JP5723156B2 - 食道腺癌の診断及び治療のための方法及び組成物 - Google Patents
食道腺癌の診断及び治療のための方法及び組成物 Download PDFInfo
- Publication number
- JP5723156B2 JP5723156B2 JP2010529072A JP2010529072A JP5723156B2 JP 5723156 B2 JP5723156 B2 JP 5723156B2 JP 2010529072 A JP2010529072 A JP 2010529072A JP 2010529072 A JP2010529072 A JP 2010529072A JP 5723156 B2 JP5723156 B2 JP 5723156B2
- Authority
- JP
- Japan
- Prior art keywords
- expression
- mir
- tissue
- sample
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97930007P | 2007-10-11 | 2007-10-11 | |
| US60/979,300 | 2007-10-11 | ||
| PCT/US2008/079482 WO2009049129A1 (en) | 2007-10-11 | 2008-10-10 | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501943A JP2011501943A (ja) | 2011-01-20 |
| JP2011501943A5 JP2011501943A5 (enExample) | 2011-12-01 |
| JP5723156B2 true JP5723156B2 (ja) | 2015-05-27 |
Family
ID=40549579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529072A Expired - Fee Related JP5723156B2 (ja) | 2007-10-11 | 2008-10-10 | 食道腺癌の診断及び治療のための方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100285471A1 (enExample) |
| EP (1) | EP2212440A4 (enExample) |
| JP (1) | JP5723156B2 (enExample) |
| CN (2) | CN103937876B (enExample) |
| AU (1) | AU2008310704B2 (enExample) |
| CA (1) | CA2702241A1 (enExample) |
| WO (1) | WO2009049129A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007016548A2 (en) | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| US8481505B2 (en) | 2005-09-12 | 2013-07-09 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of BCL2-associated cancers |
| EP2484782B1 (en) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| AU2007205234B2 (en) | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| ES2425387T3 (es) | 2006-07-13 | 2013-10-15 | The Ohio State University Research Foundation | Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| JP2010516291A (ja) | 2007-01-31 | 2010-05-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性白血病(aml)の診断、予後及び治療のためのマイクロrnaに基づく方法及び組成物 |
| US8465917B2 (en) | 2007-06-08 | 2013-06-18 | The Ohio State University Research Foundation | Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| EP2173911B1 (en) | 2007-07-31 | 2014-06-18 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| WO2009055773A2 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| MX2010004916A (es) * | 2007-10-30 | 2010-05-20 | Veridex Llc | Proceso para predecir el pronostico de cancer en celulas escamosas de pulmon. |
| WO2009152300A1 (en) | 2008-06-11 | 2009-12-17 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| TWI419974B (zh) | 2008-10-27 | 2013-12-21 | Qiagen Gaithersburg Inc | 於自動平台上之快速結果雜交捕捉法 |
| US20120108655A1 (en) * | 2009-03-05 | 2012-05-03 | Brown University | Methods of Diagnosing and Treating Carcinomas |
| EP2283846A1 (en) | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| JP2014509852A (ja) | 2011-03-07 | 2014-04-24 | ジ・オハイオ・ステート・ユニバーシティ | マイクロRNA−155(miR−155)により誘導される変異誘発活性は炎症および癌を結び付ける |
| WO2012135091A2 (en) * | 2011-03-28 | 2012-10-04 | The Johns Hopkins University | Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac) |
| US20140255353A1 (en) * | 2011-08-29 | 2014-09-11 | University Of Miami | Compositions, kits and methods for treating obesity, diabetes and hyperglycemia |
| WO2013029116A1 (en) * | 2011-08-31 | 2013-03-07 | Monash University | Method for predicting treatment responsiveness |
| US20130078632A1 (en) * | 2011-09-23 | 2013-03-28 | Academisch Medisch Centrum | Materials and methods for prognosis of progression of barrett's esophagus |
| CA2852066A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| US20140243240A1 (en) * | 2011-10-26 | 2014-08-28 | Georgetown University | microRNA EXPRESSION PROFILING OF THYROID CANCER |
| EP2788486A4 (en) * | 2011-12-10 | 2015-08-12 | Ohio State Innovation Foundation | MIARN USEFUL IN REDUCING TUMORIGENESIS OF LUNG CANCER AND ASSOCIATED COMPOSITIONS AND METHODS |
| EP2790735A4 (en) | 2011-12-13 | 2015-12-09 | Ohio State Innovation Foundation | METHODS AND COMPOSITIONS RELATING TO MIR-21 AND MIR-29A, EXOSOME INHIBITION, AND CANCER METASTASIS |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| KR101445560B1 (ko) * | 2012-05-10 | 2014-09-29 | 한국수력원자력 주식회사 | 저준위 전리방사선에 민감한 유전자 검출 방법 및 상기 방법으로 검출된 유전자 |
| WO2014100216A1 (en) * | 2012-12-19 | 2014-06-26 | The Regents Of The University Of California | Cancer-Associated MicroRNAs and Related Antibodies |
| GB201303078D0 (en) * | 2013-02-21 | 2013-04-10 | Cambridge Entpr Ltd | Methods |
| EP3000088A4 (en) * | 2013-05-23 | 2018-06-27 | Iphenotype LLC | Method and system for maintaining or improving wellness |
| WO2015175748A1 (en) * | 2014-05-14 | 2015-11-19 | Evorx Technologies, Inc. | Methods and compositions for controlling gene expression and treating cancer |
| EP3816302B1 (en) * | 2014-06-18 | 2024-12-25 | Toray Industries, Inc. | Esophageal cancer detection kit or device, and detection method |
| CN105368822A (zh) * | 2014-08-29 | 2016-03-02 | 香港大学 | 一种miRNA标记物、其方法和应用 |
| CN104774929B (zh) * | 2015-03-18 | 2017-06-30 | 中山大学肿瘤防治中心 | miR‑455‑3p在食管鳞状细胞癌中的诊断、治疗和预后的应用 |
| KR101657033B1 (ko) * | 2016-03-25 | 2016-09-13 | 성균관대학교산학협력단 | V-ATPase subunit V1E1의 단백질 발현 수준을 측정하여 식도암 환자의 생존율과 예후를 예측하는 방법 |
| CN106177994A (zh) * | 2016-07-18 | 2016-12-07 | 浙江大学 | miR‑1在制备治疗胃癌和乳腺癌药物中的应用 |
| KR20190077309A (ko) * | 2016-08-04 | 2019-07-03 | 베일러 리서치 인스티튜트 | 식도암 진단 및 치료 방법 |
| CN106119392B (zh) * | 2016-08-25 | 2019-12-31 | 朱伟 | 一种与食管鳞癌辅助诊断相关的血清miRNA标志物及其应用 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CN108103201B (zh) * | 2018-03-05 | 2022-03-01 | 江苏为真生物医药技术股份有限公司 | 外泌体microRNA分子标志物的应用及用于诊断食管癌的试剂盒 |
| CN108828229B (zh) * | 2018-06-15 | 2021-03-16 | 深圳华大生命科学研究院 | 食管癌肿瘤标志物组合及其应用 |
| CN109633156B (zh) * | 2018-12-19 | 2022-02-22 | 湖南中南大学湘雅口腔医院 | 生物标志物在评估口腔鳞癌危险程度中的应用 |
| CN109825596B (zh) * | 2019-04-19 | 2022-03-15 | 中国医学科学院肿瘤医院 | 食管癌样本的内参miRNA及其应用 |
| CN113151455B (zh) * | 2020-01-22 | 2023-04-21 | 中国药科大学 | 外泌体miR-181b-5p在食管鳞癌诊断和治疗中的应用 |
| WO2021162065A1 (ja) * | 2020-02-10 | 2021-08-19 | 国立大学法人広島大学 | 食道扁平上皮癌の検出を補助する方法 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN111778339B (zh) * | 2020-08-16 | 2021-01-15 | 徐州医科大学 | 与食管癌相关的miRNA标志物及其应用 |
| CN113736886A (zh) * | 2021-09-14 | 2021-12-03 | 河北医科大学第四医院 | 用于食管癌诊断的生物标志物及其应用 |
| WO2023069510A1 (en) * | 2021-10-19 | 2023-04-27 | The United States Government As Represented By The Department Of Veterans Affairs | Cannabinoid compositions for gastroesophageal disorders |
| CN113969318A (zh) * | 2021-11-10 | 2022-01-25 | 广东省人民医院 | 组合的焦亡相关基因在食管腺癌预后模型中的应用 |
| CN116121377A (zh) * | 2022-11-01 | 2023-05-16 | 山西医科大学 | 一种食管鳞癌外泌体富含的miRNA作为诊断食管鳞癌的标志物中的应用 |
| CN118957067B (zh) * | 2024-08-12 | 2025-03-18 | 西北大学 | 一种胸部肿瘤诊断标志物cpd及其相关诊断产品和应用 |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DE68921918T2 (de) | 1988-05-09 | 1995-09-07 | Univ Temple | Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten. |
| US5198338A (en) * | 1989-05-31 | 1993-03-30 | Temple University | Molecular probing for human t-cell leukemia and lymphoma |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| US6040140A (en) * | 1991-12-11 | 2000-03-21 | Thomas Jefferson University | Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities |
| US5633135A (en) * | 1991-12-11 | 1997-05-27 | Thomas Jefferson University | Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities |
| WO1993012136A1 (en) * | 1991-12-11 | 1993-06-24 | Thomas Jefferson University | Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| EP0667920B1 (en) * | 1992-10-29 | 2003-01-15 | Thomas Jefferson University | Methods of detecting micrometastasis of prostate cancer |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US7175995B1 (en) * | 1994-10-27 | 2007-02-13 | Thomas Jefferson University | TCL-1 protein and related methods |
| US5928884A (en) * | 1996-02-09 | 1999-07-27 | Croce; Carlo M. | FHIT proteins and nucleic acids and methods based thereon |
| US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| WO1998035707A1 (en) * | 1997-02-18 | 1998-08-20 | Thomas Jefferson University | Compositions that bind to pancreatic cancer cells and methods of using the same |
| EP1098968A4 (en) * | 1998-07-20 | 2002-01-02 | Univ Jefferson | NITRILASE APPROVALS |
| US6255293B1 (en) * | 1998-07-24 | 2001-07-03 | Yeda Research And Development Co., Ltd. | Prevention of metastasis with 5-aza-2′-deoxycytidine |
| US7141417B1 (en) * | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
| CA2406366A1 (en) * | 2000-04-11 | 2001-10-18 | Thomas Jefferson University | Muir-torre-like syndrome infhit deficient mice |
| US7060811B2 (en) * | 2000-10-13 | 2006-06-13 | Board Of Regents, The University Of Texas System | WWOX: a tumor suppressor gene mutated in multiple cancers |
| US20020173478A1 (en) | 2000-11-14 | 2002-11-21 | The Trustees Of The University Of Pennsylvania | Post-transcriptional gene silencing by RNAi in mammalian cells |
| US20040033502A1 (en) * | 2001-03-28 | 2004-02-19 | Amanda Williams | Gene expression profiles in esophageal tissue |
| EP2428570B1 (en) * | 2001-09-28 | 2018-05-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| GB0128898D0 (en) * | 2001-12-03 | 2002-01-23 | Biotech Res Ventures Pte Ltd | Materials and methods relating to the stabilization and activation of a tumour suppressor protein |
| WO2003069853A1 (en) * | 2002-02-12 | 2003-08-21 | Nokia Corporation | Method for controlling data transmission, and data transmission system |
| US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| EP1496928A4 (en) * | 2002-04-08 | 2005-08-10 | Ciphergen Biosystems Inc | SERUM BIOMARKERS IN HEPATOCELLULAR CARCINOMA |
| CA2484920A1 (en) * | 2002-04-29 | 2003-11-13 | Thomas Jefferson University | Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression |
| AU2003273542A1 (en) * | 2002-05-31 | 2003-12-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of identifying and isolating stem cells and cancer stem cells |
| JP2005536195A (ja) | 2002-05-31 | 2005-12-02 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | 哺乳動物細胞における効率的なrna干渉のための方法 |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| WO2004033659A2 (en) * | 2002-10-11 | 2004-04-22 | Thomas Jefferson University | Novel tumor suppressor gene and compositions and methods for making and using the same |
| ATE546528T1 (de) * | 2002-11-13 | 2012-03-15 | Univ Jefferson | Zusammensetzungen und verfahren zur diagnose und behandlung von krebs |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| WO2004081196A2 (en) * | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
| WO2006031210A1 (en) * | 2003-05-29 | 2006-03-23 | Board Of Regents, The University Of Texas Systems | Jabi as a prognostic marker and a therapeutic target for human cancer |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050037362A1 (en) * | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| WO2005028675A2 (en) * | 2003-09-24 | 2005-03-31 | Oncotherapy Science, Inc. | Methods for detecting, diagnosing and treating hepatocellular carcinomas (hcc) |
| EP1713938A2 (en) * | 2004-02-09 | 2006-10-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| US20060134639A1 (en) * | 2004-04-06 | 2006-06-22 | Huffel Christophe V | Method for the determination of cellular transcriptional regulation |
| CA2566519C (en) * | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
| EP2471924A1 (en) * | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| WO2006007529A2 (en) * | 2004-07-01 | 2006-01-19 | University Of Pittsburgh Of The Commonwealth System For Higher Education | Immunosuppressive exosomes |
| US20060037088A1 (en) * | 2004-08-13 | 2006-02-16 | Shulin Li | Gene expression levels as predictors of chemoradiation response of cancer |
| DK1797183T3 (da) * | 2004-09-02 | 2012-10-01 | Univ Yale | Regulering af onkogener med mikrornas |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| FR2877350B1 (fr) * | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
| ES2534300T3 (es) * | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| US20070099196A1 (en) * | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| JP2008528003A (ja) * | 2005-01-25 | 2008-07-31 | ロゼッタ インファーマティックス エルエルシー | 小rna分子の定量方法 |
| RS53128B (sr) * | 2005-02-23 | 2014-06-30 | Genentech Inc. | Produžavanje vremena progresije bolesti ili preživljavanja kod pacijenata obolelih od kancera jajnika korišćenjem pertuzumaba |
| US20070065840A1 (en) * | 2005-03-23 | 2007-03-22 | Irena Naguibneva | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| AU2006279906B2 (en) * | 2005-08-10 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20070092882A1 (en) * | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| US8445198B2 (en) * | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| US7390792B2 (en) * | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
| WO2007081680A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| AU2007205234B2 (en) * | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| CA3042781C (en) * | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| CN101472470B (zh) * | 2006-04-24 | 2013-07-24 | 俄亥俄州立大学研究基金会 | miR155转基因小鼠中前B细胞增殖和淋巴母细胞性白血病/高度淋巴瘤 |
| WO2008036741A2 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| US8071292B2 (en) * | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| EP2145001A2 (en) * | 2006-09-19 | 2010-01-20 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| CA2664383C (en) * | 2006-09-19 | 2017-08-22 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| WO2008054828A2 (en) * | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| JP2010510769A (ja) * | 2006-11-28 | 2010-04-08 | キャピタルバイオ コーポレーション | 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 |
| US8293684B2 (en) * | 2006-11-29 | 2012-10-23 | Exiqon | Locked nucleic acid reagents for labelling nucleic acids |
| CN101622348A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-20调节的基因和途径 |
| WO2008073919A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| EP2104737B1 (en) * | 2006-12-08 | 2013-04-10 | Asuragen, INC. | Functions and targets of let-7 micro rnas |
| EP2104735A2 (en) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| JP2010516291A (ja) * | 2007-01-31 | 2010-05-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性白血病(aml)の診断、予後及び治療のためのマイクロrnaに基づく方法及び組成物 |
| WO2008104974A2 (en) * | 2007-02-27 | 2008-09-04 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| JP5331714B2 (ja) * | 2007-03-16 | 2013-10-30 | コヴァルクス・アーゲー | タンパク質複合体をターゲティングする薬物候補の直接質量分析 |
| CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
| US20090005336A1 (en) * | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| US8053186B2 (en) * | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| GB2459228B (en) * | 2007-07-25 | 2012-06-20 | Univ Louisville Res Found | Exosome-associated microrna as a diagnostic marker |
| US20090061424A1 (en) * | 2007-08-30 | 2009-03-05 | Sigma-Aldrich Company | Universal ligation array for analyzing gene expression or genomic variations |
| US20090123933A1 (en) * | 2007-11-12 | 2009-05-14 | Wake Forest University Health Sciences | Microrna biomarkers in lupus |
| AU2009212543B2 (en) * | 2008-02-01 | 2015-07-09 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| US20110054009A1 (en) * | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders |
| US20110107440A1 (en) * | 2008-06-04 | 2011-05-05 | Andor Pivarcsi | Skin cancer associated micrornas |
| US20100021734A1 (en) * | 2008-07-22 | 2010-01-28 | Covalent Materials Corporation | Ceramic particles and producing method thereof |
| KR101031305B1 (ko) * | 2008-07-23 | 2011-04-29 | 국립암센터 | 마이크로rna-21 저해제를 포함하는 방사선 민감성증진용 조성물 |
| US8728745B2 (en) * | 2008-09-04 | 2014-05-20 | Ventana Medical Sysems, Inc. | Method for prediction of the progression risk of tumors |
| CA2715518A1 (en) * | 2009-09-23 | 2011-03-23 | Wilson Roa | Microrna expression profiles associated with lung cancer |
| US8709732B2 (en) * | 2010-02-11 | 2014-04-29 | The Hong Kong Polytechnic University | Biomarkers of gastric cancer and use thereof |
-
2008
- 2008-10-10 EP EP08838376A patent/EP2212440A4/en not_active Withdrawn
- 2008-10-10 CN CN201410040769.6A patent/CN103937876B/zh not_active Expired - Fee Related
- 2008-10-10 AU AU2008310704A patent/AU2008310704B2/en not_active Ceased
- 2008-10-10 US US12/682,318 patent/US20100285471A1/en not_active Abandoned
- 2008-10-10 CN CN200880116343.7A patent/CN101861401B/zh not_active Expired - Fee Related
- 2008-10-10 JP JP2010529072A patent/JP5723156B2/ja not_active Expired - Fee Related
- 2008-10-10 CA CA2702241A patent/CA2702241A1/en not_active Abandoned
- 2008-10-10 WO PCT/US2008/079482 patent/WO2009049129A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008310704A1 (en) | 2009-04-16 |
| EP2212440A4 (en) | 2011-04-06 |
| CN103937876A (zh) | 2014-07-23 |
| AU2008310704B2 (en) | 2014-03-20 |
| CN103937876B (zh) | 2016-08-17 |
| CN101861401B (zh) | 2014-03-12 |
| EP2212440A1 (en) | 2010-08-04 |
| WO2009049129A1 (en) | 2009-04-16 |
| CN101861401A (zh) | 2010-10-13 |
| US20100285471A1 (en) | 2010-11-11 |
| JP2011501943A (ja) | 2011-01-20 |
| CA2702241A1 (en) | 2009-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2008310704B2 (en) | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas | |
| JP5401460B2 (ja) | ヒト卵巣癌中のマイクロrnaシグネチャー | |
| CN103866018B (zh) | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 | |
| CN101627134B (zh) | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 | |
| EP2152900B1 (en) | Methods for determining hepatocellular carcinoma subtype | |
| JP5743982B2 (ja) | 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物 | |
| US20110152357A1 (en) | Micro-RNA-Based Compositions and Methods for the Diagnosis, Prognosis and Treatment of Multiple Myeloma | |
| CN103589784A (zh) | 用于诊断和治疗结肠癌相关疾病的基于微小rna的方法和组合物 | |
| CN101809169A (zh) | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111007 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111007 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120806 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130730 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131029 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140604 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140902 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150226 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150327 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5723156 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |