ATE263162T1 - Harnstoffderivate und ihr gebrauch als zell adhesion modulatoren - Google Patents

Harnstoffderivate und ihr gebrauch als zell adhesion modulatoren

Info

Publication number
ATE263162T1
ATE263162T1 AT00927523T AT00927523T ATE263162T1 AT E263162 T1 ATE263162 T1 AT E263162T1 AT 00927523 T AT00927523 T AT 00927523T AT 00927523 T AT00927523 T AT 00927523T AT E263162 T1 ATE263162 T1 AT E263162T1
Authority
AT
Austria
Prior art keywords
linkage
heteroaryldiyl
compounds
aryldiyl
heterocycloalkylene
Prior art date
Application number
AT00927523T
Other languages
English (en)
Inventor
Paul Robert Aventis P Eastwood
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910405.1A external-priority patent/GB9910405D0/en
Priority claimed from GBGB9910417.6A external-priority patent/GB9910417D0/en
Priority claimed from GBGB9910396.2A external-priority patent/GB9910396D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of ATE263162T1 publication Critical patent/ATE263162T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT00927523T 1999-05-05 2000-05-05 Harnstoffderivate und ihr gebrauch als zell adhesion modulatoren ATE263162T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9910405.1A GB9910405D0 (en) 1999-05-05 1999-05-05 Chemical compounds
GBGB9910417.6A GB9910417D0 (en) 1999-05-05 1999-05-05 Chemical compounds
GBGB9910396.2A GB9910396D0 (en) 1999-05-05 1999-05-05 Chemical compounds
US15286199P 1999-09-08 1999-09-08
US15285599P 1999-09-08 1999-09-08
US15286099P 1999-09-08 1999-09-08
PCT/GB2000/001734 WO2000068223A1 (en) 1999-05-05 2000-05-05 Ureas and their use as cell adhesion modulators

Publications (1)

Publication Number Publication Date
ATE263162T1 true ATE263162T1 (de) 2004-04-15

Family

ID=27547334

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00927523T ATE263162T1 (de) 1999-05-05 2000-05-05 Harnstoffderivate und ihr gebrauch als zell adhesion modulatoren

Country Status (8)

Country Link
US (1) US6620832B2 (de)
EP (1) EP1177186B1 (de)
AT (1) ATE263162T1 (de)
AU (1) AU4591800A (de)
CA (1) CA2370805C (de)
DE (1) DE60009480T2 (de)
ES (1) ES2218156T3 (de)
WO (1) WO2000068223A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7157487B2 (en) 2000-12-28 2007-01-02 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
JP4982685B2 (ja) * 2001-12-03 2012-07-25 バイエル、ファーマシューテイカルズ、コーポレイション ヒトがんを処置するための他の細胞毒剤又は細胞増殖抑制剤と組合わせたアリール尿素化合物
MXPA04007830A (es) 2002-02-11 2005-07-01 Bayer Pharmaceuticals Corp Arilureas como inhibidores de cinasa.
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
US20050192314A1 (en) * 2003-11-13 2005-09-01 Ambit Biosciences Corporation Urea derivatives as C-kit modulators
JP5299810B2 (ja) 2004-02-27 2013-09-25 アムジエン・インコーポレーテツド 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法
US20070021612A1 (en) * 2004-11-04 2007-01-25 University Of Notre Dame Du Lac Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
US7235688B1 (en) 2004-11-04 2007-06-26 University Of Notre Dame Du Lac Process for preparing histone deacetylase inhibitors and intermediates thereof
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
CA2662305C (en) * 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
AU2007292816B2 (en) * 2006-09-07 2011-11-17 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
EP2139843B1 (de) * 2007-04-16 2013-12-25 Amgen, Inc Substituierte biphenyl phenoxy-, thiophenyl- und aminophenylpropansäure als gpr40-modulatoren
CN102083783A (zh) 2007-10-10 2011-06-01 安姆根有限公司 取代的联苯gpr40调节剂
WO2009111056A1 (en) * 2008-03-06 2009-09-11 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
AU2009303475B2 (en) * 2008-10-15 2012-09-13 Amgen Inc. Spirocyclic GPR40 modulators
WO2015145371A1 (en) * 2014-03-27 2015-10-01 Piramal Enterprises Limited Ror-gamma modulators and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212320A (en) * 1990-05-21 1993-05-18 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives and their use for testosterone 5-alpha-reductase-mediated diseases
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
BR9811730B1 (pt) * 1997-08-22 2014-04-08 Hoffmann La Roche Derivados de n-aroilfenilalanina, uso dos mesmos, medicamentos contendo os mesmos.
AU1361499A (en) * 1997-10-21 1999-05-10 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
EE200000486A (et) * 1998-02-25 2002-02-15 Genetics Institute, Inc. Fosfolipaasensüümide inhibiitorid, neid sisaldav farmatseutiline kompositsioon ning meetod põletikulise reaktsiooni raviks imetajal
WO2000015612A1 (en) * 1998-08-26 2000-03-23 Aventis Pharma Limited Aza-bicycles which modulate the inhibition of cell adhesion
ES2297943T3 (es) * 1998-12-23 2008-05-01 Aventis Pharma Limited Dihidro-benzo(1,4)oxacinas y tetrahidroquinoxalinas.
SE514227C2 (sv) 1999-01-20 2001-01-22 Tore Kaellander Anordning inrättad att kyla ett maskinaggregat som är inrättat att vara associerat med en motor

Also Published As

Publication number Publication date
EP1177186B1 (de) 2004-03-31
US6620832B2 (en) 2003-09-16
CA2370805C (en) 2012-07-03
EP1177186A1 (de) 2002-02-06
CA2370805A1 (en) 2000-11-16
DE60009480T2 (de) 2005-09-01
WO2000068223A8 (en) 2001-03-01
DE60009480D1 (de) 2004-05-06
AU4591800A (en) 2000-11-21
US20020082255A1 (en) 2002-06-27
WO2000068223A1 (en) 2000-11-16
ES2218156T3 (es) 2004-11-16

Similar Documents

Publication Publication Date Title
ATE263162T1 (de) Harnstoffderivate und ihr gebrauch als zell adhesion modulatoren
NO20020725D0 (no) Celleadhesjonsinhibitorer
DE60017389D1 (de) Substituierte bicyclische heteroaryl-verbindungen als integrin antagonisten
US5519005A (en) Method of inhibition of cellular and molecular level biological interactions utilizing non-peptidic surrogates of the Arg-Gly-Asp sequence
TW368500B (en) 1-Benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives
HUP0302969A2 (hu) NPY Y5 antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP9802859A2 (hu) Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként
MXPA01001995A (es) Aza-biciclos que modulan la inhibicion de adhesion celular.
PE106499A1 (es) Antagonistas del receptor ccr-3
ATE390404T1 (de) Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta
TR199901674T2 (de)
DK148392D0 (da) Heterocykliske forbindelser
CA2324418A1 (en) Novel opiate compounds, methods of making and methods of use
MA33107B1 (fr) Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met
DE60027700D1 (de) Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden
ATE466861T1 (de) Aminderivate
ATE281433T1 (de) Substituierte pyrrolidine als inhibitoren der zelladhäsion
AR015964A1 (es) Compuestos de isoquinolina, su uso, procedimiento para tratar una afeccion, procedimiento de preparacion del compuesto, composicion farmaceutica que locontiene y compuesto util en dicho procedimiento
CO5140091A1 (es) Derivados de piperidina y piperazina, su preparacion, su uso como productos farmaceuticos y composiciones farmaceuticas que los contienen
JO2235B1 (en) Derivatives of phenyl
NO970513L (no) Urokinase-reseptorligander
AP2000001924A0 (en) Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines.
HUP9702149A2 (hu) Tachykinin receptor antagonista heterociklikus piperazinonszármazékok, intermedierjeik, előállításuk és alkalmazásuk, valamint a vegyületeket tartalmazó gyógyászati készítmények
DK0827500T3 (da) (2-morpholinylmethyl)benzamid-derivater
YU71501A (sh) Supstituisana biciklična heteroaril jedinjenja kao antagonisti integrina

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties