AU2005317903C1 - Radiolabelled conjugates of RGD-containing peptides and methods for their preparation via click-chemistry - Google Patents

Radiolabelled conjugates of RGD-containing peptides and methods for their preparation via click-chemistry Download PDF

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Publication number
AU2005317903C1
AU2005317903C1 AU2005317903A AU2005317903A AU2005317903C1 AU 2005317903 C1 AU2005317903 C1 AU 2005317903C1 AU 2005317903 A AU2005317903 A AU 2005317903A AU 2005317903 A AU2005317903 A AU 2005317903A AU 2005317903 C1 AU2005317903 C1 AU 2005317903C1
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AU
Australia
Prior art keywords
formula
compound
vector
peptide
catalyst
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Ceased
Application number
AU2005317903A
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English (en)
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AU2005317903B8 (en
AU2005317903B2 (en
AU2005317903A1 (en
Inventor
Erik Arstad
Matthias Eberhard Glaser
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Hammersmith Imanet Ltd
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Hammersmith Imanet Ltd
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Publication of AU2005317903A1 publication Critical patent/AU2005317903A1/en
Publication of AU2005317903B2 publication Critical patent/AU2005317903B2/en
Publication of AU2005317903B8 publication Critical patent/AU2005317903B8/en
Application granted granted Critical
Publication of AU2005317903C1 publication Critical patent/AU2005317903C1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2005317903A 2004-12-22 2005-12-09 Radiolabelled conjugates of RGD-containing peptides and methods for their preparation via click-chemistry Ceased AU2005317903C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0428012.9A GB0428012D0 (en) 2004-12-22 2004-12-22 Radiolabelling methods
GB0428012.9 2004-12-22
PCT/GB2005/004729 WO2006067376A2 (en) 2004-12-22 2005-12-09 Radiolabelled conjugates of rgd-containing peptides and methods for their preparation via click-chemistry

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011250795A Division AU2011250795A1 (en) 2004-12-22 2011-11-15 Radiolabelling methods

Publications (4)

Publication Number Publication Date
AU2005317903A1 AU2005317903A1 (en) 2006-06-29
AU2005317903B2 AU2005317903B2 (en) 2011-12-01
AU2005317903B8 AU2005317903B8 (en) 2012-01-19
AU2005317903C1 true AU2005317903C1 (en) 2012-05-10

Family

ID=34112991

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005317903A Ceased AU2005317903C1 (en) 2004-12-22 2005-12-09 Radiolabelled conjugates of RGD-containing peptides and methods for their preparation via click-chemistry

Country Status (13)

Country Link
US (2) US7972588B2 (enExample)
EP (4) EP2258403A1 (enExample)
JP (2) JP5743372B2 (enExample)
KR (1) KR101314460B1 (enExample)
CN (2) CN105012972A (enExample)
AU (1) AU2005317903C1 (enExample)
BR (1) BRPI0519317A2 (enExample)
CA (2) CA2817636A1 (enExample)
GB (1) GB0428012D0 (enExample)
MX (1) MX2007007560A (enExample)
NO (1) NO341638B1 (enExample)
RU (1) RU2419627C2 (enExample)
WO (1) WO2006067376A2 (enExample)

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US8722014B2 (en) * 2009-05-01 2014-05-13 Washington University 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof
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EP2515650A4 (en) * 2009-12-23 2013-05-29 Univ Nebraska TARGETED RADIOACTIVELY MARKED COMPOUNDS AND THEIR USE FOR THE TREATMENT AND DIAGNOSIS OF CANCER
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US9649394B2 (en) 2010-11-22 2017-05-16 The General Hospital Corporation Compositions and methods for in vivo imaging
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GB201021517D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Radioiodinated guanidines
KR20130132939A (ko) 2010-12-22 2013-12-05 지이 헬쓰케어 리미티드 １８ｆ - 함유 유기실리콘 화합물로 표지된 ｈｅｒ２ 결합 펩티드
KR20180042442A (ko) 2010-12-22 2018-04-25 제너럴 일렉트릭 캄파니 방사성표지 ｈｅｒ２ 결합 펩티드
RU2013140291A (ru) * 2011-03-01 2015-04-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Меченые радиоактивной меткой аналоги октреотата в качестве рет-индикаторов
US20120251448A1 (en) * 2011-03-03 2012-10-04 Hefti Franz F Compounds for Use in the Detection of Neurodegenerative Diseases
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WO2014065413A1 (ja) * 2012-10-26 2014-05-01 日本たばこ産業株式会社 トリアゾール・イソオキサゾール化合物およびその医薬用途
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Also Published As

Publication number Publication date
EP2258403A1 (en) 2010-12-08
EP2266629A1 (en) 2010-12-29
EP2266629B1 (en) 2015-12-09
JP2008528445A (ja) 2008-07-31
NO20073157L (no) 2007-06-20
BRPI0519317A2 (pt) 2009-01-13
CN101084020A (zh) 2007-12-05
US8679455B2 (en) 2014-03-25
RU2007122804A (ru) 2009-01-27
AU2005317903B8 (en) 2012-01-19
CA2817636A1 (en) 2006-06-29
AU2005317903B2 (en) 2011-12-01
WO2006067376A2 (en) 2006-06-29
EP2275145A1 (en) 2011-01-19
NO341638B1 (no) 2017-12-18
CA2589136C (en) 2015-10-06
MX2007007560A (es) 2007-11-21
US7972588B2 (en) 2011-07-05
KR101314460B1 (ko) 2013-10-10
US20090311177A1 (en) 2009-12-17
JP5743372B2 (ja) 2015-07-01
US20110236311A1 (en) 2011-09-29
JP2012254998A (ja) 2012-12-27
EP1830890A2 (en) 2007-09-12
WO2006067376A3 (en) 2007-07-26
GB0428012D0 (en) 2005-01-26
AU2005317903A1 (en) 2006-06-29
CN105012972A (zh) 2015-11-04
RU2419627C2 (ru) 2011-05-27
KR20070091626A (ko) 2007-09-11
CA2589136A1 (en) 2006-06-29

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 23 DEC 2011.

TH Corrigenda

Free format text: IN VOL 25, NO 47, PAGE(S) 6006 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME HAMMERSMITH IMANET LIMITED, APPLICATION NO. 2005317903, UNDER INID (54) CORRECT THE TITLE TO READ RADIOLABELLED CONJUGATES OF RGD-CONTAINING PEPTIDES AND METHODS FOR THEIR PREPARATION VIA CLICK-CHEMISTRY

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 23 DEC 2011

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired