JP2010509232A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010509232A5 JP2010509232A5 JP2009535474A JP2009535474A JP2010509232A5 JP 2010509232 A5 JP2010509232 A5 JP 2010509232A5 JP 2009535474 A JP2009535474 A JP 2009535474A JP 2009535474 A JP2009535474 A JP 2009535474A JP 2010509232 A5 JP2010509232 A5 JP 2010509232A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- rebaudioside
- antidiabetic
- amount
- diabetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 65
- 239000003472 antidiabetic agent Substances 0.000 claims 40
- 230000003178 anti-diabetic Effects 0.000 claims 38
- 239000001512 FEMA 4601 Substances 0.000 claims 20
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 claims 20
- HELXLJCILKEWJH-NCGAPWICSA-N Stevioside A3 Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 20
- 235000019203 rebaudioside A Nutrition 0.000 claims 20
- 239000011780 sodium chloride Substances 0.000 claims 13
- 229920005862 polyol Polymers 0.000 claims 8
- 150000003077 polyols Chemical class 0.000 claims 8
- 235000003599 food sweetener Nutrition 0.000 claims 7
- -1 organic acid salt Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000003765 sweetening agent Substances 0.000 claims 7
- 230000000875 corresponding Effects 0.000 claims 5
- 150000007522 mineralic acids Chemical class 0.000 claims 4
- 150000007524 organic acids Chemical class 0.000 claims 4
- 235000019605 sweet taste sensations Nutrition 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N Maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 2
- QSRAJVGDWKFOGU-WBXIDTKBSA-N Rebaudioside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CC[C@H]2[C@@]3(C)[C@@H]([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-WBXIDTKBSA-N 0.000 claims 2
- RLLCWNUIHGPAJY-RYBZXKSASA-N Rebaudioside E Natural products O=C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@@H](O)[C@@H](O)[C@H](CO)O1)[C@]1(C)[C@@H]2[C@@](C)([C@@H]3[C@@]4(CC(=C)[C@@](O[C@@H]5[C@@H](O[C@@H]6[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O6)[C@H](O)[C@@H](O)[C@H](CO)O5)(C4)CC3)CC2)CCC1 RLLCWNUIHGPAJY-RYBZXKSASA-N 0.000 claims 2
- OMHUCGDTACNQEX-OSHKXICASA-N Steviolbioside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OMHUCGDTACNQEX-OSHKXICASA-N 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 150000002215 flavonoids Chemical class 0.000 claims 2
- 229930003935 flavonoids Natural products 0.000 claims 2
- 235000017173 flavonoids Nutrition 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 239000003531 protein hydrolysate Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004386 Erythritol Substances 0.000 claims 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N Erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 1
- 229940009714 Erythritol Drugs 0.000 claims 1
- 239000001776 FEMA 4720 Substances 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N Inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229960000367 Inositol Drugs 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- SERLAGPUMNYUCK-DCUALPFSSA-N Isomalt Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- DRSKVOAJKLUMCL-UHFFFAOYSA-N Rebaudioside B Chemical compound C1CC2C3(C)CCCC(C)(C(O)=O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O DRSKVOAJKLUMCL-UHFFFAOYSA-N 0.000 claims 1
- QSRAJVGDWKFOGU-GOUXMWOMSA-N Rebaudioside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CCC2[C@@]3(C)C([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-GOUXMWOMSA-N 0.000 claims 1
- HYLAUKAHEAUVFE-AVBZULRRSA-N Rebaudioside F Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HYLAUKAHEAUVFE-AVBZULRRSA-N 0.000 claims 1
- HYLAUKAHEAUVFE-XKDJHBDXSA-N Rebaudioside F Natural products O=C(O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HYLAUKAHEAUVFE-XKDJHBDXSA-N 0.000 claims 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims 1
- UEDUENGHJMELGK-VESORUSYSA-N Stevioside Natural products O=C(O[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 UEDUENGHJMELGK-VESORUSYSA-N 0.000 claims 1
- 229940090121 Sulfonylureas for blood glucose lowering Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N Xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 Xylitol Drugs 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000240 adjuvant Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
- 230000000181 anti-adherence Effects 0.000 claims 1
- 235000019622 astringency Nutrition 0.000 claims 1
- 235000019606 astringent taste Nutrition 0.000 claims 1
- 229940058933 biguanide antimalarials Drugs 0.000 claims 1
- 229940090145 biguanide blood glucose lower drugs Drugs 0.000 claims 1
- 150000004283 biguanides Chemical class 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229940090127 blood glucose lowering Alpha glucosidase inhibitors Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 235000019414 erythritol Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 239000000905 isomalt Substances 0.000 claims 1
- 235000010439 isomalt Nutrition 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 239000002357 osmotic agent Substances 0.000 claims 1
- 238000007493 shaping process Methods 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 229940013618 stevioside Drugs 0.000 claims 1
- 235000019202 steviosides Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
Claims (23)
- 少なくとも１つの抗糖尿病物質と、
レバウディオシドＡ組成物とポリオールを含む甘味料組成物を含む抗糖尿病組成物であって、
前記レバウディオシドＡ組成物が、乾燥ベースで約５０〜約９９．５重量％レバウディオシドＡの純度のレバウディオシドＡを含み、
前記レバウディオシドＡ組成物が、前記レバウディオシドＡを無水物、水和物、溶媒和物、非晶質又はこれらの組合せの形で含み、さらに、
前記レバウディオシドＡ組成物とポリオールが、前記甘味料組成物中に約１：５０〜約１：８００の範囲の重量比率で存在する、
抗糖尿病組成物。 - 前記レバウディオシドＡが、乾燥ベースで約９０〜約９９．５重量％レバウディオシドＡの純度を有する、請求項１に記載の抗糖尿病組成物。
- 前記レバウディオシドＡ組成物が、さらに、乾燥ベースで約１〜約５重量％の量のレバウディオシドＢ、乾燥ベースで約１〜約５重量％の量のレバウディオシドＣ、乾燥ベースで約０．１〜約４重量％の量のレバウディオシドＥ、乾燥ベースで約０．１〜約４重量％の量のレバウディオシドＦ、乾燥ベースで約０．１〜約４重量％の量のズルコシドＡ、乾燥ベースで約０．１〜約４重量％の量のズルコシドＢ、乾燥ベースで約０．５〜約５重量％の量のステビオシド及び／又は乾燥ベースで約０．１〜約４重量％の量のステビオールビオシドを含む、請求項１に記載の抗糖尿病組成物。
- 前記レバウディオシドＡ組成物が、３０％／５分より大きい溶解速度を有する、請求項１−３いずれか１項に記載の抗糖尿病組成物。
- 前記レバウディオシドＡ組成物とポリオールが、前記抗糖尿病組成物中に約１：７５〜約１：１５０の範囲の重量比率で存在する、請求項１−４いずれか１項に記載の抗糖尿病組成物。
- 前記レバウディオシドＡ組成物が、前記抗糖尿病組成物中に約１００〜約３，０００ｐｐｍの量で存在する、請求項１−５いずれか１項に記載の抗糖尿病組成物。
- 前記ポリオールが、前記抗糖尿病組成物中に約５，０００〜約３５，０００ｐｐｍの量で存在する、請求項１−６いずれか１項に記載の抗糖尿病組成物。
- 前記ポリオールが、エリスリトール、マルチトール、マンニトール、ソルビトール、ラクチトール、キシリトール、イノシトール、イソマルト、プロピレングリコール、グリセロール、及びこれらの組合せからなるから群から選択される、請求項１−７いずれか１項に記載の抗糖尿病組成物。
- 少なくとも１つの炭水化物をさらに含む、請求項１−８いずれか１項に記載の抗糖尿病組成物。
- 前記少なくとも１つの炭水化物が、前記抗糖尿病組成物中に約１，０００〜約１００，０００ｐｐｍの量で存在する、請求項９に記載の抗糖尿病組成物。
- ポリアミノ酸類及びその対応する塩、糖酸類及びその対応する塩、ヌクレオチド類、苦味化合物類、タンパク質類、タンパク質加水分解物類、フラボノイド類及びこれらの組合せからなる群から選択される少なくとも１つの甘味改善組成物をさらに含む、請求項１−１０いずれか１項に記載の抗糖尿病組成物。
- 少なくとも１つの有機酸、少なくとも１つの無機酸、少なくとも１つの有機酸塩及び少なくとも１つの無機酸塩をさらに含む、請求項１−１１いずれか１項に記載の抗糖尿病組成物。
- 少なくとも１つの有機酸、少なくとも１つの無機酸、少なくとも１つの有機酸塩及び少なくとも１つの無機酸塩を含む甘味改善組成物の組み合わせを含む、請求項１−１２いずれか１項に記載の抗糖尿病組成物であって、
前記抗糖尿病組成物中に存在する少なくとも１つの有機酸の総量が、抗糖尿病組成物の約１０〜約５，０００ｐｐｍの範囲であり、
前記抗糖尿病組成物中に存在する少なくとも１つの有機酸塩の総量が、抗糖尿病組成物の約２０〜約１０，０００ｐｐｍの範囲であり、
前記抗糖尿病組成物中に存在する少なくとも１つの無機酸の総量が、抗糖尿病組成物の約２５〜約５，０００ｐｐｍの範囲であり、
前記抗糖尿病組成物中に存在する少なくとも１つの無機酸塩の総量が、抗糖尿病組成物の約２５〜約５，０００ｐｐｍの範囲である、
抗糖尿病組成物。 - 炭水化物類、アミノ酸類及びその対応する塩、ポリアミノ酸類及びその対応する塩、糖酸類及びその対応する塩、有機酸類、無機酸類、有機塩類、無機塩類、苦味化合物類、香味料類、渋味化合物類、ポリマー類、タンパク質類又はタンパク質加水分解物類、界面活性剤類、乳化剤類、フラボノイド類、アルコール類、合成甘味料及びこれらの組合せからなる群から選択される少なくとも１つの甘味改善組成物をさらに含む、請求項１−１３いずれか１項に記載の抗糖尿病組成物。
- 約３０〜約２，０００ｐｐｍの量の少なくとも１つのポリマーをさらに含む、請求項１−１４いずれか１項に記載の抗糖尿病組成物。
- 約１〜約５，０００ｐｐｍの量の少なくとも１つの界面活性剤をさらに含む、請求項１−１５いずれか１項に記載の抗糖尿病組成物。
- 約１００〜約２５，０００ｐｐｍの量の少なくとも１つのアミノ酸をさらに含む、請求項１−１６いずれか１項に記載の抗糖尿病組成物。
- 約３０〜約２，０００ｐｐｍの量の少なくとも１つのポリアミノ酸をさらに含む、請求項１−１７いずれか１項に記載の抗糖尿病組成物。
- 少なくとも１つの抗糖尿病物質を、レバウディオシドＡ組成物とポリオールを含む甘味料組成物と混合する工程を含む、より砂糖様の経時的プロファイル、より砂糖様の香味プロファイル又はその両方を抗糖尿病組成物に与える方法であって、
前記レバウディオシドＡ組成物が、乾燥ベースで約５０〜約９９．５重量％レバウディオシドＡの純度のレバウディオシドＡを含み、
前記レバウディオシドＡ組成物が、前記レバウディオシドＡを無水物、水和物、溶媒和物、非晶質又はこれらの組合せの形で含み、さらに、
前記レバウディオシドＡ組成物とポリオールが、前記甘味料組成物中に約１：５０〜約１：８００の範囲の重量比率で存在する、方法。 - 前記抗糖尿病物質が、スルホニル尿素類、メグリチニド類、ビグアニド類、チアゾリデイネジオン類、αグルコシダーゼ阻害剤、インスリン、ギムネマシルベスタ及びこれらの
抽出物、及びこれらの組合せからなる群から選択される物質を含む、請求項１−１８いずれか１項に記載の抗糖尿病組成物。 - 粘着防止剤、結合剤、コーティング剤、崩壊剤、充填剤、希釈剤、柔軟剤、乳化剤、香味剤、着色剤、補助剤、潤滑剤、機能性剤、粘度調整剤、増量剤、界面活性剤、浸透圧剤、希釈剤、及びこれらの組合せからなる群から選択される賦形材料をさらに含む、請求項１−１８及び２０いずれか１項に記載の抗糖尿病組成物。
- 膨張性甘味料をさらに含む、請求項１−１８、２０及び２１いずれか１項に記載の抗糖尿病組成物。
- 前記甘味改善組成物が膨張性甘味料として機能する、請求項１−１８、２０及び２１いずれか１項に記載の抗糖尿病組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/555,825 US20080107787A1 (en) | 2006-11-02 | 2006-11-02 | Anti-Diabetic Composition with High-Potency Sweetener |
| PCT/US2007/083379 WO2008057968A2 (en) | 2006-11-02 | 2007-11-01 | Anti-diabetic composition with high-potency sweetener |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014068979A Division JP2014139224A (ja) | 2006-11-02 | 2014-03-28 | 高甘味度甘味料を含む抗糖尿病組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509232A JP2010509232A (ja) | 2010-03-25 |
| JP2010509232A5 true JP2010509232A5 (ja) | 2010-12-16 |
Family
ID=39271596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535474A Pending JP2010509232A (ja) | 2006-11-02 | 2007-11-01 | 高甘味度甘味料を含む抗糖尿病組成物 |
| JP2014068979A Pending JP2014139224A (ja) | 2006-11-02 | 2014-03-28 | 高甘味度甘味料を含む抗糖尿病組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014068979A Pending JP2014139224A (ja) | 2006-11-02 | 2014-03-28 | 高甘味度甘味料を含む抗糖尿病組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080107787A1 (ja) |
| EP (1) | EP2091356A2 (ja) |
| JP (2) | JP2010509232A (ja) |
| CN (1) | CN101568266A (ja) |
| AU (1) | AU2007317372A1 (ja) |
