JP2012500389A - 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 - Google Patents

多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 Download PDF

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JP2012500389A
JP2012500389A JP2011523144A JP2011523144A JP2012500389A JP 2012500389 A JP2012500389 A JP 2012500389A JP 2011523144 A JP2011523144 A JP 2011523144A JP 2011523144 A JP2011523144 A JP 2011523144A JP 2012500389 A JP2012500389 A JP 2012500389A
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JP2012500389A5 (enExample
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クロース，カーロ・エム
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Ohio State University Research Foundation
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Physical Education & Sports Medicine (AREA)
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  • Plant Pathology (AREA)
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2011523144A 2008-08-12 2009-08-12 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法 Pending JP2012500389A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8803608P 2008-08-12 2008-08-12
US61/088,036 2008-08-12
PCT/US2009/053586 WO2010019694A1 (en) 2008-08-12 2009-08-12 Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma

Publications (2)

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JP2012500389A true JP2012500389A (ja) 2012-01-05
JP2012500389A5 JP2012500389A5 (enExample) 2012-09-13

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JP2011523144A Pending JP2012500389A (ja) 2008-08-12 2009-08-12 多発性脊髄腫の診断、予後および治療のためのマイクロｒｎａに基づく組成物および方法

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US (1) US20110152357A1 (enExample)
EP (1) EP2323677A4 (enExample)
JP (1) JP2012500389A (enExample)
CN (1) CN102149401A (enExample)
AU (1) AU2009281969A1 (enExample)
CA (1) CA2734179A1 (enExample)
WO (1) WO2010019694A1 (enExample)

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JP2022530678A (ja) * 2019-05-03 2022-06-30 ディセルナ ファーマシューティカルズ インコーポレイテッド 短縮センス鎖を有する二本鎖核酸阻害剤分子

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CA2621441C (en) 2005-09-12 2014-05-20 The Ohio State University Research Foundation Compositions and methods for the diagnosis and therapy of bcl2-associated cancers
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ES2446362T3 (es) 2006-03-20 2014-03-07 The Ohio State University Research Foundation Huellas de microARN durante megacariocipoyesis humana
EP2436786B1 (en) 2006-07-13 2014-04-16 The Ohio State University Research Foundation MIR-10a for diagnosing poor survival prognosis colon adenocarcinoma.
ATE534752T1 (de) 2006-09-19 2011-12-15 Univ Ohio State Res Found Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll)
WO2008054828A2 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
US8034560B2 (en) 2007-01-31 2011-10-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
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JP5480132B2 (ja) 2007-06-15 2014-04-23 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｄｒｏｓｈａ媒介性のマイクロｒｎａプロセッシングを標的するための癌原性ａｌｌ−１融合タンパク質
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CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
AU2008288806B2 (en) 2007-08-22 2014-11-27 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias
EP2201112A4 (en) 2007-10-26 2011-02-02 Univ Ohio State Res Found METHOD FOR IDENTIFYING FHIT INTERACTION AND USE
EP2307028B1 (en) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
CN102241773B (zh) * 2010-05-13 2014-05-14 四川大学 抗骨髓瘤细胞多克隆抗体及其制备方法
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
US10758619B2 (en) 2010-11-15 2020-09-01 The Ohio State University Controlled release mucoadhesive systems
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JP2014511677A (ja) * 2011-03-22 2014-05-19 コーネル・ユニバーシティー 鑑別困難な良性甲状腺病変と悪性甲状腺病変との識別法
US8945829B2 (en) 2011-03-22 2015-02-03 Cornell University Distinguishing benign and malignant indeterminate thyroid lesions
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CN107080561B (zh) 2011-12-09 2020-09-11 麦特文申公司 用于神经调节的设备、系统和方法
JP2015501843A (ja) 2011-12-13 2015-01-19 オハイオ・ステイト・イノベーション・ファウンデーション ｍｉＲ−２１およびｍｉＲ−２９ａ、エキソソーム阻害、およびがん転移に関する方法および組成物
CN104685065B (zh) 2012-01-20 2017-02-22 俄亥俄州立大学 浸润性和预后的乳腺癌生物标志物标签
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EP3384050A4 (en) * 2015-12-03 2019-07-31 Alfred Health MONITORING THE TREATMENT OR PROGRESSION OF MYELOMA
CN105603087B (zh) * 2016-02-01 2019-03-01 中国医学科学院血液病医院（血液学研究所） 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒
CN113151458A (zh) * 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
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WO2010019694A1 (en) 2010-02-18
CA2734179A1 (en) 2010-02-18
AU2009281969A1 (en) 2010-02-18
EP2323677A4 (en) 2013-01-09
CN102149401A (zh) 2011-08-10
EP2323677A1 (en) 2011-05-25
US20110152357A1 (en) 2011-06-23

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