JP2010522212A5 - - Google Patents

Info

Publication number

JP2010522212A5

JP2010522212A5 JP2009554770A JP2009554770A JP2010522212A5 JP 2010522212 A5 JP2010522212 A5 JP 2010522212A5 JP 2009554770 A JP2009554770 A JP 2009554770A JP 2009554770 A JP2009554770 A JP 2009554770A JP 2010522212 A5 JP2010522212 A5 JP 2010522212A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

mesenchymal stem

stem cells

cells

Prior art date

2008-03-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 20
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 11
• 241001465754 Metazoa Species 0.000 claims 9
• 208000019693 Lung disease Diseases 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 4
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 3
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 3
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 3
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 3
• 208000006673 asthma Diseases 0.000 claims 3
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
• 208000002815 pulmonary hypertension Diseases 0.000 claims 3
• 230000037396 body weight Effects 0.000 claims 2
• 231100000241 scar Toxicity 0.000 claims 2
• 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
• 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 210000002950 fibroblast Anatomy 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 230000004199 lung function Effects 0.000 claims 1
• 238000011084 recovery Methods 0.000 claims 1
• 230000007115 recruitment Effects 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1