CN101855339A - 人类癌症干细胞 - Google Patents
人类癌症干细胞 Download PDFInfo
- Publication number
- CN101855339A CN101855339A CN200880009078A CN200880009078A CN101855339A CN 101855339 A CN101855339 A CN 101855339A CN 200880009078 A CN200880009078 A CN 200880009078A CN 200880009078 A CN200880009078 A CN 200880009078A CN 101855339 A CN101855339 A CN 101855339A
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- China
- Prior art keywords
- cancer stem
- stem cells
- cells
- cell
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88149707P | 2007-01-22 | 2007-01-22 | |
| US60/881,497 | 2007-01-22 | ||
| US90718007P | 2007-03-23 | 2007-03-23 | |
| US60/907,180 | 2007-03-23 | ||
| US92424707P | 2007-05-04 | 2007-05-04 | |
| US60/924,247 | 2007-05-04 | ||
| US95071407P | 2007-07-19 | 2007-07-19 | |
| US60/950,714 | 2007-07-19 | ||
| US97261307P | 2007-09-14 | 2007-09-14 | |
| US60/972,613 | 2007-09-14 | ||
| PCT/US2008/051730 WO2008091908A2 (en) | 2007-01-22 | 2008-01-22 | Human cancer stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101855339A true CN101855339A (zh) | 2010-10-06 |
Family
ID=39641454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880009078A Pending CN101855339A (zh) | 2007-01-22 | 2008-01-22 | 人类癌症干细胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8309354B2 (enExample) |
| EP (1) | EP2109668A4 (enExample) |
| JP (1) | JP2010516259A (enExample) |
| KR (1) | KR101523698B1 (enExample) |
| CN (1) | CN101855339A (enExample) |
| AU (1) | AU2008207945A1 (enExample) |
| CA (1) | CA2675521C (enExample) |
| IL (1) | IL199836A (enExample) |
| WO (1) | WO2008091908A2 (enExample) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106537148A (zh) * | 2014-06-25 | 2017-03-22 | 泰尔哈绍梅尔医学研究基础设施和服务有限公司 | 癌症干细胞的鉴定及其用于诊断和治疗的用途 |
| CN107430127A (zh) * | 2015-01-24 | 2017-12-01 | 中央研究院 | 癌症标记及其使用方法 |
| CN107904206A (zh) * | 2017-11-17 | 2018-04-13 | 张家港澳洋医院有限公司 | 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法 |
| CN109652377A (zh) * | 2019-01-15 | 2019-04-19 | 广州医科大学 | 一种肺癌干细胞的制备方法及应用 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
| US10618973B2 (en) | 2014-05-27 | 2020-04-14 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
| US10918714B2 (en) | 2013-09-06 | 2021-02-16 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| CN113069547A (zh) * | 2021-04-16 | 2021-07-06 | 同济大学附属第一妇婴保健院 | Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用 |
| US11267870B2 (en) | 2009-12-02 | 2022-03-08 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11319567B2 (en) | 2014-05-27 | 2022-05-03 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11884739B2 (en) | 2014-05-27 | 2024-01-30 | Academia Sinica | Anti-CD20 glycoantibodies and uses thereof |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309354B2 (en) | 2007-01-22 | 2012-11-13 | Macrogenics West, Inc. | Human cancer stem cells |
| EP2361988B1 (en) | 2008-10-27 | 2016-04-13 | Sapporo Medical University | Molecular marker for cancer stem cell |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| PT2542256T (pt) | 2010-03-04 | 2019-09-05 | Macrogenics Inc | Anticorpos reativos com b7-h3, fragmentos imunologicamente ativos dos mesmos e sua utilização |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| KR20130055591A (ko) * | 2010-04-13 | 2013-05-28 | 가부시키가이샤 르네상스 에너지 인베스트먼트 | 암 조직 유래 세포괴 또는 암 세포 응집괴로부터 얻어지는 암 치료용 조성물과 그것을 이용한 면역요법제의 제조 방법 및 면역요법 효과 평가 방법 |
| EP2596119B8 (en) | 2010-07-23 | 2021-06-02 | Astellas Institute for Regenerative Medicine | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| WO2012031280A2 (en) | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
| US9778264B2 (en) * | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
| AU2011295715B9 (en) * | 2010-09-03 | 2017-02-23 | Abbvie Stemcentrx Llc | Novel modulators and methods of use |
| SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
| RU2592672C9 (ru) | 2010-12-08 | 2016-11-27 | СтемСентРкс, Инк. | Новые модуляторы и способы их применения |
| KR101182549B1 (ko) * | 2010-12-16 | 2012-09-12 | 엘지이노텍 주식회사 | 3차원 입체 카메라 모듈 |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| PL2689249T3 (pl) * | 2011-03-24 | 2017-09-29 | The Rogosin Institute | Oznaczenie dla badania przesiewowego związków, które selektywnie zmniejszają liczbę rakowych komórek macierzystych |
| NZ703939A (en) | 2011-05-21 | 2016-01-29 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| WO2013062083A1 (ja) | 2011-10-28 | 2013-05-02 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞特異的分子 |
| EP2817620B1 (en) | 2012-02-22 | 2016-06-01 | Verik Bio, Inc. | A system for immunotherapy targeting tumor propagation and progression |
| JP6401060B2 (ja) | 2012-02-24 | 2018-10-03 | アッヴィ・ステムセントルクス・エル・エル・シー | 抗sez6抗体及び使用方法 |
| HUE037021T2 (hu) | 2012-02-24 | 2018-08-28 | Abbvie Stemcentrx Llc | DLL3- modulátorok és eljárások alkalmazásukra |
| JP6090735B2 (ja) * | 2012-03-02 | 2017-03-08 | 国立大学法人山口大学 | 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法 |
| ES2699817T3 (es) | 2012-03-19 | 2019-02-12 | Stemline Therapeutics Inc | Métodos para tratar y controlar el estado de un cáncer |
| SI3536334T1 (sl) | 2012-05-16 | 2021-11-30 | Stemline Therapeutics Inc. | Cepiva proti raku, ki ciljajo na rakave matične celice |
| ME03394B (me) | 2013-02-22 | 2020-01-20 | Medimmune Ltd | Antidllз-antitelo-pbd konjugati i nihovа upotreba |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| AU2014248711A1 (en) * | 2013-03-13 | 2015-09-10 | Neostem Oncology, Llc | Individualized high purity colon carcinoma stem cells, methods and use of the same |
| JP6640086B2 (ja) * | 2013-08-12 | 2020-02-05 | ミネルバ バイオテクノロジーズ コーポレーション | 腫瘍成長を増強する方法 |
| BR112016004245A2 (pt) | 2013-08-28 | 2017-10-17 | Stemcentrx Inc | moduladores de sez6 e métodos de uso |
| KR20160044042A (ko) | 2013-08-28 | 2016-04-22 | 스템센트알엑스 인코포레이티드 | 부위-특이적 항체 접합 방법 및 조성물 |
| JP6515111B2 (ja) | 2013-11-06 | 2019-05-22 | アッヴィ・ステムセントルクス・エル・エル・シー | 新規の抗クローディン抗体および使用方法 |
| PE20160993A1 (es) | 2013-12-12 | 2016-10-14 | Abbvie Stemcentrx Llc | Nuevos anticuerpos anti-dpep3 y metodos de uso |
| EA201691683A1 (ru) | 2014-02-21 | 2017-04-28 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Антитела против dll3 и конъюгаты антитело-лекарственное средство для применения при меланоме |
| US20170191034A1 (en) * | 2014-09-04 | 2017-07-06 | Agency For Science Technology And Research | A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
| US10501552B2 (en) | 2015-01-26 | 2019-12-10 | Macrogenics, Inc. | Multivalent molecules comprising DR5-binding domains |
| KR20160109356A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 자가 면역 질환 예방 또는 치료용 조성물 |
| KR102036029B1 (ko) | 2015-03-11 | 2019-10-24 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| KR20160109358A (ko) | 2015-03-11 | 2016-09-21 | 이화여자대학교 산학협력단 | 면역 질환 예방 또는 치료용 조성물 |
| JP6161828B2 (ja) * | 2015-04-20 | 2017-07-12 | 国立大学法人 岡山大学 | がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法 |
| EP3208331A1 (en) * | 2016-02-17 | 2017-08-23 | PromoCell bioscience alive GmbH Biomedizinische Produkte | Chemically defined medium for the culture of cancer stem cell (csc) containing cell populations |
| PE20190353A1 (es) | 2016-04-15 | 2019-03-07 | Macrogenics Inc | Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos |
| US10934359B2 (en) | 2016-04-21 | 2021-03-02 | Abbvie Stemcentrx Llc | Anti-BMPR1B antibodies and methods of use |
| GB201700952D0 (en) * | 2017-01-19 | 2017-03-08 | Univ Cape Town | In vitro propagation of primary cancer cells |
| AU2019284405B2 (en) * | 2018-06-13 | 2025-08-21 | Genex Health Co.,Ltd | Colorectal cancer solid tumour primary cell and colorectal cancer ascitic fluid primary tumour cell culturing method, and matching reagent |
| KR102089476B1 (ko) | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| KR102130493B1 (ko) | 2018-07-11 | 2020-07-06 | 이화여자대학교 산학협력단 | 건선 예방 또는 치료용 조성물 |
| JP2022546578A (ja) * | 2019-09-04 | 2022-11-04 | ブイセル セラピューティックス,インコーポレイテッド | 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法 |
| KR20190120141A (ko) | 2019-10-16 | 2019-10-23 | 이화여자대학교 산학협력단 | 골수 부전 예방 또는 치료용 조성물 |
| CN113444690A (zh) * | 2021-07-29 | 2021-09-28 | 大连大学 | 一种基于三维培养体系的肿瘤细胞耐照射模型的建立方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US20050136066A1 (en) | 1996-06-12 | 2005-06-23 | Yajun Guo | Cellular vaccines and immunotherapeutics and methods for their preparation |
| US7348015B2 (en) | 1998-01-14 | 2008-03-25 | Morphogenesis, Inc. | Antigen modified cancer cell vaccines for cancer therapy |
| US6416999B1 (en) | 2000-04-07 | 2002-07-09 | Raven Biotechnologies, Inc. | Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US7148038B2 (en) | 2001-10-16 | 2006-12-12 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof |
| AU2003223600A1 (en) | 2002-04-11 | 2003-10-27 | Altarex Medical Corporation | Binding agents and their use in targeting tumor cells |
| WO2004001381A2 (en) | 2002-06-19 | 2003-12-31 | Raven Biotechnologies, Inc. | Novel raag10 cell surface target and a family of antibodies recognizing that target |
| WO2005028626A2 (en) | 2003-09-18 | 2005-03-31 | Raven Biotechnologies, Inc. | Cell culture media |
| GB0406215D0 (en) | 2004-03-19 | 2004-04-21 | Procure Therapeutics Ltd | Prostate stem cell |
| AU2005252699B2 (en) | 2004-06-07 | 2010-12-23 | Macrogenics West, Inc. | Transferrin receptor antibodies |
| ITRM20040438A1 (it) | 2004-09-15 | 2004-12-15 | Univ Palermo | Metodo per la purificazione e l'amplificazione di cellule staminali tumorali. |
| WO2006051405A2 (en) | 2004-11-12 | 2006-05-18 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
| JP2008526256A (ja) | 2005-01-12 | 2008-07-24 | レイベン バイオテクノロジーズ,インコーポレイティド | Kid31およびkid31に結合する抗体 |
| WO2006084075A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Adam-9 modulators |
| WO2006084078A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Jam-3 and antibodies that bind thereto |
| US7572896B2 (en) | 2005-02-03 | 2009-08-11 | Raven Biotechnologies, Inc. | Antibodies to oncostatin M receptor |
| RU2007133108A (ru) | 2005-02-04 | 2009-03-10 | Рэйвен Байотекнолоджиз, Инк. (Us) | АНТИТЕЛА, СВЯЗЫВАЮЩИЕСЯ С EphA2, И МЕТОДЫ ИХ ИСПОЛЬЗОВАНИЯ |
| EP1907572A2 (en) | 2005-07-26 | 2008-04-09 | Procure Therapeutics Limited | Prostate stem cell markers |
| US20070123448A1 (en) | 2005-11-23 | 2007-05-31 | The Hospital For Sick Children | Novel chemical entities affecting neuroblastoma tumor-initiating cells |
| CA2700573C (en) * | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| US8309354B2 (en) | 2007-01-22 | 2012-11-13 | Macrogenics West, Inc. | Human cancer stem cells |
-
2008
- 2008-01-22 US US12/018,126 patent/US8309354B2/en not_active Expired - Fee Related
- 2008-01-22 WO PCT/US2008/051730 patent/WO2008091908A2/en not_active Ceased
- 2008-01-22 CN CN200880009078A patent/CN101855339A/zh active Pending
- 2008-01-22 KR KR1020097017268A patent/KR101523698B1/ko not_active Expired - Fee Related
- 2008-01-22 JP JP2009546581A patent/JP2010516259A/ja active Pending
- 2008-01-22 EP EP08728101A patent/EP2109668A4/en not_active Withdrawn
- 2008-01-22 AU AU2008207945A patent/AU2008207945A1/en not_active Abandoned
- 2008-01-22 CA CA2675521A patent/CA2675521C/en not_active Expired - Fee Related
-
2009
- 2009-07-13 IL IL199836A patent/IL199836A/en not_active IP Right Cessation
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11267870B2 (en) | 2009-12-02 | 2022-03-08 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10918714B2 (en) | 2013-09-06 | 2021-02-16 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| US10618973B2 (en) | 2014-05-27 | 2020-04-14 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
| US11884739B2 (en) | 2014-05-27 | 2024-01-30 | Academia Sinica | Anti-CD20 glycoantibodies and uses thereof |
| US11319567B2 (en) | 2014-05-27 | 2022-05-03 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
| CN106537148B (zh) * | 2014-06-25 | 2019-10-11 | 泰尔哈绍梅尔医学研究基础设施和服务有限公司 | 癌症干细胞的鉴定及其用于诊断和治疗的用途 |
| US10883994B2 (en) | 2014-06-25 | 2021-01-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Identification of cancer stem cells markers and use of same for diagnosis and treatment |
| CN106537148A (zh) * | 2014-06-25 | 2017-03-22 | 泰尔哈绍梅尔医学研究基础设施和服务有限公司 | 癌症干细胞的鉴定及其用于诊断和治疗的用途 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| CN107430127A (zh) * | 2015-01-24 | 2017-12-01 | 中央研究院 | 癌症标记及其使用方法 |
| US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
| CN107904206A (zh) * | 2017-11-17 | 2018-04-13 | 张家港澳洋医院有限公司 | 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法 |
| CN109652377A (zh) * | 2019-01-15 | 2019-04-19 | 广州医科大学 | 一种肺癌干细胞的制备方法及应用 |
| CN109652377B (zh) * | 2019-01-15 | 2023-03-28 | 广州医科大学 | 一种肺癌干细胞的制备方法及应用 |
| CN113069547A (zh) * | 2021-04-16 | 2021-07-06 | 同济大学附属第一妇婴保健院 | Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100033471A (ko) | 2010-03-30 |
| EP2109668A2 (en) | 2009-10-21 |
| US20080175870A1 (en) | 2008-07-24 |
| CA2675521A1 (en) | 2008-07-31 |
| WO2008091908A2 (en) | 2008-07-31 |
| WO2008091908A3 (en) | 2009-12-30 |
| AU2008207945A1 (en) | 2008-07-31 |
| IL199836A (en) | 2014-02-27 |
| JP2010516259A (ja) | 2010-05-20 |
| US8309354B2 (en) | 2012-11-13 |
| IL199836A0 (en) | 2010-04-15 |
| CA2675521C (en) | 2016-04-26 |
| KR101523698B1 (ko) | 2015-05-29 |
| EP2109668A4 (en) | 2011-10-05 |
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