JP2010532774A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010532774A5 JP2010532774A5 JP2010515398A JP2010515398A JP2010532774A5 JP 2010532774 A5 JP2010532774 A5 JP 2010532774A5 JP 2010515398 A JP2010515398 A JP 2010515398A JP 2010515398 A JP2010515398 A JP 2010515398A JP 2010532774 A5 JP2010532774 A5 JP 2010532774A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- use according
- head
- lymphocytic leukemia
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 210000003128 head Anatomy 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007032507A DE102007032507A1 (de) | 2007-07-12 | 2007-07-12 | Pyridazinonderivate |
| DE102007032507.1 | 2007-07-12 | ||
| PCT/EP2008/003473 WO2009006959A1 (de) | 2007-07-12 | 2008-04-29 | Pyridazinonderivate |
| EPPCT/EP2008/003473 | 2008-04-29 | ||
| PCT/EP2008/005508 WO2009007074A1 (de) | 2007-07-12 | 2008-07-04 | Pyrimidinyl-pyridazinonderivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532774A JP2010532774A (ja) | 2010-10-14 |
| JP2010532774A5 true JP2010532774A5 (OSRAM) | 2011-08-18 |
| JP5426544B2 JP5426544B2 (ja) | 2014-02-26 |
Family
ID=39638671
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515355A Active JP5426543B2 (ja) | 2007-07-12 | 2008-04-29 | ピリダジノン誘導体 |
| JP2010515398A Active JP5426544B2 (ja) | 2007-07-12 | 2008-07-04 | ピリミジニル−ピリダジノン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515355A Active JP5426543B2 (ja) | 2007-07-12 | 2008-04-29 | ピリダジノン誘導体 |
Country Status (36)
| Country | Link |
|---|---|
| US (8) | US8580781B2 (OSRAM) |
| EP (3) | EP2754660B1 (OSRAM) |
| JP (2) | JP5426543B2 (OSRAM) |
| KR (2) | KR101553418B1 (OSRAM) |
| CN (2) | CN101743241B (OSRAM) |
| AR (2) | AR066543A1 (OSRAM) |
| AU (2) | AU2008274670B2 (OSRAM) |
| BR (2) | BRPI0814616B1 (OSRAM) |
| CA (2) | CA2693600C (OSRAM) |
| CL (1) | CL2008001392A1 (OSRAM) |
| CO (2) | CO6170360A2 (OSRAM) |
| CY (4) | CY1113137T1 (OSRAM) |
| DE (1) | DE102007032507A1 (OSRAM) |
| DK (3) | DK2164843T3 (OSRAM) |
| EA (2) | EA016782B1 (OSRAM) |
| EC (2) | ECSP109953A (OSRAM) |
| ES (3) | ES2614283T3 (OSRAM) |
| FR (1) | FR22C1024I2 (OSRAM) |
| HR (3) | HRP20150031T1 (OSRAM) |
| HU (2) | HUE030519T2 (OSRAM) |
| IL (2) | IL203094A (OSRAM) |
| LT (2) | LT2754660T (OSRAM) |
| LU (1) | LUC00264I2 (OSRAM) |
| MY (2) | MY153727A (OSRAM) |
| NL (1) | NL301176I2 (OSRAM) |
| NO (1) | NO2022015I1 (OSRAM) |
| NZ (1) | NZ583187A (OSRAM) |
| PE (1) | PE20090287A1 (OSRAM) |
| PL (3) | PL2164843T3 (OSRAM) |
| PT (3) | PT2754660T (OSRAM) |
| SG (1) | SG183739A1 (OSRAM) |
| SI (3) | SI2164843T1 (OSRAM) |
| TW (1) | TWI501768B (OSRAM) |
| UA (2) | UA99621C2 (OSRAM) |
| WO (2) | WO2009006959A1 (OSRAM) |
| ZA (1) | ZA201001023B (OSRAM) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007041115A1 (de) * | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | Thiadiazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| EA019320B1 (ru) * | 2008-12-22 | 2014-02-28 | Мерк Патент Гмбх | Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения |
| DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| KR101829595B1 (ko) * | 2009-01-08 | 2018-02-14 | 메르크 파텐트 게엠베하 | 3-（1-｛3-［5-（1-메틸-피페리딘-4일메톡시）-피리미딘-2-일］-벤질｝-6-옥소-1,6-디히드로-피리다진-3-일）-벤조니트릴 히드로클로라이드 염의 신규한 다형체 및 이의 제조 방법 |
| EP2221053A1 (de) * | 2009-02-20 | 2010-08-25 | Albert-Ludwigs-Universität Freiburg | Pharmazeutische Zusammensetzung enthaltend Hemmstoffe der Proteinmethyltransferase I und deren Verwendung zur Behandlung von Tumorerkrankungen |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| DE102011101482B4 (de) | 2011-05-13 | 2017-05-11 | Thyssenkrupp Presta Aktiengesellschaft | Sensoranordnung für eine drehbare Welle |
| CA2867637A1 (en) * | 2012-03-19 | 2013-09-26 | Merck Patent Gmbh | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with other anti-tumor compounds |
| KR101842645B1 (ko) * | 2012-04-12 | 2018-03-29 | 한국화학연구원 | 신규한 히드라진온이 치환된 피리미딘 유도체 및 그의 용도 |
| EP2906294B1 (en) * | 2012-10-11 | 2018-04-18 | Merck Patent GmbH | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor |
| RU2650679C2 (ru) * | 2012-11-02 | 2018-04-17 | Мерк Патент Гмбх | Производное 6-оксо-1,6-дигидропиридазина для применения в лечении гепатоцеллюлярной карциномы (гцк) |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| AU2013365926B9 (en) * | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| US9567320B2 (en) * | 2013-02-07 | 2017-02-14 | Merck Patent Gmbh | Pyridazinone-amides derivatives |
| SI3010503T1 (sl) | 2013-06-21 | 2020-07-31 | Zenith Epigenetics Ltd. | Novi biciklični inhibitorji bromodomene |
| ES2661437T3 (es) | 2013-06-21 | 2018-04-02 | Zenith Epigenetics Corp. | Nuevos compuestos bicíclicos sustituidos como inhibidores de bromodominio |
| CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
| PE20161065A1 (es) * | 2013-10-18 | 2016-11-19 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| HUE045209T2 (hu) * | 2013-12-04 | 2019-12-30 | Galmed Res & Development Ltd | Aramchol-sók |
| CA2935892C (en) * | 2014-01-07 | 2022-08-02 | Merck Patent Gmbh | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with gefitinib |
| AU2014377079A1 (en) * | 2014-01-07 | 2016-08-18 | Merck Patent Gmbh | A 6-oxo-1,6-dihydro-pyridazine derivative for the use for the treatment of renal cell carcinoma (RCC) |
| US9919034B2 (en) | 2014-03-28 | 2018-03-20 | Tamir Biotechnology, Inc. | Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V |
| CA2944187C (en) * | 2014-04-01 | 2018-06-19 | Merck Sharp & Dohme Corp. | Prodrugs of hiv reverse transcriptase inhibitors |
| US9642794B2 (en) * | 2014-08-18 | 2017-05-09 | Tamir Biotechnology, Inc. | Antiviral pharmaceutical for topical administration |
| US10835598B2 (en) | 2014-08-18 | 2020-11-17 | Orgenesis Inc. | Prophylactic protection against viral infections, particularly HIV |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| TWI695837B (zh) | 2014-12-04 | 2020-06-11 | 比利時商健生藥品公司 | 作為激酶調節劑之三唑並嗒 |
| ES2764299T3 (es) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Anticuerpos monoclonales humanos contra AXL |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| AU2015360006B2 (en) * | 2014-12-11 | 2020-07-16 | Merck Patent Gmbh | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative |
| KR20170090499A (ko) * | 2014-12-12 | 2017-08-07 | 메르크 파텐트 게엠베하 | Ｅｇｆｒ 억제제와 항암 활성을 갖는 6-옥소-1,6-디히드로-피리다진 유도체의 조합 |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| WO2016192831A1 (en) | 2015-05-29 | 2016-12-08 | Merck Patent Gmbh | Compositions of anions and cations with pharmacological activity |
| EP3307238A1 (en) | 2015-06-15 | 2018-04-18 | Tamir Biotechnology, Inc. | Pharmaceuticals for treatment of viral infections of the eye |
| US10501443B2 (en) * | 2016-10-27 | 2019-12-10 | Fujian Cosunter Pharmaceutical Co., Ltd. | Pyridone compound as c-met inhibitor |
| US11104690B2 (en) | 2016-11-18 | 2021-08-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| MX2020001425A (es) | 2017-08-04 | 2020-08-06 | Skyhawk Therapeutics Inc | Metodos y composiciones para modular el empalme. |
| ES2946551T3 (es) | 2017-10-17 | 2023-07-20 | Palau Pharma S L U | Síntesis de compuestos de 4-aminopirimidina |
| WO2019101178A1 (zh) | 2017-11-24 | 2019-05-31 | 南京明德新药研发股份有限公司 | 作为c-MET/AXL抑制剂的尿嘧啶类化合物 |
| IL278281B2 (en) | 2018-04-26 | 2025-01-01 | Fujian Cosunter Pharmaceutical Co Ltd | Crystalline form of C–MET inhibitor and its salt form and method for preparing them |
| CN108752322A (zh) * | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
| EP4248972A3 (en) | 2018-11-06 | 2023-12-06 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| DK3877376T3 (da) | 2018-11-06 | 2023-10-02 | Edgewise Therapeutics Inc | Pyridazinonforbindelser og anvendelser deraf |
| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| BR112021011894A2 (pt) | 2018-12-21 | 2021-09-08 | Daiichi Sankyo Company, Limited | Composição farmacêutica |
| WO2020156453A1 (zh) * | 2019-02-01 | 2020-08-06 | 南京明德新药研发有限公司 | 作为c-Met抑制剂的含嘧啶基团的三并环类化合物 |
| CN114007613A (zh) | 2019-02-05 | 2022-02-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| JP7603595B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| EP3941475A4 (en) * | 2019-03-20 | 2023-01-25 | Goldfinch Bio, Inc. | PYRIDAZINONES AND METHODS OF USE THEREOF |
| LT3996688T (lt) * | 2019-07-10 | 2023-12-27 | Merck Patent Gmbh | Farmacinis preparatas |
| CN114174298B (zh) * | 2019-08-14 | 2023-08-01 | 正大天晴药业集团南京顺欣制药有限公司 | 哒嗪酮并嘧啶类衍生物及其医药用途 |
| WO2022063869A2 (en) | 2020-09-24 | 2022-03-31 | Merck Patent Gmbh | Compounds for the treatment of viral infections |
| WO2022250350A1 (ko) * | 2021-05-26 | 2022-12-01 | 주식회사 이노큐어테라퓨틱스 | 피페리딘디온 유도체 |
| KR102489160B1 (ko) * | 2021-05-26 | 2023-01-18 | 주식회사 이노큐어테라퓨틱스 | 피페리딘디온 유도체 |
| CA3222061A1 (en) | 2021-06-04 | 2022-12-08 | Merck Patent Gmbh | Compounds for the treatment of glioblastoma |
| EP4433473A1 (en) * | 2021-11-17 | 2024-09-25 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| CN114394957B (zh) * | 2021-12-24 | 2023-05-09 | 武汉九州钰民医药科技有限公司 | Met抑制剂盐酸特泊替尼的制备方法 |
| CN119654152A (zh) | 2022-07-08 | 2025-03-18 | 阿斯利康(瑞典)有限公司 | 与hgf-受体抑制剂组合用于治疗癌症的表皮生长因子受体酪氨酸激酶抑制剂 |
| CN116496253B (zh) * | 2022-08-19 | 2024-10-11 | 中国人民解放军军事科学院军事医学研究院 | c-MET蛋白靶向降解剂及其医药应用 |
| CN115583939A (zh) * | 2022-11-04 | 2023-01-10 | 苏州莱安医药化学技术有限公司 | 一种特泊替尼中间体的合成方法 |
| WO2024112119A1 (ko) * | 2022-11-22 | 2024-05-30 | 주식회사 이노큐어테라퓨틱스 | cMET 단백질을 분해하는 디그레이더 및 이를 포함하는 약학 조성물 |
| JP2025538555A (ja) * | 2022-11-22 | 2025-11-28 | イノキュア セラピューティクス，インコーポレイテッド | 新規のｃ－ｍｅｔタンパク質リガンドを含む分解剤およびそれを含む薬学的組成物 |
| CN116082309B (zh) * | 2023-01-04 | 2023-10-24 | 广东莱恩医药研究院有限公司 | 嘧啶衍生物1d228盐酸盐晶型及其制备方法和应用 |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
| CN118084871B (zh) * | 2024-04-29 | 2024-07-09 | 中国药科大学 | 一种靶向降解c-Met蛋白的化合物及其制法和应用 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3853946A (en) | 1971-11-11 | 1974-12-10 | Hoffmann La Roche | Process for the preparation of aminomethylene malononitrile |
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| PT885198E (pt) | 1996-03-05 | 2002-06-28 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| JPH10259176A (ja) | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | 血管新生阻害作用を有する新規アミド誘導体及びその用途 |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| NZ504045A (en) | 1997-11-19 | 2001-06-29 | Kowa Co | Pyridazine derivatives with inhibitory action against interleukin-1-beta production |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AUPQ462299A0 (en) | 1999-12-13 | 2000-01-13 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| US6242461B1 (en) * | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
| DE10010422A1 (de) | 2000-03-03 | 2001-09-06 | Bayer Ag | 6-Carboxyphenylpyridazinon-Derivate und ihre Verwendung |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| EP1463509A1 (en) | 2001-10-31 | 2004-10-06 | MERCK PATENT GmbH | Type 4 phosphodiesterase inhibitors and uses thereof |
| JP2005519895A (ja) * | 2002-01-18 | 2005-07-07 | ファルマシア・コーポレーション | Ｐ３８阻害剤としての置換ピリダジノン |
| UA77526C2 (en) | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| AU2003301226A1 (en) | 2002-12-20 | 2004-07-22 | Pharmacia Corp | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
| JP2007516180A (ja) | 2003-07-02 | 2007-06-21 | スゲン，インコーポレイティド | ｃ−Ｍｅｔ阻害薬としてのアリールメチルトリアゾロおよびイミダゾピラジン類 |
| US7959919B2 (en) * | 2003-11-19 | 2011-06-14 | Novelmed Therapeutics, Inc. | Method of inhibiting factor B-mediated complement activation |
| US20070015771A1 (en) * | 2004-07-29 | 2007-01-18 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
| WO2006015263A2 (en) | 2004-07-29 | 2006-02-09 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
| US20070043057A1 (en) * | 2005-02-09 | 2007-02-22 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
| WO2007044796A2 (en) | 2005-10-11 | 2007-04-19 | Nps Pharmaceuticals, Inc. | Pyridazinone compounds as calcilytics |
| DE102005055354A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine |
| DE102005055355A1 (de) | 2005-11-21 | 2007-10-31 | Merck Patent Gmbh | 3,6-Dihydro-2-oxo-6H-[1,3,4]thiadiazinderivate |
| JP5144532B2 (ja) | 2005-11-30 | 2013-02-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｃ−Ｍｅｔ阻害剤及び用法 |
| DE102005057924A1 (de) | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| AU2006331912B2 (en) * | 2005-12-21 | 2012-08-30 | Janssen Pharmaceutica, N.V. | Triazolopyridazines as tyrosine kinase modulators |
| WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
| NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| PE20121506A1 (es) * | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| DE102007026341A1 (de) * | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| US20090099199A1 (en) | 2007-10-16 | 2009-04-16 | Joachim Nozulak | Organic compounds |
| AU2008315746A1 (en) | 2007-10-25 | 2009-04-30 | Astrazeneca Ab | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
| CA2699631A1 (en) * | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone compounds and p2x7 receptor inhibitors |
| CA2704628C (en) | 2007-11-16 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| EP2242483B1 (en) | 2007-12-21 | 2013-02-20 | Synthon B.V. | Raloxifene composition |
| US8003649B2 (en) | 2007-12-21 | 2011-08-23 | Astrazeneca Ab | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 |
| WO2009080533A1 (en) | 2007-12-21 | 2009-07-02 | F. Hoffmann-La Roche Ag | Heteroaryl derivatives as orexin receptor antagonists |
| RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
| TW200930375A (en) | 2007-12-21 | 2009-07-16 | Exelixis Inc | Benzofuropyrimidinones |
| CL2008003785A1 (es) | 2007-12-21 | 2009-10-09 | Du Pont | Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada. |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| RU2489430C2 (ru) | 2007-12-21 | 2013-08-10 | Палау Фарма, С.А. | Производные 4-аминопиримидина |
| US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| US7816540B2 (en) | 2007-12-21 | 2010-10-19 | Hoffmann-La Roche Inc. | Carboxyl- or hydroxyl-substituted benzimidazole derivatives |
| EP2072506A1 (de) | 2007-12-21 | 2009-06-24 | Bayer CropScience AG | Thiazolyloxyphenylamidine oder Thiadiazolyloxyphenylamidine und deren Verwendung als Fungizide |
| GB0725059D0 (en) | 2007-12-21 | 2008-01-30 | Syngenta Participations Ag | Novel pyridazine derivatives |
| PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| CN101538245B (zh) * | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| EP2328586A2 (en) * | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| JP5390610B2 (ja) * | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| US20120028988A1 (en) * | 2009-03-30 | 2012-02-02 | Sumitomo Chemical Company, Limited | Use of pyridazinone compound for control of harmful arthropod pests |
| AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
-
2007
- 2007-07-12 DE DE102007032507A patent/DE102007032507A1/de not_active Withdrawn
-
2008
- 2008-04-29 US US12/668,535 patent/US8580781B2/en active Active
- 2008-04-29 MY MYPI2010000066A patent/MY153727A/en unknown
- 2008-04-29 SI SI200831367T patent/SI2164843T1/sl unknown
- 2008-04-29 SI SI200831759A patent/SI2754660T1/sl unknown
- 2008-04-29 ES ES14001269T patent/ES2614283T3/es active Active
- 2008-04-29 PL PL08758359T patent/PL2164843T3/pl unknown
- 2008-04-29 PT PT140012691T patent/PT2754660T/pt unknown
- 2008-04-29 CN CN2008800241496A patent/CN101743241B/zh active Active
- 2008-04-29 EP EP14001269.1A patent/EP2754660B1/de active Active
- 2008-04-29 AU AU2008274670A patent/AU2008274670B2/en active Active
- 2008-04-29 SG SG2012061180A patent/SG183739A1/en unknown
- 2008-04-29 PL PL14001269T patent/PL2754660T3/pl unknown
- 2008-04-29 UA UAA201000999A patent/UA99621C2/ru unknown
- 2008-04-29 PT PT87583597T patent/PT2164843E/pt unknown
- 2008-04-29 KR KR1020107002999A patent/KR101553418B1/ko active Active
- 2008-04-29 EA EA201000093A patent/EA016782B1/ru unknown
- 2008-04-29 JP JP2010515355A patent/JP5426543B2/ja active Active
- 2008-04-29 BR BRPI0814616-0A patent/BRPI0814616B1/pt active IP Right Grant
- 2008-04-29 WO PCT/EP2008/003473 patent/WO2009006959A1/de not_active Ceased
- 2008-04-29 HU HUE14001269A patent/HUE030519T2/en unknown
- 2008-04-29 DK DK08758359.7T patent/DK2164843T3/en active
- 2008-04-29 CA CA2693600A patent/CA2693600C/en active Active
- 2008-04-29 DK DK14001269.1T patent/DK2754660T3/en active
- 2008-04-29 EP EP08758359.7A patent/EP2164843B1/de active Active
- 2008-04-29 ES ES08758359T patent/ES2526352T3/es active Active
- 2008-04-29 HR HRP20150031AT patent/HRP20150031T1/hr unknown
- 2008-04-29 LT LTEP14001269.1T patent/LT2754660T/lt unknown
- 2008-04-29 NZ NZ583187A patent/NZ583187A/en unknown
- 2008-05-12 PE PE2008000825A patent/PE20090287A1/es active IP Right Grant
- 2008-05-12 CL CL2008001392A patent/CL2008001392A1/es unknown
- 2008-05-13 AR ARP080102013A patent/AR066543A1/es active IP Right Grant
- 2008-05-13 TW TW097117607A patent/TWI501768B/zh active
- 2008-07-04 AU AU2008274534A patent/AU2008274534B2/en active Active
- 2008-07-04 MY MYPI2010000061A patent/MY163477A/en unknown
- 2008-07-04 EA EA201000094A patent/EA017281B1/ru unknown
- 2008-07-04 WO PCT/EP2008/005508 patent/WO2009007074A1/de not_active Ceased
- 2008-07-04 PT PT08773881T patent/PT2164844E/pt unknown
- 2008-07-04 DK DK08773881.1T patent/DK2164844T3/da active
- 2008-07-04 HR HRP20120661AT patent/HRP20120661T1/hr unknown
- 2008-07-04 EP EP08773881A patent/EP2164844B1/de active Active
- 2008-07-04 SI SI200830754T patent/SI2164844T1/sl unknown
- 2008-07-04 PL PL08773881T patent/PL2164844T3/pl unknown
- 2008-07-04 CN CN2008800230561A patent/CN101687857B/zh active Active
- 2008-07-04 KR KR1020107003000A patent/KR101544624B1/ko active Active
- 2008-07-04 ES ES08773881T patent/ES2388883T3/es active Active
- 2008-07-04 JP JP2010515398A patent/JP5426544B2/ja active Active
- 2008-07-04 US US12/668,491 patent/US8329692B2/en active Active
- 2008-07-04 UA UAA201001004A patent/UA99833C2/ru unknown
- 2008-07-04 BR BRPI0813707-2A patent/BRPI0813707B1/pt active IP Right Grant
- 2008-07-04 CA CA2692867A patent/CA2692867C/en active Active
- 2008-07-11 AR ARP080102976A patent/AR067505A1/es active IP Right Grant
-
2009
- 2009-12-02 CO CO09137749A patent/CO6170360A2/es active IP Right Grant
- 2009-12-03 CO CO09138245A patent/CO6270257A2/es active IP Right Grant
- 2009-12-31 IL IL203094A patent/IL203094A/en active IP Right Grant
- 2009-12-31 IL IL203091A patent/IL203091A/en active IP Right Grant
-
2010
- 2010-02-09 EC EC2010009953A patent/ECSP109953A/es unknown
- 2010-02-10 EC EC2010009957A patent/ECSP109957A/es unknown
- 2010-02-11 ZA ZA2010/01023A patent/ZA201001023B/en unknown
-
2012
- 2012-08-03 US US13/565,914 patent/US8658643B2/en active Active
- 2012-09-13 CY CY20121100840T patent/CY1113137T1/el unknown
-
2013
- 2013-03-05 US US13/785,471 patent/US8921357B2/en active Active
- 2013-03-05 US US13/785,580 patent/US8927540B2/en active Active
-
2014
- 2014-01-07 US US14/149,110 patent/US9062029B2/en active Active
- 2014-09-25 US US14/496,746 patent/US9284300B2/en active Active
-
2015
- 2015-01-15 CY CY20151100033T patent/CY1115925T1/el unknown
- 2015-01-22 US US14/602,921 patent/US9403799B2/en active Active
-
2017
- 2017-01-20 HR HRP20170100TT patent/HRP20170100T1/hr unknown
- 2017-01-26 CY CY20171100120T patent/CY1118498T1/el unknown
-
2022
- 2022-05-13 NO NO2022015C patent/NO2022015I1/no unknown
- 2022-05-20 LT LTPA2022009C patent/LTC2164843I2/lt unknown
- 2022-05-25 HU HUS2200024C patent/HUS2200024I1/hu unknown
- 2022-05-25 LU LU00264C patent/LUC00264I2/fr unknown
- 2022-05-30 NL NL301176C patent/NL301176I2/nl unknown
- 2022-06-02 FR FR22C1024C patent/FR22C1024I2/fr active Active
- 2022-06-10 CY CY2022017C patent/CY2022017I2/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010532774A5 (OSRAM) | ||
| JP2010536719A5 (OSRAM) | ||
| JP2012513418A5 (OSRAM) | ||
| Singh et al. | Carbon nanotubes in hyperthermia therapy | |
| JP2010507578A5 (OSRAM) | ||
| JP2012532901A5 (OSRAM) | ||
| JP2008526765A5 (OSRAM) | ||
| JP2013538825A5 (OSRAM) | ||
| JP2010507577A5 (OSRAM) | ||
| RU2013134359A (ru) | Комбинированная терапия с применением индуктора и ингибитора аутофагии для лечения новообразований | |
| JP2017505782A5 (OSRAM) | ||
| TWD122746S1 (zh) | 高爾夫球桿握把 | |
| JP2015524462A5 (OSRAM) | ||
| CN112888458A (zh) | Cldn18的抗体和化疗药物的联合治疗 | |
| NZ588587A (en) | Methods and agents for the diagnosis and treatment of hepatocellular carcinoma | |
| JP2011516501A5 (OSRAM) | ||
| JP2013520431A5 (OSRAM) | ||
| JP2016520057A5 (OSRAM) | ||
| JP2012162567A5 (OSRAM) | ||
| JP2015519396A5 (OSRAM) | ||
| JP2008154589A5 (OSRAM) | ||
| JP2013528215A5 (OSRAM) | ||
| JP2017536397A5 (OSRAM) | ||
| JP2013537228A5 (OSRAM) | ||
| JP2011520996A5 (OSRAM) |