JP2011501943A5 - - Google Patents
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- JP2011501943A5 JP2011501943A5 JP2010529072A JP2010529072A JP2011501943A5 JP 2011501943 A5 JP2011501943 A5 JP 2011501943A5 JP 2010529072 A JP2010529072 A JP 2010529072A JP 2010529072 A JP2010529072 A JP 2010529072A JP 2011501943 A5 JP2011501943 A5 JP 2011501943A5
- Authority
- JP
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- Prior art keywords
- mir
- esophagus
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- tissue
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 43
- 210000001519 tissue Anatomy 0.000 claims 41
- 239000000090 biomarker Substances 0.000 claims 32
- 208000023514 Barrett esophagus Diseases 0.000 claims 29
- 208000023665 Barrett oesophagus Diseases 0.000 claims 29
- 208000009956 adenocarcinoma Diseases 0.000 claims 21
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 21
- 108091070501 miRNA Proteins 0.000 claims 18
- 208000036764 Adenocarcinoma of the esophagus Diseases 0.000 claims 16
- 206010030137 Oesophageal adenocarcinoma Diseases 0.000 claims 16
- 208000028653 esophageal adenocarcinoma Diseases 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 8
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 8
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 8
- 108091028141 MiR-203 Proteins 0.000 claims 7
- 108091062154 Mir-205 Proteins 0.000 claims 5
- 108091062140 Mir-223 Proteins 0.000 claims 5
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 claims 5
- 108091032320 miR-146 stem-loop Proteins 0.000 claims 5
- 108091024530 miR-146a stem-loop Proteins 0.000 claims 5
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 5
- 108091007772 MIRLET7C Proteins 0.000 claims 4
- 108091033773 MiR-155 Proteins 0.000 claims 4
- 108091028695 MiR-224 Proteins 0.000 claims 4
- 108091080933 Mir-192/215 microRNA precursor Proteins 0.000 claims 4
- 108091093189 Mir-375 Proteins 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 4
- 108091037473 miR-103 stem-loop Proteins 0.000 claims 4
- 108091050539 miR-107 stem-loop Proteins 0.000 claims 4
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 4
- 108091054642 miR-194 stem-loop Proteins 0.000 claims 4
- 108091088730 miR-215 stem-loop Proteins 0.000 claims 4
- 108091063344 miR-30b stem-loop Proteins 0.000 claims 4
- 108091055059 miR-30c stem-loop Proteins 0.000 claims 4
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108091031103 miR-181a stem-loop Proteins 0.000 claims 3
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims 3
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 108091033433 MiR-191 Proteins 0.000 claims 2
- 108091028066 Mir-126 Proteins 0.000 claims 2
- 108091027766 Mir-143 Proteins 0.000 claims 2
- 108091028684 Mir-145 Proteins 0.000 claims 2
- 108091060302 Mir-320 Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims 2
- 108091007423 let-7b Proteins 0.000 claims 2
- 108091033753 let-7d stem-loop Proteins 0.000 claims 2
- 108091042844 let-7i stem-loop Proteins 0.000 claims 2
- 108091028606 miR-1 stem-loop Proteins 0.000 claims 2
- 108091026501 miR-122a stem-loop Proteins 0.000 claims 2
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 2
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 2
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 2
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 2
- 108091079012 miR-133a Proteins 0.000 claims 2
- 108091024038 miR-133a stem-loop Proteins 0.000 claims 2
- 108091045872 miR-135 stem-loop Proteins 0.000 claims 2
- 108091026523 miR-135a stem-loop Proteins 0.000 claims 2
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 2
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 2
- 108091055042 miR-181 stem-loop Proteins 0.000 claims 2
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 2
- 108091086416 miR-192 stem-loop Proteins 0.000 claims 2
- 108091063348 miR-193 stem-loop Proteins 0.000 claims 2
- 108091036762 miR-193a stem-loop Proteins 0.000 claims 2
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 2
