JP2009543552A5 - - Google Patents
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- JP2009543552A5 JP2009543552A5 JP2009519525A JP2009519525A JP2009543552A5 JP 2009543552 A5 JP2009543552 A5 JP 2009543552A5 JP 2009519525 A JP2009519525 A JP 2009519525A JP 2009519525 A JP2009519525 A JP 2009519525A JP 2009543552 A5 JP2009543552 A5 JP 2009543552A5
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- Prior art keywords
- mir
- colon cancer
- related disease
- gene product
- marker
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- 206010009944 Colon cancer Diseases 0.000 claims 57
- 208000029742 colonic neoplasm Diseases 0.000 claims 57
- 108091070501 miRNA Proteins 0.000 claims 52
- 201000010099 disease Diseases 0.000 claims 49
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 49
- 108090000623 proteins and genes Proteins 0.000 claims 45
- 239000000047 product Substances 0.000 claims 44
- 238000000034 method Methods 0.000 claims 39
- 239000003550 marker Substances 0.000 claims 27
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 25
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 25
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 108091028141 MiR-203 Proteins 0.000 claims 19
- 108091049679 miR-20a stem-loop Proteins 0.000 claims 19
- 238000012360 testing method Methods 0.000 claims 19
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 18
- 239000000523 sample Substances 0.000 claims 17
- 108091064157 miR-106a stem-loop Proteins 0.000 claims 16
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 9
- 208000005623 Carcinogenesis Diseases 0.000 claims 8
- 230000036952 cancer formation Effects 0.000 claims 8
- 231100000504 carcinogenesis Toxicity 0.000 claims 8
- 238000004393 prognosis Methods 0.000 claims 8
- 230000004044 response Effects 0.000 claims 8
- 230000004083 survival effect Effects 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 7
- 238000010171 animal model Methods 0.000 claims 6
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- 201000011510 cancer Diseases 0.000 claims 5
- 239000002679 microRNA Substances 0.000 claims 5
- 208000009956 adenocarcinoma Diseases 0.000 claims 4
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- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
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- -1 miR-106a5miRr181b Proteins 0.000 claims 1
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- 210000001519 tissue Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80730406P | 2006-07-13 | 2006-07-13 | |
| US60/807,304 | 2006-07-13 | ||
| US93273607P | 2007-06-01 | 2007-06-01 | |
| US60/932,736 | 2007-06-01 | ||
| PCT/US2007/015892 WO2008008430A2 (en) | 2006-07-13 | 2007-07-12 | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013056596A Division JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009543552A JP2009543552A (ja) | 2009-12-10 |
| JP2009543552A5 true JP2009543552A5 (enExample) | 2011-08-11 |
| JP5230619B2 JP5230619B2 (ja) | 2013-07-10 |
Family
ID=38923889
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519525A Expired - Fee Related JP5230619B2 (ja) | 2006-07-13 | 2007-07-12 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2013056596A Expired - Fee Related JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2015136948A Pending JP2015231376A (ja) | 2006-07-13 | 2015-07-08 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013056596A Expired - Fee Related JP5778708B2 (ja) | 2006-07-13 | 2013-03-19 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| JP2015136948A Pending JP2015231376A (ja) | 2006-07-13 | 2015-07-08 | 結腸癌関連疾患の診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (12) | US8084199B2 (enExample) |
| EP (11) | EP2436787B1 (enExample) |
| JP (3) | JP5230619B2 (enExample) |
| CN (2) | CN101657547B (enExample) |
| AU (1) | AU2007272947B2 (enExample) |
| CA (1) | CA2657030A1 (enExample) |
| ES (9) | ES2434090T3 (enExample) |
| WO (1) | WO2008008430A2 (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| EP2314688B1 (en) | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| CN103866018B (zh) * | 2005-08-01 | 2016-05-25 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| ES2524018T3 (es) | 2006-01-05 | 2014-12-03 | The Ohio State University Research Foundation | Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares |
| EP2487260B1 (en) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2007081720A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| JP5501766B2 (ja) | 2006-11-01 | 2014-05-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 肝細胞癌における生存および転移を予測するためのマイクロｒｎａ発現サイン |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| WO2008154098A2 (en) * | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
| CA2690144A1 (en) | 2007-06-08 | 2008-12-18 | The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services | Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| AU2008283997B2 (en) | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| CN101836112A (zh) | 2007-08-22 | 2010-09-15 | 俄亥俄州立大学研究基金会 | 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物 |
