JP2010530364A - ポリペプチド、抗体可変ドメインおよびアンタゴニスト - Google Patents

ポリペプチド、抗体可変ドメインおよびアンタゴニスト Download PDF

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JP2010530364A
JP2010530364A JP2010510888A JP2010510888A JP2010530364A JP 2010530364 A JP2010530364 A JP 2010530364A JP 2010510888 A JP2010510888 A JP 2010510888A JP 2010510888 A JP2010510888 A JP 2010510888A JP 2010530364 A JP2010530364 A JP 2010530364A
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variable domain
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vegf
dom15
domain
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JP2010530364A5 (https=
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スチュワード，マイケル
プペッカ，マウゴジャータ
エム トムリンソン，イアン
エネヴァー，キャロリン
エス ジェスパース，ローレント
ディナック バツワンガラ，ティル
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ドマンティス リミテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/00—Immunoglobulins specific features
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
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JP2010510888A 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト Pending JP2010530364A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
GBGB0724331.4A GB0724331D0 (en) 2007-12-13 2007-12-13 Compositions for pulmonary delivery
PCT/GB2008/050407 WO2008149150A2 (en) 2007-06-06 2008-06-04 Polypeptides, antibody variable domains and antagonists

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JP2010530364A true JP2010530364A (ja) 2010-09-09
JP2010530364A5 JP2010530364A5 (https=) 2011-07-21

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JP2010510888A Pending JP2010530364A (ja) 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP2010510886A Expired - Fee Related JP5325211B2 (ja) 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP2010510887A Active JP5444215B2 (ja) 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト

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JP2010510886A Expired - Fee Related JP5325211B2 (ja) 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP2010510887A Active JP5444215B2 (ja) 2007-06-06 2008-06-04 ポリペプチド、抗体可変ドメインおよびアンタゴニスト

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US (5) US8398979B2 (https=)
EP (5) EP2162468A2 (https=)
JP (3) JP2010530364A (https=)
KR (4) KR20100018040A (https=)
CN (4) CN101778865B (https=)
AR (3) AR066850A1 (https=)
AU (4) AU2008259590A1 (https=)
BR (3) BRPI0812268A2 (https=)
CA (6) CA2688433A1 (https=)
CL (3) CL2008001674A1 (https=)
CO (2) CO6251321A2 (https=)
CR (2) CR11194A (https=)
CY (1) CY1116762T1 (https=)
DK (1) DK2162467T3 (https=)
DO (1) DOP2009000268A (https=)
EA (5) EA200901494A1 (https=)
ES (1) ES2546943T3 (https=)
HR (1) HRP20151024T1 (https=)
HU (1) HUE025899T2 (https=)
IL (2) IL201398A0 (https=)
MA (2) MA31403B1 (https=)
MX (4) MX2009013137A (https=)
NZ (1) NZ581372A (https=)
PE (3) PE20090763A1 (https=)
PL (1) PL2162467T3 (https=)
PT (1) PT2162467E (https=)
SG (2) SG182151A1 (https=)
SI (1) SI2162467T1 (https=)
TW (6) TW200911832A (https=)
WO (3) WO2008149150A2 (https=)
ZA (1) ZA200908470B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014505698A (ja) * 2011-02-02 2014-03-06 グラクソ グループ リミテッド 新規抗原結合タンパク質
JP2014523746A (ja) * 2011-07-27 2014-09-18 グラクソ グループ リミテッド Ｆｃドメインと融合した抗ｖｅｇｆ単一可変ドメイン

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JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
WO2006122787A1 (en) 2005-05-18 2006-11-23 Ablynx Nv Serum albumin binding proteins
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
WO2008149147A2 (en) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
CA2688433A1 (en) 2007-06-06 2008-12-11 Domantis Limited Methods for selecting protease resistant polypeptides
CN102131827A (zh) * 2007-12-13 2011-07-20 葛兰素集团有限公司 用于肺部传递给药的组合物
EP2268668A1 (en) 2008-04-17 2011-01-05 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
LT3216803T (lt) 2008-06-25 2020-06-10 Novartis Ag Stabilūs ir tirpūs antikūnai, slopinantys vegf
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
CN102224169A (zh) * 2008-11-26 2011-10-19 葛兰素集团有限公司 多肽、抗体可变结构域和拮抗剂
WO2010081787A1 (en) 2009-01-14 2010-07-22 Domantis Limited IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS
SG173488A1 (en) * 2009-02-19 2011-09-29 Glaxo Group Ltd Improved anti-serum albumin binding variants
CA2767752C (en) 2009-02-19 2020-07-07 Glaxo Group Limited Improved anti-serum albumin binding variants
CN102405236A (zh) 2009-02-19 2012-04-04 葛兰素集团有限公司 改进的抗-tnfr1多肽，抗体可变结构域和拮抗剂
JP2012518398A (ja) 2009-02-24 2012-08-16 グラクソ グループ リミテッド 抗原結合性構築物
JP2012532620A (ja) 2009-07-16 2012-12-20 グラクソ グループ リミテッド 改良型抗血清アルブミン結合単一可変ドメイン
EP2453920A2 (en) 2009-07-16 2012-05-23 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
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