JP2008534581A5 - - Google Patents

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Publication number
JP2008534581A5
JP2008534581A5 JP2008503954A JP2008503954A JP2008534581A5 JP 2008534581 A5 JP2008534581 A5 JP 2008534581A5 JP 2008503954 A JP2008503954 A JP 2008503954A JP 2008503954 A JP2008503954 A JP 2008503954A JP 2008534581 A5 JP2008534581 A5 JP 2008534581A5
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JP
Japan
Prior art keywords
amino
trifluoromethyl
dihydropyrido
oxobutyl
butyl
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JP2008503954A
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English (en)
Japanese (ja)
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JP4977685B2 (ja
JP2008534581A (ja
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Priority claimed from PCT/KR2006/001169 external-priority patent/WO2006104356A1/en
Publication of JP2008534581A publication Critical patent/JP2008534581A/ja
Publication of JP2008534581A5 publication Critical patent/JP2008534581A5/ja
Application granted granted Critical
Publication of JP4977685B2 publication Critical patent/JP4977685B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2008503954A 2005-04-01 2006-03-30 ジペプチジルペプチダーゼ−ｉｖ阻害化合物、同化合物および同化合物を活性物質として含む医薬組成物の製造方法 Expired - Lifetime JP4977685B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
KR10-2005-0027756 2005-04-01
KR20050027756 2005-04-01
KR10-2005-0053761 2005-06-22
KR20050053761 2005-06-22
KR10-2005-0085980 2005-09-15
KR20050085980 2005-09-15
KR10-2005-0122361 2005-12-13
KR20050122361 2005-12-13
PCT/KR2006/001169 WO2006104356A1 (en) 2005-04-01 2006-03-30 Dipeptidyl peptidase-iv inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent

Publications (3)

Publication Number Publication Date
JP2008534581A JP2008534581A (ja) 2008-08-28
JP2008534581A5 true JP2008534581A5 (enExample) 2008-10-09
JP4977685B2 JP4977685B2 (ja) 2012-07-18

Family

ID=37053586

Family Applications (1)

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JP2008503954A Expired - Lifetime JP4977685B2 (ja) 2005-04-01 2006-03-30 ジペプチジルペプチダーゼ−ｉｖ阻害化合物、同化合物および同化合物を活性物質として含む医薬組成物の製造方法

Country Status (28)

Country Link
US (1) US7879848B2 (enExample)
EP (1) EP1863812B1 (enExample)
JP (1) JP4977685B2 (enExample)
KR (3) KR100776623B1 (enExample)
CN (1) CN101151265B (enExample)
AR (1) AR053195A1 (enExample)
AT (1) ATE473976T1 (enExample)
AU (1) AU2006229520B2 (enExample)
BR (1) BRPI0609424B8 (enExample)
CA (1) CA2602248C (enExample)
DE (1) DE602006015443D1 (enExample)
DK (1) DK1863812T3 (enExample)
EA (1) EA012591B1 (enExample)
ES (1) ES2349178T3 (enExample)
IL (1) IL185479A (enExample)
MA (1) MA29586B1 (enExample)
MX (1) MX2007012175A (enExample)
MY (1) MY150102A (enExample)
NZ (1) NZ560789A (enExample)
PE (1) PE20061354A1 (enExample)
PL (1) PL1863812T3 (enExample)
PT (1) PT1863812E (enExample)
SI (1) SI1863812T1 (enExample)
TW (1) TWI357902B (enExample)
UA (1) UA89396C2 (enExample)
UY (1) UY29448A1 (enExample)
WO (1) WO2006104356A1 (enExample)
ZA (1) ZA200708304B (enExample)

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EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
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TWI519533B (zh) * 2010-11-01 2016-02-01 Ｌｇ生命科學有限公司 １－｛（２Ｓ）－２－胺基－４－［２，４－雙（三氟甲基）－５，８－二氫吡啶并［３，４－ｄ］嘧啶－７（６Ｈ）－基］－４－側氧丁基｝－５，５－二氟哌啶－２－酮酒石酸鹽之水合物
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WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
CN105085528A (zh) * 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
EP3273981B1 (en) 2015-03-24 2020-04-29 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
JP2019509272A (ja) 2016-02-23 2019-04-04 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 脊髄性筋萎縮症の治療のための併用療法
KR102068754B1 (ko) * 2017-04-20 2020-01-21 주식회사 엘지화학 의약품 합성용 중간체 화합물의 제조 방법
RU2741389C1 (ru) * 2017-11-16 2021-01-25 ЭлДжи КЕМ, ЛТД. Способ получения промежуточного соединения для синтеза лекарственного средства
CN108191647B (zh) * 2018-02-22 2020-09-29 江苏尚莱特医药化工材料有限公司 2,2-二氟二羧酸二烷基酯的合成方法
BR112021002207A2 (pt) 2018-08-10 2021-05-04 Diapin Therapeutics, Llc tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios
CN111537622B (zh) * 2019-11-29 2021-11-26 杭州华东医药集团新药研究院有限公司 一种度格列汀及其盐的杂质的检测方法
CN117682981A (zh) * 2022-09-02 2024-03-12 中国科学院大连化学物理研究所 一种吉格列汀药物前体的制备方法
KR20250097733A (ko) 2023-12-21 2025-06-30 이니스트에스티 주식회사 디펩티딜 펩티데이즈-iv (dpp-iv) 억제제의 신규한 염, 이의 제조 방법 및 이를 포함하는 약제학적 조성물
KR20250137744A (ko) 2024-03-11 2025-09-19 엠에프씨 주식회사 제미글립틴의 신규 결정형 및 이의 제조방법
KR20250147756A (ko) 2024-03-27 2025-10-14 엠에프씨 주식회사 신규한 형태의 제미글립틴 말산염 결정형 및 이의 제조방법
KR20250155700A (ko) 2024-04-24 2025-10-31 주식회사 다산제약 제미글립틴 산부가염 제조방법 및 이를 유효성분으로 포함하는 dpp-4 저해용 조성물
KR20260008397A (ko) 2024-07-09 2026-01-16 주식회사 경보제약 제미글립틴 옥살레이트 1 수화물 염 및 이의 제조방법

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