RU2419627C2 - Меченные радиоактивным изотопом конъюгаты rgd-содержащих пептидов и способы их получения с помощью click-химии - Google Patents

Меченные радиоактивным изотопом конъюгаты rgd-содержащих пептидов и способы их получения с помощью click-химии Download PDF

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Publication number
RU2419627C2
RU2419627C2 RU2007122804/04A RU2007122804A RU2419627C2 RU 2419627 C2 RU2419627 C2 RU 2419627C2 RU 2007122804/04 A RU2007122804/04 A RU 2007122804/04A RU 2007122804 A RU2007122804 A RU 2007122804A RU 2419627 C2 RU2419627 C2 RU 2419627C2
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RU
Russia
Prior art keywords
compound
formula
peptide
vector
conjugates
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RU2007122804/04A
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English (en)
Russian (ru)
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RU2007122804A (ru
Inventor
Эрик АРСТАД (GB)
Эрик АРСТАД
Маттиас Эберхард ГЛАЗЕР (GB)
Маттиас Эберхард ГЛАЗЕР
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Хаммерсмит Иманет Лтд.
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Publication of RU2007122804A publication Critical patent/RU2007122804A/ru
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Publication of RU2419627C2 publication Critical patent/RU2419627C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
RU2007122804/04A 2004-12-22 2005-12-09 Меченные радиоактивным изотопом конъюгаты rgd-содержащих пептидов и способы их получения с помощью click-химии RU2419627C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0428012.9A GB0428012D0 (en) 2004-12-22 2004-12-22 Radiolabelling methods
GB0428012.9 2004-12-22

Publications (2)

Publication Number Publication Date
RU2007122804A RU2007122804A (ru) 2009-01-27
RU2419627C2 true RU2419627C2 (ru) 2011-05-27

Family

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Family Applications (1)

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RU2007122804/04A RU2419627C2 (ru) 2004-12-22 2005-12-09 Меченные радиоактивным изотопом конъюгаты rgd-содержащих пептидов и способы их получения с помощью click-химии

Country Status (13)

Country Link
US (2) US7972588B2 (enExample)
EP (4) EP2275145A1 (enExample)
JP (2) JP5743372B2 (enExample)
KR (1) KR101314460B1 (enExample)
CN (2) CN101084020A (enExample)
AU (1) AU2005317903C1 (enExample)
BR (1) BRPI0519317A2 (enExample)
CA (2) CA2817636A1 (enExample)
GB (1) GB0428012D0 (enExample)
MX (1) MX2007007560A (enExample)
NO (1) NO341638B1 (enExample)
RU (1) RU2419627C2 (enExample)
WO (1) WO2006067376A2 (enExample)

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KR20140010096A (ko) * 2011-03-01 2014-01-23 지이 헬쓰케어 리미티드 Ｐｅｔ 트레이서로서 방사능표지된 옥트레오테이트 유사체
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Also Published As

Publication number Publication date
NO341638B1 (no) 2017-12-18
EP2266629B1 (en) 2015-12-09
CN101084020A (zh) 2007-12-05
BRPI0519317A2 (pt) 2009-01-13
WO2006067376A2 (en) 2006-06-29
AU2005317903A1 (en) 2006-06-29
US8679455B2 (en) 2014-03-25
AU2005317903C1 (en) 2012-05-10
CN105012972A (zh) 2015-11-04
AU2005317903B2 (en) 2011-12-01
JP5743372B2 (ja) 2015-07-01
JP2012254998A (ja) 2012-12-27
JP2008528445A (ja) 2008-07-31
AU2005317903B8 (en) 2012-01-19
MX2007007560A (es) 2007-11-21
KR101314460B1 (ko) 2013-10-10
RU2007122804A (ru) 2009-01-27
EP1830890A2 (en) 2007-09-12
US7972588B2 (en) 2011-07-05
EP2266629A1 (en) 2010-12-29
CA2817636A1 (en) 2006-06-29
EP2258403A1 (en) 2010-12-08
NO20073157L (no) 2007-06-20
WO2006067376A3 (en) 2007-07-26
US20110236311A1 (en) 2011-09-29
GB0428012D0 (en) 2005-01-26
EP2275145A1 (en) 2011-01-19
CA2589136A1 (en) 2006-06-29
US20090311177A1 (en) 2009-12-17
KR20070091626A (ko) 2007-09-11
CA2589136C (en) 2015-10-06

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Effective date: 20151210