JP2008524117A - Fviiiの特定部位の変更 - Google Patents

Fviiiの特定部位の変更 Download PDF

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Publication number
JP2008524117A
JP2008524117A JP2007541405A JP2007541405A JP2008524117A JP 2008524117 A JP2008524117 A JP 2008524117A JP 2007541405 A JP2007541405 A JP 2007541405A JP 2007541405 A JP2007541405 A JP 2007541405A JP 2008524117 A JP2008524117 A JP 2008524117A
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Prior art keywords
polypeptide
factor viii
complex
fviii
binding
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Pending
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JP2007541405A
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Japanese (ja)
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JP2008524117A5 (https=
Inventor
パン,クラーク・キユー
マーフイー,ジヨン・イー
メイ,ベイソング
ストラウス,ジヨナサン・エス
ツアンドラ,ヘンドリ
チエン,ジヤンミン
バーネツト,トーマス
タング,リアング
ワング,デキアン
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of JP2008524117A publication Critical patent/JP2008524117A/ja
Publication of JP2008524117A5 publication Critical patent/JP2008524117A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • C07K17/08Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
JP2007541405A 2004-11-12 2005-11-14 Fviiiの特定部位の変更 Pending JP2008524117A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62727704P 2004-11-12 2004-11-12
PCT/US2005/041205 WO2006053299A2 (en) 2004-11-12 2005-11-14 Site-directed modification of fviii

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012231926A Division JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更

Publications (2)

Publication Number Publication Date
JP2008524117A true JP2008524117A (ja) 2008-07-10
JP2008524117A5 JP2008524117A5 (https=) 2009-01-08

Family

ID=36337298

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2007541405A Pending JP2008524117A (ja) 2004-11-12 2005-11-14 Fviiiの特定部位の変更
JP2012231926A Expired - Lifetime JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更
JP2015022993A Expired - Lifetime JP6018238B2 (ja) 2004-11-12 2015-02-09 Fviiiの特定部位の変更
JP2016234757A Expired - Fee Related JP6559642B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更
JP2016234756A Expired - Fee Related JP6487895B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2012231926A Expired - Lifetime JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更
JP2015022993A Expired - Lifetime JP6018238B2 (ja) 2004-11-12 2015-02-09 Fviiiの特定部位の変更
JP2016234757A Expired - Fee Related JP6559642B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更
JP2016234756A Expired - Fee Related JP6487895B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更

Country Status (32)

Country Link
US (4) US7632921B2 (https=)
EP (9) EP2772500B1 (https=)
JP (5) JP2008524117A (https=)
KR (7) KR101468345B1 (https=)
CN (6) CN107082806A (https=)
AU (1) AU2005304622B2 (https=)
BE (1) BE2019C523I2 (https=)
BR (2) BR122016022033B8 (https=)
CA (1) CA2586379C (https=)
CY (3) CY1119292T1 (https=)
DK (3) DK2371856T3 (https=)
ES (4) ES2821832T3 (https=)
FR (1) FR19C1031I2 (https=)
HN (1) HN2007015683A (https=)
HR (2) HRP20070268B1 (https=)
HU (5) HUE059193T2 (https=)
IL (3) IL182903A (https=)
LT (5) LT3130601T (https=)
LU (1) LUC00118I2 (https=)
MA (1) MA29663B1 (https=)
MX (3) MX392760B (https=)
NL (1) NL300989I2 (https=)
NO (3) NO20210454A1 (https=)
NZ (1) NZ555032A (https=)
PH (2) PH12014500352B1 (https=)
PL (3) PL1824988T3 (https=)
PT (4) PT2371856T (https=)
RU (1) RU2423380C2 (https=)
SI (4) SI3130601T1 (https=)
UA (1) UA95225C2 (https=)
WO (1) WO2006053299A2 (https=)
ZA (1) ZA200703696B (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012505917A (ja) * 2008-10-17 2012-03-08 バクスター・インターナショナル・インコーポレイテッド 低度の水溶性ポリマーを含む改変血液因子
JP2012508172A (ja) * 2008-11-03 2012-04-05 バイエル・ヘルスケア・エルエルシー 血友病の治療方法
JP2013520441A (ja) * 2010-02-21 2013-06-06 バイエル・ヘルスケア・エルエルシー 生体分子を活性化およびコンジュゲートする方法
JP2013525414A (ja) * 2010-04-30 2013-06-20 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 共役血液凝固第viii因子
JP2014520094A (ja) * 2011-05-27 2014-08-21 バクスター・インターナショナル・インコーポレイテッド 増加した半減期を有する治療用タンパク質およびそれを調製する方法
JP2015509365A (ja) * 2012-02-15 2015-03-30 バイオジェン・アイデック・エムエイ・インコーポレイテ 組換え第viii因子タンパク質
JP2016518321A (ja) * 2013-03-15 2016-06-23 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC 組み換え因子viii配合物
JP2016519120A (ja) * 2013-04-28 2016-06-30 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC 凝固因子タンパク質に対する免疫寛容を誘導するための組成物
US12030925B2 (en) 2018-05-18 2024-07-09 Bioverativ Therapeutics Inc. Methods of treating hemophilia A
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors

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EP2055189A1 (en) 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
KR101146160B1 (ko) * 2004-06-30 2012-07-16 넥타르 테라퓨틱스 중합체­인자 ix 부분의 접합체
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
KR101468345B1 (ko) 2004-11-12 2014-12-03 바이엘 헬스케어 엘엘씨 Fviii의 부위 지향 변형
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