ES2526352T3 - Derivados de piridazinona - Google Patents
Derivados de piridazinona Download PDFInfo
- Publication number
- ES2526352T3 ES2526352T3 ES08758359T ES08758359T ES2526352T3 ES 2526352 T3 ES2526352 T3 ES 2526352T3 ES 08758359 T ES08758359 T ES 08758359T ES 08758359 T ES08758359 T ES 08758359T ES 2526352 T3 ES2526352 T3 ES 2526352T3
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- nhet
- conr3
- nhconh
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- nhet1
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Oncology (AREA)
Abstract
Compuestos de la fórmula I**Fórmula** en donde R1 representa Ar o Het, R2 representa un heterociclo insaturado, saturado o aromático de 6 miembros con 1 a 4 átomos de N-, O- y/o S, que es mono-, di- o tri- sustituido por N>=CR3N(R3)2, SR3, NO2, CN, COOR3; CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, [C(R3)2]nN(R3)2, [C(R3)2]nHet, O[C(R3)2]pOR3, O[C(R3)2]nN(R3)2, O[C(R3)2]nC>=C[C(R3)2]nN(R3)2, O[C(R3)2]nN+O-(R3)2, O[C(R3)2]nHet, S[C(R3)2]nN(R3)2, S[C(R3)2]nHet, NR3[C(R3)2]nN(R3)2, NR3[C(R3)2]nHet, NHCON(R3)2, NHCONH[C(R3)2]nN(R3)2, NHCONH[C(R3)2]nHet, [C(R3)2]nNHCO[C(R3)2]nN(R3)2, [C(R3)2]nNHCO[C(R3)2]nHet, CON(R3)2, CONR3[C(R3)2]nN(R3)2, CONR3[C(R3)2]nNR3COOA, CONR3[C(R3) 2]nOR3, CONR3[C(R3)2]nHet, COHet, COA, CH>=CH-COOR3 y/o CH>=CH-N(R3)2, R3 representa H o A, R4, R4, respectivamente de forma independiente el uno del otro, representan H, Hal, A, OR3, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2 ó S(O)mA, Ar representa fenilo, naftilo o bifenilo no sustituido o mono-, di- o tri- sustituido por Hal, A, [C(R3)2]nOR3, [C(R3)2]nN(R3)2, SR3, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, CO-Het, Het, O[C(R3)2]nN(R3)2. O[C(R3)2]nHet, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]nN(R3)2, NHCOO[C(R3)2]nHet, NHCONH[C(R3)2]nN(R3)2, NHCONH[ C(R3)2]nHet, OCONH[C(R3)2]nN(R3)2, OCONH[C(R3)2]nHet, CONR3[C(R3)2]nN(R3)2, CONR3[C(R320 )2]nHet y/o COA, Het representa un heterociclo saturado, insaturado o aromático mononuclear, binuclear o trinuclear con 1 a 4 átomos de N, O y/o S, que puede ser no sustituido o mono- di-, tri-, tetra- o penta- sustituido por Hal, A, [C(R3)2]nOR3, [C(R3)2]nN(R3)2, SR3, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2, S(O)mA, CO-Het1, [C(R3)2]nHet1, O[C(R3)2]n(R3)2, O[C(R3)2]nHet1, NHCOOA, NHCON(R3)2, NHCOO[C(R3)2]nN(R3)2, NHCOO[C(R3)2]nHet1, NHCONH[C(R3)2]nN(R3)2, NHCONH[C(R3)2]nHet1, OCONH[C(R3)2]nN(R3)2, OCONH[C(R3)2]nHet1, CO-Het1, CHO, COA, >=S, >=NH, >=NA y/o >=O (oxígeno de carbonilo), y donde un nitrógeno anular puede ser oxidado, Het1 representa un heterociclo saturado mononuclear con 1 a 2 átomos de N y/o de O que puede ser mono- o disustituido por A, OA, OH, Hal y/o >=O (oxígeno de carbonilo), A representa alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden ser reemplazados por F, y/o en donde uno o dos grupos CH2 no contiguos pueden ser reemplazados por O, NH, S, SO, SO2 y/o por grupos CH>=CH, o alquilo cíclico con 3-7 átomos de C, Hal representa F, Cl, Br o I, m representa 0, 1 ó 2, n representa 0, 1, 2, 3 ó 4, p representa 1, 2, 3 ó 4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE102007032507A DE102007032507A1 (de) | 2007-07-12 | 2007-07-12 | Pyridazinonderivate |
DE102007032507 | 2007-07-12 | ||
PCT/EP2008/003473 WO2009006959A1 (de) | 2007-07-12 | 2008-04-29 | Pyridazinonderivate |
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ES2526352T3 true ES2526352T3 (es) | 2015-01-09 |
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ES14001269T Active ES2614283T3 (es) | 2007-07-12 | 2008-04-29 | Derivados de piridazinona |
ES08758359T Active ES2526352T3 (es) | 2007-07-12 | 2008-04-29 | Derivados de piridazinona |
ES08773881T Active ES2388883T3 (es) | 2007-07-12 | 2008-07-04 | Derivados de pirimidinil-piridazinona |
Family Applications Before (1)
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ES14001269T Active ES2614283T3 (es) | 2007-07-12 | 2008-04-29 | Derivados de piridazinona |
Family Applications After (1)
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ES08773881T Active ES2388883T3 (es) | 2007-07-12 | 2008-07-04 | Derivados de pirimidinil-piridazinona |
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EP (3) | EP2754660B1 (es) |
JP (2) | JP5426543B2 (es) |
KR (2) | KR101553418B1 (es) |
CN (2) | CN101743241B (es) |
AR (2) | AR066543A1 (es) |
AU (2) | AU2008274670B2 (es) |
BR (2) | BRPI0814616B1 (es) |
CA (2) | CA2693600C (es) |
CL (1) | CL2008001392A1 (es) |
CO (2) | CO6170360A2 (es) |
CY (4) | CY1113137T1 (es) |
DE (1) | DE102007032507A1 (es) |
DK (3) | DK2754660T3 (es) |
EA (2) | EA016782B1 (es) |
EC (2) | ECSP109953A (es) |
ES (3) | ES2614283T3 (es) |
FR (1) | FR22C1024I2 (es) |
HK (2) | HK1142891A1 (es) |
HR (3) | HRP20120661T1 (es) |
HU (2) | HUE030519T2 (es) |
IL (2) | IL203091A (es) |
LT (2) | LT2754660T (es) |
MY (2) | MY153727A (es) |
NL (1) | NL301176I2 (es) |
NO (1) | NO2022015I1 (es) |
NZ (1) | NZ583187A (es) |
PE (1) | PE20090287A1 (es) |
PL (3) | PL2164843T3 (es) |
PT (3) | PT2164843E (es) |
SG (1) | SG183739A1 (es) |
SI (3) | SI2164843T1 (es) |
TW (1) | TWI501768B (es) |
UA (2) | UA99621C2 (es) |
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