CN102725632A - 肺病的miRNA生物标志物 - Google Patents

肺病的miRNA生物标志物 Download PDF

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CN102725632A
CN102725632A CN201080048520XA CN201080048520A CN102725632A CN 102725632 A CN102725632 A CN 102725632A CN 201080048520X A CN201080048520X A CN 201080048520XA CN 201080048520 A CN201080048520 A CN 201080048520A CN 102725632 A CN102725632 A CN 102725632A
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mir
mirna
cancer
lung cancer
mirnas
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E.马姆博
D.布朗
A.T.阿达伊
T.桑福德
S.沃尔兹
A.乔达里
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Asuragen Inc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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CN201080048520XA 2009-08-28 2010-08-27 肺病的miRNA生物标志物 Pending CN102725632A (zh)

Applications Claiming Priority (3)

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US23797209P 2009-08-28 2009-08-28
US61/237,972 2009-08-28
PCT/US2010/046916 WO2011025919A1 (en) 2009-08-28 2010-08-27 Mirna biomarkers of lung disease

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US (2) US8735074B2 (enExample)
EP (2) EP2470897A4 (enExample)
JP (1) JP5995721B2 (enExample)
CN (1) CN102725632A (enExample)
WO (1) WO2011025919A1 (enExample)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103555724A (zh) * 2013-10-24 2014-02-05 浙江理工大学 2型糖尿病的血清miRNA生物标志物及其应用
CN103602678A (zh) * 2013-06-18 2014-02-26 潘世扬 非小细胞肺癌预后检测组合物及其应用
CN103751801A (zh) * 2013-09-10 2014-04-30 上海大学 非小细胞肺癌中miR-143基因的应用
CN104306993A (zh) * 2013-11-26 2015-01-28 上海中医药大学附属岳阳中西医结合医院 循环miR-505在高血压早期诊断及靶器官早期损伤预警作用中的应用
CN104313142A (zh) * 2014-10-16 2015-01-28 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104784704A (zh) * 2015-05-01 2015-07-22 北京泱深生物信息技术有限公司 肺腺癌转移相关的组合物及其应用
CN105087794A (zh) * 2015-08-17 2015-11-25 广东省结核病控制中心 一种检测结核病的试剂盒
CN105561339A (zh) * 2015-12-21 2016-05-11 江苏省人民医院 一种miRNA的组合制备抗非小细胞肺癌药物中的应用
EP3026121A1 (en) * 2014-11-27 2016-06-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Micro-RNA-based diagnosis of tuberculosis
WO2016177343A1 (zh) * 2015-05-05 2016-11-10 江苏命码生物科技有限公司 一种新的前体miRNA及其在肿瘤治疗中的应用
CN106164290A (zh) * 2014-01-05 2016-11-23 拜奥米尔纳控股有限公司 使用mirna比率确定肺癌
WO2017101172A1 (zh) * 2015-12-15 2017-06-22 中国人民解放军第二军医大学 一种适用于后纵韧带骨化诊断的血清miRNA标志物及应用
CN107250378A (zh) * 2015-02-24 2017-10-13 株式会社遗传科技 癌的脑转移的诊断、预防及治疗方法、以及用于通过血脑屏障的药物传输系统
CN107841560A (zh) * 2017-10-27 2018-03-27 广东省实验动物监测所 一种非小细胞肺癌miRNA检测试剂盒及其应用
CN108220427A (zh) * 2018-03-20 2018-06-29 南京大学 一种用于鉴别诊断BHD综合征与原发性自发性气胸的血浆microRNA标记物及应用
WO2018170622A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 一种同步下调微小rna-152和微小rna-185表达的方法
CN108743521A (zh) * 2018-06-01 2018-11-06 临沂大学 一种用于肺癌靶向治疗的rna纳米水凝胶及其制备方法和应用
CN108753770A (zh) * 2018-06-01 2018-11-06 临沂大学 一种用于靶向肺癌治疗的基因纳米探针及其制备方法和应用
CN108841962A (zh) * 2018-08-01 2018-11-20 博奥生物集团有限公司 一种非小细胞肺癌检测试剂盒及其应用
CN109036571A (zh) * 2014-12-08 2018-12-18 20/20基因系统股份有限公司 用于预测患有癌症的可能性或风险的方法和机器学习系统
CN113373216A (zh) * 2021-07-13 2021-09-10 南京迈迪森亚生物科技有限公司 一种同时定量检测血清中3种急性心肌梗死相关microRNA荧光探针的制备方法
CN114214422A (zh) * 2020-03-30 2022-03-22 中国医学科学院肿瘤医院 用于肺癌诊断的试剂盒、装置及方法
CN114525331A (zh) * 2021-11-23 2022-05-24 中山大学 一种快速识别重症肺炎的检测产品
CN114767865A (zh) * 2022-05-12 2022-07-22 中南大学湘雅医院 血浆外泌体对aaad伴肺损伤药物研制中应用
CN117248029A (zh) * 2023-11-17 2023-12-19 北京热景生物技术股份有限公司 一种基于外泌体miRNA的肝癌诊断标志物及其应用

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1874962A2 (en) 2005-04-14 2008-01-09 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
EP2605018A1 (en) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
CN101990577A (zh) 2007-09-19 2011-03-23 波士顿大学理事会 鉴定肺病药物开发的新途径
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US20100240049A1 (en) 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
EP2505663A1 (en) 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids
WO2012103355A2 (en) 2011-01-26 2012-08-02 Cepheid Methods of detecting lung cancer
JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ）
EE201100037A (et) 2011-05-16 2012-12-17 Tartu Ülikool MikroRNAde kasutamine biomarkeritena ja sihtm„rkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks
CN102851282B (zh) * 2011-06-30 2014-10-08 上海市肿瘤研究所 用于区分原发性肺癌与癌旁组织的microRNA标志物
CN102851283B (zh) * 2011-06-30 2014-07-30 上海市肿瘤研究所 用于区分转移与非转移肺鳞癌的microRNA标志物
EP2739734A1 (en) 2011-08-03 2014-06-11 The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System Treatment of fibrosis using microrna-19b
WO2013022953A2 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof
WO2013033640A1 (en) * 2011-09-01 2013-03-07 Allegro Diagnostics Corp. Methods and compositions for detecting cancer based on mirna expression profiles
US9745578B2 (en) 2011-11-30 2017-08-29 Cedars-Sinai Medical Center Targeting microRNA miR-409-3P to treat prostate cancer
US9753043B2 (en) 2011-12-18 2017-09-05 20/20 Genesystems, Inc. Methods and algorithms for aiding in the detection of cancer
CN102533983A (zh) * 2011-12-19 2012-07-04 苏州福英基因科技有限公司 癌症病理演变前期microrna-330水平原位杂交检测试剂盒及检测方法和应用
US9850541B2 (en) 2011-12-19 2017-12-26 Valley Health System Methods and kits for detecting subjects at risk of having cancer
US20150057173A1 (en) 2012-03-19 2015-02-26 Prestizia Methods for determining the tropism and receptor usage of a virus, in particular hiv, in body samples taken from the circulation
CN102743765A (zh) * 2012-05-24 2012-10-24 上海大学 非小细胞肺癌中miR-10a基因的应用
US10526655B2 (en) 2013-03-14 2020-01-07 Veracyte, Inc. Methods for evaluating COPD status
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US10781491B2 (en) 2014-03-16 2020-09-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. MicroRNA signature for predicting progression of Barrett's esophagus
CN103937826B (zh) * 2014-04-04 2016-04-06 东华大学 一种中枢神经系统中特异表达miR-505的载体的制备方法
FR3019901B1 (fr) * 2014-04-09 2020-10-30 Bio Rad Innovations Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots
CN106471132B (zh) 2014-06-18 2020-09-22 东丽株式会社 肺癌的检测试剂盒或装置以及检测方法
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
WO2016059241A2 (en) * 2014-10-17 2016-04-21 Biomirna Holdings Ltd. Lung cancer diagnostics and therapeutics with mir-660
EP3770274A1 (en) 2014-11-05 2021-01-27 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
WO2016071729A1 (en) * 2014-11-05 2016-05-12 Biomirna Holdings, Ltd. Methods of using micro-rna biomarkers for haemolysis detection
CN105457041B (zh) * 2015-12-09 2020-09-08 上海大学 miR-26a在非小细胞肺癌中的应用
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
ES2646826B1 (es) * 2016-05-13 2018-10-01 Servicio Andaluz De Salud MicroARNs como biomarcadores para el diagnóstico del cáncer de pulmón
US10927417B2 (en) 2016-07-08 2021-02-23 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
WO2018187624A1 (en) * 2017-04-06 2018-10-11 The United States Government As Represented By The Department Of Veterans Affairs Methods of detecting lung cancer
EP3631808B1 (en) 2017-05-31 2024-09-11 Koninklijke Philips N.V. Machine learning on raw medical imaging data for clinical decision support
CA3059119C (en) * 2017-05-31 2024-01-23 F. Hoffman-La Roche Ag Multiplex pcr detection of alk, ret, and ros fusions
EP3647422B1 (en) 2017-06-29 2024-07-24 Toray Industries, Inc. Kit, device, and method for lung cancer detection
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
KR102190910B1 (ko) * 2019-05-24 2020-12-15 한국과학기술연구원 miR-195 또는 miR-497를 활용한 폐암 치료제의 스크리닝 방법
EP4257982A3 (en) * 2019-08-26 2024-03-06 Liquid Lung DX Biomarkers for the diagnosis of lung cancers
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
JP7392224B2 (ja) * 2020-02-19 2023-12-06 国立医薬品食品衛生研究所長 びまん性肺胞傷害型薬剤性間質性肺炎のｍｉＲＮＡ診断バイオマーカー
WO2022272269A1 (en) * 2021-06-22 2022-12-29 The Curators Of The University Of Missouri Multianalyte biomarkers for lung cancer
CN117106919B (zh) * 2023-10-25 2024-01-23 上海秤信生物科技有限公司 外泌体miRNA组合在早期肺癌检测中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713619B1 (en) 1980-08-29 2004-03-30 Massachusetts Institute Of Technology Oncogenes and methods for their detection
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
ES2141088T3 (es) 1990-02-16 2000-03-16 Hoffmann La Roche Mejoras en la especificidad y conveniencia de la reaccion en cadena de la polimerasa.
US5965364A (en) 1990-10-09 1999-10-12 Benner; Steven Albert Method for selecting functional deoxyribonucleotide derivatives
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5413924A (en) 1992-02-13 1995-05-09 Kosak; Kenneth M. Preparation of wax beads containing a reagent for release by heating
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
CA2168712A1 (en) 1995-02-07 1996-08-08 John William Henderson Sutherland Use of exonuclease and/or glycosylase as supplements to anti-polymerase antibody to increase specificity in polymerase chain reaction
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5863727A (en) 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
EP1025120B1 (en) 1997-10-27 2010-08-18 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US20060204989A1 (en) 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US6140054A (en) 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6383752B1 (en) 1999-03-31 2002-05-07 Hybridon, Inc. Pseudo-cyclic oligonucleobases
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
US6140500A (en) 1999-09-03 2000-10-31 Pe Corporation Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US6191278B1 (en) 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US6403341B1 (en) 2001-08-02 2002-06-11 Wayne M. Barnes Magnesium precipitate hot start method for PCR
WO2003020739A2 (en) 2001-09-04 2003-03-13 Exiqon A/S Novel lna compositions and uses thereof
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
CA2554818A1 (en) * 2004-02-09 2005-08-25 Thomas Jefferson University Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
EP2290071B1 (en) 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
US20090186353A1 (en) * 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
US20060078894A1 (en) 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
WO2007081720A2 (en) 2006-01-05 2007-07-19 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US20090215865A1 (en) * 2006-01-10 2009-08-27 Plasterk Ronald H A Nucleic Acid Molecules and Collections Thereof, Their Application and Identification
US7955848B2 (en) * 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
AU2007299828C1 (en) * 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
WO2008147974A1 (en) * 2007-05-23 2008-12-04 University Of South Florida Micro-rnas modulating immunity and inflammation
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
US7993831B2 (en) 2007-09-14 2011-08-09 Asuragen, Inc. Methods of normalization in microRNA detection assays
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
CN101424640B (zh) 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
EP2227556B1 (en) * 2007-11-19 2014-08-27 Celera Corporation Lung cancer markers and uses thereof
US20100323357A1 (en) * 2007-11-30 2010-12-23 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer
WO2010004562A2 (en) 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer

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