JP2010513494A5 - - Google Patents
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- JP2010513494A5 JP2010513494A5 JP2009542841A JP2009542841A JP2010513494A5 JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5 JP 2009542841 A JP2009542841 A JP 2009542841A JP 2009542841 A JP2009542841 A JP 2009542841A JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5
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- JP
- Japan
- Prior art keywords
- alkyl
- solvate
- pharmaceutically acceptable
- nhso
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **[n]1c2c(*)c(*)c(CCCCC3)c3c2c(*)c1* Chemical compound **[n]1c2c(*)c(*)c(CCCCC3)c3c2c(*)c1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87661306P | 2006-12-22 | 2006-12-22 | |
| US60/876,613 | 2006-12-22 | ||
| PCT/US2007/025765 WO2008082488A1 (en) | 2006-12-22 | 2007-12-17 | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013009838A Division JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| JP2013009837A Division JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513494A JP2010513494A (ja) | 2010-04-30 |
| JP2010513494A5 true JP2010513494A5 (cg-RX-API-DMAC10.html) | 2013-03-14 |
| JP5211068B2 JP5211068B2 (ja) | 2013-06-12 |
Family
ID=39185892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542841A Expired - Fee Related JP5211068B2 (ja) | 2006-12-22 | 2007-12-17 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| JP2013009838A Pending JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| JP2013009837A Pending JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013009838A Pending JP2013121970A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| JP2013009837A Pending JP2013100331A (ja) | 2006-12-22 | 2013-01-23 | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
Country Status (14)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| CN101611002A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 用于治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
| JP5079818B2 (ja) | 2006-12-22 | 2012-11-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| CN101611025A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 5,6-环化的吲哚衍生物及其使用方法 |
| CA2697454C (en) * | 2007-08-29 | 2015-11-03 | Schering Corporation | 2-carboxy substituted indole derivatives and methods of use thereof |
| MX2010002318A (es) * | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. |
| CA2705587A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| US8765757B2 (en) * | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
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| PE20110409A1 (es) * | 2008-07-23 | 2011-06-22 | Hoffmann La Roche | Compuestos heterociclicos antiviricos |
| SG172778A1 (en) | 2008-12-22 | 2011-08-29 | Hoffmann La Roche | Heterocyclic antiviral compounds |
| EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| US20120276047A1 (en) | 2009-11-25 | 2012-11-01 | Rosenblum Stuart B | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
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| EP2545060B1 (en) | 2010-03-09 | 2015-11-25 | Merck Sharp & Dohme Corp. | Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases |
| KR101213495B1 (ko) | 2010-06-03 | 2013-01-14 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
| AU2011286276A1 (en) | 2010-07-26 | 2013-01-24 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| EP2621279B1 (en) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| CA2832459A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| US20140378416A1 (en) | 2011-09-14 | 2014-12-25 | Michael P. Dwyer | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
| US9242988B2 (en) | 2012-10-17 | 2016-01-26 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| EP2909210A4 (en) | 2012-10-17 | 2016-04-06 | Merck Sharp & Dohme | 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THE USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES |
| AU2013344757A1 (en) | 2012-11-19 | 2015-05-21 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
| WO2014204831A1 (en) | 2013-06-18 | 2014-12-24 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
| WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
| EP3063140A4 (en) | 2013-10-30 | 2017-11-08 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2017223012A1 (en) | 2016-06-20 | 2017-12-28 | Merck Sharp & Dohme Corp. | Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases |
| CN106619731B (zh) * | 2016-12-30 | 2020-06-12 | 昆明赛诺制药股份有限公司 | 一种治疗丙型肝炎的药物 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
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| JP5079818B2 (ja) | 2006-12-22 | 2012-11-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| CN101611002A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 用于治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
| CN101611025A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 5,6-环化的吲哚衍生物及其使用方法 |
| TW200924751A (en) | 2007-08-29 | 2009-06-16 | Schering Corp | 2,3-substituted indole derivatives and methods of use thereof |
| CA2697454C (en) | 2007-08-29 | 2015-11-03 | Schering Corporation | 2-carboxy substituted indole derivatives and methods of use thereof |
| MX2010002318A (es) | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. |
| US8765757B2 (en) | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
-
2007
- 2007-12-17 CN CNA2007800517016A patent/CN101611002A/zh active Pending
- 2007-12-17 CA CA2673254A patent/CA2673254C/en not_active Expired - Fee Related
- 2007-12-17 KR KR1020097015272A patent/KR20090106539A/ko not_active Ceased
- 2007-12-17 JP JP2009542841A patent/JP5211068B2/ja not_active Expired - Fee Related
- 2007-12-17 US US12/519,728 patent/US8546420B2/en not_active Expired - Fee Related
- 2007-12-17 WO PCT/US2007/025765 patent/WO2008082488A1/en not_active Ceased
- 2007-12-17 MX MX2009006878A patent/MX2009006878A/es unknown
- 2007-12-17 AU AU2007339386A patent/AU2007339386B8/en not_active Ceased
- 2007-12-17 EP EP07863006A patent/EP2064181A1/en not_active Withdrawn
- 2007-12-18 AR ARP070105706A patent/AR064429A1/es not_active Application Discontinuation
- 2007-12-18 TW TW096148494A patent/TW200833662A/zh unknown
- 2007-12-18 CL CL200703685A patent/CL2007003685A1/es unknown
-
2008
- 2008-01-02 PE PE2008000056A patent/PE20081567A1/es not_active Application Discontinuation
-
2009
- 2009-06-19 ZA ZA200904334A patent/ZA200904334B/xx unknown
-
2013
- 2013-01-23 JP JP2013009838A patent/JP2013121970A/ja active Pending
- 2013-01-23 JP JP2013009837A patent/JP2013100331A/ja active Pending