CN112566644A - 牙源干细胞及其用途 - Google Patents

牙源干细胞及其用途 Download PDF

Info

Publication number
CN112566644A
CN112566644A CN201880093954.8A CN201880093954A CN112566644A CN 112566644 A CN112566644 A CN 112566644A CN 201880093954 A CN201880093954 A CN 201880093954A CN 112566644 A CN112566644 A CN 112566644A
Authority
CN
China
Prior art keywords
stem cells
dental
dental pulp
psoriasis
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880093954.8A
Other languages
English (en)
Inventor
孟虹芳
王�华
吴祖泽
唐仲雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Sh Bio Tech Corp
Original Assignee
Beijing Sh Bio Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Sh Bio Tech Corp filed Critical Beijing Sh Bio Tech Corp
Publication of CN112566644A publication Critical patent/CN112566644A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

干细胞和基因修饰的干细胞的用途。特别是牙源干细胞和基因修饰的牙源干细胞在制备用于治疗银屑病及相关疾病的产品中的用途。包含牙源干细胞和/或基因修饰的牙源干细胞的组合物或试剂盒。HGF基因修饰的牙髓干细胞治疗银屑病的作用优于牙髓干细胞,HGF和牙源干细胞可以协同用于银屑病相关疾病的治疗。

Description

PCT国内申请,说明书已公开。

Claims (10)

  1. PCT国内申请,权利要求书已公开。
CN201880093954.8A 2018-07-17 2018-11-22 牙源干细胞及其用途 Pending CN112566644A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018107817539 2018-07-17
CN201810781753 2018-07-17
PCT/CN2018/116834 WO2020015264A1 (zh) 2018-07-17 2018-11-22 牙源干细胞及其用途

Publications (1)

Publication Number Publication Date
CN112566644A true CN112566644A (zh) 2021-03-26

Family

ID=69165015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880093954.8A Pending CN112566644A (zh) 2018-07-17 2018-11-22 牙源干细胞及其用途

Country Status (2)

Country Link
CN (1) CN112566644A (zh)
WO (1) WO2020015264A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101626772A (zh) * 2007-03-22 2010-01-13 奥西里斯治疗公司 间充质干细胞及其用途
CN103191154A (zh) * 2012-01-06 2013-07-10 上海交通大学医学院 充质干细胞及其提取方法在制备银屑病的药物中的应用
CN103585177A (zh) * 2012-08-13 2014-02-19 首都医科大学附属北京口腔医院 间充质干细胞和基因修饰的间充质干细胞的用途
CN106062184A (zh) * 2014-01-27 2016-10-26 首都医科大学附属北京口腔医院 牙源性干细胞和基因修饰的牙源性干细胞的用途
CN106492194A (zh) * 2016-11-30 2017-03-15 广州赛莱拉干细胞科技股份有限公司 一种干细胞外泌体制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1657101A (zh) * 2004-02-19 2005-08-24 中国人民解放军军事医学科学院放射医学研究所 肝细胞生长因子基因修饰骨髓间质干细胞在心肌缺血治疗中的应用
JP6781973B2 (ja) * 2016-01-29 2020-11-11 学校法人東京女子医科大学 腎臓病進行抑制細胞シート組成物、その製造方法、及び、それを用いた腎臓病進行抑制方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101626772A (zh) * 2007-03-22 2010-01-13 奥西里斯治疗公司 间充质干细胞及其用途
CN103191154A (zh) * 2012-01-06 2013-07-10 上海交通大学医学院 充质干细胞及其提取方法在制备银屑病的药物中的应用
CN103585177A (zh) * 2012-08-13 2014-02-19 首都医科大学附属北京口腔医院 间充质干细胞和基因修饰的间充质干细胞的用途
CN106062184A (zh) * 2014-01-27 2016-10-26 首都医科大学附属北京口腔医院 牙源性干细胞和基因修饰的牙源性干细胞的用途
US20160348076A1 (en) * 2014-01-27 2016-12-01 Beijing Stomatology Hospital, Capital Medical University The Usage of Odontogenic Stem Cells and Genetically Modified Odontogenic Stem Cells
CN106492194A (zh) * 2016-11-30 2017-03-15 广州赛莱拉干细胞科技股份有限公司 一种干细胞外泌体制剂及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
范瑛等: "基于干细胞探讨开通玄府、补肾培元法治疗银屑病", 《北京中医药》 *

Also Published As

Publication number Publication date
WO2020015264A1 (zh) 2020-01-23

Similar Documents

Publication Publication Date Title
Allakhverdi et al. CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation
US8808682B2 (en) Method for inducing migration of adipose-derived adult stem cells
Zhang et al. SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect
JP6306025B2 (ja) 腫瘍の処置における使用のための子癇前症胎盤間葉系幹細胞馴化培地
KR102360077B1 (ko) 탯줄 유래 중간엽 줄기세포로부터 분리된 엑소좀을 포함하는 피부 개선용 화장료 조성물
CN111518757A (zh) 一种免疫抑制或抗炎功能增强型pd-l1阳性间充质干细胞、诱导试剂盒及应用
CN109674819B (zh) 胎盘间充质干细胞制剂及其治疗硬化病的用途
CA3106188A1 (en) Mitochondrial augmentation therapy with stem cells enriched with functional mitochondria
CN112587720A (zh) 一种cgf和脐带间充质干细胞外泌体混合物、制备及应用
CN116904394A (zh) 一种抗炎性间充质干细胞来源外泌体的制备方法及其应用
CN111944748A (zh) 一种用于治疗心肌梗死的高表达il-10的人脂肪间充质干细胞外泌体及其用途
KR101843952B1 (ko) 지방조직-유래 기질혈관분획의 분리 방법
Myneni et al. Mesenchymal stromal cells from infants with simple polydactyly modulate immune responses more efficiently than adult mesenchymal stromal cells
KR20150088374A (ko) 인체 지방-유래 줄기세포를 이용한 주요 세포성장인자를 포함하는 줄기세포 배양액 및 아토피 개선 화장료 조성물
CN106011074B (zh) 一种高表达cxcr5的间充质干细胞及其制备和用途
CN112566644A (zh) 牙源干细胞及其用途
WO2022056991A1 (zh) 脐带来源的间充质干细胞及其制备方法和应用
CN113827618A (zh) 干细胞条件培养基在制备用于治疗炎症性皮肤的药物中的用途
US20220211766A1 (en) Selection of fibroblast donors for optimization of allogeneic fibroblast-mediated regeneration
CN109749981B (zh) 人源脂肪干细胞来源的肝细胞样细胞及其制备方法和应用
US20220160777A1 (en) Method for treating atopic dermatitis using monoclonal stem cells
KR101423659B1 (ko) 초기 분화된 양수 줄기세포를 포함하는 요실금 치료제
JP2024520415A (ja) 線維芽細胞及び線維芽細胞由来産物を用いる脱毛症治療のための方法及び組成物
US20200038451A1 (en) Stem cells as an individualized maternal therapy for prevention of prematurity
Heidari et al. Promotion of proliferation of murine hematopoietic stem cells by growth factors in murine amniotic fluid

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Meng Hongfang

Inventor before: Meng Hongfang

Inventor before: Wang Hua

Inventor before: Wu Zuze

Inventor before: Tang Zhongxiong

CB03 Change of inventor or designer information
RJ01 Rejection of invention patent application after publication

Application publication date: 20210326

RJ01 Rejection of invention patent application after publication