- 108091045665 miR-202 stem-loop Proteins 0.000 claims 2
- 108091039792 miR-20b stem-loop Proteins 0.000 claims 2
- 108091055878 miR-20b-1 stem-loop Proteins 0.000 claims 2
- 108091027746 miR-20b-2 stem-loop Proteins 0.000 claims 2
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 2
- 108091047189 miR-29c stem-loop Proteins 0.000 claims 2
- 108091054490 miR-29c-2 stem-loop Proteins 0.000 claims 2
- 108091057188 miR-369 stem-loop Proteins 0.000 claims 2
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 2
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 2
- 108091056170 miR-499 stem-loop Proteins 0.000 claims 2
- 108091050885 miR-499-1 stem-loop Proteins 0.000 claims 2
- 108091038523 miR-499-2 stem-loop Proteins 0.000 claims 2
- 108091030520 miR-7-2 stem-loop Proteins 0.000 claims 2
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 2
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 2
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 2
- 108091076732 miR-99a stem-loop Proteins 0.000 claims 2
- 108091064318 miR-99a-1 stem-loop Proteins 0.000 claims 2
- 108091086202 miR-99a-2 stem-loop Proteins 0.000 claims 2
- 108091024443 miRa-135-1 stem-loop Proteins 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 238000011127 radiochemotherapy Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000007433 Lymphatic Metastasis Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 230000001632 homeopathic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97930007P | 2007-10-11 | 2007-10-11 | |
| US60/979,300 | 2007-10-11 | ||
| PCT/US2008/079482 WO2009049129A1 (en) | 2007-10-11 | 2008-10-10 | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501943A JP2011501943A (ja) | 2011-01-20 |
| JP2011501943A5 true JP2011501943A5 (enExample) | 2011-12-01 |
| JP5723156B2 JP5723156B2 (ja) | 2015-05-27 |
Family
ID=40549579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529072A Expired - Fee Related JP5723156B2 (ja) | 2007-10-11 | 2008-10-10 | 食道腺癌の診断及び治療のための方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100285471A1 (enExample) |
| EP (1) | EP2212440A4 (enExample) |
| JP (1) | JP5723156B2 (enExample) |
| CN (2) | CN103937876B (enExample) |
| AU (1) | AU2008310704B2 (enExample) |
| CA (1) | CA2702241A1 (enExample) |
| WO (1) | WO2009049129A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007016548A2 (en) | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| US8481505B2 (en) | 2005-09-12 | 2013-07-09 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of BCL2-associated cancers |
| EP2484782B1 (en) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| AU2007205234B2 (en) | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| ES2425387T3 (es) | 2006-07-13 | 2013-10-15 | The Ohio State University Research Foundation | Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| JP2010516291A (ja) | 2007-01-31 | 2010-05-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性白血病（ａｍｌ）の診断、予後及び治療のためのマイクロｒｎａに基づく方法及び組成物 |
| US8465917B2 (en) | 2007-06-08 | 2013-06-18 | The Ohio State University Research Foundation | Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| EP2173911B1 (en) | 2007-07-31 | 2014-06-18 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| WO2009055773A2 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| MX2010004916A (es) * | 2007-10-30 | 2010-05-20 | Veridex Llc | Proceso para predecir el pronostico de cancer en celulas escamosas de pulmon. |
| WO2009152300A1 (en) | 2008-06-11 | 2009-12-17 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| TWI419974B (zh) | 2008-10-27 | 2013-12-21 | Qiagen Gaithersburg Inc | 於自動平台上之快速結果雜交捕捉法 |
| US20120108655A1 (en) * | 2009-03-05 | 2012-05-03 | Brown University | Methods of Diagnosing and Treating Carcinomas |
| EP2283846A1 (en) | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| JP2014509852A (ja) | 2011-03-07 | 2014-04-24 | ジ・オハイオ・ステート・ユニバーシティ | マイクロＲＮＡ−１５５（ｍｉＲ−１５５）により誘導される変異誘発活性は炎症および癌を結び付ける |
| WO2012135091A2 (en) * | 2011-03-28 | 2012-10-04 | The Johns Hopkins University | Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac) |
| US20140255353A1 (en) * | 2011-08-29 | 2014-09-11 | University Of Miami | Compositions, kits and methods for treating obesity, diabetes and hyperglycemia |
| WO2013029116A1 (en) * | 2011-08-31 | 2013-03-07 | Monash University | Method for predicting treatment responsiveness |
| US20130078632A1 (en) * | 2011-09-23 | 2013-03-28 | Academisch Medisch Centrum | Materials and methods for prognosis of progression of barrett's esophagus |
| CA2852066A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| US20140243240A1 (en) * | 2011-10-26 | 2014-08-28 | Georgetown University | microRNA EXPRESSION PROFILING OF THYROID CANCER |
| EP2788486A4 (en) * | 2011-12-10 | 2015-08-12 | Ohio State Innovation Foundation | MIARN USEFUL IN REDUCING TUMORIGENESIS OF LUNG CANCER AND ASSOCIATED COMPOSITIONS AND METHODS |
| EP2790735A4 (en) | 2011-12-13 | 2015-12-09 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS RELATING TO MIR-21 AND MIR-29A, EXOSOME INHIBITION, AND CANCER METASTASIS |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| KR101445560B1 (ko) * | 2012-05-10 | 2014-09-29 | 한국수력원자력 주식회사 | 저준위 전리방사선에 민감한 유전자 검출 방법 및 상기 방법으로 검출된 유전자 |
| WO2014100216A1 (en) * | 2012-12-19 | 2014-06-26 | The Regents Of The University Of California | Cancer-Associated MicroRNAs and Related Antibodies |
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| EP3000088A4 (en) * | 2013-05-23 | 2018-06-27 | Iphenotype LLC | Method and system for maintaining or improving wellness |
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| CN105368822A (zh) * | 2014-08-29 | 2016-03-02 | 香港大学 | 一种miRNA标记物、其方法和应用 |
| CN104774929B (zh) * | 2015-03-18 | 2017-06-30 | 中山大学肿瘤防治中心 | miR‑455‑3p在食管鳞状细胞癌中的诊断、治疗和预后的应用 |
| KR101657033B1 (ko) * | 2016-03-25 | 2016-09-13 | 성균관대학교산학협력단 | V-ATPase subunit V1E1의 단백질 발현 수준을 측정하여 식도암 환자의 생존율과 예후를 예측하는 방법 |
| CN106177994A (zh) * | 2016-07-18 | 2016-12-07 | 浙江大学 | miR‑1在制备治疗胃癌和乳腺癌药物中的应用 |
| KR20190077309A (ko) * | 2016-08-04 | 2019-07-03 | 베일러 리서치 인스티튜트 | 식도암 진단 및 치료 방법 |
| CN106119392B (zh) * | 2016-08-25 | 2019-12-31 | 朱伟 | 一种与食管鳞癌辅助诊断相关的血清miRNA标志物及其应用 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CN108103201B (zh) * | 2018-03-05 | 2022-03-01 | 江苏为真生物医药技术股份有限公司 | 外泌体microRNA分子标志物的应用及用于诊断食管癌的试剂盒 |
| CN108828229B (zh) * | 2018-06-15 | 2021-03-16 | 深圳华大生命科学研究院 | 食管癌肿瘤标志物组合及其应用 |
| CN109633156B (zh) * | 2018-12-19 | 2022-02-22 | 湖南中南大学湘雅口腔医院 | 生物标志物在评估口腔鳞癌危险程度中的应用 |
| CN109825596B (zh) * | 2019-04-19 | 2022-03-15 | 中国医学科学院肿瘤医院 | 食管癌样本的内参miRNA及其应用 |
| CN113151455B (zh) * | 2020-01-22 | 2023-04-21 | 中国药科大学 | 外泌体miR-181b-5p在食管鳞癌诊断和治疗中的应用 |
| WO2021162065A1 (ja) * | 2020-02-10 | 2021-08-19 | 国立大学法人広島大学 | 食道扁平上皮癌の検出を補助する方法 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN111778339B (zh) * | 2020-08-16 | 2021-01-15 | 徐州医科大学 | 与食管癌相关的miRNA标志物及其应用 |
| CN113736886A (zh) * | 2021-09-14 | 2021-12-03 | 河北医科大学第四医院 | 用于食管癌诊断的生物标志物及其应用 |
| WO2023069510A1 (en) * | 2021-10-19 | 2023-04-27 | The United States Government As Represented By The Department Of Veterans Affairs | Cannabinoid compositions for gastroesophageal disorders |
| CN113969318A (zh) * | 2021-11-10 | 2022-01-25 | 广东省人民医院 | 组合的焦亡相关基因在食管腺癌预后模型中的应用 |
| CN116121377A (zh) * | 2022-11-01 | 2023-05-16 | 山西医科大学 | 一种食管鳞癌外泌体富含的miRNA作为诊断食管鳞癌的标志物中的应用 |
| CN118957067B (zh) * | 2024-08-12 | 2025-03-18 | 西北大学 | 一种胸部肿瘤诊断标志物cpd及其相关诊断产品和应用 |
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- 2008-10-10 CN CN201410040769.6A patent/CN103937876B/zh not_active Expired - Fee Related
- 2008-10-10 AU AU2008310704A patent/AU2008310704B2/en not_active Ceased
- 2008-10-10 US US12/682,318 patent/US20100285471A1/en not_active Abandoned
- 2008-10-10 CN CN200880116343.7A patent/CN101861401B/zh not_active Expired - Fee Related
- 2008-10-10 JP JP2010529072A patent/JP5723156B2/ja not_active Expired - Fee Related
- 2008-10-10 CA CA2702241A patent/CA2702241A1/en not_active Abandoned
- 2008-10-10 WO PCT/US2008/079482 patent/WO2009049129A1/en not_active Ceased
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