CN102149401A - 用于多发性骨髓瘤的诊断、预后和治疗的基于微rna的组合物和方法 - Google Patents

用于多发性骨髓瘤的诊断、预后和治疗的基于微rna的组合物和方法 Download PDF

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CN102149401A
CN102149401A CN2009801354566A CN200980135456A CN102149401A CN 102149401 A CN102149401 A CN 102149401A CN 2009801354566 A CN2009801354566 A CN 2009801354566A CN 200980135456 A CN200980135456 A CN 200980135456A CN 102149401 A CN102149401 A CN 102149401A
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C·M·克罗斯
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CN2009801354566A 2008-08-12 2009-08-12 用于多发性骨髓瘤的诊断、预后和治疗的基于微rna的组合物和方法 Pending CN102149401A (zh)

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US8803608P 2008-08-12 2008-08-12
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PCT/US2009/053586 WO2010019694A1 (en) 2008-08-12 2009-08-12 Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma

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EP (1) EP2323677A4 (enExample)
JP (1) JP2012500389A (enExample)
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AU (1) AU2009281969A1 (enExample)
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Cited By (6)

* Cited by examiner, † Cited by third party
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CN105603087A (zh) * 2016-02-01 2016-05-25 中国医学科学院血液病医院(血液学研究所) 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒
CN108603232A (zh) * 2015-12-03 2018-09-28 阿尔佛雷德医疗集团 监测骨髓瘤的治疗或进展
CN110223733A (zh) * 2019-04-22 2019-09-10 福建医科大学附属第一医院 一种新型多发性骨髓瘤预后基因的筛查方法
CN110564852A (zh) * 2019-08-06 2019-12-13 中国医学科学院血液病医院(中国医学科学院血液学研究所) 与人类多发性骨髓瘤相关的miRNAs表达图谱模型、构建方法及应用
CN113151458A (zh) * 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
CN113186163A (zh) * 2021-01-18 2021-07-30 南昌五元生物科技有限公司 一种基于p53突变筛选肿瘤类器官的培养方法

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CN103866018B (zh) 2005-08-01 2016-05-25 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
CN103028120B (zh) 2005-09-12 2015-08-12 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
WO2007081720A2 (en) 2006-01-05 2007-07-19 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
EP2487260B1 (en) 2006-01-05 2015-07-08 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of solid cancers
ES2524018T3 (es) 2006-01-05 2014-12-03 The Ohio State University Research Foundation Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares
EP2369012A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Micro-RNA fingerprints during human megakaryocytopoiesis
CA2657030A1 (en) 2006-07-13 2008-01-17 The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
JP5501766B2 (ja) 2006-11-01 2014-05-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 肝細胞癌における生存および転移を予測するためのマイクロrna発現サイン
US8034560B2 (en) 2007-01-31 2011-10-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
CA2690144A1 (en) 2007-06-08 2008-12-18 The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
ES2496172T3 (es) 2007-07-31 2014-09-18 The Ohio State University Research Foundation Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B
AU2008283997B2 (en) 2007-08-03 2014-04-10 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
CN101836112A (zh) 2007-08-22 2010-09-15 俄亥俄州立大学研究基金会 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
AU2009257410B2 (en) 2008-06-11 2014-03-06 Fudan University Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
JP5960060B2 (ja) 2009-11-23 2016-08-02 ジ・オハイオ・ステート・ユニバーシティ 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法
CN102241773B (zh) * 2010-05-13 2014-05-14 四川大学 抗骨髓瘤细胞多克隆抗体及其制备方法
WO2012065049A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
CA2817982C (en) 2010-11-15 2020-06-30 The Regents Of The University Of Michigan Controlled release mucoadhesive systems
GB2486424A (en) * 2010-12-13 2012-06-20 Univ Sussex Markers for plasma cell disorders
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
CA2830602A1 (en) * 2011-03-22 2012-09-27 Thomas J. Fahey, Iii Distinguishing benign and malignant indeterminate thyroid lesions
US8945829B2 (en) 2011-03-22 2015-02-03 Cornell University Distinguishing benign and malignant indeterminate thyroid lesions
EP2766500A4 (en) 2011-10-14 2015-10-14 Univ Ohio State METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
CN104619353A (zh) 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー
US10047401B2 (en) 2012-08-20 2018-08-14 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer
US9944991B2 (en) 2012-11-02 2018-04-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
CN113795581A (zh) * 2019-05-03 2021-12-14 迪克纳制药公司 具有缩短的有义链的双链核酸抑制剂分子
US20210002698A1 (en) * 2019-07-02 2021-01-07 Quark Biosciences Taiwan, Inc. miRNA Receptivity Analysis of the Endometrium

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CA2554818A1 (en) * 2004-02-09 2005-08-25 Thomas Jefferson University Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
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US20060185027A1 (en) * 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
KR20080051113A (ko) * 2005-05-02 2008-06-10 콜드스프링하버러보러토리 Mir 17-92 클러스터를 이용한 암 진단용 조성물 및 방법
EP2369012A1 (en) * 2006-03-20 2011-09-28 The Ohio State University Research Foundation Micro-RNA fingerprints during human megakaryocytopoiesis
CA2657030A1 (en) * 2006-07-13 2008-01-17 The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
ATE553196T1 (de) * 2007-02-27 2012-04-15 Rosetta Genomics Ltd Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108603232A (zh) * 2015-12-03 2018-09-28 阿尔佛雷德医疗集团 监测骨髓瘤的治疗或进展
CN105603087A (zh) * 2016-02-01 2016-05-25 中国医学科学院血液病医院(血液学研究所) 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒
CN105603087B (zh) * 2016-02-01 2019-03-01 中国医学科学院血液病医院(血液学研究所) 检测多发性骨髓瘤克隆进化的基因探针组合物及试剂盒
CN113151458A (zh) * 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
CN110223733A (zh) * 2019-04-22 2019-09-10 福建医科大学附属第一医院 一种新型多发性骨髓瘤预后基因的筛查方法
CN110223733B (zh) * 2019-04-22 2022-02-01 福建医科大学附属第一医院 一种多发性骨髓瘤预后基因的筛查方法
CN110564852A (zh) * 2019-08-06 2019-12-13 中国医学科学院血液病医院(中国医学科学院血液学研究所) 与人类多发性骨髓瘤相关的miRNAs表达图谱模型、构建方法及应用
CN113186163A (zh) * 2021-01-18 2021-07-30 南昌五元生物科技有限公司 一种基于p53突变筛选肿瘤类器官的培养方法

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US20110152357A1 (en) 2011-06-23
JP2012500389A (ja) 2012-01-05
CA2734179A1 (en) 2010-02-18
EP2323677A4 (en) 2013-01-09
EP2323677A1 (en) 2011-05-25
WO2010019694A1 (en) 2010-02-18

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Application publication date: 20110810