JP2010516259A5 - - Google Patents
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- Publication number
- JP2010516259A5 JP2010516259A5 JP2009546581A JP2009546581A JP2010516259A5 JP 2010516259 A5 JP2010516259 A5 JP 2010516259A5 JP 2009546581 A JP2009546581 A JP 2009546581A JP 2009546581 A JP2009546581 A JP 2009546581A JP 2010516259 A5 JP2010516259 A5 JP 2010516259A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer stem
- stem cells
- human cancer
- human
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 70
- 201000011510 cancer Diseases 0.000 claims description 66
- 210000000130 stem cell Anatomy 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 17
- 230000018109 developmental process Effects 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 229940030156 cell vaccine Drugs 0.000 claims description 5
- 238000004166 bioassay Methods 0.000 claims description 4
- 239000002458 cell surface marker Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000010255 intramuscular injection Methods 0.000 claims description 2
- 239000007927 intramuscular injection Substances 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 230000009758 senescence Effects 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88149707P | 2007-01-22 | 2007-01-22 | |
| US90718007P | 2007-03-23 | 2007-03-23 | |
| US92424707P | 2007-05-04 | 2007-05-04 | |
| US95071407P | 2007-07-19 | 2007-07-19 | |
| US97261307P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/051730 WO2008091908A2 (en) | 2007-01-22 | 2008-01-22 | Human cancer stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516259A JP2010516259A (ja) | 2010-05-20 |
| JP2010516259A5 true JP2010516259A5 (enExample) | 2010-12-24 |
Family
ID=39641454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546581A Pending JP2010516259A (ja) | 2007-01-22 | 2008-01-22 | ヒトがん幹細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8309354B2 (enExample) |
| EP (1) | EP2109668A4 (enExample) |
| JP (1) | JP2010516259A (enExample) |
| KR (1) | KR101523698B1 (enExample) |
| CN (1) | CN101855339A (enExample) |
| AU (1) | AU2008207945A1 (enExample) |
| CA (1) | CA2675521C (enExample) |
| IL (1) | IL199836A (enExample) |
| WO (1) | WO2008091908A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008091908A2 (en) | 2007-01-22 | 2008-07-31 | Raven Biotechnologies | Human cancer stem cells |
| WO2010050190A1 (ja) | 2008-10-27 | 2010-05-06 | 北海道公立大学法人札幌医科大学 | がん幹細胞分子マーカー |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11536713B2 (en) | 2009-12-25 | 2022-12-27 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein |
| DK2542256T3 (da) | 2010-03-04 | 2019-08-26 | Macrogenics Inc | Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| KR20130055591A (ko) * | 2010-04-13 | 2013-05-28 | 가부시키가이샤 르네상스 에너지 인베스트먼트 | 암 조직 유래 세포괴 또는 암 세포 응집괴로부터 얻어지는 암 치료용 조성물과 그것을 이용한 면역요법제의 제조 방법 및 면역요법 효과 평가 방법 |
| EP3875599B1 (en) | 2010-07-23 | 2024-12-11 | Astellas Institute for Regenerative Medicine | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| CN106620693A (zh) | 2010-09-03 | 2017-05-10 | 艾伯维施特姆森特克斯有限责任公司 | 新型调节剂及使用方法 |
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| US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
| SG189302A1 (en) * | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
| PH12013501137A1 (en) | 2010-12-08 | 2021-06-02 | Abbvie Stemcentrx Llc | Novel modulators and methods of use |
| KR101182549B1 (ko) * | 2010-12-16 | 2012-09-12 | 엘지이노텍 주식회사 | 3차원 입체 카메라 모듈 |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| WO2012129393A1 (en) * | 2011-03-24 | 2012-09-27 | The Rogosin Institute | Assay for screening compounds that selectively decrease the number of cancer stem cells |
| WO2012162067A2 (en) | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Cd3-binding molecules capable of binding to human and non-human cd3 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| JP6077997B2 (ja) * | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| EP3603671A3 (en) | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| EP2817620B1 (en) * | 2012-02-22 | 2016-06-01 | Verik Bio, Inc. | A system for immunotherapy targeting tumor propagation and progression |
