CA2675521C - Human cancer stem cells - Google Patents

Human cancer stem cells Download PDF

Info

Publication number
CA2675521C
CA2675521C CA2675521A CA2675521A CA2675521C CA 2675521 C CA2675521 C CA 2675521C CA 2675521 A CA2675521 A CA 2675521A CA 2675521 A CA2675521 A CA 2675521A CA 2675521 C CA2675521 C CA 2675521C
Authority
CA
Canada
Prior art keywords
stem cells
cells
cell
cancer stem
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2675521A
Other languages
English (en)
French (fr)
Other versions
CA2675521A1 (en
Inventor
Jennie P. Mather
Penelope Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Raven Biotechnologies Inc
Original Assignee
Raven Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raven Biotechnologies Inc filed Critical Raven Biotechnologies Inc
Publication of CA2675521A1 publication Critical patent/CA2675521A1/en
Application granted granted Critical
Publication of CA2675521C publication Critical patent/CA2675521C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2675521A 2007-01-22 2008-01-22 Human cancer stem cells Expired - Fee Related CA2675521C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US88149707P 2007-01-22 2007-01-22
US60/881,497 2007-01-22
US90718007P 2007-03-23 2007-03-23
US60/907,180 2007-03-23
US92424707P 2007-05-04 2007-05-04
US60/924,247 2007-05-04
US95071407P 2007-07-19 2007-07-19
US60/950,714 2007-07-19
US97261307P 2007-09-14 2007-09-14
US60/972,613 2007-09-14
PCT/US2008/051730 WO2008091908A2 (en) 2007-01-22 2008-01-22 Human cancer stem cells

Publications (2)

Publication Number Publication Date
CA2675521A1 CA2675521A1 (en) 2008-07-31
CA2675521C true CA2675521C (en) 2016-04-26

Family

ID=39641454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2675521A Expired - Fee Related CA2675521C (en) 2007-01-22 2008-01-22 Human cancer stem cells

Country Status (9)

Country Link
US (1) US8309354B2 (enExample)
EP (1) EP2109668A4 (enExample)
JP (1) JP2010516259A (enExample)
KR (1) KR101523698B1 (enExample)
CN (1) CN101855339A (enExample)
AU (1) AU2008207945A1 (enExample)
CA (1) CA2675521C (enExample)
IL (1) IL199836A (enExample)
WO (1) WO2008091908A2 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008091908A2 (en) 2007-01-22 2008-07-31 Raven Biotechnologies Human cancer stem cells
WO2010050190A1 (ja) 2008-10-27 2010-05-06 北海道公立大学法人札幌医科大学 がん幹細胞分子マーカー
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11536713B2 (en) 2009-12-25 2022-12-27 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein
DK2542256T3 (da) 2010-03-04 2019-08-26 Macrogenics Inc Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
KR20130055591A (ko) * 2010-04-13 2013-05-28 가부시키가이샤 르네상스 에너지 인베스트먼트 암 조직 유래 세포괴 또는 암 세포 응집괴로부터 얻어지는 암 치료용 조성물과 그것을 이용한 면역요법제의 제조 방법 및 면역요법 효과 평가 방법
EP3875599B1 (en) 2010-07-23 2024-12-11 Astellas Institute for Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
CN106620693A (zh) 2010-09-03 2017-05-10 艾伯维施特姆森特克斯有限责任公司 新型调节剂及使用方法
CA2809864A1 (en) 2010-09-03 2012-03-08 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
SG189302A1 (en) * 2010-10-06 2013-05-31 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
PH12013501137A1 (en) 2010-12-08 2021-06-02 Abbvie Stemcentrx Llc Novel modulators and methods of use
KR101182549B1 (ko) * 2010-12-16 2012-09-12 엘지이노텍 주식회사 3차원 입체 카메라 모듈
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
WO2012129393A1 (en) * 2011-03-24 2012-09-27 The Rogosin Institute Assay for screening compounds that selectively decrease the number of cancer stem cells
WO2012162067A2 (en) 2011-05-21 2012-11-29 Macrogenics, Inc. Cd3-binding molecules capable of binding to human and non-human cd3
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
JP6077997B2 (ja) * 2011-09-07 2017-02-08 中外製薬株式会社 癌幹細胞の分離
EP3603671A3 (en) 2011-10-28 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
EP2817620B1 (en) * 2012-02-22 2016-06-01 Verik Bio, Inc. A system for immunotherapy targeting tumor propagation and progression
CN104520324A (zh) 2012-02-24 2015-04-15 施特姆森特Rx股份有限公司 Dll3调节剂及其使用方法
RU2691698C2 (ru) 2012-02-24 2019-06-17 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Антитела против sez6 и способы их применения
JP6090735B2 (ja) * 2012-03-02 2017-03-08 国立大学法人山口大学 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法
CA2902415C (en) * 2012-03-19 2024-02-06 Stemline Therapeutics, Inc. Methods for treating and monitoring the status of cancer
WO2013173411A1 (en) 2012-05-16 2013-11-21 Stemline Therapeutics, Inc Cancer stem cell targeted cancer vaccines
WO2014165101A1 (en) * 2013-03-13 2014-10-09 California Stem Cell, Inc. Individualized high purity colon carcinoma stem cells, methods and use of the same
ES2731681T3 (es) 2013-02-22 2019-11-18 Abbvie Stemcentrx Llc Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
EP4233536B1 (en) * 2013-08-12 2025-12-31 Minerva Biotechnologies Corporation TUMOR GROWTH STIMULATION METHOD
CA2922529A1 (en) 2013-08-28 2015-03-05 Stemcentrx, Inc. Novel sez6 modulators and methods of use
JP2016531915A (ja) 2013-08-28 2016-10-13 ステムセントリックス, インコーポレイテッド 部位特異的抗体コンジュゲーション方法および組成物
EP3041484B1 (en) 2013-09-06 2021-03-03 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
AU2014346792A1 (en) 2013-11-06 2016-06-02 Abbvie Stemcentrx Llc Novel anti-claudin antibodies and methods of use
KR20160097336A (ko) 2013-12-12 2016-08-17 스템센트알엑스 인코포레이티드 신규 항-dpep3 항체 및 이의 사용 방법
EP3107576A4 (en) 2014-02-21 2017-09-06 Abbvie Stemcentrx LLC Anti-dll3 antibodies and drug conjugates for use in melanoma
EP4116329A1 (en) 2014-05-27 2023-01-11 Academia Sinica Anti-her2 glycoantibodies and uses thereof
KR20170010003A (ko) 2014-05-27 2017-01-25 아카데미아 시니카 박테로이드 기원의 푸코시다제 및 이의 사용 방법
JP2017518989A (ja) 2014-05-27 2017-07-13 アカデミア シニカAcademia Sinica 抗cd20糖操作抗体群およびその使用
JP7063538B2 (ja) 2014-05-28 2022-05-09 アカデミア シニカ 抗TNFα糖操作抗体群およびその使用
KR20170041192A (ko) * 2014-06-25 2017-04-14 텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드. 암 줄기세포 마커의 동정 및 진단 및 치료를 위한 그의 사용
