JP2012500389A5 - - Google Patents
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- Publication number
- JP2012500389A5 JP2012500389A5 JP2011523144A JP2011523144A JP2012500389A5 JP 2012500389 A5 JP2012500389 A5 JP 2012500389A5 JP 2011523144 A JP2011523144 A JP 2011523144A JP 2011523144 A JP2011523144 A JP 2011523144A JP 2012500389 A5 JP2012500389 A5 JP 2012500389A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- gene product
- multiple myeloma
- marker
- mirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091070501 miRNA Proteins 0.000 claims 39
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 239000000047 product Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 108091050874 miR-19a stem-loop Proteins 0.000 claims 19
- 108091086850 miR-19a-1 stem-loop Proteins 0.000 claims 19
- 108091088468 miR-19a-2 stem-loop Proteins 0.000 claims 19
- 108091037787 miR-19b stem-loop Proteins 0.000 claims 19
- 201000000050 myeloid neoplasm Diseases 0.000 claims 19
- 108091024082 miR-32 stem-loop Proteins 0.000 claims 14
- 238000012360 testing method Methods 0.000 claims 13
- 239000003550 marker Substances 0.000 claims 11
- 208000034578 Multiple myelomas Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000002679 microRNA Substances 0.000 claims 9
- 101001120822 Homo sapiens Putative microRNA 17 host gene protein Proteins 0.000 claims 8
- 102100026055 Putative microRNA 17 host gene protein Human genes 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 230000004075 alteration Effects 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108700027336 Suppressor of Cytokine Signaling 1 Proteins 0.000 claims 1
- 102100024779 Suppressor of cytokine signaling 1 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229940124660 anti-multiple myeloma Drugs 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001632 homeopathic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000037353 metabolic pathway Effects 0.000 claims 1
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 1
- 108091074848 miR-19 stem-loop Proteins 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 230000008506 pathogenesis Effects 0.000 claims 1
- 230000007918 pathogenicity Effects 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8803608P | 2008-08-12 | 2008-08-12 | |
| US61/088,036 | 2008-08-12 | ||
| PCT/US2009/053586 WO2010019694A1 (en) | 2008-08-12 | 2009-08-12 | Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500389A JP2012500389A (ja) | 2012-01-05 |
| JP2012500389A5 true JP2012500389A5 (enExample) | 2012-09-13 |
Family
ID=41669274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011523144A Pending JP2012500389A (ja) | 2008-08-12 | 2009-08-12 | 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110152357A1 (enExample) |
| EP (1) | EP2323677A4 (enExample) |
| JP (1) | JP2012500389A (enExample) |
| CN (1) | CN102149401A (enExample) |
| AU (1) | AU2009281969A1 (enExample) |
| CA (1) | CA2734179A1 (enExample) |
| WO (1) | WO2010019694A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902559A (zh) | 2005-08-01 | 2016-08-31 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| WO2007033023A2 (en) | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| EP2487254B1 (en) | 2006-01-05 | 2015-07-29 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロｒｎａ発現異常 |
| EP2514434B1 (en) | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436787B1 (en) | 2006-07-13 | 2016-01-20 | The Ohio State University Research Foundation | MIR-21 for diagnosing poor survival prognosis colon adenocarcinoma. |
| JP5426383B2 (ja) | 2006-09-19 | 2014-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 慢性リンパ球性白血病におけるｍｉＲ−２９およびｍｉＲ−１８１によって制御されるＴＣＬ１発現 |
| CA2667617A1 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN101627134B (zh) | 2007-01-31 | 2013-11-06 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病（aml）的诊断、预后和治疗的基于微rna的方法和组合物 |
| JP5690588B2 (ja) | 2007-06-08 | 2015-03-25 | アメリカ合衆国 | 肝細胞癌のサブタイプを決定し、肝癌幹細胞を検出するための方法 |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| JP2010535782A (ja) | 2007-07-31 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | Ｄｎｍｔ３ａ及びｄｎｍｔ３ｂを標的にすることによるメチル化を元に戻す方法 |
| ES2570359T3 (es) | 2007-08-03 | 2016-05-18 | Univ Ohio State Res Found | Regiones ultraconservadas que codifican ARNnc |
