ATE110784T1 - Zyklische peptolide. - Google Patents
Zyklische peptolide.Info
- Publication number
- ATE110784T1 ATE110784T1 AT88810408T AT88810408T ATE110784T1 AT E110784 T1 ATE110784 T1 AT E110784T1 AT 88810408 T AT88810408 T AT 88810408T AT 88810408 T AT88810408 T AT 88810408T AT E110784 T1 ATE110784 T1 AT E110784T1
- Authority
- AT
- Austria
- Prior art keywords
- peptolides
- cyclic
- cyclic peptolides
- undecapeptide
- cyclisation
- Prior art date
Links
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- 241001264173 Cylindrotrichum Species 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH231787 | 1987-06-19 | ||
| CH251787 | 1987-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110784T1 true ATE110784T1 (de) | 1994-09-15 |
Family
ID=25690129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88810408T ATE110784T1 (de) | 1987-06-19 | 1988-06-15 | Zyklische peptolide. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5116816A (de) |
| EP (1) | EP0296123B1 (de) |
| JP (1) | JP2641256B2 (de) |
| KR (1) | KR970010928B1 (de) |
| AT (1) | ATE110784T1 (de) |
| AU (1) | AU623078B2 (de) |
| CA (1) | CA1338183C (de) |
| DE (1) | DE3851268T2 (de) |
| ES (1) | ES2056954T3 (de) |
| FI (1) | FI87928C (de) |
| HU (1) | HU204101B (de) |
| IE (1) | IE64008B1 (de) |
| IL (1) | IL86789A (de) |
| MY (1) | MY103735A (de) |
| NZ (1) | NZ225071A (de) |
| PH (1) | PH25933A (de) |
| PT (1) | PT87763B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU213553B (en) * | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
| JP3480848B2 (ja) * | 1992-06-19 | 2003-12-22 | タカラバイオ株式会社 | 環状ペプチドの合成方法 |
| US5260215A (en) * | 1992-07-20 | 1993-11-09 | Merck & Co., Inc. | Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds |
| US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
| NZ291168A (en) * | 1994-07-27 | 1998-06-26 | Novartis Ag | Cyclopeptolides which inhibit expression of adhesion molecules (icam-1, vcam and e-selectin) |
| JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
| CN1130373C (zh) * | 1996-09-13 | 2003-12-10 | 诺瓦蒂斯有限公司 | [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法 |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| ATE314388T1 (de) | 1997-10-08 | 2006-01-15 | Isotechnika Inc | Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien |
| CA2383086A1 (en) * | 1999-09-08 | 2001-03-15 | Joseph P. Steiner | Non-peptidic cyclophilin binding compounds and their use |
| US6656971B2 (en) | 2001-01-25 | 2003-12-02 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
| US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| US20040147433A1 (en) * | 2001-06-14 | 2004-07-29 | Marcus Keep | Neuroimmunophilins for selective neuronal radioprotection |
| ES2326040T3 (es) * | 2001-10-19 | 2009-09-29 | Isotechnika Inc. | Sintesis de analogos de ciclosporina. |
| JP2005506990A (ja) * | 2001-10-19 | 2005-03-10 | アイソテクニカ インコーポレーテッド | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
| WO2004082629A2 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| US7378391B2 (en) * | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| DE602005010607D1 (de) * | 2004-11-22 | 2008-12-04 | Astellas Pharma Inc | Zyklosporinanalog |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| KR20110071014A (ko) | 2008-10-17 | 2011-06-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 생물학적으로 활성인 알파-베타 펩티드의 제조 방법 |
| BRPI0920502A2 (pt) * | 2008-11-06 | 2015-12-22 | Debio Rech Pharma Sa | compostos cicloundecadepsipeptídeos e seu uso como medicamento |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| WO2011141891A1 (en) | 2010-05-12 | 2011-11-17 | Debio Recherche Pharmaceutique S.A. | Use of cycloundecadepsipeptide compounds |
| RU2630690C9 (ru) | 2010-12-15 | 2017-12-28 | КонтраВир Фармасьютикалз, Инк. | МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ |
| EP2705856A1 (de) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Verbindungen zur Behandlung von neurodegenerativen Erkrankungen |
| GB201217560D0 (en) * | 2012-10-02 | 2012-11-14 | Mitopharm Ltd | Novel cyclic depsipeptide compounds and their uses |
| HUP1500502A2 (en) | 2015-10-26 | 2017-04-28 | Rotachrom Tech Kft | Process for the purification of cyclosporin-a |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| JPS5665853A (en) * | 1979-11-01 | 1981-06-03 | Sankyo Co Ltd | Mycoplanesin derivative and its preparation |
| DE3260468D1 (en) * | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
| US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| DE3781878T2 (de) * | 1986-12-15 | 1993-03-11 | Lilly Co Eli | Antibiotikum-a10255-komplex und faktoren, verfahren, mikroorganismen fuer seine herstellung. |
| GB8727807D0 (en) * | 1987-11-27 | 1987-12-31 | Lepetit Spa | Novel antibiotic compounds named a/16686 factors a'1,a'2 and a'3 |
-
1988
- 1988-06-15 DE DE3851268T patent/DE3851268T2/de not_active Expired - Lifetime
- 1988-06-15 EP EP88810408A patent/EP0296123B1/de not_active Expired - Lifetime
- 1988-06-15 AT AT88810408T patent/ATE110784T1/de not_active IP Right Cessation
- 1988-06-15 ES ES88810408T patent/ES2056954T3/es not_active Expired - Lifetime
- 1988-06-16 CA CA000569655A patent/CA1338183C/en not_active Expired - Lifetime
- 1988-06-17 NZ NZ225071A patent/NZ225071A/xx unknown
- 1988-06-17 AU AU18124/88A patent/AU623078B2/en not_active Expired
- 1988-06-17 PH PH37083A patent/PH25933A/en unknown
- 1988-06-17 MY MYPI88000673A patent/MY103735A/en unknown
- 1988-06-17 IL IL86789A patent/IL86789A/xx not_active IP Right Cessation
- 1988-06-17 PT PT87763A patent/PT87763B/pt not_active IP Right Cessation
- 1988-06-17 IE IE183888A patent/IE64008B1/en not_active IP Right Cessation
- 1988-06-17 FI FI882926A patent/FI87928C/fi active IP Right Grant
- 1988-06-17 HU HU883121A patent/HU204101B/hu unknown
- 1988-06-18 JP JP63151056A patent/JP2641256B2/ja not_active Expired - Lifetime
- 1988-06-18 KR KR1019880007371A patent/KR970010928B1/ko not_active IP Right Cessation
- 1988-06-20 US US07/209,680 patent/US5116816A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI882926A (fi) | 1988-12-20 |
| DE3851268T2 (de) | 1995-01-26 |
| HUT50220A (en) | 1989-12-28 |
| HU204101B (en) | 1991-11-28 |
| JPS6425798A (en) | 1989-01-27 |
| PT87763B (pt) | 1992-10-30 |
| DE3851268D1 (de) | 1994-10-06 |
| FI87928B (fi) | 1992-11-30 |
| IE64008B1 (en) | 1995-06-28 |
| PT87763A (pt) | 1988-07-01 |
| AU1812488A (en) | 1988-12-22 |
| KR890000518A (ko) | 1989-03-15 |
| IE881838L (en) | 1988-12-19 |
| MY103735A (en) | 1993-09-30 |
| FI882926A0 (fi) | 1988-06-17 |
| JP2641256B2 (ja) | 1997-08-13 |
| EP0296123B1 (de) | 1994-08-31 |
| CA1338183C (en) | 1996-03-26 |
| PH25933A (en) | 1991-12-19 |
| ES2056954T3 (es) | 1994-10-16 |
| NZ225071A (en) | 1991-05-28 |
| KR970010928B1 (ko) | 1997-07-02 |
| US5116816A (en) | 1992-05-26 |
| EP0296123A3 (en) | 1990-06-20 |
| FI87928C (fi) | 1993-03-10 |
| IL86789A0 (en) | 1988-11-30 |
| IL86789A (en) | 1993-02-21 |
| AU623078B2 (en) | 1992-05-07 |
| EP0296123A2 (de) | 1988-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |