JP2010524932A - 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質 - Google Patents
置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質 Download PDFInfo
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- RUQQDSDHTHSCAX-GFCCVEGCSA-N methyl (3s)-3-(4-hydroxyphenyl)-5-methylhex-4-enoate Chemical compound COC(=O)C[C@@H](C=C(C)C)C1=CC=C(O)C=C1 RUQQDSDHTHSCAX-GFCCVEGCSA-N 0.000 description 1
- ASJWYIRUMPMFDW-XMMPIXPASA-N methyl (3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]-5-methylhex-4-enoate Chemical compound C1=CC([C@H](C=C(C)C)CC(=O)OC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 ASJWYIRUMPMFDW-XMMPIXPASA-N 0.000 description 1
- DYBHXRFDXNHIRP-DEOSSOPVSA-N methyl (3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]-5-methylhexanoate Chemical compound C1=CC([C@@H](CC(C)C)CC(=O)OC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 DYBHXRFDXNHIRP-DEOSSOPVSA-N 0.000 description 1
- OUBKHYRCTJQDED-DEOSSOPVSA-N methyl (3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]heptanoate Chemical compound C1=CC([C@H](CC(=O)OC)CCCC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 OUBKHYRCTJQDED-DEOSSOPVSA-N 0.000 description 1
- CRFPALUQDKKMDZ-QHCPKHFHSA-N methyl (3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]hexanoate Chemical compound C1=CC([C@H](CC(=O)OC)CCC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 CRFPALUQDKKMDZ-QHCPKHFHSA-N 0.000 description 1
- NKKKHHGOLLZXLN-LBPRGKRZSA-N methyl (3s)-3-cyclopropyl-3-(4-hydroxyphenyl)propanoate Chemical compound C1([C@H](CC(=O)OC)C=2C=CC(O)=CC=2)CC1 NKKKHHGOLLZXLN-LBPRGKRZSA-N 0.000 description 1
- VUZFNYFQYLVELK-PRSVDJLGSA-N methyl (e,3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]-6-methoxyhex-4-enoate Chemical compound C1=CC([C@@H](CC(=O)OC)/C=C/COC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 VUZFNYFQYLVELK-PRSVDJLGSA-N 0.000 description 1
- QOCJEBYBYIPHGJ-HMLKYZKVSA-N methyl (z,3r)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]hept-4-enoate Chemical compound C1=CC([C@H](CC(=O)OC)\C=C/CC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 QOCJEBYBYIPHGJ-HMLKYZKVSA-N 0.000 description 1
- LIGPZXDXIBKQJZ-YLNCNTMDSA-N methyl (z,3r)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]hex-4-enoate Chemical compound C1=CC([C@@H](\C=C/C)CC(=O)OC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 LIGPZXDXIBKQJZ-YLNCNTMDSA-N 0.000 description 1
- CICXXUQOZXKEBZ-BKSIFSGMSA-N methyl (z,3s)-3-(4-phenylmethoxyphenyl)hex-4-enoate Chemical compound C1=CC([C@H](\C=C/C)CC(=O)OC)=CC=C1OCC1=CC=CC=C1 CICXXUQOZXKEBZ-BKSIFSGMSA-N 0.000 description 1
- QOCJEBYBYIPHGJ-XXXZYALBSA-N methyl (z,3s)-3-[4-[[4-tert-butyl-3-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]hept-4-enoate Chemical compound C1=CC([C@@H](CC(=O)OC)\C=C/CC)=CC=C1OCC1=CC=C(C(C)(C)C)C(C=2C(=CC=C(OC)C=2)F)=C1 QOCJEBYBYIPHGJ-XXXZYALBSA-N 0.000 description 1
- FLYFKSWGNVAERO-UHFFFAOYSA-N methyl 2,2-dimethyl-3-(4-phenylmethoxyphenyl)propanoate Chemical compound C1=CC(CC(C)(C)C(=O)OC)=CC=C1OCC1=CC=CC=C1 FLYFKSWGNVAERO-UHFFFAOYSA-N 0.000 description 1
