CA2614700C - Medicinal composition containing ginseng secondary glycosides, its preparation method and application - Google Patents

Medicinal composition containing ginseng secondary glycosides, its preparation method and application Download PDF

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Publication number
CA2614700C
CA2614700C CA2614700A CA2614700A CA2614700C CA 2614700 C CA2614700 C CA 2614700C CA 2614700 A CA2614700 A CA 2614700A CA 2614700 A CA2614700 A CA 2614700A CA 2614700 C CA2614700 C CA 2614700C
Authority
CA
Canada
Prior art keywords
ginsenosides
ginsenoside
total secondary
total
secondary ginsenosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2614700A
Other languages
English (en)
French (fr)
Other versions
CA2614700A1 (en
Inventor
Congxin Sun
Hesheng Luo
Yongli Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI HONGYITANG BIOPHARMACEUTICAL TECHNOLOGY Co Ltd
Original Assignee
NATIONAL INSTITUTE OF PHARMACEUTICAL R&D Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN 200510083852 external-priority patent/CN1718191A/zh
Priority claimed from CNB2005100838556A external-priority patent/CN100337636C/zh
Priority claimed from CN 200510083854 external-priority patent/CN1718193A/zh
Application filed by NATIONAL INSTITUTE OF PHARMACEUTICAL R&D Co Ltd filed Critical NATIONAL INSTITUTE OF PHARMACEUTICAL R&D Co Ltd
Publication of CA2614700A1 publication Critical patent/CA2614700A1/en
Application granted granted Critical
Publication of CA2614700C publication Critical patent/CA2614700C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2614700A 2005-07-14 2006-07-05 Medicinal composition containing ginseng secondary glycosides, its preparation method and application Expired - Lifetime CA2614700C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN200510083852.2 2005-07-14
CN200510083855.6 2005-07-14
CN 200510083852 CN1718191A (zh) 2005-07-14 2005-07-14 人参总次苷口腔崩解片及其制备方法和应用
CNB2005100838556A CN100337636C (zh) 2005-07-14 2005-07-14 一种人参总次苷药物组合物及其制备方法和应用
CN200510083854.1 2005-07-14
CN 200510083854 CN1718193A (zh) 2005-07-14 2005-07-14 一种人参总次苷药物组合物及其制法和在制备治疗心肌缺血及失血性休克药物中的应用
PCT/CN2006/001574 WO2007006208A1 (en) 2005-07-14 2006-07-05 Medicinal composition containing ginseng secondary glycosides, its preparation method and application

Publications (2)

Publication Number Publication Date
CA2614700A1 CA2614700A1 (en) 2007-01-18
CA2614700C true CA2614700C (en) 2011-07-19

Family

ID=37636737

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2614700A Expired - Lifetime CA2614700C (en) 2005-07-14 2006-07-05 Medicinal composition containing ginseng secondary glycosides, its preparation method and application

Country Status (8)

Country Link
US (1) US7973014B2 (enExample)
EP (1) EP1905444B1 (enExample)
JP (1) JP2009500432A (enExample)
KR (1) KR101182917B1 (enExample)
CA (1) CA2614700C (enExample)
ES (1) ES2515891T3 (enExample)
PL (1) PL1905444T3 (enExample)
WO (1) WO2007006208A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100856083B1 (ko) * 2007-03-15 2008-09-03 (주)뉴트리 홍삼 특이 사포닌 고함유 인삼엑기스의 효율적인 제조방법
RU2463070C1 (ru) * 2008-07-23 2012-10-10 Хэбэй Илин Медицин Рисёч Инститьют Ко., Лтд. Фармацевтическая композиция для регуляции калиевых каналов в клетке сердечной мышцы, способ ее получения и ее применения
KR100919134B1 (ko) * 2008-10-22 2009-09-25 (주)해나천연물연구소 항비만 효능을 나타내는 저극성 진세노사이드를 고농도로 함유하는 인삼 추출물 및 이의 제조방법
KR101011254B1 (ko) * 2008-12-10 2011-01-27 건국대학교 산학협력단 과염소산의 산 가수분해를 이용한 진세노사이드 아글리콘 프로토파낙사디올 제조방법
JP5550995B2 (ja) * 2009-06-12 2014-07-16 ライオン株式会社 尿酸値低下組成物
JP5546851B2 (ja) * 2009-12-21 2014-07-09 ライオン株式会社 貧血改善剤及び貧血改善用組成物
CN102600214B (zh) * 2011-01-24 2014-10-08 北京大学 苦丁茶冬青叶的提取方法、总皂苷及其用途
CN102731603A (zh) * 2011-03-31 2012-10-17 上海兰蒂斯生物医药科技有限公司 人参二醇及20(r)-原人参二醇的制备方法
ES2800315T3 (es) 2011-08-19 2020-12-29 Acquascience Ltd Composición para separar proteínas de detergentes y detección de proteínas
CN103372138B (zh) * 2012-04-25 2017-07-28 天士力制药集团股份有限公司 一种含有生脉饮有效成分的药物组合物及其制备方法
JP6163359B2 (ja) * 2012-06-19 2017-07-12 花王株式会社 Ｃｇｒｐ応答性促進剤
JP6076719B2 (ja) * 2012-12-06 2017-02-08 花王株式会社 Ｃｇｒｐ応答性促進剤
CN103271891B (zh) * 2013-04-28 2016-01-06 福建南方制药股份有限公司 人参皂苷纳米胶束及其制备方法、应用和药物组合物
CN103242408B (zh) * 2013-05-08 2016-01-13 天津大学 微波辅助技术提取人参皂苷单体Rg3和Rh2的方法
CN107073023B (zh) 2015-07-16 2020-03-17 智能合成生物中心 血管渗漏综合症的预防或治疗组合物
CN105055801A (zh) * 2015-08-28 2015-11-18 霍同颜 一种医治心律失常的组合物及制法
CN108339000B (zh) * 2017-01-22 2021-08-03 上海弘医堂生物医药科技有限公司 一种人参属植物提取物及其药物组合物和应用
KR102095536B1 (ko) 2019-06-04 2020-03-31 (주)녹십자웰빙 천연물 추출물의 용출률 및 붕해성이 개선된 경구용 제제
CN111228277B (zh) * 2020-03-11 2023-07-07 大连大学 20(R)-25-羟基-达玛烷型-3β,12β,20-三醇的药物用途
CN111802613B (zh) * 2020-07-14 2022-10-11 广东老中医保健食品有限公司 人参皂苷掩味剂、含人参皂苷的具留长麦香风味组合物、口含片及其制作方法
CN112646081A (zh) * 2020-12-07 2021-04-13 石河子大学 新型硼酸功能化大孔树脂的制备以及在甜菊糖苷选择吸附中的应用
CN114910573A (zh) * 2021-02-10 2022-08-16 陕西中医药大学附属医院 一种用于体外细胞培养的中药含药血清制备及鉴定方法
CN113331421A (zh) * 2021-06-22 2021-09-03 北京澳特舒尔保健品开发有限公司 总皂苷的制备方法及其在改善睡眠、祛斑产品中的应用
CN116120389B (zh) * 2023-03-29 2023-07-18 中国农业科学院特产研究所 人参皂苷Rg5及制备和在制备过敏性鼻炎药物中的应用
CN116999449B (zh) * 2023-08-17 2024-05-03 吉林农业大学 一种人参皂苷组合物及其在制备多靶点脂肪细胞发育分化和代谢调节剂中的应用
CN117323270B (zh) * 2023-11-29 2024-03-19 江西康一参生物科技有限公司 一种抗炎症多功效的人参组合物及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5533456A (en) * 1978-08-31 1980-03-08 Koshiro Chiyuuji Shoten:Kk Separation of ginseng saponin
CN1049296C (zh) 1994-01-06 2000-02-09 东南大学 多工位半自动灯管对接机
JP3087638B2 (ja) 1995-11-30 2000-09-11 ヤマハ株式会社 音楽情報処理システム
CN1193038A (zh) 1997-03-06 1998-09-16 宋建民 加重防污染剂
CN1092204C (zh) * 1998-07-28 2002-10-09 吉林大学基础医学院科技开发中心 20(S)－人参皂甙Rg3的半合成方法及其药物用途
CN1156281C (zh) * 2000-01-31 2004-07-07 吉林省中医中药研究院 人参皂甙Rg2在制备治疗心、脑血管疾病药物中的应用
US8486464B2 (en) 2000-12-22 2013-07-16 Tasly Pharmaceutical Group Co. Ltd. Herbal composition for angina pectoris, method to prepare same and uses thereof
US6888014B2 (en) 2001-07-24 2005-05-03 Panagin Pharmaceuticals Inc. Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same
CN1193038C (zh) * 2001-11-06 2005-03-16 中国科学院大连化学物理研究所 一种人参皂甙酸水解制备人参皂甙Rg#－[3]的方法
KR20040036451A (ko) 2002-10-26 2004-04-30 한국과학기술연구원 진세노사이드 Ｒｇ３ 또는 진세노사이드 Ｒｈ２를포함하는 글루타메이트 매개 신경독성 억제 조성물
CN1331473C (zh) 2003-07-23 2007-08-15 山东绿叶天然药物研究开发有限公司 20（S）—人参皂苷—Rg3在制备治疗或预防心脑血管疾病的药物中的应用
CN1569011A (zh) 2003-07-24 2005-01-26 山东绿叶天然药物研究开发有限公司 20（R）－人参皂苷－Rg3在制备治疗或预防心脑血管疾病的药物中的应用
EP1660107A4 (en) * 2003-08-18 2008-06-04 Yuyu Inc GINSENG PREPARATION USING VINEGAR AND MANUFACTURING METHOD THEREFOR
CN100339085C (zh) * 2003-09-23 2007-09-26 天津天士力制药股份有限公司 治疗心脑血管疾病的中药组合物
CN1283267C (zh) 2004-07-19 2006-11-08 北京科信必成医药科技发展有限公司 人参茎叶总皂苷口腔崩解片制剂及其制备方法
US7371131B2 (en) 2005-04-04 2008-05-13 Fci Americas Technology, Inc. Connector having retentive rib
JPWO2008081742A1 (ja) 2006-12-28 2010-04-30 パナソニック株式会社 抵抗変化型素子、抵抗変化型記憶装置、および抵抗変化型装置
CN101586589A (zh) 2008-05-21 2009-11-25 煤炭科学研究总院上海分院 电液运动一体化模块装置

Also Published As

Publication number Publication date
EP1905444B1 (en) 2014-09-24
US7973014B2 (en) 2011-07-05
US20080234208A1 (en) 2008-09-25
ES2515891T3 (es) 2014-10-30
KR101182917B1 (ko) 2012-09-13
CA2614700A1 (en) 2007-01-18
PL1905444T3 (pl) 2015-03-31
WO2007006208A1 (en) 2007-01-18
JP2009500432A (ja) 2009-01-08
EP1905444A1 (en) 2008-04-02
HK1110520A1 (en) 2008-07-18
EP1905444A4 (en) 2011-11-30
KR20080034154A (ko) 2008-04-18

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