JP2010518006A5 - - Google Patents

Info

Publication number

JP2010518006A5

JP2010518006A5 JP2009548327A JP2009548327A JP2010518006A5 JP 2010518006 A5 JP2010518006 A5 JP 2010518006A5 JP 2009548327 A JP2009548327 A JP 2009548327A JP 2009548327 A JP2009548327 A JP 2009548327A JP 2010518006 A5 JP2010518006 A5 JP 2010518006A5

Authority

JP

Japan

Prior art keywords

actriia

composition

activin

amino acid

breast cancer

Prior art date

2008-02-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims description 47
• 206010006187 Breast cancer Diseases 0.000 claims description 43
• 208000026310 Breast neoplasm Diseases 0.000 claims description 43
• 108020001507 fusion proteins Proteins 0.000 claims description 43
• 102000037865 fusion proteins Human genes 0.000 claims description 43
• 239000005557 antagonist Substances 0.000 claims description 41
• 229920001184 polypeptide Polymers 0.000 claims description 37
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 37
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
• 150000001413 amino acids Chemical class 0.000 claims description 32
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 28
• 239000000488 activin Substances 0.000 claims description 19
• 102000005606 Activins Human genes 0.000 claims description 15
• 108010059616 Activins Proteins 0.000 claims description 15
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
• 239000003795 chemical substances by application Substances 0.000 claims description 13
• 206010065687 Bone loss Diseases 0.000 claims description 12
• 230000002401 inhibitory effect Effects 0.000 claims description 10
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• 238000009261 endocrine therapy Methods 0.000 claims description 4
• 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 claims description 4
• 238000001727 in vivo Methods 0.000 claims description 4
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• 229940079593 drug Drugs 0.000 claims description 3
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• 108020001756 ligand binding domains Proteins 0.000 claims description 3
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• 206010027476 Metastases Diseases 0.000 claims description 2
• 102000014128 RANK Ligand Human genes 0.000 claims description 2
• 108010025832 RANK Ligand Proteins 0.000 claims description 2
• 102000007562 Serum Albumin Human genes 0.000 claims description 2
• 108010071390 Serum Albumin Proteins 0.000 claims description 2
• 238000011444 antiresorptive therapy Methods 0.000 claims description 2
• 150000004663 bisphosphonates Chemical class 0.000 claims description 2
• 210000000988 bone and bone Anatomy 0.000 claims description 2
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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