DE69215444T2 - Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester - Google Patents

Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester

Info

Publication number
DE69215444T2
DE69215444T2 DE69215444T DE69215444T DE69215444T2 DE 69215444 T2 DE69215444 T2 DE 69215444T2 DE 69215444 T DE69215444 T DE 69215444T DE 69215444 T DE69215444 T DE 69215444T DE 69215444 T2 DE69215444 T2 DE 69215444T2
Authority
DE
Germany
Prior art keywords
aspartyl
methyl ester
alpha
phenylalanine methyl
crystallization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69215444T
Other languages
English (en)
Other versions
DE69215444D1 (de
Inventor
Kengo Okajima
Winfried Johannes Wout Vermijs
Tsuguo Murakami
Hidetaka Egashira
Yukio Takeshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holland Sweetener Co VOF
Original Assignee
Holland Sweetener Co VOF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co VOF filed Critical Holland Sweetener Co VOF
Publication of DE69215444D1 publication Critical patent/DE69215444D1/de
Application granted granted Critical
Publication of DE69215444T2 publication Critical patent/DE69215444T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69215444T 1991-07-19 1992-07-17 Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester Expired - Fee Related DE69215444T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20370391 1991-07-19

Publications (2)

Publication Number Publication Date
DE69215444D1 DE69215444D1 (de) 1997-01-09
DE69215444T2 true DE69215444T2 (de) 1997-06-12

Family

ID=16478456

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69215444T Expired - Fee Related DE69215444T2 (de) 1991-07-19 1992-07-17 Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester

Country Status (8)

Country Link
EP (1) EP0523813B1 (de)
KR (1) KR930702384A (de)
AT (1) ATE145650T1 (de)
CA (1) CA2089359A1 (de)
DE (1) DE69215444T2 (de)
ES (1) ES2096708T3 (de)
MX (1) MX9204243A (de)
WO (1) WO1993002100A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000009984A (ko) * 1998-07-29 2000-02-15 고두모 알파-엘-아스파틸-엘-페닐알라닌 메틸 에스테르의 결정화 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017137A1 (en) * 1989-05-22 1990-11-22 Shigeaki Irino Method for crystallizing &-l-aspartyl-l-phenylalanine methyl ester
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法

Also Published As

Publication number Publication date
WO1993002100A1 (en) 1993-02-04
DE69215444D1 (de) 1997-01-09
ES2096708T3 (es) 1997-03-16
KR930702384A (ko) 1993-09-08
MX9204243A (es) 1994-02-28
ATE145650T1 (de) 1996-12-15
EP0523813B1 (de) 1996-11-27
EP0523813A1 (de) 1993-01-20
CA2089359A1 (en) 1993-01-20

Similar Documents

Publication Publication Date Title
ATE211508T1 (de) Verfahren zur rueckgewinnung einer organischen verbindung aus loesungen
ATE43831T1 (de) Verfahren zur gewinnung von citronensaeure.
DE69113873D1 (de) Verfahren zur Ziehung von Halbleitereinkristallen.
EP0128694A3 (de) Verfahren zur Scheidung von Methylester von alpha-L-Aspartyl-L-Phenylanin durch Kristallisation
ATE131468T1 (de) Verfahren zur herstellung von carbonsäureanhydriden
ATE125249T1 (de) Verfahren zur herstellung von granulierter zitronensäure und ihrer salze.
DE69215444T2 (de) Verfahren zur Kristallisation von Alpha-L-Aspartyl-L-Phenylalaninmethylester
DE626965T1 (de) Verfahren zur Trennung von Stereoisomere von Fölinsäure.
DE68919688T2 (de) Verfahren zur kristallisation von subtilisin.
DE69813793T2 (de) Ein verfahren zur kristallisation von lactitol
DE59205377D1 (de) Mikrobiologisches Verfahren zur Herstellung von 5-Hydroxypyrazincarbonsäure
KR840004090A (ko) 씬-(2-아미노티아졸-4-일) (메톡시이미노) 아세트산의 디메틸 아세트아미드 용매화물의 제조방법
ATE145920T1 (de) Verfahren zur kristallisation von alpha-l- aspartyl-l-phenylalaninmethylester
ATE178051T1 (de) Verfahren zur herstellung einer physikalisch stabilen, kristallinen gamma-modifikation von para-aminobenzolsulfonamid
DE3876225D1 (de) Verfahren zum zuechten von einkristallen aus geschmolzener fluessigkeit.
RU93005059A (ru) Способ кристаллизации альфа- - аспартил- -фенилаланин-метилового эфира
DE68928249D1 (de) Verfahren zur Trennung von Methylester von alpha-L-aspartyl-L-phenylalaninen
JPS5228258A (en) Method for growth of crystals from liquid phase
DE69300712T2 (de) Verfahren zur Reinigung von L-Phenylalanin.
DE69303125D1 (de) Vorrichtung zur kontinuierliche Kaltstabilisierung von Tartraten von Mosten und Weinen
DE68907146D1 (de) Verfahren zur reinigung von d-hydroxyphenoxypropionsaeure.
AT386411B (de) Verfahren zur herstellung von neuem kristallinem 7-d-alpha-amino-alpha-(3-chlor-4-hydroxyphenyl) acetamido)-3-methyl-3-cephem-4-carbonsaeuremonohydrat
ATE25109T1 (de) Verfahren zur kontinuierlichen herstellung von zuckerkristallen aus zuckersaeften durch vakuumverdampfung.
DE59203987D1 (de) Verfahren zur Reinigung von Tetrahydropyran-4-carbonsäureestern.
ATE234317T1 (de) Verfahren zur herstellung von kristallin- maltulose-monohydrat

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee