CO6170360A2 - Derivados de pirimidinil - piridazinona - Google Patents

Derivados de pirimidinil - piridazinona

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Publication number
CO6170360A2
CO6170360A2 CO09137749A CO09137749A CO6170360A2 CO 6170360 A2 CO6170360 A2 CO 6170360A2 CO 09137749 A CO09137749 A CO 09137749A CO 09137749 A CO09137749 A CO 09137749A CO 6170360 A2 CO6170360 A2 CO 6170360A2
Authority
CO
Colombia
Prior art keywords
piridazinona
pirimidinil
derivatives
compounds selected
group
Prior art date
Application number
CO09137749A
Other languages
English (en)
Inventor
Oliver Schadt
Dieter Dorsch
Andree Blaukat
Frank Stieber
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CO6170360A2 publication Critical patent/CO6170360A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Los compuestos seleccionados del grupo de acuerdo con la reivindicación 1 son inhibidores de las tirosina quinasas, en especial de la Met-quinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores. 1.- Compuestos seleccionados del grupoasí como sus tautómeros y estereoisómeros, incluyendo sus mezclas en todas las proporciones.
CO09137749A 2007-07-12 2009-12-02 Derivados de pirimidinil - piridazinona CO6170360A2 (es)

Applications Claiming Priority (2)

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DE102007032507A DE102007032507A1 (de) 2007-07-12 2007-07-12 Pyridazinonderivate
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