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems of using exosomes for determining phenotypes |
| US20110086348A1 (en) * | 2009-02-19 | 2011-04-14 | The Cleveland Clinic Foundation | Method for assessing heart disease |
| CA2679784A1 (en) | 2009-03-05 | 2010-09-05 | Newcastle Innovation Limited | Diagnostic, prognostic and treatment methods |
| EP2414549A4 (en) * | 2009-03-31 | 2013-08-28 | Us Health | DIFFERENTIALLY EXPRESSED MICRO-RNAS AS BIOMARKERS FOR THE DIAGNOSIS AND TREATMENT OF SJÖGREN SYNDROME |
| WO2010118979A1 (en) | 2009-04-07 | 2010-10-21 | Velin-Pharma A/S | Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system |
| CA2757711A1 (en) * | 2009-04-14 | 2010-10-21 | Merck Sharp & Dohme Corp. | Microrna as a biomarker of pancreatic islet beta-cell engagement |
| EP2433304A1 (en) | 2009-05-20 | 2012-03-28 | E. I. du Pont de Nemours and Company | Process of forming a grid electrode on the front-side of a silicon wafer |
| FR2948687B1 (fr) * | 2009-07-29 | 2015-09-04 | Centre Nat Rech Scient | Utilisation de microarn pour le traitement de pathologies respiratoires chroniques |
| CN102725632A (zh) * | 2009-08-28 | 2012-10-10 | 奥斯瑞根公司 | 肺病的miRNA生物标志物 |
| ES2597554T3 (es) | 2009-11-04 | 2017-01-19 | Diamir, Llc | Métodos de utilización de micro-ARN de fluidos corporales para el diagnóstico y control del deterioro cognitivo leve |
| US8592151B2 (en) * | 2009-11-17 | 2013-11-26 | Musc Foundation For Research Development | Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids |
| CN101942502B (zh) | 2009-12-24 | 2014-09-17 | 北京命码生科科技有限公司 | 胰腺癌标记物及其检测方法、试剂盒和生物芯片 |
| EP3124623B1 (en) | 2010-04-20 | 2018-03-28 | Hummingbird Diagnostics GmbH | Complex mirna sets as novel biomarkers for an acute coronary syndrome |
| HUE051674T2 (hu) | 2010-09-24 | 2021-03-29 | Niels Grabe | Eszközök és eljárások rákos beteg kezelésére adott válaszának elõrejelzésére |
| CN101962685B (zh) | 2010-11-11 | 2012-09-19 | 江苏省疾病预防控制中心 | 一种基于液相芯片检测微小核糖核酸的方法 |
| EP2699666B1 (en) | 2011-04-18 | 2016-10-05 | DiamiR, LLC | miRNA-BASED UNIVERSAL SCREENING TEST (UST) |
| EP2744910B1 (en) | 2011-08-19 | 2016-09-14 | Hummingbird Diagnostics GmbH | Complex sets of mirnas as non-invasive biomarkers for kidney cancer |
| WO2013036936A1 (en) | 2011-09-09 | 2013-03-14 | Van Andel Research Institute | Microrna biomarkers for diagnosing parkinson's disease |
| US9447471B2 (en) | 2011-12-29 | 2016-09-20 | Quest Diagnostics Investments Incorporated | Microrna profiling for diagnosis of dysplastic nevi and melanoma |
| US9540692B2 (en) | 2012-07-25 | 2017-01-10 | Rush University Medical Center | MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease |
| US9809857B2 (en) | 2013-02-28 | 2017-11-07 | Washington University | Methods and signatures for oropharyngeal cancer prognosis |
| JP6930832B2 (ja) | 2013-11-18 | 2021-09-01 | ディアミール, エルエルシーDiamir, Llc | パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法 |
| US9605315B2 (en) | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| US9708667B2 (en) | 2014-05-13 | 2017-07-18 | Rosetta Genomics, Ltd. | MiRNA expression signature in the classification of thyroid tumors |
| WO2017120285A1 (en) | 2016-01-05 | 2017-07-13 | Diamir, Llc | METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| EP3464639A4 (en) | 2016-05-31 | 2020-01-01 | Goetzl, Edward, J. | DIAGNOSTIC METHOD AND DRUG EFFECT TEST METHOD FOR DEMENTIA WITH THE USE OF ASTROCYTE-DERIVED EXOSOMES |
-
2012
- 2012-04-18 EP EP12774179.1A patent/EP2699666B1/en active Active
- 2012-04-18 CA CA2833389A patent/CA2833389C/en active Active
- 2012-04-18 ES ES12774179.1T patent/ES2630602T3/es active Active
- 2012-04-18 WO PCT/US2012/034025 patent/WO2012145363A1/en not_active Ceased
- 2012-04-18 EP EP16192259.6A patent/EP3133147B1/en active Active
- 2012-04-18 WO PCT/US2012/034098 patent/WO2012145409A1/en not_active Ceased
- 2012-04-18 US US14/112,765 patent/US9556487B2/en active Active
- 2012-04-18 RU RU2013146856A patent/RU2626540C2/ru active
- 2012-04-18 CN CN201610344816.5A patent/CN105861712B/zh active Active
- 2012-04-18 AU AU2012245628A patent/AU2012245628B2/en active Active
- 2012-04-18 JP JP2014506501A patent/JP6021893B2/ja active Active
- 2012-04-18 CN CN201280030033.XA patent/CN103620019B/zh active Active
- 2012-04-18 EP EP12773705.4A patent/EP2699697B1/en active Active
- 2012-04-18 AU AU2012245580A patent/AU2012245580B2/en active Active
- 2012-04-18 CN CN201280030048.6A patent/CN103620057B/zh active Active
- 2012-04-18 JP JP2014506516A patent/JP6211511B2/ja active Active
- 2012-04-18 EP EP17207859.4A patent/EP3327145A1/en not_active Withdrawn
- 2012-04-18 CA CA2833375A patent/CA2833375A1/en active Pending
- 2012-04-18 US US14/112,684 patent/US9803242B2/en active Active
-
2016
- 2016-12-23 US US15/390,110 patent/US10246747B2/en active Active
-
2017
- 2017-05-26 US US15/606,747 patent/US10472681B2/en active Active
- 2017-09-12 JP JP2017174778A patent/JP2018027089A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8735074B2 (en) | MiRNA biomarkers of lung disease | |
| CA2762986C (en) | Mirna biomarkers of prostate disease | |
| Orang et al. | MicroRNAs in colorectal cancer: from diagnosis to targeted therapy | |
| Du et al. | Role of miRNA in lung cancer-potential biomarkers and therapies | |
| Faruq et al. | microRNA: diagnostic perspective | |
| CA2833389C (en) | Mirna-based universal screening test (ust) | |
| JP2011501943A5 (enExample) | ||
| JP2014511709A5 (enExample) | ||
| Nohata et al. | MicroRNAs function as tumor suppressors or oncogenes: aberrant expression of microRNAs in head and neck squamous cell carcinoma | |
| JP2013502931A5 (enExample) | ||
| JP2015504307A5 (enExample) | ||
| CN101921759B (zh) | 一种与宫颈癌及其癌前病变相关的血清/血浆miRNA标志物及其应用 | |
| JP2010538653A5 (enExample) | ||
| EP2364367A2 (en) | Methods, compositions, and devices utilizing microrna to determine physiological conditions | |
| US20090099034A1 (en) | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers | |
| JP2012231801A5 (enExample) | ||
| JP2009100687A5 (enExample) | ||
| Janiszewska et al. | microRNAs are important players in head and neck carcinoma: a review | |
| Hannafon et al. | miRNAs as biomarkers for predicting the progression of ductal carcinoma in situ | |
| WO2018025242A3 (en) | Methods for diagnosing and treating esophageal cancer | |
| Emmett et al. | An update on cellular MicroRNA expression in human papillomavirus-associated head and neck squamous cell carcinoma | |
| Wang | Predicting cancer-related MiRNAs using expression profiles in tumor tissue | |
| Jafri | MiRNA a new insight in metabolic and human diseases: A review | |
| Bhattacharya et al. | Development of microRNA as prognostic markers in head and neck cancer | |
| Ghai et al. | Circulating miRNAs as tumor biomarkers |