| WO (1) | WO2008057968A2 (ja) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7943185B1 (en) | 2007-03-16 | 2011-05-17 | Pom Wonderful, Llc | Method and composition for producing a stable and deodorized form of pomegranate seed oil |
| US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US8318459B2 (en) | 2011-02-17 | 2012-11-27 | Purecircle Usa | Glucosyl stevia composition |
| US9392799B2 (en) | 2011-02-17 | 2016-07-19 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8334006B2 (en) | 2005-10-11 | 2012-12-18 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| US8790730B2 (en) | 2005-10-11 | 2014-07-29 | Purecircle Usa | Process for manufacturing a sweetener and use thereof |
| US8337927B2 (en) * | 2005-10-11 | 2012-12-25 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| US9386797B2 (en) | 2011-02-17 | 2016-07-12 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8889199B1 (en) | 2007-02-07 | 2014-11-18 | Pom Wonderful Llc | Method and composition for producing a stable and deodorized form of pomegranate seed oil |
| US20080226788A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Lhg compositions for reducing lingering bitter taste of steviol glycosides |
| US8277861B2 (en) * | 2007-03-14 | 2012-10-02 | Concentrate Manufacturing Company Of Ireland | Beverage products having steviol glycosides and at least one acid |
| US9877500B2 (en) * | 2007-03-14 | 2018-01-30 | Concentrate Manufacturing Company Of Ireland | Natural beverage products |
| US8029846B2 (en) * | 2007-03-14 | 2011-10-04 | The Concentrate Manufacturing Company Of Ireland | Beverage products |
| US20080226802A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Beverage having natural sweeteners with one or more stevia components and source of berry |
| US8277862B2 (en) | 2007-03-14 | 2012-10-02 | Concentrate Manufacturing Company Of Ireland | Beverage products having steviol glycosides and at least one acid |
| TWI468167B (zh) * | 2007-11-16 | 2015-01-11 | 威佛（國際）股份有限公司 | 藥學組成物 |
| MY159747A (en) * | 2008-10-28 | 2017-01-31 | Univ Putra Malaysia | Uses of curculigo latifolia (c. latifolia) extracts |
| WO2010054001A2 (en) | 2008-11-04 | 2010-05-14 | University Of Kentucky Research Foundation | D-tagatose-based compositions and methods for preventing and treating atherosclerosis, metabolic syndrome, and symptoms thereof |
| US8158683B2 (en) * | 2009-03-02 | 2012-04-17 | Fhg Corporation | Dietary supplements containing extracts of aronia and methods of using same to promote weight loss |
| US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
| US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
| CA2758976C (en) * | 2009-04-20 | 2015-02-03 | Alain Baron | Chemosensory receptor ligand-based therapies |
| PL2482676T3 (pl) | 2009-06-16 | 2015-03-31 | Epc Beijing Natural Products Co Ltd | Zmniejszanie lub eliminowanie posmaku w słodziku przy użyciu rebaudiozydu D |
| WO2011059954A1 (en) | 2009-11-12 | 2011-05-19 | Purecircle Usa | Granulation of a stevia sweetener |
| US20110144006A1 (en) * | 2009-12-15 | 2011-06-16 | Igelosa Life Science Ab | Protein composition |
| RU2500301C1 (ru) * | 2009-12-18 | 2013-12-10 | Стукли-Ван Кэмп, Инк. | Белковый восстанавливающий напиток |
| US20110189360A1 (en) * | 2010-02-04 | 2011-08-04 | Pepsico, Inc. | Method to Increase Solubility Limit of Rebaudioside D in an Aqueous Solution |
| JP4848463B2 (ja) * | 2010-03-05 | 2011-12-28 | 株式会社 伊藤園 | カルシウム含有無果汁炭酸飲料 |
| US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
| US8981081B2 (en) | 2010-03-12 | 2015-03-17 | Purecircle Usa Inc. | High-purity steviol glycosides |
| WO2011123236A1 (en) * | 2010-04-01 | 2011-10-06 | Biospherics, Inc. | D-tagatose and biguanide compositions and methods |
| US9578895B2 (en) | 2010-08-23 | 2017-02-28 | Epc (Beijing) Natural Products Co., Ltd. | Rebaudioside A and stevioside compositions |
| CN101926431A (zh) * | 2010-08-23 | 2010-12-29 | 贵阳高新创嘉创业服务有限公司 | 一种具有保健功能的组合物及其制备方法和用途 |
| EP2428123A1 (en) * | 2010-09-10 | 2012-03-14 | Nestec S.A. | A stevia-based improved sweetening composition and edible products made therewith |
| JP5859191B2 (ja) | 2010-09-29 | 2016-02-10 | 松谷化学工業株式会社 | 高甘味度甘味料に対する呈味改良組成物およびその応用 |
| SG189444A1 (en) | 2010-10-19 | 2013-05-31 | Elcelyx Therapeutics Inc | Chemosensory receptor ligand-based therapies |
| US9510611B2 (en) | 2010-12-13 | 2016-12-06 | Purecircle Sdn Bhd | Stevia composition to improve sweetness and flavor profile |
| US9029426B2 (en) | 2010-12-13 | 2015-05-12 | Purecircle Sdn Bhd | Highly soluble Rebaudioside D |
| US9572784B2 (en) | 2011-01-07 | 2017-02-21 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US11759441B2 (en) | 2011-01-07 | 2023-09-19 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| US9480663B2 (en) | 2011-01-07 | 2016-11-01 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| SI2661266T1 (sl) | 2011-01-07 | 2021-01-29 | Anji Pharma (Us) Llc | Terapije, na osnovi kemosenzoričnih receptorskih ligandov |
| US8796338B2 (en) | 2011-01-07 | 2014-08-05 | Elcelyx Therapeutics, Inc | Biguanide compositions and methods of treating metabolic disorders |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| BR112013018374A2 (pt) * | 2011-01-25 | 2016-10-11 | Monell Chemical Senses Centre | composições e métodos para fornecer ou modular o sabor doce e métodos para rastrear os mesmos |
| AR083480A1 (es) | 2011-01-28 | 2013-02-27 | Tate & Lyle Ingredients | Mezclas de stevia que contienen rebaudiosida b |
| BR112013020511B1 (pt) | 2011-02-10 | 2018-05-22 | Purecircle Usa Inc. | Composição de rebaudiosida b e seu processo de produção, bem como composições de adoçante e de sabor, ingrediente alimentício, bebida e produto cosmético ou farmacêutico compreendendo a dita composição de rebaudiosida b |
| US9603373B2 (en) | 2011-02-17 | 2017-03-28 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US11690391B2 (en) | 2011-02-17 | 2023-07-04 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9474296B2 (en) | 2011-02-17 | 2016-10-25 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| CN102166274B (zh) * | 2011-02-25 | 2012-05-23 | 四川大学 | 从无患子中提取小肠α-葡萄糖苷酶抑制剂的方法 |
| US9795156B2 (en) | 2011-03-17 | 2017-10-24 | E.P.C (Beijing) Plant Pharmaceutical Technology Co., Ltd | Rebaudioside B and derivatives |
| US9894922B2 (en) | 2011-05-18 | 2018-02-20 | Purecircle Sdn Bhd | Glucosyl rebaudioside C |
| ES2727031T3 (es) | 2011-05-31 | 2019-10-11 | Purecircle Usa Inc | Composición de Estevia |
| ES2579827T3 (es) | 2011-06-03 | 2016-08-17 | Purecircle Usa | Composición de estevia |
| ES2713573T3 (es) | 2011-06-20 | 2019-05-22 | Purecircle Usa Inc | Composición de estevia |
| US9771434B2 (en) | 2011-06-23 | 2017-09-26 | Purecircle Sdn Bhd | Products from stevia rebaudiana |
| US10480019B2 (en) | 2011-08-10 | 2019-11-19 | Purecircle Sdn Bhd | Process for producing high-purity rubusoside |
| US20140171520A1 (en) | 2011-09-07 | 2014-06-19 | Avetik Markosyan | Highly soluble stevia sweetener |
| CN103906437A (zh) * | 2011-09-15 | 2014-07-02 | Cj第一制糖株式会社 | 含有可缓慢消化成分的用于减轻糖尿病的甜味剂组合物 |
| JP5575734B2 (ja) * | 2011-12-01 | 2014-08-20 | ▲たか▼森 涼子 | チョコレート |
| MX2014008189A (es) | 2012-01-06 | 2015-02-12 | Elcelyx Therapeutics Inc | Composiciones y metodos para tratar trastornos metabolicos. |
| MX2014008190A (es) | 2012-01-06 | 2015-02-04 | Elcelyx Therapeutics Inc | Composiciones de biguanida y métodos para tratar transtornos metabólicos. |
| WO2013108263A1 (en) | 2012-01-18 | 2013-07-25 | Zota Health Care Ltd | Pharmaceutical formulation to reduce inflammation of bones and joint friction with improved cartilage quality |
| US8877259B2 (en) | 2012-02-09 | 2014-11-04 | Mary Kay Inc. | Cosmetic formulation |
| BR112014028819A2 (pt) | 2012-05-22 | 2017-07-25 | Purecircle Sdn Bhd | glicosídeos de esteviol de pureza elevada |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| CN102697022B (zh) * | 2012-06-19 | 2014-07-09 | 天津北方食品有限公司 | 一种代糖制品及其制备方法 |
| US9138011B2 (en) | 2012-06-27 | 2015-09-22 | Nutrinova Nutrition Specialist & Food Ingredients Gmbh | Taste-masking compositions, sweetener compositions and consumable product compositions containing the same |
| JP6087112B2 (ja) * | 2012-11-09 | 2017-03-01 | Ｍｃフードスペシャリティーズ株式会社 | 飲食品の甘味の味質改善方法 |
| US20140272068A1 (en) * | 2013-03-14 | 2014-09-18 | Indra Prakash | Beverages containing rare sugars |
| US20140342044A1 (en) | 2013-05-14 | 2014-11-20 | Pepsico, Inc. | Compositions and Comestibles |
| CN105682467A (zh) | 2013-06-07 | 2016-06-15 | 谱赛科美国股份有限公司 | 含有选择的甜叶菊醇糖苷作为香、咸和甜度特征修饰物的甜叶菊提取物 |
| US10952458B2 (en) | 2013-06-07 | 2021-03-23 | Purecircle Usa Inc | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| JP6669497B2 (ja) | 2013-06-10 | 2020-03-18 | サントリーホールディングス株式会社 | ジケトピペラジンを含有する植物エキス及びその製造方法 |
| CN103393074A (zh) * | 2013-07-24 | 2013-11-20 | 兴化格林生物制品有限公司 | 一种低糖复合甜味剂 |
| US10264811B2 (en) | 2014-05-19 | 2019-04-23 | Epc Natural Products Co., Ltd. | Stevia sweetener with improved solubility |
| US10357052B2 (en) | 2014-06-16 | 2019-07-23 | Sweet Green Fields USA LLC | Rebaudioside A and stevioside with improved solubilities |
| US10485256B2 (en) | 2014-06-20 | 2019-11-26 | Sweet Green Fields International Co., Limited | Stevia sweetener with improved solubility with a cyclodextrin |
| CN107072237B (zh) | 2014-09-02 | 2021-12-14 | 谱赛科有限责任公司 | 甜菊提取物 |
| EP3247403A1 (de) * | 2015-01-22 | 2017-11-29 | Pfeifer & Langen GmbH & Co. KG | Cellobiose in zusammensetzungen zum verzehr oder zur einnahme |
| JP6777632B2 (ja) * | 2015-07-27 | 2020-10-28 | サントリーホールディングス株式会社 | 環状ジペプチド及び甘味料を含有する組成物 |
| BR112018008489B1 (pt) | 2015-10-26 | 2023-03-14 | Purecircle Usa Inc | Método para melhorar o perfil de doçura de um adoçante de estévia |
| WO2017106577A1 (en) | 2015-12-15 | 2017-06-22 | Purecircle Usa Inc. | Steviol glycoside compositions |
| KR101898210B1 (ko) * | 2016-07-15 | 2018-09-12 | 인그리디언코리아 유한회사 | 저당함량 감미제 및 이를 포함하는 식품 조성물 |
| BR112019004997A2 (pt) | 2016-09-16 | 2019-06-04 | Pepsico Inc | composições e métodos para melhorar o sabor de adoçantes não nutritivos |
| US20180133243A1 (en) * | 2016-11-16 | 2018-05-17 | Holista Colltech Ltd | Method and composition for crude formulations of fortified sugar for glycemic control |
| CN106727481B (zh) * | 2016-12-09 | 2023-06-20 | 四川九章生物科技有限公司 | 绿原酸在制备增强食欲的药物或保健品中的用途 |
| CN106820070B (zh) * | 2017-02-20 | 2020-09-11 | 湖南艾达伦科技有限公司 | 一种天然复配甜味剂及其制备方法 |
| WO2019018940A1 (en) * | 2017-07-27 | 2019-01-31 | Cavaleri Franco | SWEETENERS FOR FOOD AND DRINKS |
| US11898184B2 (en) | 2017-09-07 | 2024-02-13 | Sweet Sense Inc. | Low glycemic sugar composition |
| CN111683671A (zh) | 2017-10-06 | 2020-09-18 | 嘉吉公司 | 制备马黛茶提取物组合物的方法 |
| IT201800009539A1 (it) * | 2018-10-17 | 2020-04-17 | Hosmer Zambelli Francesca | Composizione dolcificante |
| EP3952667A1 (en) | 2019-04-06 | 2022-02-16 | Cargill, Incorporated | Sensory modifiers |
| CN110907604A (zh) * | 2019-12-06 | 2020-03-24 | 浙江华康药业股份有限公司 | 一种用于改善糖醇类物质感官属性的方法及其应用 |
| IT202000017242A1 (it) * | 2020-07-16 | 2022-01-16 | Sinergy Pharma S R L | Composizione orale per il mantenimento dei livelli normali di zuccheri nel sangue |
Family Cites Families (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US723585A (en) * | 1902-12-27 | 1903-03-24 | Charlton B Corwin | Back-seam trimmer. |
| US3717477A (en) * | 1970-01-16 | 1973-02-20 | Ajinomoto Kk | Sweetening agent containing tryptophane and saccharin |
| US4007288A (en) * | 1970-07-16 | 1977-02-08 | General Foods Corporation | Low calorie sweetening composition and method for making same |
| US3725453A (en) * | 1970-10-16 | 1973-04-03 | American Home Prod | L-4{40 -cyano-3-(2,2,2-trihaloacetamido) succinanilic acids |
| CH585370A5 (ja) * | 1975-04-29 | 1977-02-28 | Von Roll Ag | |
| JPS51142570A (en) * | 1975-06-04 | 1976-12-08 | Morita Kagaku Kogyo | Method of imparting sweetness to food or pharmaceutical agent |
| US4256641A (en) * | 1976-06-22 | 1981-03-17 | Hoffmann-La Roche Inc. | Novel syntheses of tryptophans |
| US4316847A (en) * | 1979-07-30 | 1982-02-23 | Hoffmann-La Roche Inc. | Pyrroles and pyrrolidines |
| US4894464A (en) * | 1980-01-21 | 1990-01-16 | Pfizer Inc. | Branched amides of L-aspartyl-D-amino acid dipeptides |
| US4797298A (en) * | 1980-01-21 | 1989-01-10 | Pfizer, Inc. | Branched amides of L-aspartyl-D-amino acid dipeptides |
| US4804782A (en) * | 1980-01-21 | 1989-02-14 | Pfizer, Inc. | Branched amides of L-aspartyl-D-amino acid dipeptides |
| US4492755A (en) * | 1982-06-30 | 1985-01-08 | Nabisco Brands, Inc. | Process for isomerizing L-mannose to L-fructose |
| US4440855A (en) * | 1982-06-30 | 1984-04-03 | Nabisco Brands, Inc. | Process for preparing L-glucosone |
| CA1206370A (en) * | 1982-08-17 | 1986-06-24 | Ajinomoto Co., Inc. | Stabilized aspartame compositions |
| US4738854A (en) * | 1984-12-04 | 1988-04-19 | Nabisco Brands, Inc. | Comestible containing moisture and shelf storage stabilized L-aspartic acid derivative |
| US4638071A (en) * | 1984-12-27 | 1987-01-20 | General Foods Corporation | Cycloalkyl ethers and thioethers of dipeptides |
| US4652457A (en) * | 1985-05-06 | 1987-03-24 | General Foods Corporation | L-aminodicarboxylic acid aminoalkenoic acid ester amides |
| US4654439A (en) * | 1985-05-24 | 1987-03-31 | General Foods Corporation | L-aminodicarboxylic acid amides of alkoxyalkylamines |
| US4731246A (en) * | 1985-10-31 | 1988-03-15 | Product Resources International, Inc. | Liquid bran drink |
| US4814172A (en) * | 1985-10-31 | 1989-03-21 | Product Resources International, Inc. | Liquid bran drink |
| US4737375A (en) * | 1985-12-26 | 1988-04-12 | The Procter & Gamble Company | Beverages and beverage concentrates nutritionally supplemented with calcium |
| US5087460A (en) * | 1986-12-10 | 1992-02-11 | Warner-Lambert Company | Reduced-calorie confectionery coated chewing gum compositions and methods for preparing same |
| US5387431A (en) * | 1991-10-25 | 1995-02-07 | Fuisz Technologies Ltd. | Saccharide-based matrix |
| US5739409A (en) * | 1987-06-19 | 1998-04-14 | The Regents Of The University Of California | Endogenously sweetened transgenic plant products |
| FR2624699B1 (fr) * | 1987-12-18 | 1990-04-13 | Bernard Lyon I Universite Clau | Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-glycine ou beta-alanine utiles comme agents edulcorants |
| JP3084530B2 (ja) * | 1989-03-30 | 2000-09-04 | 東和化成工業株式会社 | 脂肪代替物としてのマルチトールを含有する低脂肪食品の製造方法 |
| US5108763A (en) * | 1991-04-03 | 1992-04-28 | Warner-Lambert Company | Microencapsulated high intensity sweetening agents having prolonged sweetness release and methods for preparing same |
| US5484593A (en) * | 1991-05-28 | 1996-01-16 | Iwasaki; Kazuo | Diet composition comprising gymnema inodrum and a method for suppressing the absorption of saccharides |
| JP3069458B2 (ja) * | 1992-01-29 | 2000-07-24 | 武田薬品工業株式会社 | 口腔内崩壊型錠剤およびその製造法 |
| JPH05316960A (ja) * | 1992-05-21 | 1993-12-03 | Takasago Internatl Corp | 飲食品の香味を改善する方法 |
| FR2697844B1 (fr) * | 1992-11-12 | 1995-01-27 | Claude Nofre | Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation. |
| US5298272A (en) * | 1992-12-02 | 1994-03-29 | The Regents Of The University Of California | Bridged carboxylic ortho ester sweetener |
| US5527555A (en) * | 1993-02-16 | 1996-06-18 | Wisconsin Alumni Research Foundation | Brazzein sweetener |
| BE1007425A3 (nl) * | 1993-08-30 | 1995-06-13 | Holland Sweetener Co | Werkwijze en inrichting voor de terugwinning van grondstoffen in het aspartaambereidingsproces. |
| US5498702A (en) * | 1993-12-16 | 1996-03-12 | California Natural Products | Treated pectinic acid process and product |
| ATE214397T1 (de) * | 1995-06-30 | 2002-03-15 | Holland Sweetener Co | Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen |
| US6822070B2 (en) * | 1996-03-11 | 2004-11-23 | David Baltimore | Truncated CRAF1 inhibits CD40 signaling |
| JPH10271928A (ja) * | 1997-01-30 | 1998-10-13 | Morita Kagaku Kogyo Kk | ステビア・レバウディアナ・ベルトニーに属する新植物 |
| JP3588971B2 (ja) * | 1997-05-08 | 2004-11-17 | 三菱化学株式会社 | 低カロリー調製ココア |
| US6682766B2 (en) * | 1997-12-01 | 2004-01-27 | The Procter & Gamble Company | Beverage comprising an effective amount of flavanols as sweetness cutting composition |
| ES2224634T3 (es) * | 1998-04-29 | 2005-03-01 | Sumitomo Pharmaceuticals Company, Limited | Formulacion oral que comprende biguanida y un acido organico. |
| JP4606582B2 (ja) * | 1998-04-29 | 2011-01-05 | 大日本住友製薬株式会社 | ビグアナイド系薬物の内服製剤 |
| WO1999065336A1 (en) * | 1998-06-18 | 1999-12-23 | Kellogg Company | An edible composition containing agglomerated fortificant particles and method of making and an edible agglomerated granule |
| JP4221078B2 (ja) * | 1998-07-09 | 2009-02-12 | 株式会社林原生物化学研究所 | トレハロース２含水結晶とその製造方法並びに用途 |
| US6214402B1 (en) * | 1998-09-17 | 2001-04-10 | The Nutrasweet Company | Co-crystallization of sugar and n-[n-(3,3-dimethylbutyl)-l αaspartyl]-l-phenylalanine 1-methyl ester |
| US8236352B2 (en) * | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
| WO2000038536A2 (en) * | 1998-12-23 | 2000-07-06 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
| US6048999A (en) * | 1999-01-25 | 2000-04-11 | The Nutrasweet Company | N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends |
| US6143786A (en) * | 1999-02-02 | 2000-11-07 | Novartis Nutrition Ag | Oral arginine and insulin secretion |
| US6180157B1 (en) * | 1999-02-18 | 2001-01-30 | The Nutrasweet Company | Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate |
| US6365216B1 (en) * | 1999-03-26 | 2002-04-02 | The Nutrasweet Company | Particles of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| US6368651B1 (en) * | 1999-05-13 | 2002-04-09 | The Nutrasweet Company | Use of additives to modify the taste characteristics of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester |
| AU7627800A (en) * | 1999-08-06 | 2001-03-05 | Nutrasweet Company, The | Process for coating n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester onto a carrier |
| US20050042271A1 (en) * | 1999-11-19 | 2005-02-24 | Xel Herbaceuticals, Inc . | Transdermal delivery system for alkaloids of aconitum species |
| JP3502587B2 (ja) * | 2000-01-31 | 2004-03-02 | サラヤ株式会社 | 高純度羅漢果配糖体を含有する甘味料組成物 |
| EP1255718A1 (en) * | 2000-02-01 | 2002-11-13 | Stevia APS | A substance for the use in a dietary supplementation or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome |
| EP1125507A1 (en) * | 2000-02-15 | 2001-08-22 | Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.) | Inulin products with improved nutritional properties |
| US20020001652A1 (en) * | 2000-02-16 | 2002-01-03 | Aditi Dron | Process for making granulated N-[N- (3, 3-dimethylbutyl) -L-alpha -aspartyl] -L- phenylalanine 1-methyl ester |
| US20020150662A1 (en) * | 2000-04-19 | 2002-10-17 | Dewis Mark Lawrence | Ethyl 3-mercaptobutyrate as a flavoring or fragrance agent and methods for preparing and using same |
| US6534107B1 (en) * | 2000-05-12 | 2003-03-18 | The Coca-Cola Company | Quality fruit juice beverages having extended quality shelf-life and methods of making the same |
| JP2002045145A (ja) * | 2000-08-03 | 2002-02-12 | Toyo Seito Kk | 甘味料組成物およびその製造方法 |
| PL365135A1 (en) * | 2000-08-07 | 2004-12-27 | Ranbaxy Signature Llc | Liquid formulation of metformin |
| US7018667B2 (en) * | 2000-11-17 | 2006-03-28 | Tate & Lyle Public Limited Company | Meltable form of sucralose |
| US20030035875A1 (en) * | 2001-04-03 | 2003-02-20 | Dulebohn Joel I. | Composition for improving the taste and sweetness profile of beverages having intense sweeteners |
| EP1377280B1 (en) * | 2001-04-09 | 2007-07-18 | Danisco USA, Inc. | Use of bulking agents as satiety agents |
| US7815956B2 (en) * | 2001-04-27 | 2010-10-19 | Pepsico | Use of erythritol and D-tagatose in diet or reduced-calorie beverages and food products |
| US20020192350A1 (en) * | 2001-04-30 | 2002-12-19 | Hynes Michael P. | Food products |
| US20030049352A1 (en) * | 2001-05-31 | 2003-03-13 | Haile Mehansho | Fortified drinking water |
| DE10130504B4 (de) * | 2001-06-25 | 2005-02-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Xanthin- und Phenazon-Acesulfam-H-Komplexe mit verbessertem Geschmack, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US20030021874A1 (en) * | 2001-07-02 | 2003-01-30 | The Procter & Gamble Co. | Stabilized compositions and processes of their preparation |
| US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| JP3378577B1 (ja) * | 2001-09-28 | 2003-02-17 | 花王株式会社 | 飲 料 |
| KR100966035B1 (ko) * | 2001-11-30 | 2010-06-25 | 아지노모토 가부시키가이샤 | 모나틴의 비천연형 입체이성체 염의 결정 및 이의 사용 |
| CN1435203A (zh) * | 2002-01-30 | 2003-08-13 | 王美岭 | 降糖宁口含片及其生产方法 |
| US6998480B2 (en) * | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
| US20040170735A2 (en) * | 2002-04-05 | 2004-09-02 | Mcneil-Ppc, Inc. | Methods and compositions for altering the sweetness delivery profile of sucralose |
| WO2003103415A1 (en) * | 2002-06-07 | 2003-12-18 | Ann De Wees Allen | Novel sweetener compositions and methods of use |
| US20040058050A1 (en) * | 2002-09-25 | 2004-03-25 | Peilin Guo | Herbal sweetening composition |
| US6855359B2 (en) * | 2002-11-15 | 2005-02-15 | Cargill, Incorporated | Soluble isoflavone compositions |
| US7526998B2 (en) * | 2003-02-10 | 2009-05-05 | Pepperball Technologies, Inc. | Stabilized non-lethal projectile systems |
| AU2003901230A0 (en) * | 2003-03-18 | 2003-04-03 | Wharton, Geoffrey Mr | New generation of electrical plugs and socket systems |
| EP1608341A1 (en) * | 2003-03-21 | 2005-12-28 | Ranbaxy Laboratories, Ltd. | Water-soluble tablets of metformin |
| US6984732B2 (en) * | 2003-03-31 | 2006-01-10 | Mcneil-Ppc, Inc. | High-intensity sweetener composition and delivery of same |
| WO2004089343A1 (en) * | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Water soluble tablets |
| JP2004331576A (ja) * | 2003-05-08 | 2004-11-25 | Noevir Co Ltd | 急激な血糖値の上昇を抑制する血糖値上昇抑制剤及び食品 |
| US20040253327A1 (en) * | 2003-06-12 | 2004-12-16 | Niazi Sarfaraz K. | Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides, and sugar and preventing or treating cardiovascular diseases |
| CN1835762B (zh) * | 2003-06-30 | 2010-05-12 | 雀巢技术公司 | 用于治疗和/或预防与2型糖尿病有关的功能障碍和抗胰岛素性的组合物 |
| US7390518B2 (en) * | 2003-07-11 | 2008-06-24 | Cadbury Adams Usa, Llc | Stain removing chewing gum composition |
| FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
| JPWO2005027656A1 (ja) * | 2003-09-22 | 2007-11-15 | 株式会社ユース・テクノコーポレーション | 機能性甘味料 |
| DE10348723A1 (de) * | 2003-10-16 | 2005-05-12 | Nutrinova Gmbh | Süßstoffkombination zur Süßung von Obstkonserven |
| ES2235642B2 (es) * | 2003-12-18 | 2006-03-01 | Gat Formulation Gmbh | Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos. |
| US20050136121A1 (en) * | 2003-12-22 | 2005-06-23 | Shear/Kershman Laboratories, Inc. | Oral peptide delivery system with improved bioavailability |
| US20050146255A1 (en) * | 2004-01-06 | 2005-07-07 | Irving Sabo | Outdoor storage container having hinged and removable lids |
| JP2005200330A (ja) * | 2004-01-14 | 2005-07-28 | Meiji Seika Kaisha Ltd | 血糖改善剤 |
| CA2552988A1 (en) * | 2004-01-21 | 2005-08-04 | Janssen Pharmaceutica Nv | Mitratapide oral solution |
| WO2005072717A1 (ja) * | 2004-01-29 | 2005-08-11 | Dainippon Sumitomo Pharma Co., Ltd. | ビグアナイド系薬物の内服製剤 |
| GB0406048D0 (en) * | 2004-03-18 | 2004-04-21 | Ardana Bioscience Ltd | Drug formulations |
| JP5168712B2 (ja) * | 2004-04-01 | 2013-03-27 | 味の素株式会社 | ナテグリニド含有製剤 |
| JP2005320281A (ja) * | 2004-05-10 | 2005-11-17 | Shiratori Pharmaceutical Co Ltd | インスリン分泌促進剤及び飲食品 |
| US20050276839A1 (en) * | 2004-06-10 | 2005-12-15 | Rifkin Calman H | Appetite satiation and hydration beverage |
| US20060013842A1 (en) * | 2004-07-15 | 2006-01-19 | Matkin John R | Natural mixture of long-chain fatty alcohols and long-chain fatty acids, its obtension from animal and vegetable waxes and its nutraceutical uses |
| US20060024245A1 (en) * | 2004-07-29 | 2006-02-02 | Cadbury Adams, Llc. | Tooth whitening compositions and delivery systems therefor |
| US7641892B2 (en) * | 2004-07-29 | 2010-01-05 | Cadburry Adams USA, LLC | Tooth whitening compositions and delivery systems therefor |
| PL1786272T3 (pl) * | 2004-08-11 | 2015-02-27 | Intercontinental Great Brands Llc | Kompozycje rozgrzewające i układy do ich dostarczania |
| US20060063737A1 (en) * | 2004-08-18 | 2006-03-23 | Holmdahl Lisa K | Liquid paroxetine compositions |
| BRPI0514999A (pt) * | 2004-08-25 | 2008-07-01 | Cadbury Adams Usa Llc | composição para goma de mascar recheada com lìquido |
| US7641926B2 (en) * | 2004-08-25 | 2010-01-05 | Cadbury Adams Usa, Llc | Liquid-filled chewing gum composition |
| US20060062872A1 (en) * | 2004-09-23 | 2006-03-23 | Cadbury Adams Usa Llc | Pressurized chewing gum compositions and dispensing method |
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| US20060188590A1 (en) * | 2005-01-05 | 2006-08-24 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| JP4344334B2 (ja) * | 2005-03-04 | 2009-10-14 | 佐藤製薬株式会社 | ステビア由来甘味物質を含有する甘味料 |
| WO2006118137A1 (ja) * | 2005-04-26 | 2006-11-09 | Dainippon Sumitomo Pharma Co., Ltd. | ビグアナイド系薬物を含有する粒状製剤 |
| JP2006314240A (ja) * | 2005-05-12 | 2006-11-24 | Meiji Seika Kaisha Ltd | 血糖値上昇抑制低カロリー甘味料 |
| CN1330298C (zh) * | 2005-05-26 | 2007-08-08 | 贵阳新天药业股份有限公司 | 盐酸二甲双胍口服溶液及其制备方法 |
| US20070082048A1 (en) * | 2005-06-08 | 2007-04-12 | Ronald Warner | Sleep aid formulations |
| WO2007006320A1 (en) * | 2005-07-12 | 2007-01-18 | Sherine Hassan Abbas Helmy | Drinkable oral insulin liquid and capsules |
| MX2008001540A (es) * | 2005-08-12 | 2008-02-15 | Cadbury Adams Usa Llc | Composiciones para humectar la boca, sistemas para su administracion y metodos para fabricar las mismas. |
| WO2007033277A2 (en) * | 2005-09-13 | 2007-03-22 | Quantum Food Design, Llc. | Polysaccharide sweetener compounds, process for manufacture, and method of selecting components for polysaccharide sweetener compounds based on user specific sweetener applications |
| CA2623545C (en) * | 2005-10-05 | 2013-04-09 | Cadbury Adams Usa Llc | Cooling compositions |
| US7807206B2 (en) * | 2005-10-11 | 2010-10-05 | Purecircle Sdn Bhd | Sweetner and use |
| US7862845B2 (en) * | 2005-10-11 | 2011-01-04 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
-
2006
- 2006-11-02 US US11/555,825 patent/US20080107787A1/en not_active Abandoned
-
2007
- 2007-11-01 EP EP07854561A patent/EP2091356A2/en not_active Withdrawn
- 2007-11-01 AU AU2007317372A patent/AU2007317372A1/en not_active Abandoned
- 2007-11-01 WO PCT/US2007/083379 patent/WO2008057968A2/en active Application Filing
- 2007-11-01 CN CNA2007800403354A patent/CN101568266A/zh active Pending
- 2007-11-01 JP JP2009535474A patent/JP2010509232A/ja active Pending
-
2014
- 2014-03-28 JP JP2014068979A patent/JP2014139224A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010509232A5 (ja) | ||
| JP2009517031A5 (ja) | ||
| CN1981588B (zh) | 含有木糖醇或赤藓糖醇的无冷却效应的无糖甜点 | |
| JP2009517384A5 (ja) | ||
| JP3672934B2 (ja) | 甘味料を含むチューインガム | |
| JP3336590B2 (ja) | ハード・キャラメル | |
| JP2009517034A5 (ja) | ||
| ES2407281T3 (es) | Jarabes que no cristalizan que contienen sorbitol y su uso en goma de mascar | |
| CN108135213B (zh) | 含有阿洛酮糖的口香糖 | |
| JP2010508823A5 (ja) | ||
| US20040234648A1 (en) | Syrups containing sorbitol, a plasticizing agent and hydrogenated starch hydrolyzate, and their use in chewing gum and other confectionaries | |
| US20060246175A1 (en) | Shaped chewing gum products and methods of making same | |
| RU2530513C2 (ru) | Усиленное выделение липофильных ингредиентов из жевательной резинки с гидроколлоидом | |
| CN103113699B (zh) | 非粘性口香糖胶基质、由其制备的口香糖及其制备方法 | |
| BR112013017768B1 (pt) | Composição de bala dura com açúcar reduzido | |
| PT94083B (pt) | Processo para a preparacao de polidextrose pulverizada substancialmente isenta de acidos e de composicoes alimentares que as contem | |
| KR100559644B1 (ko) | 감미 조성물 및 이의 사용 방법 | |
| JP2004222723A (ja) | 環境にやさしいチューインガムおよびその製造方法 | |
| KR19990083574A (ko) | 감미조성물및이를함유하는식품 | |
| RU2002110457A (ru) | Твердые карамели с улучшенной стабильностью при хранении | |
| JPS6231892B2 (ja) | ||
| JP6509528B2 (ja) | ガムベース及びその製造方法並びにチューインガム組成物 | |
| JP2015537019A5 (ja) | ||
| JP6069620B2 (ja) | チューインガム製造工程におけるチューインガムコア組成物のコンディショニング時間を短縮する方法 | |
| EP2793877B2 (en) | Chewing gum products containing [(2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester |