JP2009530396A5 - - Google Patents
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- Publication number
- JP2009530396A5 JP2009530396A5 JP2009501567A JP2009501567A JP2009530396A5 JP 2009530396 A5 JP2009530396 A5 JP 2009530396A5 JP 2009501567 A JP2009501567 A JP 2009501567A JP 2009501567 A JP2009501567 A JP 2009501567A JP 2009530396 A5 JP2009530396 A5 JP 2009530396A5
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- pyrimido
- tetrahydro
- pyridin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 -NR e R f Chemical group 0.000 claims 104
- 125000000217 alkyl group Chemical group 0.000 claims 81
- 150000001875 compounds Chemical class 0.000 claims 47
- 125000001424 substituent group Chemical group 0.000 claims 28
- 239000002207 metabolite Substances 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 23
- 229940002612 prodrug Drugs 0.000 claims 22
- 239000000651 prodrug Substances 0.000 claims 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- GKRCRSXACZSEML-UHFFFAOYSA-N 2-N,2-dimethyl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydro-1H-pyrimido[4,5-d]azepine-2,4-diamine Chemical compound CC1(N=C(C2=C(CCN(CC2)C2=NC=CC=C2C(F)(F)F)N1)N)NC GKRCRSXACZSEML-UHFFFAOYSA-N 0.000 claims 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 10
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 9
- 125000004076 pyridyl group Chemical group 0.000 claims 9
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 6
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 5
- 125000004321 azepin-2-yl group Chemical group [H]N1C([H])=C([H])C([H])=C([H])C([H])=C1* 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Substances N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003725 azepanyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- VCIDLFZYHBUOJH-UHFFFAOYSA-N n-[2-[2-propan-2-yl-4-[4-(trifluoromethyl)anilino]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-7-yl]phenyl]methanesulfonamide Chemical compound N=1C(C(C)C)=NC=2CCN(C=3C(=CC=CC=3)NS(C)(=O)=O)CCC=2C=1NC1=CC=C(C(F)(F)F)C=C1 VCIDLFZYHBUOJH-UHFFFAOYSA-N 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 1
- KZMYIZZZFUEQJF-UHFFFAOYSA-N 1-[4-[[2-propan-2-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]phenyl]ethanone Chemical compound N=1C(C(C)C)=NC=2CCN(C=3C(=CC=CN=3)C(F)(F)F)CCC=2C=1NC1=CC=C(C(C)=O)C=C1 KZMYIZZZFUEQJF-UHFFFAOYSA-N 0.000 claims 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 1
- 125000003070 2-(2-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 1
- SENDDIPZFAVZNJ-UHFFFAOYSA-N 2-[4-[[2-(azepan-1-yl)-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]phenyl]propan-2-ol Chemical compound C1=CC(C(C)(O)C)=CC=C1NC1=NC(N2CCCCCC2)=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 SENDDIPZFAVZNJ-UHFFFAOYSA-N 0.000 claims 1
- KKICAXULBIYBLY-UHFFFAOYSA-N 2-[4-[[2-(azetidin-1-yl)-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]phenyl]propan-2-ol Chemical compound C1=CC(C(C)(O)C)=CC=C1NC1=NC(N2CCC2)=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 KKICAXULBIYBLY-UHFFFAOYSA-N 0.000 claims 1
- SRLFKTHONBGNEO-UHFFFAOYSA-N 2-[4-[[2-(dimethylamino)-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-yl]amino]phenyl]-2-methylpropanenitrile Chemical compound N=1C(N(C)C)=NC=2CCN(C=3C(=CC=CN=3)C(F)(F)F)CCC=2C=1NC1=CC=C(C(C)(C)C#N)C=C1 SRLFKTHONBGNEO-UHFFFAOYSA-N 0.000 claims 1
