ATE553196T1 - Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod - Google Patents

Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod

Info

Publication number
ATE553196T1
ATE553196T1 AT08710243T AT08710243T ATE553196T1 AT E553196 T1 ATE553196 T1 AT E553196T1 AT 08710243 T AT08710243 T AT 08710243T AT 08710243 T AT08710243 T AT 08710243T AT E553196 T1 ATE553196 T1 AT E553196T1
Authority
AT
Austria
Prior art keywords
composition
cell proliferation
modulating
cell death
cell
Prior art date
Application number
AT08710243T
Other languages
English (en)
Inventor
Moshe Oren
Nina Raver-Shapira
Yeal Spector
Efi Marciano
Original Assignee
Rosetta Genomics Ltd
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39608185&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE553196(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rosetta Genomics Ltd, Yeda Res & Dev filed Critical Rosetta Genomics Ltd
Application granted granted Critical
Publication of ATE553196T1 publication Critical patent/ATE553196T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT08710243T 2007-02-27 2008-02-26 Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod ATE553196T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90352607P 2007-02-27 2007-02-27
PCT/IL2008/000243 WO2008104974A2 (en) 2007-02-27 2008-02-26 Composition and methods for modulating cell proliferation and cell death

Publications (1)

Publication Number Publication Date
ATE553196T1 true ATE553196T1 (de) 2012-04-15

Family

ID=39608185

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08710243T ATE553196T1 (de) 2007-02-27 2008-02-26 Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod

Country Status (6)

Country Link
US (1) US8765702B2 (de)
EP (1) EP2126078B2 (de)
AT (1) ATE553196T1 (de)
AU (1) AU2008220438A1 (de)
CA (1) CA2699418A1 (de)
WO (1) WO2008104974A2 (de)

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EP2505669A3 (de) 2006-01-05 2013-02-13 The Ohio State University Research Foundation Verfahren auf Mikro-RNA-Basis zur Diagnose von Darm-, Bauchspeicheldrüsen-, Prostata- und Magenkrebs
EP1968622B1 (de) * 2006-01-05 2014-08-27 The Ohio State University Research Foundation Mikro-rna-expressions-anomalien in pankreas- und azinus-tumoren
US7985584B2 (en) 2006-03-20 2011-07-26 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
EP2436787B1 (de) 2006-07-13 2016-01-20 The Ohio State University Research Foundation Micro-ARN-21 zur Diagnose von Darm Adenokarzinom mit schlechter Uberlebensprognose.
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
US9006206B2 (en) 2007-02-27 2015-04-14 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
EP2152722B1 (de) 2007-05-03 2016-04-27 Merck Sharp & Dohme Corp. Mir34-therapeutika enthaltende zusammensetzungen zur behandlung von krebs
WO2008157319A1 (en) 2007-06-15 2008-12-24 The Ohio State University Research Foundation ONCOGENIC ALL-1 FUSION PROTEINS FOR TARGETING DROSHA-MEDIATED microRNA PROCESSING
ES2496172T3 (es) * 2007-07-31 2014-09-18 The Ohio State University Research Foundation Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
CA2696887C (en) * 2007-08-22 2016-06-28 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
EP3048177A1 (de) * 2007-09-06 2016-07-27 The Ohio State University Research Foundation Mirna-signaturen in menschlichem ovarialkarzinom
EP2212440A4 (de) * 2007-10-11 2011-04-06 Univ Ohio State Res Found Verfahren und zusammensetzungen zur diagnose und behandlung von adenokarzinomen der speiseröhre
JP2011504093A (ja) 2007-10-26 2011-02-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 脆弱性ヒスチジン三連構造（ｆｈｉｔ）相互作用を同定するための方法およびその使用
US20100323357A1 (en) * 2007-11-30 2010-12-23 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer
CN102007223B (zh) * 2008-02-28 2014-06-18 俄亥俄州立大学研究基金会 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物
AU2009281969A1 (en) * 2008-08-12 2010-02-18 The Ohio State University Research Foundation Micro-RNA-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma
WO2011063382A1 (en) 2009-11-23 2011-05-26 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
US8846631B2 (en) 2010-01-14 2014-09-30 Regulus Therapeutics Inc. MicroRNA compositions and methods
US20130150430A1 (en) * 2010-08-04 2013-06-13 The Ohio State University Methods for Impairing the P53/HDM2 Auto-Regulatory Loop in Multiple Myeloma Development Using mIR-192, mIR-194 and mIR-215
CN103648505B (zh) 2010-11-12 2016-09-28 俄亥俄州立大学研究基金会 与微rna-21、错配修复和结肠直肠癌相关的材料和方法
BR112013011942A2 (pt) 2010-11-15 2016-11-01 Univ Michigan formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida.
CA2828772A1 (en) 2011-03-07 2012-09-13 The Ohio State University Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer
CN104364390B (zh) 2011-10-14 2016-08-24 俄亥俄州立大学 与卵巢癌相关的方法和材料
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
US20160145628A1 (en) 2013-06-18 2016-05-26 Ramot At Tel-Aviv University Ltd. Nanocarrier system for micrornas and uses thereof
US10722599B2 (en) 2015-02-04 2020-07-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid assemblies and uses thereof and some pH and electrostatic modulating lipids to be used in said assemblies
CN113041255B (zh) * 2021-04-13 2022-10-11 上海中医药大学 一种新发现miRNA–mRNA调控轴介导肺腺癌NCI-H1299细胞焦亡的方法

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CA2617581A1 (en) * 2005-08-01 2007-02-08 The Ohio State University Research Foundation Microrna-based methods for the diagnosis of breast cancer
WO2008088858A2 (en) 2007-01-17 2008-07-24 The Johns Hopkins University Compositions and methods featuring micronas for treating neoplasia

Also Published As

Publication number Publication date
EP2126078B2 (de) 2023-01-04
EP2126078A2 (de) 2009-12-02
EP2126078B1 (de) 2012-04-11
CA2699418A1 (en) 2008-09-04
US20100104662A1 (en) 2010-04-29
WO2008104974A2 (en) 2008-09-04
AU2008220438A1 (en) 2008-09-04
US8765702B2 (en) 2014-07-01
WO2008104974A3 (en) 2009-03-05

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