JP2009501141A5 - 骨腫瘍の治療のための抗igf-ir抗体 - Google Patents
骨腫瘍の治療のための抗igf-ir抗体 Download PDFInfo
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- JP2009501141A5 JP2009501141A5 JP2008517219A JP2008517219A JP2009501141A5 JP 2009501141 A5 JP2009501141 A5 JP 2009501141A5 JP 2008517219 A JP2008517219 A JP 2008517219A JP 2008517219 A JP2008517219 A JP 2008517219A JP 2009501141 A5 JP2009501141 A5 JP 2009501141A5
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- 206010028980 Neoplasm Diseases 0.000 title claims 7
- 210000000988 Bone and Bones Anatomy 0.000 title claims 5
- 102000004965 antibodies Human genes 0.000 title claims 3
- 108090001123 antibodies Proteins 0.000 title claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 239000003098 androgen Substances 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000001419 dependent Effects 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 102000027656 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091007921 receptor tyrosine kinases Proteins 0.000 claims 1
Claims (9)
- 配列番号41を有する重鎖可変ドメイン及び配列番号51を有する軽鎖可変ドメインを含む抗体又は抗体フラグメントを含有する、骨腫瘍を患う被験体を治療するための薬剤。
- 骨腫瘍が原発性腫瘍又は二次性腫瘍である、請求項1に記載の薬剤。
- 骨腫瘍がアンドロゲン依存性又はアンドロゲン非依存性である、請求項1又は2に記載の薬剤。
- 骨腫瘍が、前立腺癌、乳癌又は肺癌から転移される、請求項1〜3のいずれか1項に記載の薬剤。
- 第2の受容体チロシンキナーゼのアンタゴニストと同時投与される、請求項1〜4のいずれか1項に記載の薬剤。
- 有効量の抗腫瘍剤と同時投与される、請求項1〜5のいずれか1項に記載の薬剤。
- 抗腫瘍剤が化学療法剤である、請求項6に記載の薬剤。
- 抗腫瘍剤がドセタキセル又はドキソルビシンである、請求項7に記載の薬剤。
- 抗腫瘍剤が放射線療法である、請求項6に記載の薬剤。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69192005P | 2005-06-17 | 2005-06-17 | |
PCT/US2006/023856 WO2006138729A2 (en) | 2005-06-17 | 2006-06-19 | Receptor antagonists for treatment of metastatic bone cancer |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009033512A Division JP5154470B2 (ja) | 2005-06-17 | 2009-02-17 | 二次性骨腫瘍の治療のための抗PDGFRα抗体 |
JP2009033517A Division JP5436883B2 (ja) | 2005-06-17 | 2009-02-17 | 抗PDGFRα抗体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009501141A JP2009501141A (ja) | 2009-01-15 |
JP2009501141A5 true JP2009501141A5 (ja) | 2010-01-21 |
Family
ID=37571297
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008517219A Pending JP2009501141A (ja) | 2005-06-17 | 2006-06-19 | 転移性骨癌の治療のための受容体アンタゴニスト |
JP2009033517A Active JP5436883B2 (ja) | 2005-06-17 | 2009-02-17 | 抗PDGFRα抗体 |
JP2009033512A Expired - Fee Related JP5154470B2 (ja) | 2005-06-17 | 2009-02-17 | 二次性骨腫瘍の治療のための抗PDGFRα抗体 |
JP2012134040A Pending JP2012179060A (ja) | 2005-06-17 | 2012-06-13 | 転移性骨癌の治療のための受容体アンタゴニスト |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009033517A Active JP5436883B2 (ja) | 2005-06-17 | 2009-02-17 | 抗PDGFRα抗体 |
JP2009033512A Expired - Fee Related JP5154470B2 (ja) | 2005-06-17 | 2009-02-17 | 二次性骨腫瘍の治療のための抗PDGFRα抗体 |
JP2012134040A Pending JP2012179060A (ja) | 2005-06-17 | 2012-06-13 | 転移性骨癌の治療のための受容体アンタゴニスト |
Country Status (21)
Country | Link |
---|---|
US (3) | US8128929B2 (ja) |
EP (4) | EP2505205A1 (ja) |
JP (4) | JP2009501141A (ja) |
KR (3) | KR20080047529A (ja) |
CN (3) | CN101612399B (ja) |
BR (2) | BRPI0611984A2 (ja) |
CA (3) | CA2680945C (ja) |
CY (3) | CY1114603T1 (ja) |
DK (2) | DK2100614T3 (ja) |
ES (2) | ES2435727T3 (ja) |
HK (1) | HK1135917A1 (ja) |
HU (1) | HUS1700015I1 (ja) |
IL (3) | IL188151A0 (ja) |
LT (1) | LTC2100614I2 (ja) |
LU (1) | LUC00012I2 (ja) |
NL (1) | NL300869I2 (ja) |
PL (2) | PL2100618T3 (ja) |
PT (2) | PT2100618E (ja) |
RU (3) | RU2008101772A (ja) |
SI (2) | SI2100618T1 (ja) |
WO (1) | WO2006138729A2 (ja) |
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