- JPJMSPSEWRPRDC-UHFFFAOYSA-N methyl 2-[(4-hydroxyphenyl)methyl]pent-4-enoate Chemical compound COC(=O)C(CC=C)CC1=CC=C(O)C=C1 JPJMSPSEWRPRDC-UHFFFAOYSA-N 0.000 description 1
- LTHUPXWEXMHSGB-UHFFFAOYSA-N methyl 2-[(4-phenylmethoxyphenyl)methyl]butanoate Chemical compound C1=CC(CC(CC)C(=O)OC)=CC=C1OCC1=CC=CC=C1 LTHUPXWEXMHSGB-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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| US92501407P | 2007-04-16 | 2007-04-16 | |
| PCT/US2008/004701 WO2008130514A1 (en) | 2007-04-16 | 2008-04-10 | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
Publications (2)
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| JP2010524932A true JP2010524932A (ja) | 2010-07-22 |
| JP2010524932A5 JP2010524932A5 (enExample) | 2011-06-16 |
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| US (1) | US7572934B2 (enExample) |
| EP (1) | EP2139843B1 (enExample) |
| JP (1) | JP2010524932A (enExample) |
| AU (1) | AU2008241490B2 (enExample) |
| CA (1) | CA2683751C (enExample) |
| ES (1) | ES2446419T3 (enExample) |
| WO (1) | WO2008130514A1 (enExample) |
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- 2008-04-10 JP JP2010504053A patent/JP2010524932A/ja active Pending
- 2008-04-10 US US12/082,645 patent/US7572934B2/en not_active Expired - Fee Related
- 2008-04-10 AU AU2008241490A patent/AU2008241490B2/en not_active Ceased
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| JP2013528647A (ja) * | 2010-06-16 | 2013-07-11 | メタボレックス， インコーポレイテッド | Ｇｐｒ１２０受容体作動薬及びその使用 |
| JP2016503409A (ja) * | 2012-11-09 | 2016-02-04 | エルジー・ライフ・サイエンシーズ・リミテッドＬＧ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | Ｇｐｒ４０受容体アゴニスト、この製造方法およびこれを活性成分として含有する医薬組成物 |
| US9988379B2 (en) | 2012-11-09 | 2018-06-05 | Lg Chem, Ltd. | GPR40 receptor agonist, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
| JP2018184454A (ja) * | 2012-11-09 | 2018-11-22 | エルジー・ケム・リミテッド | Ｇｐｒ４０受容体アゴニスト、この製造方法およびこれを活性成分として含有する医薬組成物 |
| CN110003169A (zh) * | 2012-11-09 | 2019-07-12 | 株式会社Lg化学 | Gpr40受体激动剂、制备其的方法和含有其作为活性成分的药物组合物 |
| JP2016513135A (ja) * | 2013-02-28 | 2016-05-12 | エスケー ケミカルズ カンパニー リミテッド | 三環式化合物およびその使用 |
| JP2016518366A (ja) * | 2013-04-18 | 2016-06-23 | ヒュンダイ ファーム カンパニー リミテッド | 新規３−（４−（ベンジルオキシ）フェニル）ヘキサ−４−イン酸誘導体、その製造方法、並びに有効成分としてそれを含む、代謝性疾患を予防及び治療するための医薬組成物 |
| JP2017534582A (ja) * | 2014-10-17 | 2017-11-24 | ヒュンダイ ファーム カンパニー リミテッド | 新規な３−（４−（ベンジルオキシ）フェニル）ヘキス−４−イノイック酸誘導体、及び異なる有効成分を含む代謝性疾患の予防または治療用複合製剤 |
| US10821110B2 (en) | 2014-10-17 | 2020-11-03 | Hyundai Pharm Co., Ltd. | Composite preparation, containing novel 3-(4--(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2139843B1 (en) | 2013-12-25 |
| ES2446419T3 (es) | 2014-03-07 |
| WO2008130514A1 (en) | 2008-10-30 |
| AU2008241490B2 (en) | 2011-07-21 |
| US20090111859A1 (en) | 2009-04-30 |
| US7572934B2 (en) | 2009-08-11 |
| CA2683751A1 (en) | 2008-10-30 |
| EP2139843A1 (en) | 2010-01-06 |
| AU2008241490A1 (en) | 2008-10-30 |
| CA2683751C (en) | 2013-01-08 |
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