JP2008531576A - Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長 - Google Patents

Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長 Download PDF

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JP2008531576A
JP2008531576A JP2007557136A JP2007557136A JP2008531576A JP 2008531576 A JP2008531576 A JP 2008531576A JP 2007557136 A JP2007557136 A JP 2007557136A JP 2007557136 A JP2007557136 A JP 2007557136A JP 2008531576 A JP2008531576 A JP 2008531576A
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antibody
cancer
her2
antibodies
patient
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JP2008531576A5 (enExample
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デリンク，ミカ・ケイ
ケルシー，スティーブン・エム
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007557136A 2005-02-23 2006-02-21 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長 Pending JP2008531576A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65527705P 2005-02-23 2005-02-23
PCT/US2006/006334 WO2006091693A2 (en) 2005-02-23 2006-02-21 Extending time to disease progression or survival in cancer patients using a her dimerization inhibitor

Related Child Applications (1)

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JP2012145491A Division JP2012211173A (ja) 2005-02-23 2012-06-28 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長

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JP2008531576A true JP2008531576A (ja) 2008-08-14
JP2008531576A5 JP2008531576A5 (enExample) 2009-04-02

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JP2007557136A Pending JP2008531576A (ja) 2005-02-23 2006-02-21 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2012145491A Pending JP2012211173A (ja) 2005-02-23 2012-06-28 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2014169847A Pending JP2014240414A (ja) 2005-02-23 2014-08-22 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2017022540A Pending JP2017105822A (ja) 2005-02-23 2017-02-09 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2018085020A Pending JP2018135369A (ja) 2005-02-23 2018-04-26 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2019149767A Pending JP2019214601A (ja) 2005-02-23 2019-08-19 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長

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JP2012145491A Pending JP2012211173A (ja) 2005-02-23 2012-06-28 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2014169847A Pending JP2014240414A (ja) 2005-02-23 2014-08-22 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2017022540A Pending JP2017105822A (ja) 2005-02-23 2017-02-09 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2018085020A Pending JP2018135369A (ja) 2005-02-23 2018-04-26 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長
JP2019149767A Pending JP2019214601A (ja) 2005-02-23 2019-08-19 Ｈｅｒ二量体化阻害剤を使用した、ガン患者における疾患の進行までの期間または生存の延長

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US (6) US20060188509A1 (enExample)
EP (3) EP2399605A1 (enExample)
JP (6) JP2008531576A (enExample)
KR (1) KR101253576B1 (enExample)
CN (2) CN103251946A (enExample)
AR (1) AR054426A1 (enExample)
AU (1) AU2006216732C1 (enExample)
BR (1) BRPI0606542A8 (enExample)
CA (1) CA2596133C (enExample)
CL (1) CL2015000428A1 (enExample)
CR (1) CR9312A (enExample)
DK (1) DK1850874T3 (enExample)
DO (1) DOP2006000052A (enExample)
ES (1) ES2440481T3 (enExample)
GT (1) GT200600092A (enExample)
HR (1) HRP20131235T1 (enExample)
IL (2) IL184884A (enExample)
MA (1) MA29331B1 (enExample)
MX (1) MX2007009889A (enExample)
MY (1) MY152164A (enExample)
NO (1) NO20074824L (enExample)
NZ (1) NZ590431A (enExample)
PL (1) PL1850874T3 (enExample)
PT (1) PT1850874E (enExample)
RS (1) RS53128B (enExample)
RU (1) RU2404806C2 (enExample)
SI (1) SI1850874T1 (enExample)
TW (2) TWI435730B (enExample)
UA (1) UA95902C2 (enExample)
WO (1) WO2006091693A2 (enExample)
ZA (1) ZA200707078B (enExample)

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* Cited by examiner, † Cited by third party
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JP2016504399A (ja) * 2013-01-11 2016-02-12 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗ｈｅｒ３抗体と抗ｈｅｒ２抗体の併用療法
JP2019513699A (ja) * 2016-03-24 2019-05-30 バイエル・ファルマ・アクティエンゲゼルシャフト 放射性医薬錯体

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