RU2626540C2 - Способы обнаружения патологических изменений в органе или системе органов - Google Patents

Способы обнаружения патологических изменений в органе или системе органов Download PDF

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RU2626540C2
RU2626540C2 RU2013146856A RU2013146856A RU2626540C2 RU 2626540 C2 RU2626540 C2 RU 2626540C2 RU 2013146856 A RU2013146856 A RU 2013146856A RU 2013146856 A RU2013146856 A RU 2013146856A RU 2626540 C2 RU2626540 C2 RU 2626540C2
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mir
mirna
microrna
normalizing
mirnas
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Кира С. ШЕЙНЕРМАН
Владимир ЦИВИНСКИЙ
Самуил Р. УМАНСКИЙ
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Диамир, Ллс
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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RU2013146856A 2011-04-18 2012-04-18 Способы обнаружения патологических изменений в органе или системе органов RU2626540C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161476591P 2011-04-18 2011-04-18
US61/476,591 2011-04-18
US201161478766P 2011-04-25 2011-04-25
US61/478,766 2011-04-25
US201161546431P 2011-10-12 2011-10-12
US61/546,431 2011-10-12
PCT/US2012/034098 WO2012145409A1 (en) 2011-04-18 2012-04-18 miRNA-BASED UNIVERSAL SCREENING TEST (UST)

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RU2013146856A RU2013146856A (ru) 2015-05-27
RU2626540C2 true RU2626540C2 (ru) 2017-07-28

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US (4) US9803242B2 (enExample)
EP (4) EP2699666B1 (enExample)
JP (3) JP6211511B2 (enExample)
CN (3) CN103620057B (enExample)
AU (2) AU2012245580B2 (enExample)
CA (2) CA2833375A1 (enExample)
ES (1) ES2630602T3 (enExample)
RU (1) RU2626540C2 (enExample)
WO (2) WO2012145363A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677280C1 (ru) * 2018-05-17 2019-01-16 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ диагностики многососудистого атеросклеротического поражения коронарных артерий у больных ишемической болезнью сердца при абдоминальном ожирении

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc miRNAに基づくユニバーサルスクリーニングテスト(UST)
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
US20140100124A1 (en) * 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
CN104903468B (zh) 2012-11-16 2019-04-23 萨尔大学 用于帕金森氏病的新诊断MiRNA标志物
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
JP2014128249A (ja) * 2012-12-28 2014-07-10 Hokkaido Univ 神経変性疾患の検査と治療に対するmiRNA又はその標的遺伝子の利用
CN103805693B (zh) * 2013-10-29 2017-01-11 宁夏医科大学 微小分子RNA-508-5p作为抗肿瘤标志物的用途
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
CA2939343A1 (en) * 2014-02-18 2015-08-27 Baylor Research Institute Mir-320e and colorectal cancer
EP4560026A3 (en) * 2014-04-10 2025-08-27 The Trustees of the University of Pennsylvania Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy
CN103937888B (zh) * 2014-04-14 2016-08-17 上海交通大学 鉴别胃癌的血浆microRNA标志物的筛选与应用
WO2015164431A2 (en) * 2014-04-22 2015-10-29 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers
WO2015181825A1 (en) * 2014-05-28 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of glucocorticoid therapy and determining responsiveness thereof
CN111910002B (zh) * 2014-06-18 2024-04-12 东丽株式会社 食道癌的检测试剂盒或装置以及检测方法
WO2016138287A1 (en) * 2015-02-25 2016-09-01 Washington University METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs
AU2016267392B2 (en) * 2015-05-28 2021-12-09 Immunexpress Pty Ltd Validating biomarker measurement
RU2718534C2 (ru) 2015-06-05 2020-04-08 Мираджен Терапьютикс, Инк. Ингибиторы mir-155 для лечения кожной t-клеточной лимфомы (ctcl)
CN104940954B (zh) * 2015-06-23 2017-12-26 同济大学 MicroRNA‑7在制备抗胶质化药物中的应用
CN108026570A (zh) * 2015-09-11 2018-05-11 康宁股份有限公司 从血液样品中纯化核酸的组合物和方法
ES2734678T3 (es) * 2015-12-22 2019-12-11 Siemens Ag Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
WO2017120285A1 (en) * 2016-01-05 2017-07-13 Diamir, Llc METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
WO2017186719A1 (en) * 2016-04-25 2017-11-02 Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk Microrna biomarkers in blood for diagnosis of alzheimer's disease
BR112019005172A2 (pt) * 2016-09-16 2019-07-02 Dyax Corp. método e kit para analisar uma amostra
CN106544435A (zh) * 2016-09-30 2017-03-29 河北医科大学第医院 检测miR‑206所需逆转录引物对在制备预测试剂盒中的应用
GB201616691D0 (en) * 2016-09-30 2016-11-16 King S College London Assay
SG10201709799SA (en) * 2016-11-29 2018-06-28 Helios Bioelectronics Inc Method for quantitatively profiling nucleic acids
US20190345551A1 (en) * 2016-12-28 2019-11-14 National University Corporation Kumamoto University METHOD FOR DETECTING MITOCHONDRIAL tRAN MODIFICATION
WO2018139759A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 알츠하이머병 진단방법
AU2018300159A1 (en) * 2017-07-12 2020-02-06 Texas Tech University System MicroRNA-455-3p as a peripheral biomarker for Alzheimer's disease
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
KR101830583B1 (ko) * 2017-08-11 2018-02-20 주식회사 인피니트헬스케어 Wsi 스트리밍 방법
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
CN107811609B (zh) * 2017-09-22 2020-06-09 中国医学科学院北京协和医院 一种脑老化评估系统
US11377699B2 (en) * 2017-11-30 2022-07-05 Provincial Health Services Authority Methods for evaluating head and neck cancers
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
EP3754019B1 (en) 2018-02-13 2024-01-31 Toray Industries, Inc. Use of a kit or device and method for detecting dementia
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
US11332789B2 (en) 2018-05-21 2022-05-17 Temple University-Of The Commonwealth System Of Higher Education Compositions and methods for diagnosing and treating hyperlipidemia-related diseases
EP3807422B1 (en) 2018-06-15 2025-12-03 Universitat Autònoma de Barcelona Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease
WO2020056418A1 (en) 2018-09-14 2020-03-19 Neuroenhancement Lab, LLC System and method of improving sleep
CN109055541B (zh) * 2018-09-26 2020-08-28 上海市精神卫生中心(上海市心理咨询培训中心) Ad所致mci诊断标志物及其应用
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
US20230256119A1 (en) * 2019-06-17 2023-08-17 Biorchestra Co., Ltd. Compositions and methods for preparing an alzheimer's disease animal model using microrna
US11198908B2 (en) 2019-06-17 2021-12-14 Biorchestra Co., Ltd. Method for diagnosis of Alzheimer's disease using microRNA
CA3175419A1 (en) * 2020-04-23 2021-10-28 Jin-Hyeob RYU Diagnostic methods using mir-485-3p expression
US20220073992A1 (en) * 2020-11-24 2022-03-10 Hossein Abdul Tehrani Abdul Tehrani Diagnosis of chronic kidney disease (ckd) and its subgroups
CN112562867A (zh) * 2021-02-22 2021-03-26 天津迈德新医药科技有限公司 一种预测极早期hiv感染风险的装置、存储介质和电子装置
CN112980954B (zh) * 2021-03-03 2022-02-25 首都医科大学宣武医院 一种预测神经退行性疾病风险的试剂盒及其用途
CN115976194A (zh) * 2022-12-12 2023-04-18 天津市肿瘤医院空港医院 一种基于外泌体微小rna的神经系统疾病诊断方法
WO2025089057A1 (ja) * 2023-10-24 2025-05-01 アークレイ株式会社 スモールrna測定用血液試料の調製方法及び保存方法、スモールrnaの発現量の測定方法、疾患の判定方法、検査方法、モデルの生成方法、検査装置、検査システム、検査プログラム、並びに記録媒体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2367959C1 (ru) * 2008-03-05 2009-09-20 Государственное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" Способ лабораторной диагностики заболеваний ротовой полости по элементному составу слюны
WO2009120877A2 (en) * 2008-03-26 2009-10-01 The Johns Hopkins University Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases
WO2009133915A1 (ja) * 2008-04-30 2009-11-05 日本電気株式会社 癌マーカー、それを用いた癌の評価方法および評価試薬
WO2010117829A2 (en) * 2009-03-31 2010-10-14 The United States Of America As Represented By The Secretary Department Of Health And Human Services Differentially expressed micrornas as biomarkers for the diagnosis and treatment of sjögren's syndrome
WO2011015720A1 (fr) * 2009-07-29 2011-02-10 Centre National De La Recherche Scientifique Utilisation de microarn pour le traitement de pathologies liées à un dysfonctionnement des cils des cellules épithéliales multiciliées

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071A (en) 1847-04-17 George page
US743A (en) 1838-05-17 Improvement in plows
FR2552909B1 (fr) 1983-09-30 1985-11-08 Thomson Csf Appareil indicateur cartographique de relief et son u tilisation pour la navigation aerienne
US4829304A (en) 1986-05-20 1989-05-09 Harris Corp. Map-aided navigation system employing TERCOM-SITAN signal processing
KR940002799B1 (ko) 1986-07-28 1994-04-02 가부시끼가이샤 도요다지도오쇽기 세이사꾸쇼 보텀 드래프트 로울러의 청소장치
US4939663A (en) 1988-04-04 1990-07-03 Harris Corporation Elevation map-referenced mechanism for updating vehicle navigation system estimates
EP0381178A1 (en) 1989-02-02 1990-08-08 Honeywell Inc. Method and apparatus for aircraft navigation
US5071743A (en) 1989-10-27 1991-12-10 Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada Process for conducting site-directed mutagenesis
JP3442774B2 (ja) 1991-07-01 2003-09-02 バーレックス ラボラトリーズ,インコーポレイティド 新規な突然変異誘発法および組成物
US5789166A (en) 1995-12-08 1998-08-04 Stratagene Circular site-directed mutagenesis
US6242222B1 (en) 1996-06-07 2001-06-05 Massachusetts Institute Of Technology Programmed sequential mutagenesis
US5780270A (en) 1996-07-17 1998-07-14 Promega Corporation Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
EP2314688B1 (en) * 2004-11-12 2014-07-16 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
EP1966390A1 (en) 2005-12-29 2008-09-10 Exiqon A/S Detection of tissue origin of cancer
EP2487260B1 (en) * 2006-01-05 2015-07-08 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of solid cancers
WO2007100911A2 (en) 2006-02-28 2007-09-07 University Of Louisville Research Foundation Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
AU2007299828C1 (en) * 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
EP2081442B1 (en) 2006-10-10 2016-08-10 TrovaGene, Inc. Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
US8586725B2 (en) * 2007-02-16 2013-11-19 The Johns Hopkins University MicroRNAome
US20100167948A1 (en) 2007-05-22 2010-07-01 The Brigham And Women's Hospital, Inc. MicroRNA Expression Profiling of Cerebrospinal Fluid
US20090004668A1 (en) 2007-06-22 2009-01-01 The Board Of Trustees Of The Leland Stanford Junior University Pre-miRNA loop-modulated target regulation
WO2009009457A1 (en) 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Alzheimer's disease-specific micro-rna microarray and related methods
KR20100049079A (ko) 2007-07-18 2010-05-11 더 리젠트스 오브 더 유니버시티 오브 콜로라도 인간의 정상 심장과 기능부진 심장에서 마이크로 rna의 차등 발현
CA2676113C (en) 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
CN101861399B (zh) 2007-08-22 2015-11-25 特罗瓦基因公司 使用miRNA检测体内细胞死亡情况的方法
US7653509B2 (en) 2007-08-29 2010-01-26 Verity Software House Probability state models
US7993831B2 (en) * 2007-09-14 2011-08-09 Asuragen, Inc. Methods of normalization in microRNA detection assays
US8455199B2 (en) 2007-09-14 2013-06-04 The Ohio State University Research Foundation MicroRNA expression in human peripheral blood microvesicles and uses thereof
US20100323357A1 (en) 2007-11-30 2010-12-23 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer
EP2604704B1 (en) 2008-02-01 2018-10-03 The General Hospital Corporation Use of microvesicles in diagnosis and prognosis of brain tumor
CA2716906A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer
US20110160285A1 (en) 2008-03-13 2011-06-30 The Regents Of The University Of Colorado Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy
WO2009132273A2 (en) 2008-04-25 2009-10-29 Merck & Co., Inc. Microrna biomarkers of tissue injury
US20110160290A1 (en) 2008-05-21 2011-06-30 Muneesh Tewari Use of extracellular rna to measure disease
US20100167937A1 (en) 2008-07-08 2010-07-01 Power3 Medical Products, Inc. Multiple forms of Alzheimer's disease based on differences in concentrations of protein biomarkers in blood serum
WO2010054386A2 (en) 2008-11-10 2010-05-14 Battelle Memorial Institute Methods, compositions, and devices utilizing microrna to determine physiological conditions
EP3181705A1 (en) * 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
US20110086348A1 (en) 2009-02-19 2011-04-14 The Cleveland Clinic Foundation Method for assessing heart disease
US20100227908A1 (en) * 2009-03-05 2010-09-09 Newcastle Innovation Limited Diagnostic, prognostic and treatment methods
AU2010237191A1 (en) 2009-04-07 2011-11-03 Velin-Pharma A/S Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system
CA2757711A1 (en) 2009-04-14 2010-10-21 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement
JP5898065B2 (ja) 2009-05-20 2016-04-06 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company シリコンウエハの前面上にグリッド電極を形成する方法
US8735074B2 (en) 2009-08-28 2014-05-27 Asuragen, Inc. MiRNA biomarkers of lung disease
EP3118334A1 (en) 2009-11-04 2017-01-18 DiamiR, LLC Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
US8592151B2 (en) * 2009-11-17 2013-11-26 Musc Foundation For Research Development Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids
CN101942502B (zh) 2009-12-24 2014-09-17 北京命码生科科技有限公司 胰腺癌标记物及其检测方法、试剂盒和生物芯片
EP2865765B1 (en) 2010-04-20 2016-08-17 Hummingbird Diagnostics GmbH Complex miRNA sets as novel biomarkers for an acute coronary syndrome
EP2619576B1 (en) 2010-09-24 2020-06-10 Niels Grabe Means and methods for the prediction of treatment response of a cancer patient
CN101962685B (zh) 2010-11-11 2012-09-19 江苏省疾病预防控制中心 一种基于液相芯片检测微小核糖核酸的方法
JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc miRNAに基づくユニバーサルスクリーニングテスト(UST)
US9790554B2 (en) 2011-08-19 2017-10-17 Hummingbird Diagnostics Gmbh Complex sets of miRNAs as non-invasive biomarkers for kidney cancer
US20140302068A1 (en) 2011-09-09 2014-10-09 The Regents Of The University Of Colorado MicroRNA Biomarkers for Diagnosing Parkinson's Disease
US9447471B2 (en) 2011-12-29 2016-09-20 Quest Diagnostics Investments Incorporated Microrna profiling for diagnosis of dysplastic nevi and melanoma
US9540692B2 (en) 2012-07-25 2017-01-10 Rush University Medical Center MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease
US9809857B2 (en) 2013-02-28 2017-11-07 Washington University Methods and signatures for oropharyngeal cancer prognosis
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US9605315B2 (en) 2014-03-26 2017-03-28 The University Of Montana Detection of traumatic brain injury
US9708667B2 (en) 2014-05-13 2017-07-18 Rosetta Genomics, Ltd. MiRNA expression signature in the classification of thyroid tumors
WO2017120285A1 (en) 2016-01-05 2017-07-13 Diamir, Llc METHODS OF USING miRNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEVELOPMENTAL DISORDERS
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
US9933440B2 (en) 2016-05-31 2018-04-03 Edward J. Goetzl Drug efficacy test method for dementias utilizing astrocyte-derived exosomes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2367959C1 (ru) * 2008-03-05 2009-09-20 Государственное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" Способ лабораторной диагностики заболеваний ротовой полости по элементному составу слюны
WO2009120877A2 (en) * 2008-03-26 2009-10-01 The Johns Hopkins University Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases
WO2009133915A1 (ja) * 2008-04-30 2009-11-05 日本電気株式会社 癌マーカー、それを用いた癌の評価方法および評価試薬
WO2010117829A2 (en) * 2009-03-31 2010-10-14 The United States Of America As Represented By The Secretary Department Of Health And Human Services Differentially expressed micrornas as biomarkers for the diagnosis and treatment of sjögren's syndrome
WO2011015720A1 (fr) * 2009-07-29 2011-02-10 Centre National De La Recherche Scientifique Utilisation de microarn pour le traitement de pathologies liées à un dysfonctionnement des cils des cellules épithéliales multiciliées

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677280C1 (ru) * 2018-05-17 2019-01-16 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ диагностики многососудистого атеросклеротического поражения коронарных артерий у больных ишемической болезнью сердца при абдоминальном ожирении

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