SG11201701728PA (en) * 2014-09-04 2017-04-27 Agency Science Tech & Res A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
TWI710571B (zh) * 2015-01-24 2020-11-21 中央研究院 腫瘤標記及其使用方法
CN107250161A (zh) 2015-01-26 2017-10-13 宏观基因有限公司 包含dr5‑结合结构域的多价分子
KR20160109356A (ko) 2015-03-11 2016-09-21 이화여자대학교 산학협력단 자가 면역 질환 예방 또는 치료용 조성물
KR20160109358A (ko) 2015-03-11 2016-09-21 이화여자대학교 산학협력단 면역 질환 예방 또는 치료용 조성물
KR102036029B1 (ko) 2015-03-11 2019-10-24 이화여자대학교 산학협력단 골수 부전 예방 또는 치료용 조성물
WO2016170938A1 (ja) * 2015-04-20 2016-10-27 国立大学法人岡山大学 がんの非ヒトモデル動物及びその作製方法、がん幹細胞及びその製造方法
EP3208331A1 (en) * 2016-02-17 2017-08-23 PromoCell bioscience alive GmbH Biomedizinische Produkte Chemically defined medium for the culture of cancer stem cell (csc) containing cell populations
CN109069633A (zh) 2016-04-15 2018-12-21 宏观基因有限公司 新颖的b7-h3-结合分子、其抗体药物缀合物及其使用方法
EP3454864A4 (en) 2016-04-21 2021-01-13 Abbvie Stemcentrx LLC Novel anti-bmpr1b antibodies and methods of use
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
GB201700952D0 (en) * 2017-01-19 2017-03-08 Univ Cape Town In vitro propagation of primary cancer cells
CN107904206A (zh) * 2017-11-17 2018-04-13 张家港澳洋医院有限公司 一种脂多糖诱导肿瘤细胞生成肿瘤干细胞的用途和方法
EP3896154A4 (en) * 2018-06-13 2022-03-09 Genex Health Co.,Ltd PRIMARY CELL OF SOLID TUMOR IN COLORECTAL CANCER AND METHODS FOR CULTIVATION OF PRIMARY TUMOR CELL FROM ASCITES IN COLORECTAL CANCER AND RELEVANT REAGENT
KR102130493B1 (ko) 2018-07-11 2020-07-06 이화여자대학교 산학협력단 건선 예방 또는 치료용 조성물
KR102089476B1 (ko) 2018-07-11 2020-03-16 이화여자대학교 산학협력단 피부 염증 질환 예방 또는 치료용 조성물
CN109652377B (zh) * 2019-01-15 2023-03-28 广州医科大学 一种肺癌干细胞的制备方法及应用
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス,インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法
KR20190120141A (ko) 2019-10-16 2019-10-23 이화여자대학교 산학협력단 골수 부전 예방 또는 치료용 조성물
CN113069547B (zh) * 2021-04-16 2023-01-24 同济大学附属第一妇婴保健院 Bap1作为肿瘤治疗靶点在制备预防或治疗肿瘤药物中的应用
CN113444690A (zh) * 2021-07-29 2021-09-28 大连大学 一种基于三维培养体系的肿瘤细胞耐照射模型的建立方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US20050136066A1 (en) 1996-06-12 2005-06-23 Yajun Guo Cellular vaccines and immunotherapeutics and methods for their preparation
US7348015B2 (en) 1998-01-14 2008-03-25 Morphogenesis, Inc. Antigen modified cancer cell vaccines for cancer therapy
US6416999B1 (en) 2000-04-07 2002-07-09 Raven Biotechnologies, Inc. Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
CA2463927A1 (en) 2001-10-16 2003-04-24 Raven Biotechnologies, Inc. Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof
HRP20041037A2 (en) 2002-04-11 2005-06-30 Altarex Medical Corporation Binding agents and their use in targeting tumor cells
ATE488530T1 (de) 2002-06-19 2010-12-15 Raven Biotechnologies Inc Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel
WO2005028626A2 (en) 2003-09-18 2005-03-31 Raven Biotechnologies, Inc. Cell culture media
GB0406215D0 (en) 2004-03-19 2004-04-21 Procure Therapeutics Ltd Prostate stem cell
KR101295139B1 (ko) 2004-06-07 2013-08-12 레이븐 바이오테크놀로지스, 인코퍼레이티드 트랜스페린 리셉터 항체
ITRM20040438A1 (it) 2004-09-15 2004-12-15 Univ Palermo Metodo per la purificazione e l'amplificazione di cellule staminali tumorali.
WO2006051405A2 (en) 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
EP1846767B1 (en) 2005-01-12 2012-06-06 MacroGenics West, Inc. Kid31 and antibodies that bind thereto
WO2006084078A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
JP5328155B2 (ja) 2005-02-02 2013-10-30 マクロジェニックス ウエスト, インコーポレイテッド Adam−9モジュレータ
CA2597171A1 (en) 2005-02-03 2006-08-10 Raven Biotechnologies, Inc. Antibodies to oncostatin m receptor
BRPI0607450A2 (pt) 2005-02-04 2009-09-01 Raven Biotechnologies Inc anticorpos que se ligam a epha2 e métodos para sua utilização
EP1907572A2 (en) * 2005-07-26 2008-04-09 Procure Therapeutics Limited Prostate stem cell markers
US20070123448A1 (en) 2005-11-23 2007-05-31 The Hospital For Sick Children Novel chemical entities affecting neuroblastoma tumor-initiating cells
CA2700573C (en) 2006-09-26 2016-11-22 Cedars-Sinai Medical Center Cancer stem cell antigen vaccines and methods
WO2008091908A2 (en) 2007-01-22 2008-07-31 Raven Biotechnologies Human cancer stem cells

Also Published As

Publication number Publication date
KR101523698B1 (ko) 2015-05-29
US8309354B2 (en) 2012-11-13
WO2008091908A2 (en) 2008-07-31
IL199836A0 (en) 2010-04-15
WO2008091908A3 (en) 2009-12-30
CN101855339A (zh) 2010-10-06
IL199836A (en) 2014-02-27
KR20100033471A (ko) 2010-03-30
JP2010516259A (ja) 2010-05-20
AU2008207945A1 (en) 2008-07-31
EP2109668A4 (en) 2011-10-05
EP2109668A2 (en) 2009-10-21
CA2675521A1 (en) 2008-07-31
US20080175870A1 (en) 2008-07-24

Similar Documents

Publication Publication Date Title
US8309354B2 (en) Human cancer stem cells
JP6207783B2 (ja) 抗原特異的t細胞の増殖のための方法
Grange et al. Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice
JP6630074B2 (ja) 新規に単離された細胞の治療組成物の操作および送達
CN103756964B (zh) 一种高效扩增cd3-cd56+的自然杀伤细胞培养系统的方法
KR20200003913A (ko) 액상 종양으로부터의 종양 침윤 림프구의 확장 및 그의 치료 용도
KR102944529B1 (ko) 항-pd-1 항체에 불응성인 nsclc 환자의 치료
US20240366664A1 (en) Treatment of cancer with nk cells and an egfr targeted antibody
EP4262830A1 (en) Treatment of cancer with nk cells and a cd20 targeted antibody
CN107541498A (zh) 一种tcr基因修饰的cd8+t记忆性干细胞的制备方法及其用途
IL303762A (en) Expanded and stimulated natural killer cells
EP4426350A2 (en) Treatment of cancer with nk cells and multispecific engagers
KR20160093654A (ko) 종양을 치료하는 방법
ES2984777T3 (es) Proceso mejorado de cultivo de linfocitos infiltrantes de tumores para uso terapéutico
TW202208616A (zh) 改良之腫瘤反應性t細胞的選擇
CN113544262B (zh) 包括细胞因子诱导的杀伤细胞的活化淋巴细胞及其制备方法
JP7733640B2 (ja) 不死化された筋芽細胞株及びその使用
CN112755051B (zh) 一种nk细胞的制备及治疗癌症中的应用
EP4183872A1 (en) Immunotherapy method of targeted chemokine and cytokine delivery by mesenchymal stem cell
US12440565B1 (en) Dendritic cell preparation and preparation method thereof
US10022402B2 (en) Allogenic mesendritic vector for ovarian cancer
Ge et al. Vaccination with immature dendritic cells combined with CD40 mAb induces protective immunity against B lymphoma in hu-SCID mice
HK40059384B (en) Activated lymphocytes comprising cytokine-induced killer cells and preparation method therefor
WO2025096638A2 (en) Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same
Jæhger Preclinical Evaluation of Novel Drug Delivery Platforms for the Improvement of Adoptive T cell Therapy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130121

MKLA Lapsed

Effective date: 20190122