JP2009500432A5 - - Google Patents
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- JP2009500432A5 JP2009500432A5 JP2008520691A JP2008520691A JP2009500432A5 JP 2009500432 A5 JP2009500432 A5 JP 2009500432A5 JP 2008520691 A JP2008520691 A JP 2008520691A JP 2008520691 A JP2008520691 A JP 2008520691A JP 2009500432 A5 JP2009500432 A5 JP 2009500432A5
- Authority
- JP
- Japan
- Prior art keywords
- ginseng
- ginsenoside
- pharmaceutical composition
- total
- secondary glycoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 67
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 66
- 235000008434 ginseng Nutrition 0.000 claims description 66
- 229930182470 glycoside Natural products 0.000 claims description 55
- 150000002338 glycosides Chemical group 0.000 claims description 55
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 229930182494 ginsenoside Natural products 0.000 claims description 18
- 239000003960 organic solvent Substances 0.000 claims description 15
- AGBCLJAHARWNLA-DQUQINEDSA-N Ginsenoside RG2 Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@@](C)(O)CCC=C(C)C)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O AGBCLJAHARWNLA-DQUQINEDSA-N 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 229930182490 saponin Natural products 0.000 claims description 14
- 150000007949 saponins Chemical class 0.000 claims description 14
- 235000017709 saponins Nutrition 0.000 claims description 14
- 238000010828 elution Methods 0.000 claims description 13
- 238000006460 hydrolysis reaction Methods 0.000 claims description 13
- 230000007062 hydrolysis Effects 0.000 claims description 12
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 claims description 11
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 claims description 11
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 claims description 11
- 239000012535 impurity Substances 0.000 claims description 10
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 10
- 238000001179 sorption measurement Methods 0.000 claims description 10
- 241000196324 Embryophyta Species 0.000 claims description 9
- AGBCLJAHARWNLA-UHFFFAOYSA-N (20R)-ginsenoside Rg2 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C3C(C)(C)C(O)CCC3(C)C3C(C4(CCC(C4C(O)C3)C(C)(O)CCC=C(C)C)C)(C)C2)OC(CO)C(O)C1O AGBCLJAHARWNLA-UHFFFAOYSA-N 0.000 claims description 8
- RWXIFXNRCLMQCD-JBVRGBGGSA-N (20S)-ginsenoside Rg3 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RWXIFXNRCLMQCD-JBVRGBGGSA-N 0.000 claims description 8
- PYXFVCFISTUSOO-HKUCOEKDSA-N (20S)-protopanaxadiol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@H]([C@@](C)(O)CCC=C(C)C)[C@H]4[C@H](O)C[C@@H]3[C@]21C PYXFVCFISTUSOO-HKUCOEKDSA-N 0.000 claims description 8
- 244000000626 Daucus carota Species 0.000 claims description 8
- RAQNTCRNSXYLAH-UHFFFAOYSA-N Ginsenoside Rh1 Natural products CC(C)=CCCC(C)(O)C1CCC(C2(C3)C)(C)C1C(O)CC2C1(C)CCC(O)C(C)(C)C1C3OC1OC(CO)C(O)C(O)C1O RAQNTCRNSXYLAH-UHFFFAOYSA-N 0.000 claims description 8
- PYXFVCFISTUSOO-UHFFFAOYSA-N betulafolienetriol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC(C(C)(O)CCC=C(C)C)C4C(O)CC3C21C PYXFVCFISTUSOO-UHFFFAOYSA-N 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 8
- SWQINCWATANGKN-UHFFFAOYSA-N protopanaxadiol Natural products CC(CCC=C(C)C)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3CCC21C SWQINCWATANGKN-UHFFFAOYSA-N 0.000 claims description 8
- SHCBCKBYTHZQGZ-DLHMIPLTSA-N protopanaxatriol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2[C@@H](O)C[C@@]3(C)[C@]4(C)CC[C@H]([C@](C)(O)CCC=C(C)C)[C@H]4[C@H](O)C[C@@H]3[C@]21C SHCBCKBYTHZQGZ-DLHMIPLTSA-N 0.000 claims description 8
- BBEUDPAEKGPXDG-UHFFFAOYSA-N protopanaxatriol Natural products CC(CCC=C(C)C)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(O)CC23C BBEUDPAEKGPXDG-UHFFFAOYSA-N 0.000 claims description 8
- RAQNTCRNSXYLAH-RFCGZQMISA-N (20S)-ginsenoside Rh1 Chemical compound O([C@@H]1[C@H]2C(C)(C)[C@@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@H]3[C@@]([C@@]2(C1)C)(C)CC[C@@H]3[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RAQNTCRNSXYLAH-RFCGZQMISA-N 0.000 claims description 7
- 235000002767 Daucus carota Nutrition 0.000 claims description 7
- XIRZPICFRDZXPF-UHFFFAOYSA-N Ginsenoside Rg3 Natural products CC(C)=CCCC(C)(O)C1CCC(C2(CC(O)C3C4(C)C)C)(C)C1C(O)CC2C3(C)CCC4OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(O)C1O XIRZPICFRDZXPF-UHFFFAOYSA-N 0.000 claims description 7
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 claims description 7
- JURZHOVRCOWZFN-UHFFFAOYSA-N notoginsenoside R1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(COC7OCC(O)C(O)C7O)C(O)C(O)C6O)C JURZHOVRCOWZFN-UHFFFAOYSA-N 0.000 claims description 7
- 239000006191 orally-disintegrating tablet Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 208000031225 myocardial ischemia Diseases 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 206010003119 arrhythmia Diseases 0.000 claims description 3
- 230000006793 arrhythmia Effects 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 230000003301 hydrolyzing effect Effects 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 28
- 229920002472 Starch Polymers 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- 239000008107 starch Substances 0.000 claims 5
- 235000019698 starch Nutrition 0.000 claims 5
- 229940126585 therapeutic drug Drugs 0.000 claims 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 4
- 229940089161 ginsenoside Drugs 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 3
- 230000000873 masking effect Effects 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- 239000004604 Blowing Agent Substances 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
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| CN 200510083854 CN1718193A (zh) | 2005-07-14 | 2005-07-14 | 一种人参总次苷药物组合物及其制法和在制备治疗心肌缺血及失血性休克药物中的应用 |
| PCT/CN2006/001574 WO2007006208A1 (en) | 2005-07-14 | 2006-07-05 | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
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| KR100856083B1 (ko) * | 2007-03-15 | 2008-09-03 | (주)뉴트리 | 홍삼 특이 사포닌 고함유 인삼엑기스의 효율적인 제조방법 |
| RU2463070C1 (ru) * | 2008-07-23 | 2012-10-10 | Хэбэй Илин Медицин Рисёч Инститьют Ко., Лтд. | Фармацевтическая композиция для регуляции калиевых каналов в клетке сердечной мышцы, способ ее получения и ее применения |
| KR100919134B1 (ko) * | 2008-10-22 | 2009-09-25 | (주)해나천연물연구소 | 항비만 효능을 나타내는 저극성 진세노사이드를 고농도로 함유하는 인삼 추출물 및 이의 제조방법 |
| KR101011254B1 (ko) * | 2008-12-10 | 2011-01-27 | 건국대학교 산학협력단 | 과염소산의 산 가수분해를 이용한 진세노사이드 아글리콘 프로토파낙사디올 제조방법 |
| JP5550995B2 (ja) * | 2009-06-12 | 2014-07-16 | ライオン株式会社 | 尿酸値低下組成物 |
| JP5546851B2 (ja) * | 2009-12-21 | 2014-07-09 | ライオン株式会社 | 貧血改善剤及び貧血改善用組成物 |
| CN102600214B (zh) * | 2011-01-24 | 2014-10-08 | 北京大学 | 苦丁茶冬青叶的提取方法、总皂苷及其用途 |
| CN102731603A (zh) * | 2011-03-31 | 2012-10-17 | 上海兰蒂斯生物医药科技有限公司 | 人参二醇及20(r)-原人参二醇的制备方法 |
| ES2800315T3 (es) | 2011-08-19 | 2020-12-29 | Acquascience Ltd | Composición para separar proteínas de detergentes y detección de proteínas |
| CN103372138B (zh) * | 2012-04-25 | 2017-07-28 | 天士力制药集团股份有限公司 | 一种含有生脉饮有效成分的药物组合物及其制备方法 |
| JP6163359B2 (ja) * | 2012-06-19 | 2017-07-12 | 花王株式会社 | Ｃｇｒｐ応答性促進剤 |
| JP6076719B2 (ja) * | 2012-12-06 | 2017-02-08 | 花王株式会社 | Ｃｇｒｐ応答性促進剤 |
| CN103271891B (zh) * | 2013-04-28 | 2016-01-06 | 福建南方制药股份有限公司 | 人参皂苷纳米胶束及其制备方法、应用和药物组合物 |
| CN103242408B (zh) * | 2013-05-08 | 2016-01-13 | 天津大学 | 微波辅助技术提取人参皂苷单体Rg3和Rh2的方法 |
| CN107073023B (zh) | 2015-07-16 | 2020-03-17 | 智能合成生物中心 | 血管渗漏综合症的预防或治疗组合物 |
| CN105055801A (zh) * | 2015-08-28 | 2015-11-18 | 霍同颜 | 一种医治心律失常的组合物及制法 |
| CN108339000B (zh) * | 2017-01-22 | 2021-08-03 | 上海弘医堂生物医药科技有限公司 | 一种人参属植物提取物及其药物组合物和应用 |
| KR102095536B1 (ko) | 2019-06-04 | 2020-03-31 | (주)녹십자웰빙 | 천연물 추출물의 용출률 및 붕해성이 개선된 경구용 제제 |
| CN111228277B (zh) * | 2020-03-11 | 2023-07-07 | 大连大学 | 20(R)-25-羟基-达玛烷型-3β,12β,20-三醇的药物用途 |
| CN111802613B (zh) * | 2020-07-14 | 2022-10-11 | 广东老中医保健食品有限公司 | 人参皂苷掩味剂、含人参皂苷的具留长麦香风味组合物、口含片及其制作方法 |
| CN112646081A (zh) * | 2020-12-07 | 2021-04-13 | 石河子大学 | 新型硼酸功能化大孔树脂的制备以及在甜菊糖苷选择吸附中的应用 |
| CN114910573A (zh) * | 2021-02-10 | 2022-08-16 | 陕西中医药大学附属医院 | 一种用于体外细胞培养的中药含药血清制备及鉴定方法 |
| CN113331421A (zh) * | 2021-06-22 | 2021-09-03 | 北京澳特舒尔保健品开发有限公司 | 总皂苷的制备方法及其在改善睡眠、祛斑产品中的应用 |
| CN116120389B (zh) * | 2023-03-29 | 2023-07-18 | 中国农业科学院特产研究所 | 人参皂苷Rg5及制备和在制备过敏性鼻炎药物中的应用 |
| CN116999449B (zh) * | 2023-08-17 | 2024-05-03 | 吉林农业大学 | 一种人参皂苷组合物及其在制备多靶点脂肪细胞发育分化和代谢调节剂中的应用 |
| CN117323270B (zh) * | 2023-11-29 | 2024-03-19 | 江西康一参生物科技有限公司 | 一种抗炎症多功效的人参组合物及其应用 |
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| JPS5533456A (en) * | 1978-08-31 | 1980-03-08 | Koshiro Chiyuuji Shoten:Kk | Separation of ginseng saponin |
| CN1049296C (zh) | 1994-01-06 | 2000-02-09 | 东南大学 | 多工位半自动灯管对接机 |
| JP3087638B2 (ja) | 1995-11-30 | 2000-09-11 | ヤマハ株式会社 | 音楽情報処理システム |
| CN1193038A (zh) | 1997-03-06 | 1998-09-16 | 宋建民 | 加重防污染剂 |
| CN1092204C (zh) * | 1998-07-28 | 2002-10-09 | 吉林大学基础医学院科技开发中心 | 20(S)－人参皂甙Rg3的半合成方法及其药物用途 |
| CN1156281C (zh) * | 2000-01-31 | 2004-07-07 | 吉林省中医中药研究院 | 人参皂甙Rg2在制备治疗心、脑血管疾病药物中的应用 |
| US8486464B2 (en) | 2000-12-22 | 2013-07-16 | Tasly Pharmaceutical Group Co. Ltd. | Herbal composition for angina pectoris, method to prepare same and uses thereof |
| US6888014B2 (en) | 2001-07-24 | 2005-05-03 | Panagin Pharmaceuticals Inc. | Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same |
| CN1193038C (zh) * | 2001-11-06 | 2005-03-16 | 中国科学院大连化学物理研究所 | 一种人参皂甙酸水解制备人参皂甙Rg#－[3]的方法 |
| KR20040036451A (ko) | 2002-10-26 | 2004-04-30 | 한국과학기술연구원 | 진세노사이드 Ｒｇ３ 또는 진세노사이드 Ｒｈ２를포함하는 글루타메이트 매개 신경독성 억제 조성물 |
| CN1331473C (zh) | 2003-07-23 | 2007-08-15 | 山东绿叶天然药物研究开发有限公司 | 20（S）—人参皂苷—Rg3在制备治疗或预防心脑血管疾病的药物中的应用 |
| CN1569011A (zh) | 2003-07-24 | 2005-01-26 | 山东绿叶天然药物研究开发有限公司 | 20（R）－人参皂苷－Rg3在制备治疗或预防心脑血管疾病的药物中的应用 |
| EP1660107A4 (en) * | 2003-08-18 | 2008-06-04 | Yuyu Inc | GINSENG PREPARATION USING VINEGAR AND MANUFACTURING METHOD THEREFOR |
| CN100339085C (zh) * | 2003-09-23 | 2007-09-26 | 天津天士力制药股份有限公司 | 治疗心脑血管疾病的中药组合物 |
| CN1283267C (zh) | 2004-07-19 | 2006-11-08 | 北京科信必成医药科技发展有限公司 | 人参茎叶总皂苷口腔崩解片制剂及其制备方法 |
| US7371131B2 (en) | 2005-04-04 | 2008-05-13 | Fci Americas Technology, Inc. | Connector having retentive rib |
| JPWO2008081742A1 (ja) | 2006-12-28 | 2010-04-30 | パナソニック株式会社 | 抵抗変化型素子、抵抗変化型記憶装置、および抵抗変化型装置 |
| CN101586589A (zh) | 2008-05-21 | 2009-11-25 | 煤炭科学研究总院上海分院 | 电液运动一体化模块装置 |
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- 2006-07-05 ES ES06761360.4T patent/ES2515891T3/es not_active Expired - Lifetime
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