FR3052451A1 - - Google Patents

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Publication number
FR3052451A1
FR3052451A1 FR1655387A FR1655387A FR3052451A1 FR 3052451 A1 FR3052451 A1 FR 3052451A1 FR 1655387 A FR1655387 A FR 1655387A FR 1655387 A FR1655387 A FR 1655387A FR 3052451 A1 FR3052451 A1 FR 3052451A1
Authority
FR
France
Prior art keywords
methyl
carbonyl
pyrrolo
pyrimidin
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR1655387A
Other languages
English (en)
French (fr)
Other versions
FR3052451B1 (fr
Inventor
Andras Kotschy
Csaba Weber
Attila Vasas
Balazs Molnar
Arpad Kiss
Alba Macias
James Brooke Murray
Elodie Lewkowicz
Olivier Geneste
Maia Chanrion
Didier Demarles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Vernalis R&D Ltd
Original Assignee
Les Laboratoires Servier SAS
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS, Vernalis R&D Ltd filed Critical Les Laboratoires Servier SAS
Priority to FR1655387A priority Critical patent/FR3052451B1/fr
Priority to US16/306,941 priority patent/US10654849B2/en
Priority to PL17728567T priority patent/PL3468971T3/pl
Priority to EP17728567.3A priority patent/EP3468971B1/en
Priority to LTEP17728567.3T priority patent/LT3468971T/lt
Priority to ARP170101586A priority patent/AR108705A1/es
Priority to DK17728567.3T priority patent/DK3468971T3/da
Priority to GEAP201714982A priority patent/GEP20207161B/en
Priority to PE2018003132A priority patent/PE20220948A1/es
Priority to BR112018075284-3A priority patent/BR112018075284A2/pt
Priority to MA45223A priority patent/MA45223B1/fr
Priority to MDE20190461T priority patent/MD3468971T2/ro
Priority to UY0001037289A priority patent/UY37289A/es
Priority to HUE17728567A priority patent/HUE048590T2/hu
Priority to MX2018015212A priority patent/MX374443B/es
Priority to UAA201900070A priority patent/UA123793C2/uk
Priority to KR1020197000798A priority patent/KR102003532B1/ko
Priority to CN201780047088.4A priority patent/CN109563094B/zh
Priority to JP2018564752A priority patent/JP6985299B2/ja
Priority to GEAP202014982A priority patent/GEAP202014982A/en
Priority to TW106119243A priority patent/TWI647228B/zh
Priority to SG11201810576QA priority patent/SG11201810576QA/en
Priority to CU2018000146A priority patent/CU20180146A7/es
Priority to AU2017277732A priority patent/AU2017277732B2/en
Priority to RS20200510A priority patent/RS60279B1/sr
Priority to SI201730267T priority patent/SI3468971T1/sl
Priority to MYPI2018002417A priority patent/MY196328A/en
Priority to HRP20200556TT priority patent/HRP20200556T1/hr
Priority to CR20180563A priority patent/CR20180563A/es
Priority to PCT/EP2017/064062 priority patent/WO2017212010A1/en
Priority to RU2018147424A priority patent/RU2742271C2/ru
Priority to CA3027008A priority patent/CA3027008C/en
Priority to PT177285673T priority patent/PT3468971T/pt
Priority to ES17728567T priority patent/ES2778700T3/es
Priority to TNP/2018/000395A priority patent/TN2018000395A1/en
Publication of FR3052451A1 publication Critical patent/FR3052451A1/fr
Application granted granted Critical
Publication of FR3052451B1 publication Critical patent/FR3052451B1/fr
Priority to PH12018502516A priority patent/PH12018502516B1/en
Priority to SV2018005792A priority patent/SV2018005792A/es
Priority to IL263455A priority patent/IL263455B/en
Priority to DO2018000264A priority patent/DOP2018000264A/es
Priority to ECSENADI201890046A priority patent/ECSP18090046A/es
Priority to CL2018003473A priority patent/CL2018003473A1/es
Priority to CONC2018/0013141A priority patent/CO2018013141A2/es
Priority to ZA2018/08286A priority patent/ZA201808286B/en
Priority to NI201800133A priority patent/NI201800133A/es
Priority to CY20201100451T priority patent/CY1123069T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1655387A 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR3052451B1 (fr)

Priority Applications (45)

Application Number Priority Date Filing Date Title
FR1655387A FR3052451B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US16/306,941 US10654849B2 (en) 2016-06-10 2017-06-09 (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
PL17728567T PL3468971T3 (pl) 2016-06-10 2017-06-09 Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycje
EP17728567.3A EP3468971B1 (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
LTEP17728567.3T LT3468971T (lt) 2016-06-10 2017-06-09 Nauji (hetero)aril-pakeistieji-piperidinilo dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos
ARP170101586A AR108705A1 (es) 2016-06-10 2017-06-09 Derivados piperidinilo sustituidos con (hetero)arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
DK17728567.3T DK3468971T3 (da) 2016-06-10 2017-06-09 Nye (hetero)aryl-substituterede piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem
GEAP201714982A GEP20207161B (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
PE2018003132A PE20220948A1 (es) 2016-06-10 2017-06-09 Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen
BR112018075284-3A BR112018075284A2 (pt) 2016-06-10 2017-06-09 derivados de piperidinila substituída por (hetero)arila, processo para sua preparação e composições farmacêuticas contendo-os
MA45223A MA45223B1 (fr) 2016-06-10 2017-06-09 Nouveaux dérivés de pipéridinyle subsitués par (hétéro)aryle, leur procédé de préparation et compositions pharmaceutiques les contenant
MDE20190461T MD3468971T2 (ro) 2016-06-10 2017-06-09 Noi derivați de piperidinil (hetero)aril-substituiţi, procedeu de obţinere a acestora și compoziții farmaceutice care îi conțin
UY0001037289A UY37289A (es) 2016-06-10 2017-06-09 Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
HUE17728567A HUE048590T2 (hu) 2016-06-10 2017-06-09 Új (hetero)aril-szubsztituált piperidinil-származékok, eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények
MX2018015212A MX374443B (es) 2016-06-10 2017-06-09 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparacion y composiciones farmaceuticas que los contienen
UAA201900070A UA123793C2 (uk) 2016-06-10 2017-06-09 Нові (гетеро)арил-заміщені похідні піперидинілу, спосіб їхнього одержання та фармацевтичні композиції, що їх містять
KR1020197000798A KR102003532B1 (ko) 2016-06-10 2017-06-09 새로운 (헤테로)아릴-치환된-피페리디닐 유도체, 이의 제조를 위한 방법 및 이를 함유하는 약학적 조성물
CN201780047088.4A CN109563094B (zh) 2016-06-10 2017-06-09 新的(杂)芳基取代的哌啶基衍生物、它们的制备方法和含有它们的药物组合物
JP2018564752A JP6985299B2 (ja) 2016-06-10 2017-06-09 新規（ヘテロ）アリール置換ピペリジニル誘導体、それを調製するためのプロセス、及びそれを含有する医薬組成物
GEAP202014982A GEAP202014982A (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
TW106119243A TWI647228B (zh) 2016-06-10 2017-06-09 新穎之經(雜)芳基取代之哌啶基衍生物、其製備方法及含其之醫藥組合物
SG11201810576QA SG11201810576QA (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
CU2018000146A CU20180146A7 (es) 2016-06-10 2017-06-09 Compuestos derivados de (piperidin-1-ilo)(piperidin-4-ilo) sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen
AU2017277732A AU2017277732B2 (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
RS20200510A RS60279B1 (sr) 2016-06-10 2017-06-09 Novi derivati piperidinila supstituisanog (hetero)arilom, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
SI201730267T SI3468971T1 (sl) 2016-06-10 2017-06-09 Novi derivati piperidinila, substituiranega s (hetero)arilom, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
MYPI2018002417A MY196328A (en) 2016-06-10 2017-06-09 New (Hetero)Aryl-Substituted-Piperidinyl Derivatives, A Process For Their Preparation And Pharmaceutical Compositions Containing Them
HRP20200556TT HRP20200556T1 (hr) 2016-06-10 2017-06-09 Novi (hetero) aril-supstituirani-piperidinil derivati, postupak za njihovu pripravu i farmaceutski pripravci koji ih sadrže
CR20180563A CR20180563A (es) 2016-06-10 2017-06-09 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que lo contienen
PCT/EP2017/064062 WO2017212010A1 (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
RU2018147424A RU2742271C2 (ru) 2016-06-10 2017-06-09 Новые (гетеро)арил-замещенные пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их
CA3027008A CA3027008C (en) 2016-06-10 2017-06-09 (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
PT177285673T PT3468971T (pt) 2016-06-10 2017-06-09 Novos derivados de piperidinilo substituídos em (hetero)arilo, um processo para a sua preparação e composições farmacêuticas que os contêm
ES17728567T ES2778700T3 (es) 2016-06-10 2017-06-09 Nuevos derivados de piperidinilo sustituidos con (hetero)arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
TNP/2018/000395A TN2018000395A1 (en) 2016-06-10 2017-06-09 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
PH12018502516A PH12018502516B1 (en) 2016-06-10 2018-11-28 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
SV2018005792A SV2018005792A (es) 2016-06-10 2018-11-29 Nuevos derivados piperidinilo sustituidos con hetero (arilo), un proceso para su preparacion y composiciones farmaceuticas que los contienen
IL263455A IL263455B (en) 2016-06-10 2018-12-03 New (hetero)aryl-converted-piperidinyl compounds, a process for their preparation and pharmaceutical preparations containing them
DO2018000264A DOP2018000264A (es) 2016-06-10 2018-12-03 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen
ECSENADI201890046A ECSP18090046A (es) 2016-06-10 2018-12-04 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen
CL2018003473A CL2018003473A1 (es) 2016-06-10 2018-12-04 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen.
CONC2018/0013141A CO2018013141A2 (es) 2016-06-10 2018-12-04 Nuevos derivados piperidinilo sustituidos con hetero(arilo), un proceso para su preparación y composiciones farmacéuticas que los contienen
ZA2018/08286A ZA201808286B (en) 2016-06-10 2018-12-07 New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
NI201800133A NI201800133A (es) 2016-06-10 2018-12-07 Nuevos derivados piperidinilo sustituidos con (hetero) arilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
CY20201100451T CY1123069T1 (el) 2016-06-10 2020-05-18 Νεα (ετερο)αρυλ-υποκατεστημενα-πιπεριδινυλ παραγωγα, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1655387 2016-06-10
FR1655387A FR3052451B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR3052451A1 true FR3052451A1 (enExample) 2017-12-15
FR3052451B1 FR3052451B1 (fr) 2018-06-22

Family

ID=56896722

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1655387A Expired - Fee Related FR3052451B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (2)

Country Link
AR (1) AR108705A1 (enExample)
FR (1) FR3052451B1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021123051A1 (en) 2019-12-20 2021-06-24 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008108957A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain
WO2013030218A1 (en) * 2011-09-02 2013-03-07 Hybrigenics Sa Selective and reversible inhibitors of ubiquitin specific protease 7

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008108957A2 (en) * 2007-03-02 2008-09-12 Schering Corporation Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain
WO2013030218A1 (en) * 2011-09-02 2013-03-07 Hybrigenics Sa Selective and reversible inhibitors of ubiquitin specific protease 7

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021123051A1 (en) 2019-12-20 2021-06-24 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof

Also Published As

Publication number Publication date
FR3052451B1 (fr) 2018-06-22
AR108705A1 (es) 2018-09-19

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