BRPI0519317A2 - mÉtodo para marcar um vetor, composto, composiÇço radiofarmacÊutica, uso de um composto, e, mÉtodos para gerar uma imagem de um corpo humano ou animal e para monitorar o efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condiÇço associada com cÂncer - Google Patents

mÉtodo para marcar um vetor, composto, composiÇço radiofarmacÊutica, uso de um composto, e, mÉtodos para gerar uma imagem de um corpo humano ou animal e para monitorar o efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condiÇço associada com cÂncer

Info

Publication number
BRPI0519317A2
BRPI0519317A2 BRPI0519317-6A BRPI0519317A BRPI0519317A2 BR PI0519317 A2 BRPI0519317 A2 BR PI0519317A2 BR PI0519317 A BRPI0519317 A BR PI0519317A BR PI0519317 A2 BRPI0519317 A2 BR PI0519317A2
Authority
BR
Brazil
Prior art keywords
compound
human
animal body
methods
formula
Prior art date
Application number
BRPI0519317-6A
Other languages
English (en)
Inventor
Erik Arstad
Matthias Eberhard Glaser
Original Assignee
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hammersmith Imanet Ltd filed Critical Hammersmith Imanet Ltd
Publication of BRPI0519317A2 publication Critical patent/BRPI0519317A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

MÉTODO PARA MARCAR UM VETOR, COMPOSTO, COMPOSIÇçO RADIOFARMACÊUTICA, USO DE UM COMPOSTO, E, MÉTODOS PARA GERAR UMA IMAGEM DE UM CORPO HUMANO OU ANIMAL E PARA MONITORAR O EFEITO DO TRATAMENTO DE UM CORPO HUMANO OU ANIMAL COM UMA DROGA PARA COMBATER UMA CONDIÇçO ASSOCIADA COM CÂNCER. A invenção diz respeito a agentes de radiodiagnóstico e radioterapêuticos, incluindo vetores biologicamente ativos marcados com radionuclídeos. Ainda diz respeito aos métodos e reagentes que marcam um vetor tal como um peptídeo compreendendo a reação de um composto de fórmula (I) com um composto de fórmula (II) ou, um composto de fórmula (III) com um composto de fórmula (IV) na presença de um catalisador de Cu (1). Os conjugados marcados resultantes são úteis como agentes de diagnóstico, por exemplo, como radiofarmacéuticos mais especificamente para uso na Tomografia por Emissão de Pósitron (PET) ou Tomografia Computadorizada por Emissão de Mono-fótons (SPECT) ou para radioterapia.
BRPI0519317-6A 2004-12-22 2005-12-09 mÉtodo para marcar um vetor, composto, composiÇço radiofarmacÊutica, uso de um composto, e, mÉtodos para gerar uma imagem de um corpo humano ou animal e para monitorar o efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condiÇço associada com cÂncer BRPI0519317A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0428012.9A GB0428012D0 (en) 2004-12-22 2004-12-22 Radiolabelling methods
PCT/GB2005/004729 WO2006067376A2 (en) 2004-12-22 2005-12-09 Radiolabelled conjugates of rgd-containing peptides and methods for their preparation via click-chemistry

Publications (1)

Publication Number Publication Date
BRPI0519317A2 true BRPI0519317A2 (pt) 2009-01-13

Family

ID=34112991

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519317-6A BRPI0519317A2 (pt) 2004-12-22 2005-12-09 mÉtodo para marcar um vetor, composto, composiÇço radiofarmacÊutica, uso de um composto, e, mÉtodos para gerar uma imagem de um corpo humano ou animal e para monitorar o efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condiÇço associada com cÂncer

Country Status (13)

Country Link
US (2) US7972588B2 (pt)
EP (4) EP2266629B1 (pt)
JP (2) JP5743372B2 (pt)
KR (1) KR101314460B1 (pt)
CN (2) CN105012972A (pt)
AU (1) AU2005317903C1 (pt)
BR (1) BRPI0519317A2 (pt)
CA (2) CA2817636A1 (pt)
GB (1) GB0428012D0 (pt)
MX (1) MX2007007560A (pt)
NO (1) NO341638B1 (pt)
RU (1) RU2419627C2 (pt)
WO (1) WO2006067376A2 (pt)

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Also Published As

Publication number Publication date
AU2005317903A1 (en) 2006-06-29
GB0428012D0 (en) 2005-01-26
EP2275145A1 (en) 2011-01-19
EP2266629B1 (en) 2015-12-09
EP1830890A2 (en) 2007-09-12
RU2007122804A (ru) 2009-01-27
KR20070091626A (ko) 2007-09-11
NO341638B1 (no) 2017-12-18
EP2266629A1 (en) 2010-12-29
JP2008528445A (ja) 2008-07-31
CN105012972A (zh) 2015-11-04
CN101084020A (zh) 2007-12-05
US7972588B2 (en) 2011-07-05
NO20073157L (no) 2007-06-20
CA2817636A1 (en) 2006-06-29
JP2012254998A (ja) 2012-12-27
MX2007007560A (es) 2007-11-21
WO2006067376A3 (en) 2007-07-26
AU2005317903B8 (en) 2012-01-19
AU2005317903C1 (en) 2012-05-10
AU2005317903B2 (en) 2011-12-01
CA2589136A1 (en) 2006-06-29
US20110236311A1 (en) 2011-09-29
KR101314460B1 (ko) 2013-10-10
JP5743372B2 (ja) 2015-07-01
EP2258403A1 (en) 2010-12-08
US8679455B2 (en) 2014-03-25
WO2006067376A2 (en) 2006-06-29
RU2419627C2 (ru) 2011-05-27
US20090311177A1 (en) 2009-12-17
CA2589136C (en) 2015-10-06

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