JP2009114217A5 - - Google Patents
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- Publication number
- JP2009114217A5 JP2009114217A5 JP2009050902A JP2009050902A JP2009114217A5 JP 2009114217 A5 JP2009114217 A5 JP 2009114217A5 JP 2009050902 A JP2009050902 A JP 2009050902A JP 2009050902 A JP2009050902 A JP 2009050902A JP 2009114217 A5 JP2009114217 A5 JP 2009114217A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- fatty acid
- composition
- formula
- acid triglyceride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- -1 bicyclic compound Chemical class 0.000 claims 7
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 6
- 150000004667 medium chain fatty acids Chemical class 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 206010010774 Constipation Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 230000002475 laxative effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical group CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/655,760 US6414016B1 (en) | 2000-09-05 | 2000-09-05 | Anti-constipation composition |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Division JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213058A Division JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009114217A JP2009114217A (ja) | 2009-05-28 |
| JP2009114217A5 true JP2009114217A5 (https=) | 2009-11-12 |
| JP4684334B2 JP4684334B2 (ja) | 2011-05-18 |
Family
ID=24630250
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Pending JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
| JP2009050902A Expired - Fee Related JP4684334B2 (ja) | 2000-09-05 | 2009-03-04 | 下剤組成物 |
| JP2009213058A Pending JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524492A Pending JP2004508327A (ja) | 2000-09-05 | 2001-09-04 | 下剤組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213058A Pending JP2009286806A (ja) | 2000-09-05 | 2009-09-15 | 下剤組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US6414016B1 (https=) |
| EP (2) | EP1857105B1 (https=) |
| JP (3) | JP2004508327A (https=) |
| KR (2) | KR100918223B1 (https=) |
| CN (1) | CN100335049C (https=) |
| AR (2) | AR030609A1 (https=) |
| AT (1) | ATE476975T1 (https=) |
| AU (2) | AU2001282615B2 (https=) |
| BR (1) | BRPI0114042B8 (https=) |
| CA (1) | CA2419741C (https=) |
| CZ (1) | CZ304740B6 (https=) |
| DE (2) | DE60142810D1 (https=) |
| DK (2) | DK1857105T3 (https=) |
| ES (2) | ES2296786T3 (https=) |
| HU (1) | HU229319B1 (https=) |
| IL (2) | IL154534A0 (https=) |
| MX (1) | MXPA03001959A (https=) |
| NL (1) | NL300757I1 (https=) |
| NO (1) | NO332701B1 (https=) |
| NZ (1) | NZ524401A (https=) |
| PT (2) | PT1315485E (https=) |
| RU (1) | RU2694361C3 (https=) |
| TW (1) | TWI305147B (https=) |
| WO (1) | WO2002020007A1 (https=) |
| ZA (1) | ZA200301673B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0014869B8 (pt) * | 1999-10-15 | 2021-05-25 | Sucampo Ag | prostaglandinas bicíclicas, composições estabilizadas das mesmas, bem como processo para sua estabilização |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| AR037524A1 (es) | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| NZ539582A (en) * | 2002-10-23 | 2007-07-27 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| EP1575596B1 (en) * | 2002-12-27 | 2016-06-22 | Sucampo AG | Derivatives of prostaglandins for treating irritable bowel syndrome and/or functional dyspepsia |
| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| TWI495471B (zh) * | 2003-08-12 | 2015-08-11 | R Tech Ueno Ltd | 促進毛髮生長之組成物及方法 |
| RU2392941C2 (ru) * | 2004-09-02 | 2010-06-27 | Сукампо Аг | Производные простагландинов для лечения желудочно-кишечного нарушения |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| US8202909B2 (en) * | 2005-01-27 | 2012-06-19 | Sucampo Ag | Method for treating central nervous system disorders |
| KR20160120809A (ko) * | 2005-03-04 | 2016-10-18 | 수캄포 아게 | 말초 혈관 질환 치료를 위한 방법 및 조성물 |
| ES2714198T3 (es) * | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| RU2468800C2 (ru) * | 2005-04-12 | 2012-12-10 | Сукампо Аг | Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний |
| JP5265369B2 (ja) | 2006-01-24 | 2013-08-14 | 株式会社アールテック・ウエノ | 二環式化合物を含む医薬組成物およびその二環式化合物の安定化方法 |
| KR101437302B1 (ko) * | 2006-02-07 | 2014-09-02 | 가부시키가이샤 아루떼꾸 우에노 | 프로스타글란딘 유도체의 제조 방법 |
| US20090012165A1 (en) * | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
| US20090030072A1 (en) * | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
| US8513441B2 (en) * | 2008-08-29 | 2013-08-20 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| PT2349250T (pt) * | 2008-10-31 | 2017-07-25 | Lipid Pharmaceuticals Ehf | Ácidos gordos para uso como um medicamento |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| CA2750487A1 (en) | 2009-01-22 | 2010-07-29 | Apotex Pharmachem Inc. | Methods of making lubiprostone and intermediates thereof |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| AU2010295464B2 (en) * | 2009-09-18 | 2015-11-26 | Merck Sharp & Dohme Corp. | Use of opioid receptor antagonist for gastrointestinal tract disorders |
| CA2779736A1 (en) * | 2009-11-03 | 2011-05-12 | Bernard Charles Sherman | Stable pharmaceutical formulations comprising lubiprostone |
| CA2784933A1 (en) * | 2009-12-18 | 2011-06-23 | Apotex Pharmachem Inc. | Processes for the purification of lubiprostone |
| EP2536705A4 (en) | 2010-01-28 | 2013-08-07 | Apotex Pharmachem Inc | POLYMORPHIC FORMS OF LUBIPROSTON |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| EP3277274B1 (en) | 2015-04-01 | 2024-06-12 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
| AR105029A1 (es) * | 2015-06-19 | 2017-08-30 | Sucampo Ag | Composición farmacéutica que comprende derivado de ácido graso |
| JP6957610B2 (ja) | 2016-10-06 | 2021-11-02 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 医薬品用途のための多層ビーズ |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| CN110494721B (zh) * | 2017-04-20 | 2022-06-24 | 株式会社岛津制作所 | 分光光度计 |
| US10422729B1 (en) | 2019-03-08 | 2019-09-24 | Biodesix, Inc. | Blood sample separation devices and methods |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5720305B2 (https=) | 1973-02-28 | 1982-04-27 | ||
| US4034003A (en) | 1974-04-11 | 1977-07-05 | Ono Pharmaceutical Co., Ltd. | 15-Cycloalkyl-prostaglandins |
| JPS5350141A (en) | 1976-10-18 | 1978-05-08 | Ono Pharmaceut Co Ltd | Stabilization of prostaglandin and prostaglandin analogues |
| JPS5391110A (en) | 1977-01-20 | 1978-08-10 | Yamanouchi Pharmaceut Co Ltd | Novel drug composition for rectal infusion |
| JPS6022708B2 (ja) | 1977-07-14 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| US4308595A (en) * | 1979-12-19 | 1981-12-29 | International Business Machines Corporation | Array driver |
| US4670569A (en) | 1981-04-02 | 1987-06-02 | G. D. Searle & Co. | 5-fluoro-PGI2 compounds |
| US4579958A (en) | 1983-12-23 | 1986-04-01 | G. D. Searle & Co. | 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds |
| US4687864A (en) | 1983-12-23 | 1987-08-18 | G. D. Searle & Co. | 5-fluoro-3-oxa-prostacyclin compounds |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| ES2051862T3 (es) | 1987-10-02 | 1994-07-01 | Ueno Seiyaku Oyo Kenkyujo Kk | Un metodo para producir un medicamento que tiene un efecto catartico. |
| US5317032A (en) | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| JPH0681728B2 (ja) * | 1987-10-02 | 1994-10-19 | 株式会社上野製薬応用研究所 | 下 剤 |
| JP2579193B2 (ja) | 1988-07-19 | 1997-02-05 | 小野薬品工業株式会社 | １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体 |
| CA2030345C (en) | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
| CA2030346C (en) * | 1989-11-22 | 2000-04-11 | Ryuji Ueno | Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds |
| JP2515442B2 (ja) * | 1990-05-01 | 1996-07-10 | 株式会社上野製薬応用研究所 | 膵臓疾患処置剤 |
| ATE174221T1 (de) * | 1990-05-01 | 1998-12-15 | R Tech Ueno Ltd | Behandlung von pankreaskrankheit mit 15-keto- prostaglandin e-derivaten |
| JP2938579B2 (ja) | 1990-12-15 | 1999-08-23 | 株式会社上野製薬応用研究所 | 消化管壁保護剤 |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| US5958876A (en) | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
| AUPO665397A0 (en) * | 1997-05-07 | 1997-05-29 | Borody, Thomas Julius | Novel therapy for constipation |
| DE69910183T2 (de) | 1998-03-11 | 2004-06-03 | Grelan Pharmaceutical Co., Ltd., Hamura | Darmlösliche sprudelnde zusammensetzungen |
| US6471085B1 (en) | 1999-10-04 | 2002-10-29 | Anthony J. Gallo | Temperature cup |
| BRPI0014869B8 (pt) * | 1999-10-15 | 2021-05-25 | Sucampo Ag | prostaglandinas bicíclicas, composições estabilizadas das mesmas, bem como processo para sua estabilização |
| AU2001287580A1 (en) * | 2000-07-14 | 2002-01-30 | Henkel Kommanditgesellschaft Auf Aktien | Hollow bodies with compartments |
| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
-
2000
- 2000-09-05 US US09/655,760 patent/US6414016B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 EP EP07016834A patent/EP1857105B1/en not_active Expired - Lifetime
- 2001-09-04 KR KR1020087021218A patent/KR100918223B1/ko not_active Expired - Lifetime
- 2001-09-04 MX MXPA03001959A patent/MXPA03001959A/es active IP Right Grant
- 2001-09-04 JP JP2002524492A patent/JP2004508327A/ja active Pending
- 2001-09-04 ES ES01961333T patent/ES2296786T3/es not_active Expired - Lifetime
- 2001-09-04 IL IL15453401A patent/IL154534A0/xx unknown
- 2001-09-04 TW TW090121835A patent/TWI305147B/zh not_active IP Right Cessation
- 2001-09-04 AT AT07016834T patent/ATE476975T1/de active
- 2001-09-04 HU HU0302422A patent/HU229319B1/hu unknown
- 2001-09-04 CZ CZ2003-787A patent/CZ304740B6/cs not_active IP Right Cessation
- 2001-09-04 AU AU2001282615A patent/AU2001282615B2/en not_active Expired
- 2001-09-04 DK DK07016834.9T patent/DK1857105T3/da active
- 2001-09-04 RU RU2003109622A patent/RU2694361C3/ru active Protection Beyond IP Right Term
- 2001-09-04 ES ES07016834T patent/ES2347697T3/es not_active Expired - Lifetime
- 2001-09-04 WO PCT/JP2001/007628 patent/WO2002020007A1/en not_active Ceased
- 2001-09-04 KR KR1020037003261A patent/KR100901102B1/ko not_active Expired - Lifetime
- 2001-09-04 DE DE60142810T patent/DE60142810D1/de not_active Expired - Lifetime
- 2001-09-04 AU AU8261501A patent/AU8261501A/xx active Pending
- 2001-09-04 EP EP01961333A patent/EP1315485B1/en not_active Expired - Lifetime
- 2001-09-04 PT PT01961333T patent/PT1315485E/pt unknown
- 2001-09-04 NZ NZ524401A patent/NZ524401A/en not_active IP Right Cessation
- 2001-09-04 CA CA2419741A patent/CA2419741C/en not_active Expired - Lifetime
- 2001-09-04 PT PT07016834T patent/PT1857105E/pt unknown
- 2001-09-04 DK DK01961333T patent/DK1315485T3/da active
- 2001-09-04 BR BRPI0114042A patent/BRPI0114042B8/pt not_active IP Right Cessation
- 2001-09-04 CN CNB018183239A patent/CN100335049C/zh not_active Ceased
- 2001-09-04 DE DE60131547T patent/DE60131547T2/de not_active Expired - Lifetime
- 2001-09-05 AR ARP010104216A patent/AR030609A1/es unknown
-
2002
- 2002-05-06 US US10/138,650 patent/US6610732B2/en not_active Expired - Fee Related
-
2003
- 2003-02-19 IL IL154534A patent/IL154534A/en not_active IP Right Cessation
- 2003-02-28 ZA ZA200301673A patent/ZA200301673B/xx unknown
- 2003-03-04 NO NO20030996A patent/NO332701B1/no not_active IP Right Cessation
- 2003-05-22 US US10/443,046 patent/US20030216465A1/en not_active Abandoned
-
2005
- 2005-06-02 US US11/142,251 patent/US8071613B2/en not_active Expired - Fee Related
-
2009
- 2009-03-04 JP JP2009050902A patent/JP4684334B2/ja not_active Expired - Fee Related
- 2009-09-15 JP JP2009213058A patent/JP2009286806A/ja active Pending
-
2011
- 2011-10-17 US US13/274,612 patent/US8114890B1/en not_active Expired - Lifetime
- 2011-12-27 US US13/337,488 patent/US8748454B2/en not_active Expired - Fee Related
-
2013
- 2013-08-26 AR ARP130103006A patent/AR100291A2/es not_active Application Discontinuation
-
2014
- 2014-04-30 US US14/265,467 patent/US20140235665A1/en not_active Abandoned
-
2015
- 2015-08-28 NL NL300757C patent/NL300757I1/nl unknown
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