JP2008535838A5 - - Google Patents
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- JP2008535838A5 JP2008535838A5 JP2008505426A JP2008505426A JP2008535838A5 JP 2008535838 A5 JP2008535838 A5 JP 2008535838A5 JP 2008505426 A JP2008505426 A JP 2008505426A JP 2008505426 A JP2008505426 A JP 2008505426A JP 2008535838 A5 JP2008535838 A5 JP 2008535838A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- adjuvant
- aluminum
- crm
- carrier protein
- Prior art date
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- 230000002163 immunogen Effects 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 230000000240 adjuvant Effects 0.000 claims 12
- 239000002671 adjuvant Substances 0.000 claims 12
- 150000004676 glycans Polymers 0.000 claims 8
- 229920001282 polysaccharide Polymers 0.000 claims 8
- 239000005017 polysaccharide Substances 0.000 claims 8
- 150000004804 polysaccharides Polymers 0.000 claims 8
- ILRRQNADMUWWFW-UHFFFAOYSA-K Aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 6
- 102000014914 Carrier Proteins Human genes 0.000 claims 6
- 108010078791 Carrier Proteins Proteins 0.000 claims 6
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 4
- 229940031000 Streptococcus pneumoniae Drugs 0.000 claims 4
- 229910052782 aluminium Inorganic materials 0.000 claims 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K Aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- DIZPMCHEQGEION-UHFFFAOYSA-H Aluminium sulfate Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 2
- 241000588650 Neisseria meningitidis Species 0.000 claims 2
- 229940052778 Neisseria meningitidis Drugs 0.000 claims 2
- 229940074404 Sodium succinate Drugs 0.000 claims 2
- ZDQYSKICYIVCPN-UHFFFAOYSA-L disodium butanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000008362 succinate buffer Substances 0.000 claims 2
- 210000002966 Serum Anatomy 0.000 claims 1
Description
本特許出願に特定されている全ての学術論文、他の参考文献、特許、および特許出願は、参照によってその全体が組み込まれる。
参考文献
１．Hausdorff WP, Bryant J, Paradiso PR, Siber GR. Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part 1. ain Infect Dis 2000; 30:100-21.
２．Hausdorff WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 2000; 30:122-40.
３．Whitney CO, Farley MM, Nadler J, et al. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. New Engl J Med 2003; 348(18):1737-46.
４．Black S, Shinefield H, Hansen J, et al. Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2001; 20;1105-7.
５．Robinson KA, Baughman W, Rothrock G, at al. Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995-1998: Opportunities for prevention in the conjugate vaccine era. JAMA 2001; 285:1729-35.
６．Butler J, Breiman R, Lipman H, et al. Serotype distribution of Streptococcus pneumoniae infections among preschool children in the United States, 1978-1994. J Infect Dis 1995; 171:885-9.
７．Whitney CO, Farley MM, Nadler J, et al. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N EngI J Med 2000; 343:1917-24.
８．Hofmann J, Cetron MS, Farley MM, et al. The prevalence of drug-resistant Streptococcus pneumoniae in Atlanta. N Engi J Med 1995; 333:481-6.
９．Joloba ML, Windau A, Bajaksouzian S, Appelbaum PC Hausdorff WP, Jacobs MR. Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media. Clin Infect Dis 2001; 33:1489-94.
１０．Black S, Shinefield H, Fireman B, et al. Efficacy, safety, and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J 2000; 19:187-95.
１１．Rudolph KM, Parkinson AJ, Reasonover AL, Bulkow LR, Parks DJ, Butler JC. Serotype distribution and antimicrobial resistance pattenrs of invasive isolates of Streptococcus pneumoniae: Alaska, 1991-1998. J Infect Dis 2000; 182:490-6.
１２．Sniadack DH, Schwartz B, Lipman H, et al. Potential interventions for the prevention of childhood pneumonia: geographic and temporal differences in serotype and serogroup distribution of sterile site pneumococcal isolates from children: implications for vaccine strategies. Pediatr Infect Dis J 1995; 14:503-10.
１３．Fagan RL, Hanna JN, Messer RD, Brookes DL, Murphy DM. The epidemiology of invasive pneumococcal disease in children in Far North Queensland. J. Paediatr Child Health 2001; 37:571-5.
１４．Kertesz DA, DI Fabio JL, de Cunto Brandileone MC, et al. Invasive Streptococcus pneumoniae infection in Latin American children: results of the Pan American Health Organization Surveillance. Study. Clin Infect Dis 1998; 26:1355-61.
１５．Hausdorff W, Sitter G, Paradiso P. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children. Lancet 2001; 357:950-52.
１６．Buckingham SC, King MD, Miller ML. Incidence and etiologies of complicated parapneumonic effusions in children, 1996 to 2001. Pediatr Infect Dis J 2003; 22:499-504.
１７．Byington C, Spencer L, Johnson T, et al. An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis 2002; 34:434-40.
１８．Tan T, Mason E, Wald E, et al. Clinical characteristics with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics 2002; 110:1-6.
１９．Block SL, Hedrick J, Harrison CJ, et al. Pneumococcal serotypes from acute otitis media in rural Kentucky. Pediatr Infect Dis J 2002; 21:859-65.
２０．Hausdorff WP, Yothers G, Dagan R, et al. Multinational study of pneumococcal serotypes causing acute otitis media in children. Pediatr Infect Dis J 2002; 21:1008-16.
２１．Robbins JB, Austrian R, Lee CJ, et al. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis 1983; 148:1136-59.
２２．Nahm MH, Olander JV, Magyarlaki M. Identification of cross-reactive antibodies with low opsonophagocytic activity for Streptococcus pneumoniae. J Infect Dis 1997; 176:698-703.
２３．Yu X, Gray B, Chang S, Ward J1, Edwards KM, Nahm MH. Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants. J Infect Dis 1999; 180:1569-76.
２４．Vakevainen M, Eklund C, Eskola J, Kayhty H. Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants. J Infect Dis 2001; 184:789-93.
２５．Ekstrom N, Kilpi T, Landenkari M, Lehtonen H, Ahman H, Kayhty, H. Immune response to cross-reacting pneumococcal serotypes 6A16B and 19N19F in the FinOM vaccine trial, Third World of Congress of Pediatric Infectious Diseases, Santiago, Chile, November 19-23, 2003.
２６．Penn RL, Lewin EB, Douglas RG, Jr., Schifiman G, Lee CJ, Robbins JB. Antibody responses in adult volunteers to pneumococcal polysaccharide types 19F and 19A administered singly and in combination. Infect Immun 1982; 36:1261-2.
２７．Giebink GS, Meier JD, Quartey MK, Liebeler CL, Le CT. Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model. J Infect Dis 1996; 173:119-27.
２８．Saeland E, Jakobsen H, Ingolfsdottir G, Sigurdardottir ST, Jonsdottir I. Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B. J Infect Dis 2001; 183:253-60.
２９．Jakobsen H, Sigurdsson VD, Sigurdardottir S, Schulz D, Jonsdottir I. Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity in serotype 19A in a murine pneumococcal pneumonia model. Infect Immun 2003; 71:2956-9.
３０．Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, Pierce N. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engi J Med 2003; 349;1341-8.
３１．O'Brien KL, Moulton LH, Reid R, et al. Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomised trial. Lancet 2003; 362:355-61.
３２．Eskola J, Kilpi T, Palmu A, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engi J Med 2001: 344:403-9.
３３．Pilishvili T, Farley M, Vazquez M, Reingold A, Nyquist A, et al. Effectiveness of heptavalent pneumococcal conjugate vaccine in children. Abst G-1079, ICAAC, Chicago, IL, 2003.
３４．U.S. Patent No. 4,673,574.
３５．U.S. Patent No. 4,902,506.
参考文献
１．Hausdorff WP, Bryant J, Paradiso PR, Siber GR. Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part 1. ain Infect Dis 2000; 30:100-21.
２．Hausdorff WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 2000; 30:122-40.
３．Whitney CO, Farley MM, Nadler J, et al. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. New Engl J Med 2003; 348(18):1737-46.
４．Black S, Shinefield H, Hansen J, et al. Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2001; 20;1105-7.
５．Robinson KA, Baughman W, Rothrock G, at al. Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995-1998: Opportunities for prevention in the conjugate vaccine era. JAMA 2001; 285:1729-35.
６．Butler J, Breiman R, Lipman H, et al. Serotype distribution of Streptococcus pneumoniae infections among preschool children in the United States, 1978-1994. J Infect Dis 1995; 171:885-9.
７．Whitney CO, Farley MM, Nadler J, et al. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N EngI J Med 2000; 343:1917-24.
８．Hofmann J, Cetron MS, Farley MM, et al. The prevalence of drug-resistant Streptococcus pneumoniae in Atlanta. N Engi J Med 1995; 333:481-6.
９．Joloba ML, Windau A, Bajaksouzian S, Appelbaum PC Hausdorff WP, Jacobs MR. Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media. Clin Infect Dis 2001; 33:1489-94.
１０．Black S, Shinefield H, Fireman B, et al. Efficacy, safety, and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis J 2000; 19:187-95.
１１．Rudolph KM, Parkinson AJ, Reasonover AL, Bulkow LR, Parks DJ, Butler JC. Serotype distribution and antimicrobial resistance pattenrs of invasive isolates of Streptococcus pneumoniae: Alaska, 1991-1998. J Infect Dis 2000; 182:490-6.
１２．Sniadack DH, Schwartz B, Lipman H, et al. Potential interventions for the prevention of childhood pneumonia: geographic and temporal differences in serotype and serogroup distribution of sterile site pneumococcal isolates from children: implications for vaccine strategies. Pediatr Infect Dis J 1995; 14:503-10.
１３．Fagan RL, Hanna JN, Messer RD, Brookes DL, Murphy DM. The epidemiology of invasive pneumococcal disease in children in Far North Queensland. J. Paediatr Child Health 2001; 37:571-5.
１４．Kertesz DA, DI Fabio JL, de Cunto Brandileone MC, et al. Invasive Streptococcus pneumoniae infection in Latin American children: results of the Pan American Health Organization Surveillance. Study. Clin Infect Dis 1998; 26:1355-61.
１５．Hausdorff W, Sitter G, Paradiso P. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children. Lancet 2001; 357:950-52.
１６．Buckingham SC, King MD, Miller ML. Incidence and etiologies of complicated parapneumonic effusions in children, 1996 to 2001. Pediatr Infect Dis J 2003; 22:499-504.
１７．Byington C, Spencer L, Johnson T, et al. An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis 2002; 34:434-40.
１８．Tan T, Mason E, Wald E, et al. Clinical characteristics with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics 2002; 110:1-6.
１９．Block SL, Hedrick J, Harrison CJ, et al. Pneumococcal serotypes from acute otitis media in rural Kentucky. Pediatr Infect Dis J 2002; 21:859-65.
２０．Hausdorff WP, Yothers G, Dagan R, et al. Multinational study of pneumococcal serotypes causing acute otitis media in children. Pediatr Infect Dis J 2002; 21:1008-16.
２１．Robbins JB, Austrian R, Lee CJ, et al. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis 1983; 148:1136-59.
２２．Nahm MH, Olander JV, Magyarlaki M. Identification of cross-reactive antibodies with low opsonophagocytic activity for Streptococcus pneumoniae. J Infect Dis 1997; 176:698-703.
２３．Yu X, Gray B, Chang S, Ward J1, Edwards KM, Nahm MH. Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants. J Infect Dis 1999; 180:1569-76.
２４．Vakevainen M, Eklund C, Eskola J, Kayhty H. Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants. J Infect Dis 2001; 184:789-93.
２５．Ekstrom N, Kilpi T, Landenkari M, Lehtonen H, Ahman H, Kayhty, H. Immune response to cross-reacting pneumococcal serotypes 6A16B and 19N19F in the FinOM vaccine trial, Third World of Congress of Pediatric Infectious Diseases, Santiago, Chile, November 19-23, 2003.
２６．Penn RL, Lewin EB, Douglas RG, Jr., Schifiman G, Lee CJ, Robbins JB. Antibody responses in adult volunteers to pneumococcal polysaccharide types 19F and 19A administered singly and in combination. Infect Immun 1982; 36:1261-2.
２７．Giebink GS, Meier JD, Quartey MK, Liebeler CL, Le CT. Immunogenicity and efficacy of Streptococcus pneumoniae polysaccharide-protein conjugate vaccines against homologous and heterologous serotypes in the chinchilla otitis media model. J Infect Dis 1996; 173:119-27.
２８．Saeland E, Jakobsen H, Ingolfsdottir G, Sigurdardottir ST, Jonsdottir I. Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B. J Infect Dis 2001; 183:253-60.
２９．Jakobsen H, Sigurdsson VD, Sigurdardottir S, Schulz D, Jonsdottir I. Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity in serotype 19A in a murine pneumococcal pneumonia model. Infect Immun 2003; 71:2956-9.
３０．Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, Pierce N. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engi J Med 2003; 349;1341-8.
３１．O'Brien KL, Moulton LH, Reid R, et al. Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomised trial. Lancet 2003; 362:355-61.
３２．Eskola J, Kilpi T, Palmu A, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engi J Med 2001: 344:403-9.
３３．Pilishvili T, Farley M, Vazquez M, Reingold A, Nyquist A, et al. Effectiveness of heptavalent pneumococcal conjugate vaccine in children. Abst G-1079, ICAAC, Chicago, IL, 2003.
３４．U.S. Patent No. 4,673,574.
３５．U.S. Patent No. 4,902,506.
Claims (17)
- １３種類の異なる多糖類−タンパク質コンジュゲートを、生理学的に許容できるビヒクルと共に含む多価免疫原性組成物であって、そのコンジュゲートの各々がＣＲＭ １９７ キャリアタンパク質にコンジュゲートしたストレプトコッカスニューモニエの異なる血清型からの莢膜多糖類を含み、その莢膜多糖類が血清型１、３、４、５、６Ａ、６Ｂ、７Ｆ、９Ｖ、１４、１８Ｃ、１９Ａ、１９Ｆおよび２３Ｆから調製され、その各莢膜多糖類が別々にＣＲＭ １９７ キャリアタンパク質にコンジュゲートしている、多価免疫原性組成物。
- さらにアジュバントを含む、請求項１記載の免疫原性組成物。
- アジュバントがアルミニウムをベースとするアジュバントであるところの、請求項２記載の免疫原性組成物。
- アジュバントがリン酸アルミニウム、硫酸アルミニウムおよび水酸化アルミニウムからなる群より選択されるところの、請求項３記載の免疫原性組成物。
- アジュバントがリン酸アルミニウムであるところの、請求項４記載の免疫原性組成物。
- ストレプトコッカスニューモニエ莢膜多糖類コンジュゲートに対する免疫応答を誘発するための医薬の製造における、請求項１に記載の免疫原性組成物の使用。
- 投与される免疫原性組成物が、０．５ｍＬの単回用量にて、６Ｂを４μｇとすることを除き、各糖類を２μｇにて；ＣＲＭ１９７キャリアタンパク質を約２９μｇにて；アルミニウム元素を０．１２５ｍｇ（リン酸アルミニウムを０．５ｍｇ）のアジュバントにて；ならびに賦形剤としての塩化ナトリウムおよびコハク酸ナトリウム緩衝液を含有するように処方されるところの、請求項６記載の使用。
- さらに、ネイセリアメニンジタイディスタイプＢからの１種または複数のタンパク質を含む、請求項１記載の免疫原性組成物。
- 多糖類−タンパク質コンジュゲートを生理学的に許容できるビヒクルと共に含む多価免疫原性組成物であって、そのコンジュゲートの各々がＣＲＭ １９７ キャリアタンパク質にコンジュゲートしたストレプトコッカスニューモニエの異なる血清型からの莢膜多糖類を含み、その莢膜多糖類が血清型３および少なくとも１種類の付加的な血清型から調製され、その各莢膜多糖類が別々にＣＲＭ １９７ キャリアタンパク質にコンジュゲートしている、多価免疫原性組成物。
- 付加的な血清型が血清型１、４、５、６Ａ、６Ｂ、７Ｆ、９Ｖ、１４、１８Ｃ、１９Ａ、１９Ｆおよび２３Ｆからなる群より選択されるところの、請求項９記載の免疫原性組成物。
- さらにアジュバントを含む、請求項９記載の免疫原性組成物。
- アジュバントがアルミニウムをベースとするアジュバントであるところの、請求項１１記載の免疫原性組成物。
- アジュバントがリン酸アルミニウム、硫酸アルミニウムおよび水酸化アルミニウムからなる群より選択されるところの、請求項１２記載の免疫原性組成物。
- アジュバントがリン酸アルミニウムであるところの、請求項１３記載の免疫原性組成物。
- ストレプトコッカスニューモニエ莢膜多糖類コンジュゲートに対する免疫応答を誘発するための医薬の製造における、請求項９に記載の免疫原性組成物の使用。
- 投与される免疫原性組成物が、０．５ｍＬの単回用量にて、６Ｂを４μｇとすることを除き、各糖類を２μｇにて；ＣＲＭ１９７キャリアタンパク質を約２９μｇにて；アルミニウム元素を０．１２５ｍｇ（リン酸アルミニウムを０．５ｍｇ）のアジュバントにて；ならびに賦形剤としての塩化ナトリウムおよびコハク酸ナトリウム緩衝液を含有するように処方されるところの、請求項１５記載の使用。
- さらに、ネイセリアメニンジタイディスタイプＢからの１種または複数のタンパク質を含む、請求項９記載の免疫原性組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66960505P | 2005-04-08 | 2005-04-08 | |
| PCT/US2006/012354 WO2006110381A1 (en) | 2005-04-08 | 2006-03-31 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009106688A Division JP5173920B2 (ja) | 2005-04-08 | 2009-04-24 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008535838A JP2008535838A (ja) | 2008-09-04 |
| JP2008535838A5 true JP2008535838A5 (ja) | 2009-06-18 |
| JP4472770B2 JP4472770B2 (ja) | 2010-06-02 |
Family
ID=36709976
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505426A Active JP4472770B2 (ja) | 2005-04-08 | 2006-03-31 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
| JP2009106688A Active JP5173920B2 (ja) | 2005-04-08 | 2009-04-24 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
| JP2012225307A Active JP5730261B2 (ja) | 2005-04-08 | 2012-10-10 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009106688A Active JP5173920B2 (ja) | 2005-04-08 | 2009-04-24 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
| JP2012225307A Active JP5730261B2 (ja) | 2005-04-08 | 2012-10-10 | 多価肺炎球菌多糖類−タンパク質コンジュゲート組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (9) | US20060228380A1 (ja) |
| EP (9) | EP2425855A1 (ja) |
| JP (3) | JP4472770B2 (ja) |
| KR (11) | KR20150061019A (ja) |
| CN (6) | CN113198012A (ja) |
| AR (2) | AR053354A1 (ja) |
| AT (1) | ATE548051T1 (ja) |
| AU (1) | AU2006235013B2 (ja) |
| BR (1) | BRPI0607025B8 (ja) |
| CA (4) | CA3165042A1 (ja) |
| CL (2) | CL2016000566A1 (ja) |
| CY (1) | CY1112777T1 (ja) |
| DK (1) | DK1868645T3 (ja) |
| ES (1) | ES2382048T3 (ja) |
| HK (3) | HK1120416A1 (ja) |
| HR (1) | HRP20120278T1 (ja) |
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