ATE214397T1 - Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen - Google Patents

Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

Info

Publication number
ATE214397T1
ATE214397T1 AT95201794T AT95201794T ATE214397T1 AT E214397 T1 ATE214397 T1 AT E214397T1 AT 95201794 T AT95201794 T AT 95201794T AT 95201794 T AT95201794 T AT 95201794T AT E214397 T1 ATE214397 T1 AT E214397T1
Authority
AT
Austria
Prior art keywords
crystallization
aspartyl
alpha
methyl ester
phenylalanine methyl
Prior art date
Application number
AT95201794T
Other languages
English (en)
Inventor
Marinus Petrus Wilhelm Rijkers
Alexander Peter Marie Vrinzen
Original Assignee
Holland Sweetener Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co filed Critical Holland Sweetener Co
Application granted granted Critical
Publication of ATE214397T1 publication Critical patent/ATE214397T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95201794T 1995-06-30 1995-06-30 Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen ATE214397T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201794A EP0751146B1 (de) 1995-06-30 1995-06-30 Kristallisierung von alpha-L-aspartyl-L-phenylalaninmethylester aus wässerigen Lösungen

Publications (1)

Publication Number Publication Date
ATE214397T1 true ATE214397T1 (de) 2002-03-15

Family

ID=8220443

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95201794T ATE214397T1 (de) 1995-06-30 1995-06-30 Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

Country Status (9)

Country Link
US (1) US5733883A (de)
EP (1) EP0751146B1 (de)
KR (1) KR100426247B1 (de)
CN (1) CN1135237C (de)
AT (1) ATE214397T1 (de)
CA (1) CA2180207A1 (de)
DE (1) DE69525839T2 (de)
RU (1) RU2155771C2 (de)
TW (1) TW323270B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
IL122068A (en) * 1997-10-29 2001-01-28 Yissum Res Dev Co Process for the preparation of crystal form of aspartame
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US8956677B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
US9144251B2 (en) * 2005-11-23 2015-09-29 The Coca-Cola Company High-potency sweetener composition with mineral and compositions sweetened therewith
US8956678B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with preservative and compositions sweetened therewith
US20070116831A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Dental Composition with High-Potency Sweetener
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070116825A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Confection with High-Potency Sweetener
US20070116836A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Osteoporosis and Compositions Sweetened Therewith
US20070134391A1 (en) * 2005-11-23 2007-06-14 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith
US20070116822A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-potency sweetener composition with saponin and compositions sweetened therewith
CA2629556A1 (en) * 2005-11-23 2007-07-19 The Coca Cola Company Synthetic sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US8993027B2 (en) * 2005-11-23 2015-03-31 The Coca-Cola Company Natural high-potency tabletop sweetener compositions with improved temporal and/or flavor profile, methods for their formulation, and uses
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
US9101161B2 (en) * 2006-11-02 2015-08-11 The Coca-Cola Company High-potency sweetener composition with phytoestrogen and compositions sweetened therewith

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101755A1 (de) * 1982-08-31 1984-03-07 Chimicasa Gmbh Wassarlösliche, durch Pressen verfestigte Süssungstablette
AT394854B (de) * 1986-06-12 1992-07-10 Biochemie Gmbh Verfahren zur herstellung von n-l-alpha-aspartyl-l-phenylalanin(nieder)alkylestern
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
DE68925450T2 (de) * 1988-10-03 1996-09-19 Ajinomoto Kk Verfahren zur Herstellung von trockenen IB Kristallen des alpha-L-Aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit besitzen
JP2946853B2 (ja) * 1991-05-09 1999-09-06 味の素株式会社 アスパルテームの晶析法
JP2970107B2 (ja) * 1991-05-23 1999-11-02 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
RU2098425C1 (ru) * 1991-07-19 1997-12-10 Тосох корпорейшн Способ кристаллизации метилового эфира альфа-l-аспартил-l-фенилаланина и кристаллический метиловый эфир альфа-l-аспартил-l-фенилаланина
RU2092490C1 (ru) * 1991-07-19 1997-10-10 Тосох корпорейшн Способ кристаллизации метилового эфира альфа-l-аспартил-l-фенилаланина
EP0533222B1 (de) * 1991-07-19 1996-12-04 Holland Sweetener Company V.O.F. Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester
DE69215444T2 (de) * 1991-07-19 1997-06-12 Holland Sweetener Co Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester
JP3094684B2 (ja) * 1992-09-04 2000-10-03 味の素株式会社 ジペプチド甘味料顆粒の製造法
RU2083585C1 (ru) * 1994-12-13 1997-07-10 Волгоградское акционерное общество открытого типа "Химпром" Способ получения метилового эфира n-бензилоксикарбонил-l-аспартил-l-фенилаланина

Also Published As

Publication number Publication date
US5733883A (en) 1998-03-31
DE69525839D1 (de) 2002-04-18
CN1135237C (zh) 2004-01-21
CA2180207A1 (en) 1996-12-31
TW323270B (de) 1997-12-21
KR970001370A (ko) 1997-01-24
KR100426247B1 (ko) 2004-06-30
CN1143649A (zh) 1997-02-26
DE69525839T2 (de) 2002-10-31
EP0751146B1 (de) 2002-03-13
RU2155771C2 (ru) 2000-09-10
EP0751146A1 (de) 1997-01-02

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