JP2014513528A5 - - Google Patents
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- JP2014513528A5 JP2014513528A5 JP2014506501A JP2014506501A JP2014513528A5 JP 2014513528 A5 JP2014513528 A5 JP 2014513528A5 JP 2014506501 A JP2014506501 A JP 2014506501A JP 2014506501 A JP2014506501 A JP 2014506501A JP 2014513528 A5 JP2014513528 A5 JP 2014513528A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- mirna
- ratio
- subject
- mci
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091070501 miRNA Proteins 0.000 claims 66
- 239000002679 microRNA Substances 0.000 claims 61
- 239000000523 sample Substances 0.000 claims 33
- 210000001124 body fluid Anatomy 0.000 claims 26
- 239000010839 body fluid Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 11
- 210000002241 neurite Anatomy 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000000946 synaptic effect Effects 0.000 claims 9
- 108091036633 miR-370 stem-loop Proteins 0.000 claims 8
- 108091031103 miR-181a stem-loop Proteins 0.000 claims 7
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims 7
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims 7
- 108091069917 miR-491 stem-loop Proteins 0.000 claims 7
- 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 claims 6
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 6
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 6
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 6
- 108091028080 MiR-132 Proteins 0.000 claims 5
- 108091093073 MiR-134 Proteins 0.000 claims 5
- 108091032985 miR-382 Proteins 0.000 claims 5
- 108091050135 miR-382 stem-loop Proteins 0.000 claims 5
- 108091028076 Mir-127 Proteins 0.000 claims 4
- 108091064399 miR-10b stem-loop Proteins 0.000 claims 4
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 4
- 108091058688 miR-141 stem-loop Proteins 0.000 claims 4
- 108091062225 miR-323 stem-loop Proteins 0.000 claims 4
- 108091084058 miR-874 stem-loop Proteins 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 210000004556 brain Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000000977 initiatory effect Effects 0.000 claims 3
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 2
- -1 miR-292-5p Proteins 0.000 claims 2
- 108091007685 MIR541 Proteins 0.000 claims 1
- 108091007700 MIR543 Proteins 0.000 claims 1
- 108091034054 MiR-138 Proteins 0.000 claims 1
- 108091093082 MiR-146 Proteins 0.000 claims 1
- 108091007419 MiR-27 Proteins 0.000 claims 1
- 108091027966 Mir-137 Proteins 0.000 claims 1
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 108091056924 miR-124 stem-loop Proteins 0.000 claims 1
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 1
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 1
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 1
- 108091030496 miR-138 stem-loop Proteins 0.000 claims 1
- 108091059964 miR-154 stem-loop Proteins 0.000 claims 1
- 108091023796 miR-182 stem-loop Proteins 0.000 claims 1
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 1
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 1
- 108091074450 miR-200c stem-loop Proteins 0.000 claims 1
- 108091040176 miR-218 stem-loop Proteins 0.000 claims 1
- 108091085564 miR-25 stem-loop Proteins 0.000 claims 1
- 108091080167 miR-25-1 stem-loop Proteins 0.000 claims 1
- 108091083056 miR-25-2 stem-loop Proteins 0.000 claims 1
- 108091061970 miR-26a stem-loop Proteins 0.000 claims 1
- 108091083275 miR-26b stem-loop Proteins 0.000 claims 1
- 108091023455 miR-297 stem-loop Proteins 0.000 claims 1
- 108091059493 miR-322 stem-loop Proteins 0.000 claims 1
- 108091072797 miR-325 stem-loop Proteins 0.000 claims 1
- 108091089005 miR-329 stem-loop Proteins 0.000 claims 1
- 108091090692 miR-337 stem-loop Proteins 0.000 claims 1
- 108091065159 miR-339 stem-loop Proteins 0.000 claims 1
- 108091044951 miR-339-2 stem-loop Proteins 0.000 claims 1
- 108091088856 miR-345 stem-loop Proteins 0.000 claims 1
- 108091056360 miR-350 stem-loop Proteins 0.000 claims 1
- 108091061985 miR-350-1 stem-loop Proteins 0.000 claims 1
- 108091086625 miR-350-2 stem-loop Proteins 0.000 claims 1
- 108091029214 miR-351 stem-loop Proteins 0.000 claims 1
- 108091057188 miR-369 stem-loop Proteins 0.000 claims 1
- 108091028761 miR-409 stem-loop Proteins 0.000 claims 1
- 108091090987 miR-425 stem-loop Proteins 0.000 claims 1
- 108091059135 miR-429 stem-loop Proteins 0.000 claims 1
- 108091084055 miR-433 stem-loop Proteins 0.000 claims 1
- 108091080309 miR-483 stem-loop Proteins 0.000 claims 1
- 108091035982 miR-485 stem-loop Proteins 0.000 claims 1
- 108091062429 miR-487b stem-loop Proteins 0.000 claims 1
- 108091092564 miR-494 stem-loop Proteins 0.000 claims 1
- 108091031190 miR-495 stem-loop Proteins 0.000 claims 1
- 108091085103 miR-496 stem-loop Proteins 0.000 claims 1
- 108091023526 miR-541 stem-loop Proteins 0.000 claims 1
- 108091076271 miR-543 stem-loop Proteins 0.000 claims 1
- 108091089548 miR-656 stem-loop Proteins 0.000 claims 1
- 108091025542 miR-668 stem-loop Proteins 0.000 claims 1
- 108091049552 miR-889 stem-loop Proteins 0.000 claims 1
- 108091071148 miR-935 stem-loop Proteins 0.000 claims 1
- 108091062136 miR-939 stem-loop Proteins 0.000 claims 1
- 108091007422 miR-98 Proteins 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000225 synapse Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476591P | 2011-04-18 | 2011-04-18 | |
| US61/476,591 | 2011-04-18 | ||
| US201161478766P | 2011-04-25 | 2011-04-25 | |
| US61/478,766 | 2011-04-25 | ||
| US201161546431P | 2011-10-12 | 2011-10-12 | |
| US61/546,431 | 2011-10-12 | ||
| PCT/US2012/034025 WO2012145363A1 (en) | 2011-04-18 | 2012-04-18 | METHODS OF USING miRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513528A JP2014513528A (ja) | 2014-06-05 |
| JP2014513528A5 true JP2014513528A5 (enExample) | 2015-06-18 |
| JP6021893B2 JP6021893B2 (ja) | 2016-11-09 |
Family
ID=47041896
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
| JP2014506501A Active JP6021893B2 (ja) | 2011-04-18 | 2012-04-18 | 軽度認知機能障害（ＭＣＩ）およびアルツハイマー病（ＡＤ）の早期検出ならびにモニタリングのために体液からのｍｉＲＮＡを使用する方法 |
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506516A Active JP6211511B2 (ja) | 2011-04-18 | 2012-04-18 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017174778A Pending JP2018027089A (ja) | 2011-04-18 | 2017-09-12 | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9803242B2 (enExample) |
| EP (4) | EP2699666B1 (enExample) |
| JP (3) | JP6211511B2 (enExample) |
| CN (3) | CN103620057B (enExample) |
| AU (2) | AU2012245580B2 (enExample) |
| CA (2) | CA2833375A1 (enExample) |
| ES (1) | ES2630602T3 (enExample) |
| RU (1) | RU2626540C2 (enExample) |
| WO (2) | WO2012145363A1 (enExample) |
Families Citing this family (56)
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| JP6211511B2 (ja) | 2011-04-18 | 2017-10-11 | ディアミール, エルエルシーDiamir, Llc | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
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| AU2016267392B2 (en) * | 2015-05-28 | 2021-12-09 | Immunexpress Pty Ltd | Validating biomarker measurement |
| RU2718534C2 (ru) | 2015-06-05 | 2020-04-08 | Мираджен Терапьютикс, Инк. | Ингибиторы mir-155 для лечения кожной t-клеточной лимфомы (ctcl) |
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