CN105012972A - 放射性标记方法 - Google Patents
放射性标记方法 Download PDFInfo
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- CN105012972A CN105012972A CN201510494983.3A CN201510494983A CN105012972A CN 105012972 A CN105012972 A CN 105012972A CN 201510494983 A CN201510494983 A CN 201510494983A CN 105012972 A CN105012972 A CN 105012972A
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- 238000012546 transfer Methods 0.000 description 1
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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- A—HUMAN NECESSITIES
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| US8071718B2 (en) | 2004-12-22 | 2011-12-06 | General Electric Company | Selective radiolabeling of biomolecules |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| EP2029616A1 (en) * | 2006-06-21 | 2009-03-04 | Hammersmith Imanet Limited | Chemical methods and apparatus |
| US8211403B2 (en) | 2006-06-21 | 2012-07-03 | Hammersmith Imanet Limited | Radiolabelling methods |
| EP2056886A2 (en) * | 2006-08-28 | 2009-05-13 | GE Healthcare Limited | 68ga-labeled peptide-based radiopharmaceuticals |
| WO2008025886A1 (en) * | 2006-09-01 | 2008-03-06 | Wallac Oy | Metal chelates and chelating agents containing triazolyl subunits |
| EP2155259A2 (en) * | 2007-05-10 | 2010-02-24 | The Trustees of Columbia University in the City of New York | Methods for diagnosing diseases and evaluating treatments therefor using pet |
| AU2008340449B2 (en) | 2007-12-20 | 2014-05-22 | Ge Healthcare Limited | Selective radiolabeling of biomolecules |
| EP2147684A1 (en) * | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| GB0815831D0 (en) * | 2008-09-01 | 2008-10-08 | Imp Innovations Ltd | Compounds |
| AU2009289062B2 (en) | 2008-09-05 | 2015-01-22 | Hammersmith Imanet Limited | Isatin derivatives for use as in vivo imaging agents |
| DK2346870T3 (en) * | 2008-10-10 | 2015-08-17 | Merck & Cie | 18F-LABELED FOLATES AS PET RADIO MARKERS |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| EP2210882A1 (en) * | 2009-01-16 | 2010-07-28 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Synthesis of new protected azahistidine, their processes and their use in synthesises |
| WO2010099273A1 (en) * | 2009-02-27 | 2010-09-02 | Genentech, Inc. | Methods and compositions for protein labelling |
| US8722014B2 (en) * | 2009-05-01 | 2014-05-13 | Washington University | 1 H-[1, 2, 3] triazole substituted amino acids and uses thereof |
| GB0914543D0 (en) | 2009-08-20 | 2009-09-30 | Ge Healthcare Ltd | Radioiodination method |
| WO2011058002A1 (en) * | 2009-11-11 | 2011-05-19 | Neurosearch A/S | Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods |
| GB0921573D0 (en) * | 2009-12-10 | 2010-01-27 | Ge Healthcare Ltd | Iodine radiolabelling method |
| GB0922304D0 (en) | 2009-12-22 | 2010-02-03 | Ge Healthcare Ltd | Radioiodinated compounds |
| WO2011079245A1 (en) * | 2009-12-23 | 2011-06-30 | Board Of Regents Of The University Of Nebraska | Targeted radiolabeled compounds and their use for the treatment and diagnosis of cancer |
| WO2011130530A1 (en) * | 2010-04-14 | 2011-10-20 | The Mclean Hospital Corporation | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof |
| WO2011153250A2 (en) * | 2010-06-01 | 2011-12-08 | Advanced Proteome Therapeutics Inc. | Crosslinking of proteins and other entities via conjugates of alpha-haloacetophenones, benzyl halides, quinones, and their derivatives |
| US10434197B2 (en) * | 2010-07-23 | 2019-10-08 | University Of Delaware | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes |
| GB201014023D0 (en) * | 2010-08-20 | 2010-10-06 | Ucl Business Plc | Process for producing bioconjugates and products thereof |
| WO2012074840A2 (en) | 2010-11-22 | 2012-06-07 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
| GB201019824D0 (en) | 2010-11-23 | 2011-01-05 | Ge Healthcare Ltd | Radioiodination method |
| GB201021369D0 (en) | 2010-12-16 | 2011-01-26 | Ge Healthcare Ltd | Radioiodinated fatty acids |
| GB201021517D0 (en) | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Radioiodinated guanidines |
| BR112013015798A2 (pt) | 2010-12-22 | 2019-09-24 | Ge Healthcare Ltd | composição de agente de formação de imagem, método de preparar uma composição de agente de formação de imagem, e, composição farmacêutica |
| EP2654804A1 (en) | 2010-12-22 | 2013-10-30 | GE Healthcare UK Limited | Her2 binding peptides labeled with aluminium-[18]fluoride complexed by nota |
| US10201625B2 (en) * | 2011-03-01 | 2019-02-12 | Imperial College | Radiolabelled octreotate analogues as PET tracers |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| US9023318B2 (en) * | 2011-06-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
| WO2013048832A1 (en) | 2011-09-29 | 2013-04-04 | Ge Healthcare Limited | 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells |
| WO2013048811A1 (en) | 2011-09-30 | 2013-04-04 | Ge Healthcare Limited | Imaging and radiotherapy methods for tumour stem cells |
| WO2013082508A1 (en) * | 2011-12-02 | 2013-06-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment and analysis of neurological disorders |
| GB201121911D0 (en) | 2011-12-20 | 2012-02-01 | Ge Healthcare Ltd | Radiofluorination method |
| EP2809356A1 (en) * | 2012-02-03 | 2014-12-10 | Aarhus Universitet | Radiolabeled bile acids and bile acid derivatives |
| EP2657213A1 (en) * | 2012-04-24 | 2013-10-30 | Institut National de la Santé et de la Recherche Medicale | Labelled quinoxaline derivatives as multimodal radiopharmaceuticals and their precursors |
| US20140065070A1 (en) * | 2012-08-28 | 2014-03-06 | Mcmaster University | Methods of preparing triazole-containing radioiodinated compounds |
| US20160137639A1 (en) * | 2012-10-26 | 2016-05-19 | Japan Tobacco Inc. | Triazole-isoxazole compound and medical use thereof |
| US20150023877A1 (en) * | 2013-07-18 | 2015-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of parkinsons disease diagnosis and monitoring treatment |
| CN106458935B (zh) * | 2014-01-05 | 2019-05-28 | 华盛顿大学 | 用于聚(adp-核糖)聚合酶-1(parp-1)的放射性标记示踪物，其方法和用途 |
| US20160022846A1 (en) * | 2014-07-22 | 2016-01-28 | Ge Healthcare Limited | Iodine radiolabelling method |
| PE20180498A1 (es) * | 2015-06-19 | 2018-03-09 | Eisai Randd Man Co Ltd | Inmunoglobulinas conjugadas en cys80 |
| WO2017023999A1 (en) * | 2015-08-03 | 2017-02-09 | Emory University | Methylsulfonamide derivatives and uses related thereto |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| CN112638415B (zh) * | 2018-07-26 | 2024-07-02 | 大有华夏生物医药集团有限公司 | 用于成像的组合物和方法 |
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| US4913891A (en) * | 1986-04-17 | 1990-04-03 | The United States Of America As Represented By The United States Department Of Energy | Positron emitter labeled enzyme inhibitors |
| NZ520875A (en) * | 2000-03-24 | 2005-04-29 | Euro Celtique S | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker |
| US6350360B1 (en) | 2000-04-07 | 2002-02-26 | Sandia Coroporation | Method of fabricating a 3-dimensional tool master |
| WO2001077145A2 (en) * | 2000-04-12 | 2001-10-18 | Amersham Health As | Integrin binding peptide derivatives |
| GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| EP1404371B1 (en) | 2001-07-10 | 2019-03-13 | GE Healthcare UK Limited | Peptide-based compounds for targeting intergin receptors |
| WO2003101972A1 (en) | 2002-05-30 | 2003-12-11 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| WO2004055160A2 (en) * | 2002-12-13 | 2004-07-01 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
| CN103215227B (zh) | 2003-04-17 | 2015-09-16 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| JP5275566B2 (ja) * | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| NO20033115D0 (no) | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| JP2008515876A (ja) * | 2004-10-07 | 2008-05-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | イメージング及び治療用のイメージング及び治療のエンドキットにおけるシュタウディンガーライゲーションの使用 |
| GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
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- 2005-12-09 BR BRPI0519317-6A patent/BRPI0519317A2/pt not_active Application Discontinuation
- 2005-12-09 EP EP10179446.9A patent/EP2266629B1/en not_active Expired - Lifetime
- 2005-12-09 CN CN201510494983.3A patent/CN105012972A/zh active Pending
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- 2005-12-09 KR KR1020077014048A patent/KR101314460B1/ko not_active Expired - Fee Related
- 2005-12-09 JP JP2007547612A patent/JP5743372B2/ja not_active Expired - Lifetime
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- 2005-12-09 CN CNA2005800441130A patent/CN101084020A/zh active Pending
- 2005-12-09 EP EP05818037A patent/EP1830890A2/en not_active Withdrawn
- 2005-12-09 EP EP20100179459 patent/EP2258403A1/en not_active Withdrawn
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| MX2007007560A (es) | 2007-11-21 |
| CA2589136C (en) | 2015-10-06 |
| AU2005317903B2 (en) | 2011-12-01 |
| JP2008528445A (ja) | 2008-07-31 |
| BRPI0519317A2 (pt) | 2009-01-13 |
| GB0428012D0 (en) | 2005-01-26 |
| US7972588B2 (en) | 2011-07-05 |
| AU2005317903C1 (en) | 2012-05-10 |
| NO341638B1 (no) | 2017-12-18 |
| EP2266629A1 (en) | 2010-12-29 |
| KR101314460B1 (ko) | 2013-10-10 |
| CN101084020A (zh) | 2007-12-05 |
| NO20073157L (no) | 2007-06-20 |
| AU2005317903A1 (en) | 2006-06-29 |
| EP2266629B1 (en) | 2015-12-09 |
| KR20070091626A (ko) | 2007-09-11 |
| RU2007122804A (ru) | 2009-01-27 |
| JP2012254998A (ja) | 2012-12-27 |
| RU2419627C2 (ru) | 2011-05-27 |
| AU2005317903B8 (en) | 2012-01-19 |
| US8679455B2 (en) | 2014-03-25 |
| JP5743372B2 (ja) | 2015-07-01 |
| EP2275145A1 (en) | 2011-01-19 |
| WO2006067376A3 (en) | 2007-07-26 |
| WO2006067376A2 (en) | 2006-06-29 |
| CA2589136A1 (en) | 2006-06-29 |
| EP2258403A1 (en) | 2010-12-08 |
| CA2817636A1 (en) | 2006-06-29 |
| US20090311177A1 (en) | 2009-12-17 |
| EP1830890A2 (en) | 2007-09-12 |
| US20110236311A1 (en) | 2011-09-29 |
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