JP2010523582A - グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法 - Google Patents

グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法 Download PDF

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Publication number
JP2010523582A
JP2010523582A JP2010502245A JP2010502245A JP2010523582A JP 2010523582 A JP2010523582 A JP 2010523582A JP 2010502245 A JP2010502245 A JP 2010502245A JP 2010502245 A JP2010502245 A JP 2010502245A JP 2010523582 A JP2010523582 A JP 2010523582A
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JP
Japan
Prior art keywords
peptide
csf
group
glycosyl
modifying group
Prior art date
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Pending
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JP2010502245A
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English (en)
Japanese (ja)
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JP2010523582A5 (enExample
Inventor
エイ． ゾフ、デイビッド
ルベナウ、ハインツ
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Ratiopharm GmbH
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Biogenerix GmbH
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Publication of JP2010523582A publication Critical patent/JP2010523582A/ja
Publication of JP2010523582A5 publication Critical patent/JP2010523582A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jib Cranes (AREA)
JP2010502245A 2007-04-03 2008-04-01 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法 Pending JP2010523582A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90991707P 2007-04-03 2007-04-03
US91178807P 2007-04-13 2007-04-13
US98624007P 2007-11-07 2007-11-07
PCT/US2008/059045 WO2008124406A2 (en) 2007-04-03 2008-04-01 Methods of treatment using glycopegylated g-csf

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013161498A Division JP5922065B2 (ja) 2007-04-03 2013-08-02 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法

Publications (2)

Publication Number Publication Date
JP2010523582A true JP2010523582A (ja) 2010-07-15
JP2010523582A5 JP2010523582A5 (enExample) 2011-04-21

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010502245A Pending JP2010523582A (ja) 2007-04-03 2008-04-01 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法
JP2013161498A Active JP5922065B2 (ja) 2007-04-03 2013-08-02 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法
JP2015208224A Pending JP2016029088A (ja) 2007-04-03 2015-10-22 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法

Family Applications After (2)

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JP2013161498A Active JP5922065B2 (ja) 2007-04-03 2013-08-02 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法
JP2015208224A Pending JP2016029088A (ja) 2007-04-03 2015-10-22 グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法

Country Status (21)

Country Link
US (1) US9050304B2 (enExample)
EP (1) EP2144923B1 (enExample)
JP (3) JP2010523582A (enExample)
KR (2) KR20150064246A (enExample)
CN (1) CN101796063B (enExample)
AU (1) AU2008237411B2 (enExample)
BR (1) BRPI0809670A8 (enExample)
CA (1) CA2682897C (enExample)
CY (2) CY1114517T1 (enExample)
DK (1) DK2144923T3 (enExample)
EA (1) EA017770B1 (enExample)
ES (1) ES2406267T3 (enExample)
HR (1) HRP20130382T1 (enExample)
IL (1) IL201203A (enExample)
LT (1) LTC2144923I2 (enExample)
NO (1) NO2014002I1 (enExample)
NZ (1) NZ580030A (enExample)
PL (1) PL2144923T3 (enExample)
PT (1) PT2144923E (enExample)
RS (1) RS52845B (enExample)
WO (1) WO2008124406A2 (enExample)

Cited By (1)

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KR101623906B1 (ko) 2014-07-23 2016-05-24 주식회사 이큐스앤자루 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

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JPN6012065189; ＤｅＦｒｅｅｓ　Ｓ，　ｅｔ　ａｌ．: 'ＧｌｙｃｏＰＥＧｙｌａｔｉｏｎ　ｏｆ　ｒｅｃｏｍｂｉｎａｎｔ　ｔｈｅｒａｐｅｕｔｉｃ　ｐｒｏｔｅｉｎｓ　ｐｒｏｄｕｃｅｄ　ｉｎ　Ｅｓｃｈｅｒｉｃｈｉａ　ｃｏｌｉ' Ｇｌｙｃｏｂｉｏｌｏｇｙ Ｖｏｌ．　１６，　Ｎｏ．　９, 200609, ｐ．　８３３-８４３ *
JPN6012065191; Ｈｉｌｌ　ＧＲ，　ｅｔ　ａｌ．: 'Ａｌｌｏｇｅｎｅｉｃ　ｓｔｅｍ　ｃｅｌｌ　ｔｒａｎｓｐｌａｎｔａｔｉｏｎ　ｗｉｔｈ　ｐｅｒｉｐｈｅｒａｌ　ｂｌｏｏｄ　ｓｔｅｍ　ｃｅｌｌｓ　ｍｏｂｉｌｉｚｅｄ　ｂｙ　ｐｅｇｙｌａｔｅｄ　Ｇ-ＣＳＦ' Ｂｉｏｌｏｇｙ　ｏｆ　Ｂｌｏｏｄ　ａｎｄ　Ｍａｒｒｏｗ　Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．　１２，　Ｎｏ．　６, 200606, ｐ．　６０３-６０７ *
JPN6012065192; Ｈｕｂｅｌ　Ｋ，　ｅｔ　ａｌ．: 'Ｃｌｉｎｉｃａｌ　ａｐｐｌｉｃａｔｉｏｎｓ　ｏｆ　ｇｒａｎｕｌｏｃｙｔｅ　ｃｏｌｏｎｙ-ｓｔｉｍｕｌａｔｉｎｇ　ｆａｃｔｏｒ：　ａｎ　ｕｐｄａｔｅ　ａｎｄ　ｓｕｍｍａｒｙ' Ａｎｎａｌｓ　ｏｆ　Ｈｅｍａｔｏｌｏｇｙ Ｖｏｌ．　８２，　Ｎｏ．　４, 200304, ｐ．　２０７-２１３ *
JPN6012065193; Ｆｌｏｍｅｎｂｅｒｇ　Ｎ，　ｅｔ　ａｌ．: 'Ｔｈｅ　ｕｓｅ　ｏｆ　ＡＭＤ３１００　ｐｌｕｓ　Ｇ-ＣＳＦ　ｆｏｒ　ａｕｔｏｌｏｇｏｕｓ　ｈｅｍａｔｏｐｏｉｅｔｉｃ　ｐｒｏｇｅｎｉｔｏｒ　ｃｅｌｌ　ｍｏｂｉｌｉｚａｔｉｏｎ　ｉｓ　ｓｕｐｅｒｉｏｒ' Ｂｌｏｏｄ Ｖｏｌ．　１０６，　Ｎｏ．　５, 20050901, ｐ．　１８６７-１８７４ *
JPN6012065194; Ｌｉｌｅｓ　ＷＣ，　ｅｔ　ａｌ．: 'Ａｕｇｍｅｎｔｅｄ　ｍｏｂｉｌｉｚａｔｉｏｎ　ａｎｄ　ｃｏｌｌｅｃｔｉｏｎ　ｏｆ　ＣＤ３４＋　ｈｅｍａｔｏｐｏｉｅｔｉｃ　ｃｅｌｌｓ　ｆｒｏｍ　ｎｏｒｍａｌ　ｈｕｍａｎ　ｖｏｌｕｎｔｅｅｒｓ　ｓｔｉｍ' Ｔｒａｎｓｆｕｓｉｏｎ Ｖｏｌ．　４５，　Ｎｏ．　３, 200503, ｐ．　２９５-３００ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101623906B1 (ko) 2014-07-23 2016-05-24 주식회사 이큐스앤자루 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

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EA017770B1 (ru) 2013-03-29
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