| WO2009036332A1 (en) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| CN101980712B (zh) * | 2007-10-29 | 2015-02-18 | 雷古拉斯治疗公司 | 用于肝癌治疗的靶向微小rna |
| DE102007052114B4 (de) * | 2007-10-30 | 2011-01-05 | T2Cure Gmbh | Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| JP5116026B2 (ja) * | 2008-01-23 | 2013-01-09 | 富士フイルム株式会社 | 癌の検出方法および癌抑制剤 |
| WO2009105520A2 (en) * | 2008-02-19 | 2009-08-27 | University Of Georgia Research Foundation | Methods, devices, and compositions for the highly-sensitive detection and identification of diverse molecular entities |
| CA2716906A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer |
| JP2011515078A (ja) * | 2008-03-01 | 2011-05-19 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ＳＰＡＲＣ特異的ｍｉＲＮＡを使用する、治療、診断、及び拮抗物質発見方法 |
| WO2009111643A2 (en) * | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
| EP2285960B1 (en) | 2008-05-08 | 2015-07-08 | Asuragen, INC. | Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis |
| US20110107440A1 (en) * | 2008-06-04 | 2011-05-05 | Andor Pivarcsi | Skin cancer associated micrornas |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| ES2532153T3 (es) * | 2008-07-18 | 2015-03-24 | Trovagene, Inc. | Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR |
| WO2010019694A1 (en) * | 2008-08-12 | 2010-02-18 | The Ohio State University Research Foundation | Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma |
| JP5960060B2 (ja) | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| CN102078621B (zh) * | 2009-11-27 | 2013-04-10 | 中国科学院上海生命科学研究院 | 调控浆细胞样树突状细胞i型干扰素表达的方法和组合物 |
| CN102933719B (zh) * | 2009-12-24 | 2015-05-06 | 复旦大学 | 用于结直肠癌血浆中的微rna表达谱分析的组合物和方法 |
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| CN101831461B (zh) * | 2010-04-30 | 2012-01-04 | 浙江大学 | 一种人小RNA-148a表达载体及应用 |
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| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| ES2548039T3 (es) * | 2010-12-01 | 2015-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Modo de predicción del desenlace de un cáncer de colon analizando la expresión de miARN |
| CN103384829A (zh) * | 2011-01-13 | 2013-11-06 | 财团法人工业技术研究院 | 预测大肠直肠癌复发的生物标记 |
| JP2014506797A (ja) | 2011-02-17 | 2014-03-20 | ノースウエスタン ユニバーシティ | 超微細構造マーカーおよび分子マーカーの検出による癌スクリーニング |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| CN102899392A (zh) * | 2011-07-28 | 2013-01-30 | 上海生物芯片有限公司 | 用于肠癌诊断的一组miRNA的检测方法和应用 |
| WO2013026685A1 (en) * | 2011-08-19 | 2013-02-28 | Febit Holding Gmbh | Complex sets of mirnas as non-invasive biomarkers for colon cancer |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| EP2766500A4 (en) | 2011-10-14 | 2015-10-14 | Univ Ohio State | METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER |
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| CN102443644A (zh) * | 2011-12-20 | 2012-05-09 | 苏州福英基因科技有限公司 | 结肠癌病理演变前期microrna-29a水平原位杂交检测试剂盒及检测方法和应用 |
| US10174314B2 (en) * | 2011-12-22 | 2019-01-08 | Interna Technologies B.V. | MiRNA for treating head and neck cancer |
| JP2015511121A (ja) * | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| WO2014100216A1 (en) * | 2012-12-19 | 2014-06-26 | The Regents Of The University Of California | Cancer-Associated MicroRNAs and Related Antibodies |
| CN105209881B (zh) | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| US10023916B2 (en) | 2013-04-15 | 2018-07-17 | Regeneron Pharmaceuticals, Inc. | Markers of tumor cell response to anti-cancer therapy |
| US20160289763A1 (en) * | 2013-11-13 | 2016-10-06 | The Texas A&M University System | Micro-rnas that modulate lymphangiogenesis and inflammatory pathways in lymphatic vessel cells |
| CA2939343A1 (en) | 2014-02-18 | 2015-08-27 | Baylor Research Institute | Mir-320e and colorectal cancer |
| EP3196299A4 (en) * | 2014-09-18 | 2018-05-16 | Universidad de Granada | Method for the detection of circulating tumour cells, both circulating tumour cells of the epithelial phenotype and circulating tumour cells having epithelial-mesenchymal transition (emt) markers, using the mirna-21 as a biomarker |
| CN104388541B (zh) * | 2014-10-21 | 2017-07-04 | 复旦大学附属肿瘤医院 | miR‑1914*和miR‑1915的用途 |
| CN107077536B (zh) * | 2014-10-24 | 2021-09-28 | 皇家飞利浦有限公司 | 使用靶基因表达的数学建模评价TGF-β细胞信号传导途径的活性 |
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2007
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- 2007-07-12 CN CN200780033066.9A patent/CN101657547B/zh not_active Expired - Fee Related
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- 2007-07-12 AU AU2007272947A patent/AU2007272947B2/en not_active Ceased
- 2007-07-12 EP EP11196261.9A patent/EP2436784B1/en not_active Not-in-force
- 2007-07-12 WO PCT/US2007/015892 patent/WO2008008430A2/en not_active Ceased
- 2007-07-12 EP EP07810382A patent/EP2041317A4/en not_active Withdrawn
- 2007-07-12 CN CN201310396056.9A patent/CN103589784A/zh active Pending
- 2007-07-12 EP EP11196250.2A patent/EP2455493B1/en not_active Not-in-force
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- 2007-07-12 JP JP2009519525A patent/JP5230619B2/ja not_active Expired - Fee Related
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