| CN104520324A (zh) | 2012-02-24 | 2015-04-15 | 施特姆森特Rx股份有限公司 | Dll3调节剂及其使用方法 |
| RU2691698C2 (ru) | 2012-02-24 | 2019-06-17 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Антитела против sez6 и способы их применения |
| JP6090735B2 (ja) * | 2012-03-02 | 2017-03-08 | 国立大学法人山口大学 | 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法 |
| CA2902415C (en) * | 2012-03-19 | 2024-02-06 | Stemline Therapeutics, Inc. | Methods for treating and monitoring the status of cancer |
| WO2013173411A1 (en) | 2012-05-16 | 2013-11-21 | Stemline Therapeutics, Inc | Cancer stem cell targeted cancer vaccines |
| WO2014165101A1 (en) * | 2013-03-13 | 2014-10-09 | California Stem Cell, Inc. | Individualized high purity colon carcinoma stem cells, methods and use of the same |
| ES2731681T3 (es) | 2013-02-22 | 2019-11-18 | Abbvie Stemcentrx Llc | Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| EP4233536B1 (en) * | 2013-08-12 | 2025-12-31 | Minerva Biotechnologies Corporation | TUMOR GROWTH STIMULATION METHOD |
| CA2922529A1 (en) | 2013-08-28 | 2015-03-05 | Stemcentrx, Inc. | Novel sez6 modulators and methods of use |
| JP2016531915A (ja) | 2013-08-28 | 2016-10-13 | ステムセントリックス， インコーポレイテッド | 部位特異的抗体コンジュゲーション方法および組成物 |
| EP3041484B1 (en) | 2013-09-06 | 2021-03-03 | Academia Sinica | Human inkt cell activation using glycolipids with altered glycosyl groups |
| AU2014346792A1 (en) | 2013-11-06 | 2016-06-02 | Abbvie Stemcentrx Llc | Novel anti-claudin antibodies and methods of use |
| KR20160097336A (ko) | 2013-12-12 | 2016-08-17 | 스템센트알엑스 인코포레이티드 | 신규 항-ｄｐｅｐ3 항체 및 이의 사용 방법 |
| EP3107576A4 (en) | 2014-02-21 | 2017-09-06 | Abbvie Stemcentrx LLC | Anti-dll3 antibodies and drug conjugates for use in melanoma |
| EP4116329A1 (en) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| KR20170010003A (ko) | 2014-05-27 | 2017-01-25 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
| JP2017518989A (ja) | 2014-05-27 | 2017-07-13 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 抗ｃｄ２０糖操作抗体群およびその使用 |
| JP7063538B2 (ja) | 2014-05-28 | 2022-05-09 | アカデミア シニカ | 抗ＴＮＦα糖操作抗体群およびその使用 |
| KR20170041192A (ko) * | 2014-06-25 | 2017-04-14 | 텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드． | 암 줄기세포 마커의 동정 및 진단 및 치료를 위한 그의 사용 |
| SG11201701728PA (en) * | 2014-09-04 | 2017-04-27 | Agency Science Tech & Res | A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| TWI710571B (zh) * | 2015-01-24 | 2020-11-21 | 中央研究院 | 腫瘤標記及其使用方法 |
| CN107250161A (zh) | 2015-01-26 | 2017-10-13 | 宏观基因有限公司 | 包含dr5‑结合结构域的多价分子 |
| KR20160109356A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 자가 면역 질환 예방 또는 치료용 조성물 |
| KR20160109358A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 면역 질환 예방 또는 치료용 조성물 |
| KR102036029B1 (ko) | 2015-03-11 | 2019-10-24 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| WO2016170938A1 (ja) * | 2015-04-20 | 2016-10-27 | 国立大学法人岡山大学 | がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法 |
| EP3208331A1 (en) * | 2016-02-17 | 2017-08-23 | PromoCell bioscience alive GmbH Biomedizinische Produkte | Chemically defined medium for the culture of cancer stem cell (csc) containing cell populations |
| CN109069633A (zh) | 2016-04-15 | 2018-12-21 | 宏观基因有限公司 | 新颖的b7-h3-结合分子、其抗体药物缀合物及其使用方法 |
| EP3454864A4 (en) | 2016-04-21 | 2021-01-13 | Abbvie Stemcentrx LLC | Novel anti-bmpr1b antibodies and methods of use |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| GB201700952D0 (en) * | 2017-01-19 | 2017-03-08 | Univ Cape Town | In vitro propagation of primary cancer cells |
| CN107904206A (zh) * | 2017-11-17 | 2018-04-13 | 张家港澳洋医院有限公司 | 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法 |
| EP3896154A4 (en) * | 2018-06-13 | 2022-03-09 | Genex Health Co.,Ltd | PRIMARY CELL OF SOLID TUMOR IN COLORECTAL CANCER AND METHODS FOR CULTIVATION OF PRIMARY TUMOR CELL FROM ASCITES IN COLORECTAL CANCER AND RELEVANT REAGENT |
| KR102130493B1 (ko) | 2018-07-11 | 2020-07-06 | 이화여자대학교 산학협력단 | 건선 예방 또는 치료용 조성물 |
| KR102089476B1 (ko) | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| CN109652377B (zh) * | 2019-01-15 | 2023-03-28 | 广州医科大学 | 一种肺癌干细胞的制备方法及应用 |
| JP2022546578A (ja) * | 2019-09-04 | 2022-11-04 | ブイセル セラピューティックス，インコーポレイテッド | 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法 |
| KR20190120141A (ko) | 2019-10-16 | 2019-10-23 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| CN113069547B (zh) * | 2021-04-16 | 2023-01-24 | 同济大学附属第一妇婴保健院 | Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用 |
| CN113444690A (zh) * | 2021-07-29 | 2021-09-28 | 大连大学 | 一种基于三维培养体系的肿瘤细胞耐照射模型的建立方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US20050136066A1 (en) | 1996-06-12 | 2005-06-23 | Yajun Guo | Cellular vaccines and immunotherapeutics and methods for their preparation |
| US7348015B2 (en) | 1998-01-14 | 2008-03-25 | Morphogenesis, Inc. | Antigen modified cancer cell vaccines for cancer therapy |
| US6416999B1 (en) | 2000-04-07 | 2002-07-09 | Raven Biotechnologies, Inc. | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
| US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| CA2463927A1 (en) | 2001-10-16 | 2003-04-24 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof |
| HRP20041037A2 (en) | 2002-04-11 | 2005-06-30 | Altarex Medical Corporation | Binding agents and their use in targeting tumor cells |
| ATE488530T1 (de) | 2002-06-19 | 2010-12-15 | Raven Biotechnologies Inc | Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel |
| WO2005028626A2 (en) | 2003-09-18 | 2005-03-31 | Raven Biotechnologies, Inc. | Cell culture media |
| GB0406215D0 (en) | 2004-03-19 | 2004-04-21 | Procure Therapeutics Ltd | Prostate stem cell |
| KR101295139B1 (ko) | 2004-06-07 | 2013-08-12 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | 트랜스페린 리셉터 항체 |
| ITRM20040438A1 (it) | 2004-09-15 | 2004-12-15 | Univ Palermo | Metodo per la purificazione e l'amplificazione di cellule staminali tumorali. |
| WO2006051405A2 (en) | 2004-11-12 | 2006-05-18 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| EP1846767B1 (en) | 2005-01-12 | 2012-06-06 | MacroGenics West, Inc. | Kid31 and antibodies that bind thereto |
| WO2006084078A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Jam-3 and antibodies that bind thereto |
| JP5328155B2 (ja) | 2005-02-02 | 2013-10-30 | マクロジェニックス ウエスト， インコーポレイテッド | Ａｄａｍ−９モジュレータ |
| CA2597171A1 (en) | 2005-02-03 | 2006-08-10 | Raven Biotechnologies, Inc. | Antibodies to oncostatin m receptor |
| BRPI0607450A2 (pt) | 2005-02-04 | 2009-09-01 | Raven Biotechnologies Inc | anticorpos que se ligam a epha2 e métodos para sua utilização |
| EP1907572A2 (en) * | 2005-07-26 | 2008-04-09 | Procure Therapeutics Limited | Prostate stem cell markers |
| US20070123448A1 (en) | 2005-11-23 | 2007-05-31 | The Hospital For Sick Children | Novel chemical entities affecting neuroblastoma tumor-initiating cells |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| WO2008091908A2 (en) | 2007-01-22 | 2008-07-31 | Raven Biotechnologies | Human cancer stem cells |
-
2008
- 2008-01-22 WO PCT/US2008/051730 patent/WO2008091908A2/en not_active Ceased
- 2008-01-22 AU AU2008207945A patent/AU2008207945A1/en not_active Abandoned
- 2008-01-22 KR KR1020097017268A patent/KR101523698B1/ko not_active Expired - Fee Related
- 2008-01-22 US US12/018,126 patent/US8309354B2/en not_active Expired - Fee Related
- 2008-01-22 CA CA2675521A patent/CA2675521C/en not_active Expired - Fee Related
- 2008-01-22 EP EP08728101A patent/EP2109668A4/en not_active Withdrawn
- 2008-01-22 CN CN200880009078A patent/CN101855339A/zh active Pending
- 2008-01-22 JP JP2009546581A patent/JP2010516259A/ja active Pending
-
2009
- 2009-07-13 IL IL199836A patent/IL199836A/en not_active IP Right Cessation
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