JP2008515793A5 - - Google Patents
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- Publication number
- JP2008515793A5 JP2008515793A5 JP2007534071A JP2007534071A JP2008515793A5 JP 2008515793 A5 JP2008515793 A5 JP 2008515793A5 JP 2007534071 A JP2007534071 A JP 2007534071A JP 2007534071 A JP2007534071 A JP 2007534071A JP 2008515793 A5 JP2008515793 A5 JP 2008515793A5
- Authority
- JP
- Japan
- Prior art keywords
- labeled
- compound
- protected
- fdg
- alkanoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 239000000700 radioactive tracer Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000002703 mannose derivatives Chemical class 0.000 claims 2
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000012351 deprotecting agent Substances 0.000 claims 1
- 239000012025 fluorinating agent Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000001308 synthesis method Methods 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0422004.2 | 2004-10-05 | ||
| GBGB0422004.2A GB0422004D0 (en) | 2004-10-05 | 2004-10-05 | Method of deprotection |
| PCT/GB2005/003692 WO2006037950A1 (en) | 2004-10-05 | 2005-09-23 | Method of deprotection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515793A JP2008515793A (ja) | 2008-05-15 |
| JP2008515793A5 true JP2008515793A5 (enExample) | 2008-11-06 |
| JP5000521B2 JP5000521B2 (ja) | 2012-08-15 |
Family
ID=33428035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534071A Expired - Fee Related JP5000521B2 (ja) | 2004-10-05 | 2005-09-23 | 脱保護の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7714115B2 (enExample) |
| EP (1) | EP1797029A1 (enExample) |
| JP (1) | JP5000521B2 (enExample) |
| CN (1) | CN101035755B (enExample) |
| GB (1) | GB0422004D0 (enExample) |
| WO (1) | WO2006037950A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070260267A1 (en) * | 2002-10-07 | 2007-11-08 | Nicoson Zachary R | Localizing obturator |
| KR101579796B1 (ko) * | 2006-12-21 | 2015-12-24 | 니혼 메디피직스 가부시키가이샤 | 방사성 화상 진단제 |
| WO2008078589A1 (ja) | 2006-12-27 | 2008-07-03 | Nihon Medi-Physics Co., Ltd. | 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 |
| EP2119458B9 (en) * | 2007-02-13 | 2013-08-21 | Nihon Medi-Physics Co., Ltd. | Method for production of radiation diagnostic imaging agent |
| EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
| US8043316B2 (en) | 2008-05-02 | 2011-10-25 | Suros Surgical Systems, Inc. | Adjustable spacer |
| GB0905515D0 (en) * | 2009-03-31 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling methods |
| CN102712552B (zh) * | 2009-11-17 | 2015-07-22 | 拜耳医药股份有限公司 | 制备f-18标记的谷氨酸衍生物的方法 |
| EP2582713A1 (en) * | 2010-06-17 | 2013-04-24 | MSD Oss B.V. | (11 beta,17 alpha)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one |
| CN108218650A (zh) * | 2010-12-29 | 2018-06-29 | 通用电气健康护理有限公司 | 洗脱溶液 |
| WO2013093025A1 (en) * | 2011-12-21 | 2013-06-27 | Ge Healthcare Limited | 18f - fluciclovine compositions in citrate buffers |
| US9101895B2 (en) | 2011-04-15 | 2015-08-11 | General Electric Company | System for mixing and dispersing microbubble pharmaceuticals |
| KR101221483B1 (ko) * | 2011-05-13 | 2013-01-16 | 서강대학교산학협력단 | Ｆ-18 표지 방사성의약품 합성 장치 및 방법 |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| WO2015188165A1 (en) * | 2014-06-06 | 2015-12-10 | The Regents Of The University Of California | Self-shielded, benchtop chemistry system |
| EP4497477A3 (en) * | 2016-06-10 | 2025-04-02 | The Johns Hopkins University | Improved synthesis of the radiolabeled prostate-specific membrane antigen (psma) inhibitor [18f]dcfpyl |
| EP3551232B1 (en) * | 2016-12-07 | 2022-03-23 | Università degli Studi di Bari "Aldo Moro" | Stable f-dopa formulations and uses thereof |
| CN110809575A (zh) * | 2017-06-23 | 2020-02-18 | 日本医事物理股份有限公司 | 放射性卤素标记化合物的制造方法及放射性医药的制造方法 |
| WO2022196734A1 (ja) * | 2021-03-17 | 2022-09-22 | Tdk株式会社 | 含フッ素化合物および造影剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135683A (en) * | 1991-03-28 | 1992-08-04 | Arco Chemical Technology, L.P. | Process for producing a deprotected alkoxylated polyol |
| US5393908A (en) | 1992-06-25 | 1995-02-28 | Satyamurthy; Nagichettiar | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa |
| DE4330889C2 (de) * | 1993-09-11 | 2002-10-31 | Emtec Magnetics Gmbh | Verfahren zur Wiedergewinnung von Rohmaterialien aus magnetischen Aufzeichnungsträgern |
| US5922810A (en) * | 1995-07-31 | 1999-07-13 | Fmc Corporation | Deprotection of protected functional polymers |
| BE1010280A3 (fr) * | 1996-05-02 | 1998-05-05 | Coincidence S A | Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose. |
| DE10104250A1 (de) * | 2001-01-31 | 2002-08-14 | Deutsches Krebsforsch | Markierungsfähige Verbindungen zur einfachen Synthese von 3'-[18F]Fluor-3'-deoxythymidin und Verfahren zu deren Herstellung |
| EP1356827A1 (en) * | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
| US7022872B2 (en) * | 2003-12-19 | 2006-04-04 | Molecular Technologies, Inc. | Method for making fluorine labeled L-Dopa |
-
2004
- 2004-10-05 GB GBGB0422004.2A patent/GB0422004D0/en not_active Ceased
-
2005
- 2005-09-23 EP EP05784549A patent/EP1797029A1/en not_active Withdrawn
- 2005-09-23 JP JP2007534071A patent/JP5000521B2/ja not_active Expired - Fee Related
- 2005-09-23 US US11/576,625 patent/US7714115B2/en not_active Expired - Fee Related
- 2005-09-23 WO PCT/GB2005/003692 patent/WO2006037950A1/en not_active Ceased
- 2005-09-23 CN CN2005800338074A patent/CN101035755B/zh not_active Expired - Fee Related
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