- ZLHFIGAOOZKARB-UHFFFAOYSA-N 2-methoxy-n-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound N=1C(OC)=NC=2CCN(C=3C(=CC=CN=3)C(F)(F)F)CCC=2C=1NC1=CC=C(C(F)(F)F)C=C1 ZLHFIGAOOZKARB-UHFFFAOYSA-N 0.000 claims 1
- WYACYHGWXXRANR-UHFFFAOYSA-N 2-methylsulfonyl-n-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound N=1C(S(=O)(=O)C)=NC=2CCN(C=3C(=CC=CN=3)C(F)(F)F)CCC=2C=1NC1=CC=C(C(F)(F)F)C=C1 WYACYHGWXXRANR-UHFFFAOYSA-N 0.000 claims 1
- MRHHSXHMRZMNIM-UHFFFAOYSA-N 2-piperidin-1-yl-n-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1NC1=NC(N2CCCCC2)=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 MRHHSXHMRZMNIM-UHFFFAOYSA-N 0.000 claims 1
- JOMYUJCRQDDFAR-UHFFFAOYSA-N 2-thiomorpholin-4-yl-n-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1NC1=NC(N2CCSCC2)=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 JOMYUJCRQDDFAR-UHFFFAOYSA-N 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- QPJVMBTYPHYUOC-UHFFFAOYSA-N Methyl benzoate Natural products COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- 102000003566 TRPV1 Human genes 0.000 claims 1
- 101150016206 Trpv1 gene Proteins 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 125000004069 aziridinyl group Chemical group 0.000 claims 1
- 125000005874 benzothiadiazolyl group Chemical group 0.000 claims 1
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960002870 gabapentin Drugs 0.000 claims 1
- 125000005059 halophenyl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- XMMWYCARDXLWNN-UHFFFAOYSA-N n-(4-bromophenyl)-2-propan-2-yl-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound N=1C(C(C)C)=NC=2CCN(C=3C(=CC=CN=3)C(F)(F)F)CCC=2C=1NC1=CC=C(Br)C=C1 XMMWYCARDXLWNN-UHFFFAOYSA-N 0.000 claims 1
- VSZWWYRSSXYUJO-UHFFFAOYSA-N n-(4-tert-butylphenyl)-7-(3-methylquinoxalin-2-yl)-2-propan-2-yl-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound N=1C(C(C)C)=NC=2CCN(C=3C(=NC4=CC=CC=C4N=3)C)CCC=2C=1NC1=CC=C(C(C)(C)C)C=C1 VSZWWYRSSXYUJO-UHFFFAOYSA-N 0.000 claims 1
- YSARDZCQWSGVAK-UHFFFAOYSA-N n-(4-tert-butylphenyl)-7-(6-chloro-5-methylpyrimidin-4-yl)-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound CC1=C(Cl)N=CN=C1N1CCC2=C(NC=3C=CC(=CC=3)C(C)(C)C)N=CN=C2CC1 YSARDZCQWSGVAK-UHFFFAOYSA-N 0.000 claims 1
- HUWDXCSRDAPMOC-UHFFFAOYSA-N n-(4-tert-butylphenyl)-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound C1=CC(C(C)(C)C)=CC=C1NC1=NC=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 HUWDXCSRDAPMOC-UHFFFAOYSA-N 0.000 claims 1
- JPYQYVBZLSMDEY-UHFFFAOYSA-N n-[2-[2-propan-2-yl-4-[4-(trifluoromethyl)anilino]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-7-yl]pyridin-3-yl]methanesulfonamide Chemical compound N=1C(C(C)C)=NC=2CCN(C=3C(=CC=CN=3)NS(C)(=O)=O)CCC=2C=1NC1=CC=C(C(F)(F)F)C=C1 JPYQYVBZLSMDEY-UHFFFAOYSA-N 0.000 claims 1
- HSXSQLHUTDJCHN-UHFFFAOYSA-N n-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]-5,6,8,9-tetrahydropyrimido[4,5-d]azepin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1NC1=NC=NC2=C1CCN(C=1C(=CC=CN=1)C(F)(F)F)CC2 HSXSQLHUTDJCHN-UHFFFAOYSA-N 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229960005489 paracetamol Drugs 0.000 claims 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 1
- 229960001233 pregabalin Drugs 0.000 claims 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 229960004380 tramadol Drugs 0.000 claims 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 1
- 0 C*c1nc(CCN(CC2)[Al])c2c(N(*)*)n1 Chemical compound C*c1nc(CCN(CC2)[Al])c2c(N(*)*)n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78541506P | 2006-03-21 | 2006-03-21 | |
