JP2008528445A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008528445A5 JP2008528445A5 JP2007547612A JP2007547612A JP2008528445A5 JP 2008528445 A5 JP2008528445 A5 JP 2008528445A5 JP 2007547612 A JP2007547612 A JP 2007547612A JP 2007547612 A JP2007547612 A JP 2007547612A JP 2008528445 A5 JP2008528445 A5 JP 2008528445A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- vector
- compound
- peptide
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
- 150000001408 amides Chemical group 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 150000003568 thioethers Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 12
- 239000010949 copper Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 4
- 229910052802 copper Inorganic materials 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Chemical group 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0428012.9 | 2004-12-22 | ||
| GBGB0428012.9A GB0428012D0 (en) | 2004-12-22 | 2004-12-22 | Radiolabelling methods |
| PCT/GB2005/004729 WO2006067376A2 (en) | 2004-12-22 | 2005-12-09 | Radiolabelled conjugates of rgd-containing peptides and methods for their preparation via click-chemistry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012167865A Division JP2012254998A (ja) | 2004-12-22 | 2012-07-30 | 放射性標識法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528445A JP2008528445A (ja) | 2008-07-31 |
| JP2008528445A5 true JP2008528445A5 (enExample) | 2012-09-13 |
| JP5743372B2 JP5743372B2 (ja) | 2015-07-01 |
Family
ID=34112991
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547612A Expired - Lifetime JP5743372B2 (ja) | 2004-12-22 | 2005-12-09 | 放射性標識法 |
| JP2012167865A Pending JP2012254998A (ja) | 2004-12-22 | 2012-07-30 | 放射性標識法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012167865A Pending JP2012254998A (ja) | 2004-12-22 | 2012-07-30 | 放射性標識法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7972588B2 (enExample) |
| EP (4) | EP2275145A1 (enExample) |
| JP (2) | JP5743372B2 (enExample) |
| KR (1) | KR101314460B1 (enExample) |
| CN (2) | CN101084020A (enExample) |
| AU (1) | AU2005317903C1 (enExample) |
| BR (1) | BRPI0519317A2 (enExample) |
| CA (2) | CA2817636A1 (enExample) |
| GB (1) | GB0428012D0 (enExample) |
| MX (1) | MX2007007560A (enExample) |
| NO (1) | NO341638B1 (enExample) |
| RU (1) | RU2419627C2 (enExample) |
| WO (1) | WO2006067376A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| US8071718B2 (en) | 2004-12-22 | 2011-12-06 | General Electric Company | Selective radiolabeling of biomolecules |
| US8211403B2 (en) | 2006-06-21 | 2012-07-03 | Hammersmith Imanet Limited | Radiolabelling methods |
| US20100069609A1 (en) * | 2006-06-21 | 2010-03-18 | Erik Arstad | Chemical methods and apparatus |
| CN101528270A (zh) * | 2006-08-28 | 2009-09-09 | 通用电气健康护理有限公司 | 基于68Ga标记的肽的放射性药物 |
| WO2008025886A1 (en) * | 2006-09-01 | 2008-03-06 | Wallac Oy | Metal chelates and chelating agents containing triazolyl subunits |
| EP2155259A2 (en) * | 2007-05-10 | 2010-02-24 | The Trustees of Columbia University in the City of New York | Methods for diagnosing diseases and evaluating treatments therefor using pet |
| ES2662495T3 (es) | 2007-12-20 | 2018-04-06 | General Electric Company | Radiomarcación selectiva de biomoléculas |
| EP2147684A1 (en) * | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| GB0815831D0 (en) * | 2008-09-01 | 2008-10-08 | Imp Innovations Ltd | Compounds |
| CA2735970A1 (en) | 2008-09-05 | 2010-03-11 | Hammersmith Imanet Limited | Isatin derivatives for use as in vivo imaging agents |
| CN102177160B (zh) * | 2008-10-10 | 2014-11-26 | 默克及其合伙人公司 | 作为pet放射性示踪剂的18f-标记叶酸 |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| EP2210882A1 (en) * | 2009-01-16 | 2010-07-28 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Synthesis of new protected azahistidine, their processes and their use in synthesises |
| US8435488B2 (en) * | 2009-02-27 | 2013-05-07 | Genentech, Inc. | Methods and compositions for protein labelling |
| US8722014B2 (en) * | 2009-05-01 | 2014-05-13 | Washington University | 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof |
| GB0914543D0 (en) * | 2009-08-20 | 2009-09-30 | Ge Healthcare Ltd | Radioiodination method |
| EP2498826A1 (en) * | 2009-11-11 | 2012-09-19 | NeuroSearch AS | Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods |
| GB0921573D0 (en) * | 2009-12-10 | 2010-01-27 | Ge Healthcare Ltd | Iodine radiolabelling method |
| GB0922304D0 (en) | 2009-12-22 | 2010-02-03 | Ge Healthcare Ltd | Radioiodinated compounds |
| US20120269725A1 (en) * | 2009-12-23 | 2012-10-25 | Janine Baranowska-Kortylewicz | Targeted radiolabeled compounds and their use for the treatment and diagnosis of cancer |
| US9517279B2 (en) * | 2010-04-14 | 2016-12-13 | The Mclean Hospital Corporation | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof |
| EP2575897A4 (en) * | 2010-06-01 | 2016-06-01 | Advanced Proteome Therapeutics Inc | CROSSLINKING OF PROTEINS AND OTHER ENTITIES THROUGH ALPHA-HALO-ACETOPHENONES CONJUGATES, BENZYL HALIDES, QUINONES |
| CN103221398B (zh) * | 2010-07-23 | 2016-03-23 | 特拉华大学 | 用于快速构建放射性核素标记探针的四嗪-反式环辛烯连接反应 |
| GB201014023D0 (en) * | 2010-08-20 | 2010-10-06 | Ucl Business Plc | Process for producing bioconjugates and products thereof |
| WO2012074840A2 (en) | 2010-11-22 | 2012-06-07 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
| GB201019824D0 (en) | 2010-11-23 | 2011-01-05 | Ge Healthcare Ltd | Radioiodination method |
| GB201021369D0 (en) | 2010-12-16 | 2011-01-26 | Ge Healthcare Ltd | Radioiodinated fatty acids |
| GB201021517D0 (en) | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Radioiodinated guanidines |
| WO2012087912A1 (en) | 2010-12-22 | 2012-06-28 | Ge Healthcare Limited | Her2 binding peptides labelled with a 18f - containing organosilicon compound |
| MX2013007365A (es) | 2010-12-22 | 2013-09-26 | Ge Healthcare Ltd | Péptidos de enlace her2 etiquetados con fluoruro de aluminio- [18] combinados mediante nota. |
| EP2680889B1 (en) | 2011-03-01 | 2019-06-19 | GE Healthcare Limited | Radiolabelled octreotate analogues as pet tracers |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| US9023318B2 (en) * | 2011-06-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
| WO2013048832A1 (en) | 2011-09-29 | 2013-04-04 | Ge Healthcare Limited | 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells |
| WO2013048811A1 (en) | 2011-09-30 | 2013-04-04 | Ge Healthcare Limited | Imaging and radiotherapy methods for tumour stem cells |
| US20140335019A1 (en) * | 2011-12-02 | 2014-11-13 | The Regents Of The University Of Michigan | Compositions and methods for the treatment and analysis of neurological disorders |
| GB201121911D0 (en) | 2011-12-20 | 2012-02-01 | Ge Healthcare Ltd | Radiofluorination method |
| US20150017093A1 (en) * | 2012-02-03 | 2015-01-15 | Aarhus Universitet | Radiolabeled bile acids and bile acid derivatives |
| EP2657213A1 (en) * | 2012-04-24 | 2013-10-30 | Institut National de la Santé et de la Recherche Medicale | Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors |
| US20140065070A1 (en) * | 2012-08-28 | 2014-03-06 | Mcmaster University | Methods of preparing triazole-containing radioiodinated compounds |
| US20160137639A1 (en) * | 2012-10-26 | 2016-05-19 | Japan Tobacco Inc. | Triazole-isoxazole compound and medical use thereof |
| US20150023877A1 (en) * | 2013-07-18 | 2015-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of parkinsons disease diagnosis and monitoring treatment |
| ES2700348T3 (es) * | 2014-01-05 | 2019-02-15 | Univ Washington | Trazadores radioetiquetados para poli (ADP-ribosa) polimerasa-1 (PARP-1), métodos y usos para estos |
| US20160022846A1 (en) * | 2014-07-22 | 2016-01-28 | Ge Healthcare Limited | Iodine radiolabelling method |
| PT3310816T (pt) * | 2015-06-19 | 2020-10-19 | Eisai R&D Man Co Ltd | Imunoglobulinas conjugadas cys80 |
| WO2017023999A1 (en) * | 2015-08-03 | 2017-02-09 | Emory University | Methylsulfonamide derivatives and uses related thereto |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| CN112638415B (zh) * | 2018-07-26 | 2024-07-02 | 大有华夏生物医药集团有限公司 | 用于成像的组合物和方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4913891A (en) * | 1986-04-17 | 1990-04-03 | The United States Of America As Represented By The United States Department Of Energy | Positron emitter labeled enzyme inhibitors |
| HK1056164B (en) | 2000-03-24 | 2013-06-21 | Euro-Celtique S.A. | Aryl-substituted pyrazole, triazole and tetrazole, and their uses |
| US6350360B1 (en) | 2000-04-07 | 2002-02-26 | Sandia Coroporation | Method of fabricating a 3-dimensional tool master |
| CN1230441C (zh) * | 2000-04-12 | 2005-12-07 | 安盛药业有限公司 | 结合整联蛋白的肽衍生物 |
| GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| IL159310A0 (en) | 2001-07-10 | 2004-06-01 | Amersham Health As | Peptide-based compounds |
| EP2226316B1 (en) | 2002-05-30 | 2016-01-13 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| AU2003297859A1 (en) * | 2002-12-13 | 2004-07-09 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
| KR101171397B1 (ko) * | 2003-04-17 | 2012-08-07 | 더 스크립스 리서치 인스티튜트 | 진핵 유전자 코드의 확장 |
| CA2527877A1 (en) * | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| NO20033115D0 (no) | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| EP1799273A2 (en) * | 2004-10-07 | 2007-06-27 | Koninklijke Philips Electronics N.V. | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
-
2004
- 2004-12-22 GB GBGB0428012.9A patent/GB0428012D0/en not_active Ceased
-
2005
- 2005-12-09 EP EP20100179449 patent/EP2275145A1/en not_active Withdrawn
- 2005-12-09 EP EP05818037A patent/EP1830890A2/en not_active Withdrawn
- 2005-12-09 CN CNA2005800441130A patent/CN101084020A/zh active Pending
- 2005-12-09 RU RU2007122804/04A patent/RU2419627C2/ru not_active IP Right Cessation
- 2005-12-09 EP EP20100179459 patent/EP2258403A1/en not_active Withdrawn
- 2005-12-09 MX MX2007007560A patent/MX2007007560A/es active IP Right Grant
- 2005-12-09 CA CA2817636A patent/CA2817636A1/en not_active Abandoned
- 2005-12-09 US US11/721,694 patent/US7972588B2/en active Active
- 2005-12-09 CN CN201510494983.3A patent/CN105012972A/zh active Pending
- 2005-12-09 JP JP2007547612A patent/JP5743372B2/ja not_active Expired - Lifetime
- 2005-12-09 BR BRPI0519317-6A patent/BRPI0519317A2/pt not_active Application Discontinuation
- 2005-12-09 WO PCT/GB2005/004729 patent/WO2006067376A2/en not_active Ceased
- 2005-12-09 CA CA2589136A patent/CA2589136C/en not_active Expired - Fee Related
- 2005-12-09 KR KR1020077014048A patent/KR101314460B1/ko not_active Expired - Fee Related
- 2005-12-09 EP EP10179446.9A patent/EP2266629B1/en not_active Expired - Lifetime
- 2005-12-09 AU AU2005317903A patent/AU2005317903C1/en not_active Ceased
-
2007
- 2007-06-20 NO NO20073157A patent/NO341638B1/no not_active IP Right Cessation
-
2011
- 2011-06-13 US US13/158,555 patent/US8679455B2/en not_active Expired - Lifetime
-
2012
- 2012-07-30 JP JP2012167865A patent/JP2012254998A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008528445A5 (enExample) | ||
| CN1938244B (zh) | 氟化方法 | |
| JP2009541288A5 (enExample) | ||
| JP2006502283A5 (enExample) | ||
| JP2010516844A5 (ja) | 硬化性接着剤組成物 | |
| JP2016153410A5 (enExample) | ||
| JP2007530441A5 (enExample) | ||
| JP2011503184A5 (enExample) | ||
| JP2010525122A5 (enExample) | ||
| DK1678119T3 (da) | Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere | |
| JP2016523313A5 (enExample) | ||
| JP7063409B1 (ja) | Ｆｍоｃ基を除去する方法 | |
| JP2012531508A5 (enExample) | ||
| ATE355259T1 (de) | Radiofluorierungsverfahren | |
| US20220220151A1 (en) | Method for preparing peptides | |
| JP2018502174A5 (enExample) | ||
| AR091075A1 (es) | Proceso para preparar derivados monociclicos de heteroaril-cicloalquil-diamina | |
| JP7154513B1 (ja) | 液相ペプチド製造方法 | |
| RU2014102887A (ru) | Прямой синтез 18f-фторметокси соединений для пэт визуализации и новые предшественники для прямого радиосинтеза защищенных производных o-([18f]фторметил)тирозина | |
| JP2009522364A5 (enExample) | ||
| ES2578798T3 (es) | Método de ligación nativa | |
| RU2016134328A (ru) | Конъюгаты фактора свёртывания крови vii | |
| JP2013509396A5 (enExample) | ||
| CN105936626B (zh) | 一种氨基保护基的制备方法 | |
| KR101142153B1 (ko) | 개선된 플루오르-18 표지를 위한 트리아자노난 유도체 또는 이의 약학적으로 허용가능한 염 |