JP2012500389A5 - - Google Patents
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- Publication number
- JP2012500389A5 JP2012500389A5 JP2011523144A JP2011523144A JP2012500389A5 JP 2012500389 A5 JP2012500389 A5 JP 2012500389A5 JP 2011523144 A JP2011523144 A JP 2011523144A JP 2011523144 A JP2011523144 A JP 2011523144A JP 2012500389 A5 JP2012500389 A5 JP 2012500389A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- gene product
- multiple myeloma
- marker
- mirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091070501 miRNA Proteins 0.000 claims 39
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 239000000047 product Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 108091050874 miR-19a stem-loop Proteins 0.000 claims 19
- 108091086850 miR-19a-1 stem-loop Proteins 0.000 claims 19
- 108091088468 miR-19a-2 stem-loop Proteins 0.000 claims 19
- 108091037787 miR-19b stem-loop Proteins 0.000 claims 19
- 201000000050 myeloid neoplasm Diseases 0.000 claims 19
- 108091024082 miR-32 stem-loop Proteins 0.000 claims 14
- 238000012360 testing method Methods 0.000 claims 13
- 239000003550 marker Substances 0.000 claims 11
- 208000034578 Multiple myelomas Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000002679 microRNA Substances 0.000 claims 9
- 101001120822 Homo sapiens Putative microRNA 17 host gene protein Proteins 0.000 claims 8
- 102100026055 Putative microRNA 17 host gene protein Human genes 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 230000004075 alteration Effects 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108700027336 Suppressor of Cytokine Signaling 1 Proteins 0.000 claims 1
- 102100024779 Suppressor of cytokine signaling 1 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229940124660 anti-multiple myeloma Drugs 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001632 homeopathic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000037353 metabolic pathway Effects 0.000 claims 1
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 1
- 108091074848 miR-19 stem-loop Proteins 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 230000008506 pathogenesis Effects 0.000 claims 1
- 230000007918 pathogenicity Effects 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8803608P | 2008-08-12 | 2008-08-12 | |
| US61/088,036 | 2008-08-12 | ||
| PCT/US2009/053586 WO2010019694A1 (en) | 2008-08-12 | 2009-08-12 | Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500389A JP2012500389A (ja) | 2012-01-05 |
| JP2012500389A5 true JP2012500389A5 (enExample) | 2012-09-13 |
Family
ID=41669274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011523144A Pending JP2012500389A (ja) | 2008-08-12 | 2009-08-12 | 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110152357A1 (enExample) |
| EP (1) | EP2323677A4 (enExample) |
| JP (1) | JP2012500389A (enExample) |
| CN (1) | CN102149401A (enExample) |
| AU (1) | AU2009281969A1 (enExample) |
| CA (1) | CA2734179A1 (enExample) |
| WO (1) | WO2010019694A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| CA2621441C (en) | 2005-09-12 | 2014-05-20 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| ES2554531T3 (es) | 2006-01-05 | 2015-12-21 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| CN101384273B (zh) | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| ES2531052T3 (es) | 2006-01-05 | 2015-03-10 | Univ Ohio State Res Found | Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436786B1 (en) | 2006-07-13 | 2014-04-16 | The Ohio State University Research Foundation | MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma. |
| ATE534752T1 (de) | 2006-09-19 | 2011-12-15 | Univ Ohio State Res Found | Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll) |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| JP5480132B2 (ja) | 2007-06-15 | 2014-04-23 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｄｒｏｓｈａ媒介性のマイクロｒｎａプロセッシングを標的するための癌原性ａｌｌ−１融合タンパク質 |
| US8367632B2 (en) | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| CN101835902B (zh) | 2007-08-03 | 2014-03-26 | 俄亥俄州立大学研究基金会 | 编码ncrna的超保守区域 |
| AU2008288806B2 (en) | 2007-08-22 | 2014-11-27 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias |
| EP2201112A4 (en) | 2007-10-26 | 2011-02-02 | Univ Ohio State Res Found | METHOD FOR IDENTIFYING FHIT INTERACTION AND USE |
| EP2307028B1 (en) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| CN102241773B (zh) * | 2010-05-13 | 2014-05-14 | 四川大学 | 抗骨髓瘤细胞多克隆抗体及其制备方法 |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| US10758619B2 (en) | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
| GB2486424A (en) * | 2010-12-13 | 2012-06-20 | Univ Sussex | Markers for plasma cell disorders |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| JP2014511677A (ja) * | 2011-03-22 | 2014-05-19 | コーネル・ユニバーシティー | 鑑別困難な良性甲状腺病変と悪性甲状腺病変との識別法 |
| US8945829B2 (en) | 2011-03-22 | 2015-02-03 | Cornell University | Distinguishing benign and malignant indeterminate thyroid lesions |
| HK1197273A1 (en) | 2011-10-14 | 2015-01-09 | The Ohio State University | Methods and materials related to ovarian cancer |
| CN107080561B (zh) | 2011-12-09 | 2020-09-11 | 麦特文申公司 | 用于神经调节的设备、系统和方法 |
| JP2015501843A (ja) | 2011-12-13 | 2015-01-19 | オハイオ・ステイト・イノベーション・ファウンデーション | ｍｉＲ−２１およびｍｉＲ−２９ａ、エキソソーム阻害、およびがん転移に関する方法および組成物 |
| CN104685065B (zh) | 2012-01-20 | 2017-02-22 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
| US10047401B2 (en) | 2012-08-20 | 2018-08-14 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer |
| US9944991B2 (en) | 2012-11-02 | 2018-04-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
| EP3384050A4 (en) * | 2015-12-03 | 2019-07-31 | Alfred Health | MONITORING THE TREATMENT OR PROGRESSION OF MYELOMA |
| CN105603087B (zh) * | 2016-02-01 | 2019-03-01 | 中国医学科学院血液病医院（血液学研究所） | 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒 |
| CN113151458A (zh) * | 2016-07-06 | 2021-07-23 | 优美佳肿瘤技术有限公司 | 实体瘤甲基化标志物及其用途 |
| CN110223733B (zh) * | 2019-04-22 | 2022-02-01 | 福建医科大学附属第一医院 | 一种多发性骨髓瘤预后基因的筛查方法 |
| SG11202111077RA (en) * | 2019-05-03 | 2021-11-29 | Dicerna Pharmaceuticals Inc | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| US20210002698A1 (en) * | 2019-07-02 | 2021-01-07 | Quark Biosciences Taiwan, Inc. | miRNA Receptivity Analysis of the Endometrium |
| CN110564852A (zh) * | 2019-08-06 | 2019-12-13 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 与人类多发性骨髓瘤相关的miRNAs表达图谱模型、构建方法及应用 |
| CN113186163A (zh) * | 2021-01-18 | 2021-07-30 | 南昌五元生物科技有限公司 | 一种基于p53突变筛选肿瘤类器官的培养方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295604B1 (en) * | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
| EP2290068A3 (en) * | 2004-05-28 | 2012-01-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
| ES2503765T3 (es) * | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| WO2006119365A2 (en) * | 2005-05-02 | 2006-11-09 | Cold Spring Harbor Laboratory | Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster |
| ES2446362T3 (es) * | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| EP2436786B1 (en) * | 2006-07-13 | 2014-04-16 | The Ohio State University Research Foundation | MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma. |
| AU2007299748A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention |
| AU2008220438A1 (en) * | 2007-02-27 | 2008-09-04 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| US8097427B2 (en) * | 2007-03-16 | 2012-01-17 | Covalx Ag | Direct mass spectrometric analysis of drug candidates targeting protein complexes |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
-
2009
- 2009-08-12 CA CA2734179A patent/CA2734179A1/en not_active Abandoned
- 2009-08-12 CN CN2009801354566A patent/CN102149401A/zh active Pending
- 2009-08-12 JP JP2011523144A patent/JP2012500389A/ja active Pending
- 2009-08-12 AU AU2009281969A patent/AU2009281969A1/en not_active Abandoned
- 2009-08-12 WO PCT/US2009/053586 patent/WO2010019694A1/en not_active Ceased
- 2009-08-12 US US13/058,662 patent/US20110152357A1/en not_active Abandoned
- 2009-08-12 EP EP09807241A patent/EP2323677A4/en not_active Withdrawn
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