| US60/785,415 | 2006-03-21 | ||
| PCT/US2007/007166 WO2007109355A2 (en) | 2006-03-21 | 2007-03-21 | 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009530396A JP2009530396A (ja) | 2009-08-27 |
| JP2009530396A5 true JP2009530396A5 (enExample) | 2010-04-22 |
| JP5232768B2 JP5232768B2 (ja) | 2013-07-10 |
Family
ID=38353855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501567A Active JP5232768B2 (ja) | 2006-03-21 | 2007-03-21 | Ｔｒｐｖ１のモジュレーターとしてのテトラヒドロ−ピリミドアゼピン |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8673895B2 (enExample) |
| EP (1) | EP2024368B1 (enExample) |
| JP (1) | JP5232768B2 (enExample) |
| KR (1) | KR101461376B1 (enExample) |
| CN (1) | CN101448835B (enExample) |
| AR (1) | AR059985A1 (enExample) |
| AU (1) | AU2007227203B2 (enExample) |
| BR (1) | BRPI0709034B1 (enExample) |
| CA (1) | CA2646977C (enExample) |
| CR (1) | CR10387A (enExample) |
| DK (1) | DK2024368T3 (enExample) |
| EA (1) | EA017069B1 (enExample) |
| EC (1) | ECSP088807A (enExample) |
| ES (1) | ES2474152T3 (enExample) |
| HR (1) | HRP20140664T1 (enExample) |
| MX (1) | MX2008012163A (enExample) |
| NI (1) | NI200800253A (enExample) |
| NO (1) | NO341676B1 (enExample) |
| NZ (1) | NZ571343A (enExample) |
| PE (1) | PE20080145A1 (enExample) |
| PL (1) | PL2024368T3 (enExample) |
| PT (1) | PT2024368E (enExample) |
| RS (1) | RS53436B (enExample) |
| SG (1) | SG177176A1 (enExample) |
| SI (1) | SI2024368T1 (enExample) |
| TW (1) | TWI440639B (enExample) |
| UA (1) | UA92636C2 (enExample) |
| UY (1) | UY30229A1 (enExample) |
| WO (1) | WO2007109355A2 (enExample) |
| ZA (1) | ZA200808975B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1679668B1 (en) * | 1996-09-04 | 2010-01-27 | Intertrust Technologies Corp. | Trusted infrastructure support systems, methods and techniques for secure electronic commerce, electronic transactions, commerce process control and automation, distributed computing, and rights management |
| WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
| KR20090121358A (ko) * | 2007-03-23 | 2009-11-25 | 화이자 리미티드 | 5-ｈｔ2ｃ 작용제로서 피리미도 [4,5-ｄ] 아제핀 유도체 |
| JP5562865B2 (ja) * | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
| US20090156598A1 (en) * | 2007-12-17 | 2009-06-18 | Lebsack Alec D | Imidazolopyrimidine modulators of TRPV1 |
| UA101676C2 (uk) * | 2008-07-31 | 2013-04-25 | Дженентек, Инк. | Піримідинові сполуки, композиції і способи застосування |
| MX2011004680A (es) * | 2008-11-06 | 2011-05-25 | Astrazeneca Ab | Moduladores de beta amiloide. |
| CA2766151A1 (en) * | 2009-06-24 | 2010-12-29 | Genentech, Inc. | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
| MX2012005463A (es) * | 2009-11-12 | 2012-09-12 | Hoffmann La Roche | Compuestos de purina n/9 sustituida, composiciones y metodos de uso. |
| KR101447789B1 (ko) * | 2009-11-12 | 2014-10-06 | 에프. 호프만-라 로슈 아게 | Ｎ-7 치환된 퓨린 및 피라졸로피리미딘 화합물, 조성물 및 사용 방법 |
| ES2769386T3 (es) | 2010-06-23 | 2020-06-25 | Johnson Matthey Plc | Complejos de pi-alillpaladio y pi-alilníquel para uso como catalizadores en reacciones de acoplamiento carbono-carbono y carbono-nitrógeno |
| CN102154494B (zh) * | 2011-03-14 | 2013-01-02 | 中国人民解放军军事医学科学院基础医学研究所 | 一种用于儿童哮喘检测的标志物 |
| PT2958913T (pt) | 2013-02-20 | 2018-12-03 | Lg Chemical Ltd | Agonistas de recetores de esfingosina-1-fosfato, métodos para a sua preparação e composições farmacêuticas que os contêm como agente ativo |
| CN103641762A (zh) * | 2013-12-18 | 2014-03-19 | 中国药科大学 | 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途 |
| CN113727758A (zh) * | 2019-03-01 | 2021-11-30 | 锐新医药公司 | 双环杂环基化合物及其用途 |
| CN114761401A (zh) | 2019-12-03 | 2022-07-15 | 株式会社Lg化学 | 鞘氨醇-1-磷酸受体激动剂、其制备方法以及含有它作为活性成分的药物组合物 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160834A (en) | 1977-03-09 | 1979-07-10 | Eli Lilly And Company | 1-(Substituted benzoyl)-3-(substituted pyrazinyl)ureas |
| JPH03167178A (ja) | 1989-11-24 | 1991-07-19 | Taiji Nakayama | ピリミジン誘導体 |
| JPH03255077A (ja) | 1990-03-01 | 1991-11-13 | Taiji Nakayama | ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤 |
| WO1993014080A1 (en) | 1992-01-15 | 1993-07-22 | E.I. Du Pont De Nemours And Company | Bridged heterocyclic fungicides |
| JPH06172355A (ja) | 1992-04-14 | 1994-06-21 | Mect Corp | ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤 |
| JPH0625243A (ja) | 1992-07-08 | 1994-02-01 | Sankyo Co Ltd | １−メチルカルバペネム誘導体の製造法 |
| DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19624069A1 (de) | 1996-06-17 | 1997-12-18 | Thomae Gmbh Dr K | Benzazepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US6150343A (en) | 1993-06-30 | 2000-11-21 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US5834461A (en) | 1993-07-29 | 1998-11-10 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5428040A (en) | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| AR002459A1 (es) | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| WO1997019087A1 (en) | 1995-11-17 | 1997-05-29 | E.I. Du Pont De Nemours And Company | Tricyclic herbicidal heterocycles |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| AU2980797A (en) | 1996-06-11 | 1998-01-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and medicinal uses thereof |
| AU3296497A (en) | 1996-06-13 | 1998-01-07 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AU6290998A (en) | 1997-03-07 | 1998-09-29 | Novo Nordisk A/S | 4,5,6,7-tetrahydro-thieno{3,2-c}pyridine derivatives, their preparation and use |
| ZA982368B (en) | 1997-03-27 | 1998-09-23 | Akzo Nobel Nv | New therapeutic combinations |
| DE69837264T2 (de) | 1997-06-25 | 2008-01-31 | Pfizer Inc. | Dipeptidverbindungen, die Wachstumshormon-Sekretagoga sind |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6358951B1 (en) | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| JP2001097979A (ja) | 1999-07-28 | 2001-04-10 | Takeda Chem Ind Ltd | 縮合複素環化合物、その製造法および用途 |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| JP2001294572A (ja) | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| EP1149583A3 (en) | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues |
| DOP2001000154A (es) | 2000-05-25 | 2002-05-15 | Pfizer Prod Inc | Combinación de secretagogos de hormona del crecimiento y antidepresivos |
| DE60140285D1 (de) | 2000-05-31 | 2009-12-10 | Pfizer Prod Inc | Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts |
| IL143690A0 (en) | 2000-06-19 | 2002-04-21 | Pfizer Prod Inc | The use of growth hormone secretagogues to treat systemic lupus erythematosus and inflammatory bowel disease |
| KR20030017571A (ko) | 2000-06-28 | 2003-03-03 | 화이자 프로덕츠 인크. | 멜라노코르틴 수용체 리간드 |
| EP1181933A3 (en) | 2000-06-29 | 2002-04-10 | Pfizer Products Inc. | Use of growth hormone secretagogues for stimulating or increasing appetite |
| IL143942A0 (en) | 2000-06-29 | 2002-04-21 | Pfizer Prod Inc | Use of growth hormone secretagogues for treatment of physical performance decline |
| DE60116313T2 (de) | 2000-06-30 | 2006-08-31 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen zur behandlung der alzheimerischen krankheit |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| US6369222B1 (en) | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| AUPQ887100A0 (en) * | 2000-07-19 | 2000-08-10 | Dynamic Digital Depth Research Pty Ltd | Image processing and encoding techniques |
| IL144468A0 (en) | 2000-07-27 | 2002-05-23 | Pfizer Prod Inc | Use of growth hormone secretagogues for improvement of functional health status |
| DK1318997T3 (da) | 2000-09-15 | 2006-09-25 | Vertex Pharma | Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| IL145540A0 (en) | 2000-09-28 | 2002-06-30 | Pfizer Prod Inc | Use of growth hormone secretagogues in conjunction with physical exercise |
| ATE419239T1 (de) | 2000-10-20 | 2009-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung von 4-phenoxy chinolin derivaten |
| HUP0400639A3 (en) | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| EP2256104A1 (en) | 2000-12-27 | 2010-12-01 | Merck Patent GmbH | Process for the preparation of alpha-aminosubstituted carboxylic acid amides |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US6686352B2 (en) | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| EP2336133A1 (en) | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| US6916811B2 (en) | 2001-11-30 | 2005-07-12 | Schering Corporation | Adenosine A2a receptor antagonists |
| RS63204A (sr) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
| JP2003321472A (ja) | 2002-02-26 | 2003-11-11 | Takeda Chem Ind Ltd | Ｇｒｋ阻害剤 |
| US20030199514A1 (en) | 2002-03-27 | 2003-10-23 | Fryburg David A. | Methods for improving efficacy of treatment with growth hormone secretagogues |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| US7384937B2 (en) | 2002-11-06 | 2008-06-10 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| CA2515215A1 (en) | 2003-02-10 | 2004-08-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| AR045979A1 (es) | 2003-04-28 | 2005-11-23 | Astrazeneca Ab | Amidas heterociclicas |
| WO2004108120A1 (en) | 2003-06-11 | 2004-12-16 | Pfizer Products Inc. | Use of growth hormone secretagogues for treatment of fibromyalgia |
| WO2005007655A1 (en) | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Nicotine addiction reducing heteroaryl fused azapolycyclic compounds |
| AR045445A1 (es) | 2003-08-05 | 2005-10-26 | Vertex Pharma | Compuestos ihinibidores de canales ionicos regulados por voltaje |
| WO2005014548A1 (ja) | 2003-08-08 | 2005-02-17 | Sumitomo Chemical Company, Limited | ジソピラミド遊離塩基の低融点型結晶の製造方法 |
| AU2004270740A1 (en) | 2003-09-09 | 2005-03-17 | Neurogen Corporation | 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists |
| AU2004278382B2 (en) | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| MXPA06003792A (es) | 2003-10-07 | 2006-06-14 | Astrazeneca Ab | Nuevas 4-amino-tiazolo[4,5-d]-pirimidinas 2-sustituidas, utiles como antagonistas del receptor de quimiocina, especialmente cx3cr1. |
| US7816356B2 (en) | 2003-11-14 | 2010-10-19 | Daniel Yohannes | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands |
| WO2005049613A1 (en) | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| JP2005162673A (ja) | 2003-12-03 | 2005-06-23 | Kyowa Hakko Kogyo Co Ltd | 二環性ピリミジン誘導体 |
| TW200530235A (en) | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| US7312330B2 (en) | 2003-12-24 | 2007-12-25 | Renovis, Inc. | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| CA2553969A1 (en) | 2004-01-23 | 2005-08-04 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2005082865A1 (ja) * | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
| US20080269238A1 (en) | 2004-04-01 | 2008-10-30 | Takeda Pharmaceutical Company Limited | Thiazolopyrimidine Derivative |
| GB0412467D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| ITMI20041231A1 (it) | 2004-06-18 | 2004-09-18 | Pharmeste Srl | Antagonisti del recettore dei vanilloidi trpv1 |
| US7617501B2 (en) | 2004-07-09 | 2009-11-10 | Quest Software, Inc. | Apparatus, system, and method for managing policies on a computer having a foreign operating system |
| ITMI20041566A1 (it) | 2004-07-30 | 2004-10-30 | Indena Spa | "trpv1 agonisti, formulazioni che li contengono e loro usi" |
| FR2874015B1 (fr) | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| JP2006083085A (ja) | 2004-09-15 | 2006-03-30 | Kyowa Hakko Kogyo Co Ltd | 二環性ピリミジン誘導体の製造法およびその合成中間体 |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2582235A1 (en) | 2004-10-04 | 2006-04-20 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| WO2006044762A2 (en) * | 2004-10-15 | 2006-04-27 | Bayer Pharmaceuticals Corporation | Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor |
| MX2007006205A (es) | 2004-11-24 | 2009-02-13 | Abbott Lab | Compuestos de cromanilurea que inhiben al receptor del receptor vanilloide subtipo 1 (vr1), y usos de los mismos. |
| US20060128710A1 (en) | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| CA2594998A1 (en) | 2005-01-25 | 2006-08-03 | Neurogen Corporation | Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues |
| CA2608718A1 (en) | 2005-05-18 | 2006-11-23 | Pfizer Limited | 1, 2, 4-triazole derivatives as vasopressin antagonists |
| PE20070171A1 (es) | 2005-06-30 | 2007-03-08 | Boehringer Ingelheim Int | GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa |
| US20070032473A1 (en) | 2005-07-19 | 2007-02-08 | Kai Gerlach | Substituted amides and their use as medicaments |
| WO2007019083A1 (en) * | 2005-08-04 | 2007-02-15 | Janssen Pharmaceutica N.V. | Pyrimidine compounds as serotonin receptor modulators |
| US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
| WO2007047798A1 (en) | 2005-10-21 | 2007-04-26 | Sensis Corporation | Method and apparatus for providing secure access control for protected information |
| TW200738649A (en) | 2005-11-22 | 2007-10-16 | Smithkline Beecham Corp | Calcilytic compounds |
| JP4678685B2 (ja) | 2005-12-26 | 2011-04-27 | 株式会社吉野工業所 | エアゾール式液噴出器 |
| DE102005062987A1 (de) | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| WO2007098826A2 (en) | 2006-01-18 | 2007-09-07 | Siena Biotech S.P.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| EP1818330A1 (de) | 2006-02-14 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| AU2007225273A1 (en) | 2006-03-10 | 2007-09-20 | Neurogen Corporation | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues |
| EP1996577B1 (en) | 2006-03-21 | 2016-02-10 | Merck Sharp & Dohme Corp. | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
| CA2652367A1 (en) | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| US20080051387A1 (en) | 2006-06-09 | 2008-02-28 | Yuelian Xu | Tetrahydropyrido[3,4-d]pyrimidines and related analogues |
| JP2009007273A (ja) | 2007-06-27 | 2009-01-15 | Ajinomoto Co Inc | ジアミノピリミジン化合物の製造方法 |
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