EA200001077A3 - Новые соединения аминопирролина, способ их получения и содержащие их фармацевтические композиции - Google Patents
Новые соединения аминопирролина, способ их получения и содержащие их фармацевтические композицииInfo
- Publication number
- EA200001077A3 EA200001077A3 EA200001077A EA200001077A EA200001077A3 EA 200001077 A3 EA200001077 A3 EA 200001077A3 EA 200001077 A EA200001077 A EA 200001077A EA 200001077 A EA200001077 A EA 200001077A EA 200001077 A3 EA200001077 A3 EA 200001077A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- aminopyrroline
- preparation
- new
- pharmaceutical compositions
- Prior art date
Links
- NPLSMQWSKZXZPD-UHFFFAOYSA-N 2,3-dihydropyrrol-1-amine Chemical class NN1CCC=C1 NPLSMQWSKZXZPD-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005549 heteroarylene group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005649 substituted arylene group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
Описываются соединения формулы (I)n представляет 1 или 2, Х представляет алкиленовую, алкениленовую или алкиниленовую группу или необязательно замещенную ариленовую или гетероариленовую группу, Rпредставляет атом водорода или алкильную группу и Rи Rвместе образуют связь или альтернативно Rпредставляет атом водорода или алкильную группу, a Rи Rвместе образуют связь, R, Rи R, каждый независимо от других, представляет атом водорода или алкильную, гидроксиалкильную, алкокси-, алкоксикарбонильную, арильную, арилалкильную или арилоксиалкильную группу, или два из R, Rи Rобразуют циклоалкильный радикал. Описываются также лекарственные средства.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9914434A FR2801051B1 (fr) | 1999-11-17 | 1999-11-17 | Nouveaux composes aminopyrroline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
Publication Number | Publication Date |
---|---|
EA200001077A2 EA200001077A2 (ru) | 2001-06-25 |
EA200001077A3 true EA200001077A3 (ru) | 2001-08-27 |
EA004042B1 EA004042B1 (ru) | 2003-12-25 |
Family
ID=9552203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200001077A EA004042B1 (ru) | 1999-11-17 | 2000-11-16 | Новые соединения аминопирролина, способ их получения и содержащие их фармацевтические композиции |
Country Status (23)
Country | Link |
---|---|
US (1) | US6300366B1 (ru) |
EP (1) | EP1101756B1 (ru) |
JP (1) | JP3274456B2 (ru) |
KR (1) | KR100453981B1 (ru) |
CN (1) | CN1158257C (ru) |
AT (1) | ATE234815T1 (ru) |
AU (1) | AU771745B2 (ru) |
BR (1) | BR0005442A (ru) |
CA (1) | CA2325781C (ru) |
DE (1) | DE60001706T2 (ru) |
DK (1) | DK1101756T3 (ru) |
EA (1) | EA004042B1 (ru) |
ES (1) | ES2194691T3 (ru) |
FR (1) | FR2801051B1 (ru) |
HK (1) | HK1036454A1 (ru) |
HU (1) | HUP0004543A3 (ru) |
MX (1) | MXPA00011239A (ru) |
NO (1) | NO317987B1 (ru) |
NZ (1) | NZ508228A (ru) |
PL (1) | PL343920A1 (ru) |
PT (1) | PT1101756E (ru) |
SI (1) | SI1101756T1 (ru) |
ZA (1) | ZA200006731B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004000312A2 (de) | 2002-06-19 | 2003-12-31 | Solvay Pharmaceuticals Gmbh | Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen |
GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
GB201318886D0 (en) * | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
CN114716359B (zh) * | 2022-04-28 | 2023-01-17 | 广东医科大学 | 一种氢化吲哚亚胺非对映异构体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2029297A1 (de) * | 1970-06-13 | 1971-12-30 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Neue Aminophenyl-cycloamidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US3887569A (en) * | 1970-10-30 | 1975-06-03 | Mcneilab Inc | 2-Imino-piperidines |
NL7412695A (nl) * | 1974-09-26 | 1976-03-30 | Stamicarbon | De bereiding van een 2-amino-pyrrolinederivaat. |
US4579951A (en) * | 1984-03-19 | 1986-04-01 | G. D. Searle & Co. | Substituted (azacycloalk-2-yl)iminophenols and esters thereof |
DE4425070A1 (de) * | 1994-07-15 | 1996-01-18 | Degussa | Verfahren zur Herstellung optisch aktiver l-substituierter 2-(Aminomethyl)pyrrolidine |
-
1999
- 1999-11-17 FR FR9914434A patent/FR2801051B1/fr not_active Expired - Fee Related
-
2000
- 2000-11-09 DE DE60001706T patent/DE60001706T2/de not_active Expired - Fee Related
- 2000-11-09 SI SI200030067T patent/SI1101756T1/xx unknown
- 2000-11-09 ES ES00403106T patent/ES2194691T3/es not_active Expired - Lifetime
- 2000-11-09 DK DK00403106T patent/DK1101756T3/da active
- 2000-11-09 EP EP00403106A patent/EP1101756B1/fr not_active Expired - Lifetime
- 2000-11-09 AT AT00403106T patent/ATE234815T1/de not_active IP Right Cessation
- 2000-11-09 PT PT00403106T patent/PT1101756E/pt unknown
- 2000-11-14 JP JP2000346838A patent/JP3274456B2/ja not_active Expired - Fee Related
- 2000-11-15 MX MXPA00011239A patent/MXPA00011239A/es active IP Right Grant
- 2000-11-16 US US09/714,090 patent/US6300366B1/en not_active Expired - Fee Related
- 2000-11-16 EA EA200001077A patent/EA004042B1/ru not_active IP Right Cessation
- 2000-11-16 NO NO20005797A patent/NO317987B1/no unknown
- 2000-11-16 PL PL00343920A patent/PL343920A1/xx not_active Application Discontinuation
- 2000-11-16 NZ NZ508228A patent/NZ508228A/xx unknown
- 2000-11-16 HU HU0004543A patent/HUP0004543A3/hu unknown
- 2000-11-17 ZA ZA200006731A patent/ZA200006731B/xx unknown
- 2000-11-17 KR KR10-2000-0068434A patent/KR100453981B1/ko not_active IP Right Cessation
- 2000-11-17 CA CA002325781A patent/CA2325781C/fr not_active Expired - Fee Related
- 2000-11-17 AU AU71680/00A patent/AU771745B2/en not_active Ceased
- 2000-11-17 CN CNB001285394A patent/CN1158257C/zh not_active Expired - Fee Related
- 2000-11-17 BR BR0005442-9A patent/BR0005442A/pt not_active IP Right Cessation
-
2001
- 2001-10-24 HK HK01107419A patent/HK1036454A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |