JP2009073850A5 - - Google Patents
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- Publication number
- JP2009073850A5 JP2009073850A5 JP2008287205A JP2008287205A JP2009073850A5 JP 2009073850 A5 JP2009073850 A5 JP 2009073850A5 JP 2008287205 A JP2008287205 A JP 2008287205A JP 2008287205 A JP2008287205 A JP 2008287205A JP 2009073850 A5 JP2009073850 A5 JP 2009073850A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- weight
- isa
- polyoxyethylene
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 12
- 239000012736 aqueous medium Substances 0.000 claims 9
- 239000004530 micro-emulsion Substances 0.000 claims 8
- 239000003921 oil Substances 0.000 claims 8
- 235000019198 oils Nutrition 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 7
- 229920000053 polysorbate 80 Polymers 0.000 claims 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- -1 polyoxyethylene Polymers 0.000 claims 6
- 230000001506 immunosuppresive effect Effects 0.000 claims 5
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 4
- 235000015203 fruit juice Nutrition 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 229920000136 polysorbate Polymers 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- 229930003231 vitamin Natural products 0.000 claims 4
- 229940088594 vitamin Drugs 0.000 claims 4
- 235000013343 vitamin Nutrition 0.000 claims 4
- 239000011782 vitamin Substances 0.000 claims 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims 4
- 206010062016 Immunosuppression Diseases 0.000 claims 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 244000269722 Thea sinensis Species 0.000 claims 2
- 244000299461 Theobroma cacao Species 0.000 claims 2
- 235000009470 Theobroma cacao Nutrition 0.000 claims 2
- 235000015197 apple juice Nutrition 0.000 claims 2
- 229920000249 biocompatible polymer Polymers 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- 235000015201 grapefruit juice Nutrition 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 235000013616 tea Nutrition 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001219 Polysorbate 40 Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- 239000004147 Sorbitan trioleate Substances 0.000 claims 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
- 229960000391 sorbitan trioleate Drugs 0.000 claims 1
- 235000011078 sorbitan tristearate Nutrition 0.000 claims 1
- 239000001589 sorbitan tristearate Substances 0.000 claims 1
- 229960004129 sorbitan tristearate Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34620101P | 2001-10-19 | 2001-10-19 | |
| US37059702P | 2002-04-05 | 2002-04-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535753A Division JP2005506990A (ja) | 2001-10-19 | 2002-10-17 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012118377A Division JP2012158609A (ja) | 2001-10-19 | 2012-05-24 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009073850A JP2009073850A (ja) | 2009-04-09 |
| JP2009073850A5 true JP2009073850A5 (https=) | 2009-05-21 |
Family
ID=26994747
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535753A Pending JP2005506990A (ja) | 2001-10-19 | 2002-10-17 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
| JP2008287205A Pending JP2009073850A (ja) | 2001-10-19 | 2008-11-07 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
| JP2012118377A Pending JP2012158609A (ja) | 2001-10-19 | 2012-05-24 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535753A Pending JP2005506990A (ja) | 2001-10-19 | 2002-10-17 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012118377A Pending JP2012158609A (ja) | 2001-10-19 | 2012-05-24 | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7060672B2 (https=) |
| EP (2) | EP2116228A1 (https=) |
| JP (3) | JP2005506990A (https=) |
| KR (1) | KR100978836B1 (https=) |
| CN (1) | CN1274294C (https=) |
| AR (1) | AR036852A1 (https=) |
| AT (1) | ATE437629T1 (https=) |
| AU (1) | AU2002333098B2 (https=) |
| BR (1) | BR0213661A (https=) |
| CA (1) | CA2461730C (https=) |
| CO (1) | CO5580835A2 (https=) |
| DE (1) | DE60233150D1 (https=) |
| DK (1) | DK1435910T3 (https=) |
| ES (1) | ES2330625T3 (https=) |
| HR (1) | HRP20040354B1 (https=) |
| IL (3) | IL160761A0 (https=) |
| MA (1) | MA26221A1 (https=) |
| ME (1) | MEP89008A (https=) |
| MX (1) | MXPA04003623A (https=) |
| MY (1) | MY145753A (https=) |
| NO (1) | NO20042028L (https=) |
| NZ (1) | NZ531946A (https=) |
| PL (1) | PL206018B1 (https=) |
| PT (1) | PT1435910E (https=) |
| RU (1) | RU2317067C2 (https=) |
| TN (1) | TNSN04070A1 (https=) |
| WO (1) | WO2003032949A1 (https=) |
| ZA (1) | ZA200402268B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
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| HRP20040354B1 (en) * | 2001-10-19 | 2012-10-31 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| EP1603512A2 (en) | 2003-03-17 | 2005-12-14 | Albany Molecular Research, Inc. | Novel cyclosporins |
| GB0307440D0 (en) * | 2003-03-31 | 2003-05-07 | Novartis Ag | Organic compounds |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| US7378391B2 (en) | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| WO2008121096A1 (en) * | 2005-05-19 | 2008-10-09 | The Board Of Governors For Higher Education | Monitoring cyclosporine in saliva |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| US11311477B2 (en) | 2006-03-07 | 2022-04-26 | Sgn Nanopharma Inc. | Ophthalmic preparations |
| CA2645080A1 (en) * | 2006-03-07 | 2007-09-13 | Novavax,Inc. | Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| EP2104498A2 (en) * | 2006-10-31 | 2009-09-30 | Wyeth | Liquid formulations of phospholipase enzyme inhibitors |
| CN101573111A (zh) * | 2006-10-31 | 2009-11-04 | 惠氏公司 | 磷脂酶抑制剂的制剂 |
| ES2667945T3 (es) | 2007-10-08 | 2018-05-16 | Aurinia Pharmaceuticals Inc. | Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR |
| WO2009117151A2 (en) | 2008-03-20 | 2009-09-24 | Virun, Inc. | Compositions containing non-polar compounds |
| MX2010010050A (es) | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| EP2440185B1 (en) | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| JP5946770B2 (ja) | 2009-12-10 | 2016-07-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | オリゴペプチドを含む医薬組成物 |
| CN103037708B (zh) * | 2010-03-23 | 2015-05-20 | 维尔恩公司 | 含有蔗糖脂肪酸酯的纳米乳液 |
| IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| US20110319467A1 (en) * | 2010-06-23 | 2011-12-29 | Bhiku Patel | Absorption Enhancement of Statins and Omega Fatty Acids |
| EP2584915B1 (en) * | 2010-06-25 | 2015-08-12 | Firmenich SA | Ingredient delivery system |
| US9044394B2 (en) * | 2010-10-18 | 2015-06-02 | PruGen IP Holdings, Inc. | Bioavailability enhancement delivery composition |
| US20120095098A1 (en) * | 2010-10-18 | 2012-04-19 | Bhiku Patel | Bioavailability Enhancement Delivery System |
| WO2012079172A1 (en) | 2010-12-15 | 2012-06-21 | Isotechnika Pharma Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| US8609684B2 (en) * | 2011-12-12 | 2013-12-17 | PruGen IP Holdings, Inc. | Solubilization and bioavailability of acetaminophen |
| US8937081B2 (en) | 2011-12-12 | 2015-01-20 | PruGen IP Holdings, Inc. | Statin bioavailability enhancement delivery composition |
| PL2887923T3 (pl) | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
| EP3157569B1 (en) * | 2014-06-18 | 2019-07-24 | F.Hoffmann-La Roche Ag | New pharmaceutical composition comprising non-ionic surfactants |
| US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
| EP3373976B1 (en) | 2015-11-10 | 2024-01-03 | Sun Pharmaceutical Industries Limited | Topical formulations and uses thereof |
| US10918694B2 (en) | 2016-02-29 | 2021-02-16 | Sun Pharma Global Fze | Topical cyclosporine-containing formulations and uses thereof |
| WO2018100096A1 (en) | 2016-12-01 | 2018-06-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Use of anti-uchl1 igg plasma concentration for diagnosing idiopathic steroid sensitive nephrotic syndrome |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US10286036B2 (en) | 2017-05-12 | 2019-05-14 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| WO2019077123A1 (en) | 2017-10-20 | 2019-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND KITS FOR IDENTIFYING WHETHER A SUBJECT IS REACHED OR RISK OF BEING WITH AUTOIMMUNE MYOPATHY |
| EP3886813B1 (en) * | 2018-11-26 | 2023-03-22 | Hepion Pharmaceuticals, Inc. | Pharmaceutical formulations of cyclosporine analogs |
| US20220018835A1 (en) | 2018-12-07 | 2022-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale | Use of cd26 and cd39 as new phenotypic markers for assessing maturation of foxp3+ t cells and uses thereof for diagnostic purposes |
| EP3911670B1 (en) | 2019-01-15 | 2024-12-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy |
| JP7494163B2 (ja) | 2019-03-27 | 2024-06-03 | 学校法人東京医科大学 | ウォルフラム症候群の治療剤 |
| EP4146240A4 (en) | 2020-05-07 | 2024-06-19 | Aurinia Pharmaceuticals Inc. | METHODS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION |
| KR102449537B1 (ko) * | 2022-01-27 | 2022-10-05 | 주식회사 나노메디팜 | 근적외선을 이용하여 진단 생검 또는 종양 제거 수술 중에 종양 식별과 절제면 구분을 위한 종양 표적 진단 조영제 |
| WO2024153636A1 (en) | 2023-01-17 | 2024-07-25 | Institut National de la Santé et de la Recherche Médicale | Vasorin as a biomarker and biotarget in nephrology |
| WO2025021782A1 (en) | 2023-07-24 | 2025-01-30 | Institut National de la Santé et de la Recherche Médicale | Methods of determining whether a subject suffering from lupus nephritis (ln) will achieve a response with an induction therapy |
| WO2025045894A1 (en) | 2023-08-28 | 2025-03-06 | Institut National de la Santé et de la Recherche Médicale | Methods and kits for diagnosing cause of nephrotic syndrome and guiding therapy |
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-
2002
- 2002-10-17 HR HRP20040354AA patent/HRP20040354B1/hr not_active IP Right Cessation
- 2002-10-17 ES ES02801263T patent/ES2330625T3/es not_active Expired - Lifetime
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- 2002-10-17 WO PCT/CA2002/001561 patent/WO2003032949A1/en not_active Ceased
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- 2002-10-17 CA CA2461730A patent/CA2461730C/en not_active Expired - Lifetime
- 2002-10-17 PT PT02801263T patent/PT1435910E/pt unknown
- 2002-10-17 RU RU2004110936/15A patent/RU2317067C2/ru not_active IP Right Cessation
- 2002-10-17 MX MXPA04003623A patent/MXPA04003623A/es active IP Right Grant
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- 2002-10-17 AR ARP020103917A patent/AR036852A1/es not_active Application Discontinuation
- 2002-10-17 JP JP2003535753A patent/JP2005506990A/ja active Pending
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- 2002-10-17 AT AT02801263T patent/ATE437629T1/de active
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- 2002-10-17 EP EP09166128A patent/EP2116228A1/en not_active Withdrawn
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- 2004-04-16 TN TNP2004000070A patent/TNSN04070A1/en unknown
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- 2004-05-14 NO NO20042028A patent/NO20042028L/no not_active Application Discontinuation
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