CN1298872A - 新型氨基吡咯啉化合物、其制备方法以及含有它们的药物组合物 - Google Patents
新型氨基吡咯啉化合物、其制备方法以及含有它们的药物组合物 Download PDFInfo
- Publication number
- CN1298872A CN1298872A CN00128539A CN00128539A CN1298872A CN 1298872 A CN1298872 A CN 1298872A CN 00128539 A CN00128539 A CN 00128539A CN 00128539 A CN00128539 A CN 00128539A CN 1298872 A CN1298872 A CN 1298872A
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- CN
- China
- Prior art keywords
- branched
- straight
- compound
- structure formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
Abstract
Description
实施例1的化合物剂量(毫克/千克) | AP注射前(mmHg) | AP注射后(mmHg) | CF注射前(bpm) | CF注射后(bpm) |
1(i.v.) | 84 | 63 | 306 | 236 |
0.3(i.v.) | 92 | 74 | 300 | 263 |
0.03(i.c.) | 90 | 63 | 307 | 240 |
实施例 | 剂量(毫克/千克) | AP注射前(mmHg) | AP注射后(mmHg) | CF注射前(bpm) | CF注射后(bpm) |
1 | 1(i.v.) | 163 | 91 | 386 | 296 |
21 | 10(i.v.) | 166 | 138 | 375 | 320 |
21 | 0.1(i.c.) | 134 | 99 | 345 | 320 |
实验组动物的数量 | VES的平均数值 | 受保护兔子的数量 | 抗心律紊乱保护的百分比 | |
对照比枯枯灵碱 | n=8 | 1043 | 0 | 0 |
实施例9的化合物0.3毫克/千克i.c.投药 | n=8 | 84 | 7 | 87.5 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9914434A FR2801051B1 (fr) | 1999-11-17 | 1999-11-17 | Nouveaux composes aminopyrroline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR9914434 | 1999-11-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1298872A true CN1298872A (zh) | 2001-06-13 |
CN1158257C CN1158257C (zh) | 2004-07-21 |
Family
ID=9552203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB001285394A Expired - Fee Related CN1158257C (zh) | 1999-11-17 | 2000-11-17 | 新型氨基吡咯啉化合物、其制备方法以及含有它们的药物组合物 |
Country Status (23)
Country | Link |
---|---|
US (1) | US6300366B1 (zh) |
EP (1) | EP1101756B1 (zh) |
JP (1) | JP3274456B2 (zh) |
KR (1) | KR100453981B1 (zh) |
CN (1) | CN1158257C (zh) |
AT (1) | ATE234815T1 (zh) |
AU (1) | AU771745B2 (zh) |
BR (1) | BR0005442A (zh) |
CA (1) | CA2325781C (zh) |
DE (1) | DE60001706T2 (zh) |
DK (1) | DK1101756T3 (zh) |
EA (1) | EA004042B1 (zh) |
ES (1) | ES2194691T3 (zh) |
FR (1) | FR2801051B1 (zh) |
HK (1) | HK1036454A1 (zh) |
HU (1) | HUP0004543A3 (zh) |
MX (1) | MXPA00011239A (zh) |
NO (1) | NO317987B1 (zh) |
NZ (1) | NZ508228A (zh) |
PL (1) | PL343920A1 (zh) |
PT (1) | PT1101756E (zh) |
SI (1) | SI1101756T1 (zh) |
ZA (1) | ZA200006731B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1517688A2 (de) | 2002-06-19 | 2005-03-30 | Solvay Pharmaceuticals GmbH | Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen |
GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
MX2016001714A (es) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
GB201318886D0 (en) * | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
CN114716359B (zh) * | 2022-04-28 | 2023-01-17 | 广东医科大学 | 一种氢化吲哚亚胺非对映异构体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2029297A1 (de) * | 1970-06-13 | 1971-12-30 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Neue Aminophenyl-cycloamidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US3887569A (en) * | 1970-10-30 | 1975-06-03 | Mcneilab Inc | 2-Imino-piperidines |
NL7412695A (nl) * | 1974-09-26 | 1976-03-30 | Stamicarbon | De bereiding van een 2-amino-pyrrolinederivaat. |
US4579951A (en) * | 1984-03-19 | 1986-04-01 | G. D. Searle & Co. | Substituted (azacycloalk-2-yl)iminophenols and esters thereof |
DE4425070A1 (de) * | 1994-07-15 | 1996-01-18 | Degussa | Verfahren zur Herstellung optisch aktiver l-substituierter 2-(Aminomethyl)pyrrolidine |
-
1999
- 1999-11-17 FR FR9914434A patent/FR2801051B1/fr not_active Expired - Fee Related
-
2000
- 2000-11-09 DK DK00403106T patent/DK1101756T3/da active
- 2000-11-09 PT PT00403106T patent/PT1101756E/pt unknown
- 2000-11-09 EP EP00403106A patent/EP1101756B1/fr not_active Expired - Lifetime
- 2000-11-09 ES ES00403106T patent/ES2194691T3/es not_active Expired - Lifetime
- 2000-11-09 SI SI200030067T patent/SI1101756T1/xx unknown
- 2000-11-09 AT AT00403106T patent/ATE234815T1/de not_active IP Right Cessation
- 2000-11-09 DE DE60001706T patent/DE60001706T2/de not_active Expired - Fee Related
- 2000-11-14 JP JP2000346838A patent/JP3274456B2/ja not_active Expired - Fee Related
- 2000-11-15 MX MXPA00011239A patent/MXPA00011239A/es active IP Right Grant
- 2000-11-16 PL PL00343920A patent/PL343920A1/xx not_active Application Discontinuation
- 2000-11-16 US US09/714,090 patent/US6300366B1/en not_active Expired - Fee Related
- 2000-11-16 NO NO20005797A patent/NO317987B1/no unknown
- 2000-11-16 HU HU0004543A patent/HUP0004543A3/hu unknown
- 2000-11-16 EA EA200001077A patent/EA004042B1/ru not_active IP Right Cessation
- 2000-11-16 NZ NZ508228A patent/NZ508228A/xx unknown
- 2000-11-17 BR BR0005442-9A patent/BR0005442A/pt not_active IP Right Cessation
- 2000-11-17 AU AU71680/00A patent/AU771745B2/en not_active Ceased
- 2000-11-17 ZA ZA200006731A patent/ZA200006731B/xx unknown
- 2000-11-17 CA CA002325781A patent/CA2325781C/fr not_active Expired - Fee Related
- 2000-11-17 KR KR10-2000-0068434A patent/KR100453981B1/ko not_active IP Right Cessation
- 2000-11-17 CN CNB001285394A patent/CN1158257C/zh not_active Expired - Fee Related
-
2001
- 2001-10-24 HK HK01107419A patent/HK1036454A1/xx not_active IP Right Cessation
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