| JP5770472B2 (ja) | 2007-08-22 | 2015-08-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ヒト急性白血病におけるｅｐｈａ７及びｅｒｋリン酸化の調節解除を誘発するための方法及び組成物 |
| CN102137927B (zh) | 2007-10-26 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| CN102803511A (zh) | 2009-11-23 | 2012-11-28 | 俄亥俄州立大学 | 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法 |
| CN102241773B (zh) * | 2010-05-13 | 2014-05-14 | 四川大学 | 抗骨髓瘤细胞多克隆抗体及其制备方法 |
| AU2011326032B2 (en) | 2010-11-12 | 2016-10-06 | The Ohio State University Research Foundation | Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer |
| WO2012068147A1 (en) | 2010-11-15 | 2012-05-24 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| GB2486424A (en) * | 2010-12-13 | 2012-06-20 | Univ Sussex | Markers for plasma cell disorders |
| CA2828772A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer |
| JP2014511677A (ja) * | 2011-03-22 | 2014-05-19 | コーネル・ユニバーシティー | 鑑別困難な良性甲状腺病変と悪性甲状腺病変との識別法 |
| US8945829B2 (en) | 2011-03-22 | 2015-02-03 | Cornell University | Distinguishing benign and malignant indeterminate thyroid lesions |
| US9249468B2 (en) | 2011-10-14 | 2016-02-02 | The Ohio State University | Methods and materials related to ovarian cancer |
| AU2012347470B2 (en) | 2011-12-09 | 2017-02-02 | Medtronic Ireland Manufacturing Unlimited Company | Therapeutic neuromodulation of the hepatic system |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| CN105936932A (zh) | 2012-01-20 | 2016-09-14 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
| US10047401B2 (en) | 2012-08-20 | 2018-08-14 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer |
| US9944991B2 (en) | 2012-11-02 | 2018-04-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
| CN108603232A (zh) * | 2015-12-03 | 2018-09-28 | 阿尔佛雷德医疗集团 | 监测骨髓瘤的治疗或进展 |
| CN105603087B (zh) * | 2016-02-01 | 2019-03-01 | 中国医学科学院血液病医院（血液学研究所） | 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒 |
| EP3481403B1 (en) * | 2016-07-06 | 2022-02-09 | Youhealth Biotech, Limited | Solid tumor methylation markers and uses thereof |
| CN110223733B (zh) * | 2019-04-22 | 2022-02-01 | 福建医科大学附属第一医院 | 一种多发性骨髓瘤预后基因的筛查方法 |
| CN113795581A (zh) * | 2019-05-03 | 2021-12-14 | 迪克纳制药公司 | 具有缩短的有义链的双链核酸抑制剂分子 |
| US20210002698A1 (en) * | 2019-07-02 | 2021-01-07 | Quark Biosciences Taiwan, Inc. | miRNA Receptivity Analysis of the Endometrium |
| CN110564852A (zh) * | 2019-08-06 | 2019-12-13 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 与人类多发性骨髓瘤相关的miRNAs表达图谱模型、构建方法及应用 |
| CN113186163A (zh) * | 2021-01-18 | 2021-07-30 | 南昌五元生物科技有限公司 | 一种基于p53突变筛选肿瘤类器官的培养方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005078139A2 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| EP2474616B1 (en) * | 2004-05-28 | 2015-07-08 | Asuragen, Inc. | Methods and compositions involving microRNA |
| EP1838852A2 (en) * | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| CA2607256A1 (en) * | 2005-05-02 | 2006-11-09 | Cold Spring Harbor Laboratory | Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster |
| ES2446362T3 (es) * | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436787B1 (en) * | 2006-07-13 | 2016-01-20 | The Ohio State University Research Foundation | MIR-21 for diagnosing poor survival prognosis colon adenocarcinoma. |
| CA2663962A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| US8765702B2 (en) * | 2007-02-27 | 2014-07-01 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| EP2126584B1 (en) * | 2007-03-16 | 2012-12-19 | CovalX AG | Direct mass spectrometric analysis of drug candidates targeting protein complexes |
| EP3708682B1 (en) * | 2008-02-01 | 2022-11-23 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of medical diseases and conditions |
-
2009
- 2009-08-12 EP EP09807241A patent/EP2323677A4/en not_active Withdrawn
- 2009-08-12 CN CN2009801354566A patent/CN102149401A/zh active Pending
- 2009-08-12 US US13/058,662 patent/US20110152357A1/en not_active Abandoned
- 2009-08-12 CA CA2734179A patent/CA2734179A1/en not_active Abandoned
- 2009-08-12 AU AU2009281969A patent/AU2009281969A1/en not_active Abandoned
- 2009-08-12 JP JP2011523144A patent/JP2012500389A/ja active Pending
- 2009-08-12 WO PCT/US2009/053586 patent/WO2010019694A1/en not_active Ceased
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