BR112017007965A8 - Método implantado por computador para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; aparelho para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; meio de armazenamento não transitório; programa de computador; kits para medir níveis de expressão de três ou mais genes-alvo da via de sinalização celular de tgf-b em uma amostra de um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; e uso do kit - Google Patents
Método implantado por computador para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; aparelho para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; meio de armazenamento não transitório; programa de computador; kits para medir níveis de expressão de três ou mais genes-alvo da via de sinalização celular de tgf-b em uma amostra de um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; e uso do kitInfo
- Publication number
- BR112017007965A8 BR112017007965A8 BR112017007965A BR112017007965A BR112017007965A8 BR 112017007965 A8 BR112017007965 A8 BR 112017007965A8 BR 112017007965 A BR112017007965 A BR 112017007965A BR 112017007965 A BR112017007965 A BR 112017007965A BR 112017007965 A8 BR112017007965 A8 BR 112017007965A8
- Authority
- BR
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- Prior art keywords
- tgf
- individual
- signaling pathway
- cell signaling
- activity
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
Abstract
MÉTODO IMPLANTADO POR COMPUTADOR PARA INFERIR A ATIVIDADE DE UMA VIA DE SINALIZAÇÃO CELULAR DE TGF-? EM UM INDIVÍDUO; APARELHO PARA INFERIR A ATIVIDADE DE UMA VIA DE SINALIZAÇÃO CELULAR DE TGF-? EM UM INDIVÍDUO; MEIO DE ARMAZENAMENTO NÃO TRANSITÓRIO; PROGRAMA DE COMPUTADOR; KITS PARA MEDIR NÍVEIS DE EXPRESSÃO DE TRÊS OU MAIS GENES-ALVO DA VIA DE SINALIZAÇÃO CELULAR DE TGF-? EM UMA AMOSTRA DE UM INDIVÍDUO; INFERIR A ATIVIDADE DE UMA VIA DE SINALIZAÇÃO CELULAR DE TGF-? EM UM INDIVÍDUO; INFERIR A ATIVIDADE DE UMA VIA DE SINALIZAÇÃO CELULAR DE TGF-? EM UM INDIVÍDUO; E USO DO KIT. A presente invenção refere-se a um método implantado por computador para inferir a atividade de uma via de sinalização celular de TGF-beta em um indivíduo com base em níveis de expressão de três ou mais genes-alvo da via de sinalização celular de TGF-beta medidos em uma amostra do indivíduo. A presente invenção se refere adicionalmente a um aparelho, a uma mídia de armazenamento não transitório e a um programa de computador para inferir a atividade de uma via de sinalização celular de TGF-beta em um indivíduo. A presente invenção se refere adicionalmente a um kit para medir níveis de expressão de três ou mais genes-alvo da via de sinalização celular de TGF-beta em uma amostra de um indivíduo, a um kit para inferir a atividade de uma via de sinalização celular de TGF-beta em um indivíduo e ao uso de tais kits na execução do método.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP14190270 | 2014-10-24 | ||
PCT/EP2015/074700 WO2016062891A1 (en) | 2014-10-24 | 2015-10-26 | ASSESSMENT OF TGF-β CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION |
Publications (2)
Publication Number | Publication Date |
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BR112017007965A2 BR112017007965A2 (pt) | 2018-01-23 |
BR112017007965A8 true BR112017007965A8 (pt) | 2022-11-08 |
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BR112017007965A BR112017007965A8 (pt) | 2014-10-24 | 2015-10-26 | Método implantado por computador para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; aparelho para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; meio de armazenamento não transitório; programa de computador; kits para medir níveis de expressão de três ou mais genes-alvo da via de sinalização celular de tgf-b em uma amostra de um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; e uso do kit |
Country Status (10)
Country | Link |
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US (2) | US10016159B2 (pt) |
EP (1) | EP3210142B1 (pt) |
JP (1) | JP6415712B2 (pt) |
CN (1) | CN107077536B (pt) |
AU (1) | AU2015334840B2 (pt) |
BR (1) | BR112017007965A8 (pt) |
CA (1) | CA2965442A1 (pt) |
DK (1) | DK3210142T3 (pt) |
ES (1) | ES2833543T3 (pt) |
WO (1) | WO2016062891A1 (pt) |
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JP6321026B2 (ja) * | 2012-11-20 | 2018-05-09 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 画像テクスチャ特徴を用いる統合表現型解析 |
US10460831B2 (en) * | 2012-12-03 | 2019-10-29 | Koninklijke Philips N.V. | Predictive outcome assessment for chemotherapy with neoadjuvant bevacizumab |
ES2878196T3 (es) | 2012-12-26 | 2021-11-18 | Koninklijke Philips Nv | Evaluación de la actividad de la vía de señalización celular mediante el uso de una o más combinaciones lineales de expresiones de genes diana |
RU2718647C2 (ru) | 2013-04-26 | 2020-04-10 | Конинклейке Филипс Н.В. | Медицинский прогноз и предсказание результатов лечения, используя активности множества клеточных сигнальных путей |
JP6077178B2 (ja) | 2014-01-03 | 2017-02-08 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 標的遺伝子発現の数学的モデリングを用いるpi3k細胞内シグナル伝達経路活性の評価 |
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2015
- 2015-10-26 ES ES15785098T patent/ES2833543T3/es active Active
- 2015-10-26 WO PCT/EP2015/074700 patent/WO2016062891A1/en active Application Filing
- 2015-10-26 DK DK15785098.3T patent/DK3210142T3/da active
- 2015-10-26 BR BR112017007965A patent/BR112017007965A8/pt not_active Application Discontinuation
- 2015-10-26 JP JP2017522166A patent/JP6415712B2/ja active Active
- 2015-10-26 CN CN201580057321.8A patent/CN107077536B/zh active Active
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- 2015-10-26 US US14/922,561 patent/US10016159B2/en active Active
- 2015-10-26 EP EP15785098.3A patent/EP3210142B1/en active Active
- 2015-10-26 CA CA2965442A patent/CA2965442A1/en active Pending
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US20180271438A1 (en) | 2018-09-27 |
JP6415712B2 (ja) | 2018-10-31 |
AU2015334840B2 (en) | 2021-10-21 |
US20160113572A1 (en) | 2016-04-28 |
JP2018503354A (ja) | 2018-02-08 |
BR112017007965A2 (pt) | 2018-01-23 |
AU2015334840A1 (en) | 2017-06-15 |
CA2965442A1 (en) | 2016-04-28 |
CN107077536A (zh) | 2017-08-18 |
WO2016062891A1 (en) | 2016-04-28 |
DK3210142T3 (da) | 2020-11-16 |
EP3210142A1 (en) | 2017-08-30 |
ES2833543T3 (es) | 2021-06-15 |
US10016159B2 (en) | 2018-07-10 |
CN107077536B (zh) | 2021-09-28 |
EP3210142B1 (en) | 2020-09-16 |
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