JP2008504275A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008504275A5 JP2008504275A5 JP2007518277A JP2007518277A JP2008504275A5 JP 2008504275 A5 JP2008504275 A5 JP 2008504275A5 JP 2007518277 A JP2007518277 A JP 2007518277A JP 2007518277 A JP2007518277 A JP 2007518277A JP 2008504275 A5 JP2008504275 A5 JP 2008504275A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- cycloalkyl
- piperidine
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 150
- 125000000753 cycloalkyl group Chemical group 0.000 claims 146
- 125000000217 alkyl group Chemical group 0.000 claims 116
- 125000001072 heteroaryl group Chemical group 0.000 claims 112
- 125000003118 aryl group Chemical group 0.000 claims 109
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 78
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 76
- 125000003710 aryl alkyl group Chemical group 0.000 claims 69
- -1 bicyclo [2.2.1] hept-2-yl Chemical group 0.000 claims 69
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 69
- 229910052799 carbon Inorganic materials 0.000 claims 60
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 53
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 52
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 52
- 125000005843 halogen group Chemical group 0.000 claims 50
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 41
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 27
- BVOCPVIXARZNQN-UHFFFAOYSA-N nipecotamide Chemical compound NC(=O)C1CCCNC1 BVOCPVIXARZNQN-UHFFFAOYSA-N 0.000 claims 26
- 125000005466 alkylenyl group Chemical group 0.000 claims 24
- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 22
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 18
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 17
- 125000003282 alkyl amino group Chemical group 0.000 claims 16
- 125000004663 dialkyl amino group Chemical group 0.000 claims 16
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 13
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000004429 atom Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004965 chloroalkyl group Chemical group 0.000 claims 8
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- NDYJWJFQPIDNLG-HDYDNRTBSA-N (3s)-1-(benzenesulfonyl)-n-(4-pyridin-4-yloxycyclohexyl)piperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)S(=O)(=O)C=1C=CC=CC=1)NC(CC1)CCC1OC1=CC=NC=C1 NDYJWJFQPIDNLG-HDYDNRTBSA-N 0.000 claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- AMBKZGFFDSCPJG-AWEZNQCLSA-N (3s)-1-(1,3-benzoxazol-2-yl)-n-cyclohexylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1OC2=CC=CC=C2N=1)NC1CCCCC1 AMBKZGFFDSCPJG-AWEZNQCLSA-N 0.000 claims 1
- AHJAIDWSOJFPJG-HNNXBMFYSA-N (3s)-1-(2-bromophenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound BrC1=CC=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCCC2)CCC1 AHJAIDWSOJFPJG-HNNXBMFYSA-N 0.000 claims 1
- QJYURUPTZDMAJM-AWEZNQCLSA-N (3s)-1-(2-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 QJYURUPTZDMAJM-AWEZNQCLSA-N 0.000 claims 1
- FARNHWJISQHRJI-INIZCTEOSA-N (3s)-1-(2-cyanophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)S(=O)(=O)C=1C(=CC=CC=1)C#N)NC1CCCCC1 FARNHWJISQHRJI-INIZCTEOSA-N 0.000 claims 1
- ZLZOAMCBQXFVAE-ZDUSSCGKSA-N (3s)-1-(3-chloro-2-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound FC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZLZOAMCBQXFVAE-ZDUSSCGKSA-N 0.000 claims 1
- ZLPRPBUYUNTRAJ-INIZCTEOSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCCC2)CCC1 ZLPRPBUYUNTRAJ-INIZCTEOSA-N 0.000 claims 1
- ODRPEKCTTLECBX-HNNXBMFYSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ODRPEKCTTLECBX-HNNXBMFYSA-N 0.000 claims 1
- WTKUGAUSIFXIGA-AWEZNQCLSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cyclopentylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCC2)CCC1 WTKUGAUSIFXIGA-AWEZNQCLSA-N 0.000 claims 1
- SFFOXPSWWCTHRH-ZDUSSCGKSA-N (3s)-1-(3-chloro-4-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound C1=C(Cl)C(F)=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 SFFOXPSWWCTHRH-ZDUSSCGKSA-N 0.000 claims 1
- DSPKYDUEARCYFC-HNNXBMFYSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCCC2)=C1 DSPKYDUEARCYFC-HNNXBMFYSA-N 0.000 claims 1
- XOVDTJFMSZZWBV-AWEZNQCLSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 XOVDTJFMSZZWBV-AWEZNQCLSA-N 0.000 claims 1
- SROXMWXRTDHRDS-ZDUSSCGKSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cyclopentylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCC2)=C1 SROXMWXRTDHRDS-ZDUSSCGKSA-N 0.000 claims 1
- JPOSBXGZRHTMRE-KRWDZBQOSA-N (3s)-1-(4-cyano-2-methylphenyl)-n-cyclohexylpiperidine-3-carboxamide Chemical compound CC1=CC(C#N)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 JPOSBXGZRHTMRE-KRWDZBQOSA-N 0.000 claims 1
- XEDBAWHPEVFYKJ-GRTSSRMGSA-N (3s)-1-(5-bromopyridin-2-yl)-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(Br)=CC=2)CCC1 XEDBAWHPEVFYKJ-GRTSSRMGSA-N 0.000 claims 1
- VRLHYJZLHNZLLB-ZDUSSCGKSA-N (3s)-1-(5-chloro-2-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound FC1=CC=C(Cl)C=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 VRLHYJZLHNZLLB-ZDUSSCGKSA-N 0.000 claims 1
- UAUJJONANRDGHF-SFHVURJKSA-N (3s)-1-[3-(2-chlorophenoxy)phenyl]sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 UAUJJONANRDGHF-SFHVURJKSA-N 0.000 claims 1
- NNWBZHNCDBZVBJ-SFHVURJKSA-N (3s)-1-[3-(4-chlorophenoxy)phenyl]sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound C1=CC(Cl)=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 NNWBZHNCDBZVBJ-SFHVURJKSA-N 0.000 claims 1
- UQNNZVYRXWWHGK-VIQWUECVSA-N (3s)-1-[5-(3,4-difluorophenyl)pyridin-2-yl]-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=C(F)C(F)=CC=2)CCC1 UQNNZVYRXWWHGK-VIQWUECVSA-N 0.000 claims 1
- WEJLANVJOSNDMX-PELRDEGISA-N (3s)-1-[5-(4-chlorophenyl)pyridin-2-yl]-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=CC(Cl)=CC=2)CCC1 WEJLANVJOSNDMX-PELRDEGISA-N 0.000 claims 1
- NBNZATXXBBNSND-GTPINHCMSA-N (3s)-1-benzoyl-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C(=O)C=2C=CC=CC=2)CCC1 NBNZATXXBBNSND-GTPINHCMSA-N 0.000 claims 1
- NKJQWRYYURKPNV-KRWDZBQOSA-N (3s)-1-phenyl-n-(2-phenylpropan-2-yl)piperidine-3-carboxamide Chemical compound C([C@@H](C1)C(=O)NC(C)(C)C=2C=CC=CC=2)CCN1C1=CC=CC=C1 NKJQWRYYURKPNV-KRWDZBQOSA-N 0.000 claims 1
- CAERBIPFBFQLQI-OOHWJJMZSA-N (3s)-3-n-(4-hydroxycyclohexyl)-1-n-phenylpiperidine-1,3-dicarboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C(=O)NC=2C=CC=CC=2)CCC1 CAERBIPFBFQLQI-OOHWJJMZSA-N 0.000 claims 1
- RCVUAUUNAWOXMV-ONUXSRJRSA-N (3s)-n-(1-adamantyl)-1-phenylpiperidine-3-carboxamide Chemical compound C([C@@H](C1)C(NC23CC4CC(CC(C4)C2)C3)=O)CCN1C1=CC=CC=C1 RCVUAUUNAWOXMV-ONUXSRJRSA-N 0.000 claims 1
- LQIWZYZIPDRHIL-INIZCTEOSA-N (3s)-n-(1-methylcyclohexyl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1(C)CCCCC1 LQIWZYZIPDRHIL-INIZCTEOSA-N 0.000 claims 1
- RAOIEIGLRGMSIY-COIXEQEXSA-N (3s)-n-(3-hydroxy-1-adamantyl)-1-phenylpiperidine-3-carboxamide Chemical compound C([C@@H](C1)C(=O)NC23CC4CC(C2)CC(C4)(C3)O)CCN1C1=CC=CC=C1 RAOIEIGLRGMSIY-COIXEQEXSA-N 0.000 claims 1
- CRAVCTWTIULTBS-AOCRQIFASA-N (3s)-n-(4-hydroxycyclohexyl)-1-(2-methylquinolin-4-yl)piperidine-3-carboxamide Chemical compound O=C([C@H]1CCCN(C1)C=1C=C(N=C2C=CC=CC2=1)C)NC1CCC(O)CC1 CRAVCTWTIULTBS-AOCRQIFASA-N 0.000 claims 1
- WGNFHUKHVIFQDE-MWXLCCTBSA-N (3s)-n-(4-hydroxycyclohexyl)-1-(5-phenylpyridin-2-yl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=CC=CC=2)CCC1 WGNFHUKHVIFQDE-MWXLCCTBSA-N 0.000 claims 1
- SUCDTMKTAUTQGF-VIQWUECVSA-N (3s)-n-(4-hydroxycyclohexyl)-1-(6-phenylpyridazin-3-yl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=NC(=CC=2)C=2C=CC=CC=2)CCC1 SUCDTMKTAUTQGF-VIQWUECVSA-N 0.000 claims 1
- UWXIFPXJOIDSPQ-MWXLCCTBSA-N (3s)-n-(4-hydroxycyclohexyl)-1-[5-(4-methoxyphenyl)pyridin-2-yl]piperidine-3-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=CC=C(N2C[C@H](CCC2)C(=O)NC2CCC(O)CC2)N=C1 UWXIFPXJOIDSPQ-MWXLCCTBSA-N 0.000 claims 1
- QZHBVWNVTBZIDC-GTPINHCMSA-N (3s)-n-(4-hydroxycyclohexyl)-1-quinolin-4-ylpiperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2C3=CC=CC=C3N=CC=2)CCC1 QZHBVWNVTBZIDC-GTPINHCMSA-N 0.000 claims 1
- GJRDQLDITKIULZ-AWEZNQCLSA-N (3s)-n-(4-oxocyclohexyl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCC(=O)CC1 GJRDQLDITKIULZ-AWEZNQCLSA-N 0.000 claims 1
- AVJPZSVCXXJYJS-MLCCFXAWSA-N (3s)-n-(7-oxoazepan-4-yl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCNC(=O)CC1 AVJPZSVCXXJYJS-MLCCFXAWSA-N 0.000 claims 1
- XJGHZOYIEZBFLA-DAFXYXGESA-N (3s)-n-[1-(4-chlorophenyl)propan-2-yl]-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC(C)CC1=CC=C(Cl)C=C1 XJGHZOYIEZBFLA-DAFXYXGESA-N 0.000 claims 1
- LAVCBANNERWOBE-INIZCTEOSA-N (3s)-n-cycloheptyl-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCCCCC1 LAVCBANNERWOBE-INIZCTEOSA-N 0.000 claims 1
- YBNCWRNHHHSMFD-IBGZPJMESA-N (3s)-n-cyclohexyl-1-(2-fluoro-4-pyridin-4-ylphenyl)piperidine-3-carboxamide Chemical compound O=C([C@H]1CCCN(C1)C1=CC=C(C=C1F)C=1C=CN=CC=1)NC1CCCCC1 YBNCWRNHHHSMFD-IBGZPJMESA-N 0.000 claims 1
- OCGFKWMRPDCGLG-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-(2-fluorophenyl)piperidine-3-carboxamide Chemical compound FC1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 OCGFKWMRPDCGLG-AWEZNQCLSA-N 0.000 claims 1
- QZBDPAMWZLSFIX-INIZCTEOSA-N (3s)-n-cyclohexyl-1-(2-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 QZBDPAMWZLSFIX-INIZCTEOSA-N 0.000 claims 1
- LZFNWPKAIZQXGJ-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(3-methoxyphenyl)piperidine-3-carboxamide Chemical compound COC1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 LZFNWPKAIZQXGJ-HNNXBMFYSA-N 0.000 claims 1
- SWNUHFZBHNAAPU-INIZCTEOSA-N (3s)-n-cyclohexyl-1-(3-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 SWNUHFZBHNAAPU-INIZCTEOSA-N 0.000 claims 1
- OUHNBYHPDLSUQE-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(4-fluoro-2-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC(F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 OUHNBYHPDLSUQE-HNNXBMFYSA-N 0.000 claims 1
- ZZTWAHRKAKIKNH-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(4-methoxyphenyl)piperidine-3-carboxamide Chemical compound C1=CC(OC)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZZTWAHRKAKIKNH-HNNXBMFYSA-N 0.000 claims 1
- FSXIJYMGOITPDX-IBGZPJMESA-N (3s)-n-cyclohexyl-1-(4-phenoxyphenyl)piperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC(OC=2C=CC=CC=2)=CC=1)NC1CCCCC1 FSXIJYMGOITPDX-IBGZPJMESA-N 0.000 claims 1
- ICUMADNJQZSPPG-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[2-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ICUMADNJQZSPPG-AWEZNQCLSA-N 0.000 claims 1
- RKMJNYJFZLPULL-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[3-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound FC(F)(F)C1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 RKMJNYJFZLPULL-AWEZNQCLSA-N 0.000 claims 1
- ZSQBFLPIYJOWES-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[4-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZSQBFLPIYJOWES-AWEZNQCLSA-N 0.000 claims 1
- JDDUYMMKDTZDBF-ZDUSSCGKSA-N (3s)-n-cyclohexyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidine-3-carboxamide Chemical compound N1=CC(C(F)(F)F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 JDDUYMMKDTZDBF-ZDUSSCGKSA-N 0.000 claims 1
- OPXWDPIAYYNTMY-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCCCC1 OPXWDPIAYYNTMY-HNNXBMFYSA-N 0.000 claims 1
- JYQSCBJDTKZOKU-ZDUSSCGKSA-N (3s)-n-cyclohexyl-1-pyrazin-2-ylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1N=CC=NC=1)NC1CCCCC1 JYQSCBJDTKZOKU-ZDUSSCGKSA-N 0.000 claims 1
- UZUWPFYUNGCWEP-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-pyridin-2-ylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1N=CC=CC=1)NC1CCCCC1 UZUWPFYUNGCWEP-AWEZNQCLSA-N 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- ODRPEKCTTLECBX-UHFFFAOYSA-N 1-(3-chloro-2-methylphenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1CC(C(=O)NC2CCCCC2)CCC1 ODRPEKCTTLECBX-UHFFFAOYSA-N 0.000 claims 1
- XOVDTJFMSZZWBV-UHFFFAOYSA-N 1-(3-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2CC(CCC2)C(=O)NC2CCCCC2)=C1 XOVDTJFMSZZWBV-UHFFFAOYSA-N 0.000 claims 1
- RRHWEGUOHKFJBJ-UHFFFAOYSA-N 1-(4-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1CC(C(=O)NC2CCCCC2)CCC1 RRHWEGUOHKFJBJ-UHFFFAOYSA-N 0.000 claims 1
- VRLHYJZLHNZLLB-UHFFFAOYSA-N 1-(5-chloro-2-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound FC1=CC=C(Cl)C=C1S(=O)(=O)N1CC(C(=O)NC2CCCCC2)CCC1 VRLHYJZLHNZLLB-UHFFFAOYSA-N 0.000 claims 1
- QLPUJDLMGSDABO-UHFFFAOYSA-N 1-(benzenesulfonyl)-n-cyclohexyl-3-methylpiperidine-3-carboxamide Chemical compound C1C(C)(C(=O)NC2CCCCC2)CCCN1S(=O)(=O)C1=CC=CC=C1 QLPUJDLMGSDABO-UHFFFAOYSA-N 0.000 claims 1
- ILIPCBLDKZNOEK-UHFFFAOYSA-N 1-(benzenesulfonyl)-n-cyclohexyl-n-cyclopropylpiperidine-3-carboxamide Chemical compound C1CC1N(C1CCCCC1)C(=O)C(C1)CCCN1S(=O)(=O)C1=CC=CC=C1 ILIPCBLDKZNOEK-UHFFFAOYSA-N 0.000 claims 1
- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims 1
- VAJHMBLRNPFMLL-UHFFFAOYSA-N 1-piperidin-3-ylpiperidine-3-carboxamide Chemical compound C1C(C(=O)N)CCCN1C1CNCCC1 VAJHMBLRNPFMLL-UHFFFAOYSA-N 0.000 claims 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- VWGJJTQPGXBBIC-NFOMZHRRSA-N 6-[(3s)-3-[(4-hydroxycyclohexyl)carbamoyl]piperidin-1-yl]pyridine-3-carboxylic acid Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C(O)=O)CCC1 VWGJJTQPGXBBIC-NFOMZHRRSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- HEYPKRSARBOAKF-ZOBUZTSGSA-N C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(C=2C=CC=CC=2)CCC1 Chemical compound C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(C=2C=CC=CC=2)CCC1 HEYPKRSARBOAKF-ZOBUZTSGSA-N 0.000 claims 1
- GLESKIKGUNBLRB-FHWLQOOXSA-N C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(S(=O)(=O)C=2C=C(OC=3C(=CC=CC=3)Cl)C=CC=2)CCC1 Chemical compound C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(S(=O)(=O)C=2C=C(OC=3C(=CC=CC=3)Cl)C=CC=2)CCC1 GLESKIKGUNBLRB-FHWLQOOXSA-N 0.000 claims 1
- CMRVGTRQYHIEMN-FHWLQOOXSA-N C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(S(=O)(=O)C=2C=CC(OC=3C=NC=CC=3)=CC=2)CCC1 Chemical compound C1C[C@@H](O)CC[C@@H]1NC(=O)[C@@H]1CN(S(=O)(=O)C=2C=CC(OC=3C=NC=CC=3)=CC=2)CCC1 CMRVGTRQYHIEMN-FHWLQOOXSA-N 0.000 claims 1
- DVSZASYYYAFNBR-ACRUOGEOSA-N CC1=CC=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)N[C@@H]2CC[C@@H](O)CC2)=C1 Chemical compound CC1=CC=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)N[C@@H]2CC[C@@H](O)CC2)=C1 DVSZASYYYAFNBR-ACRUOGEOSA-N 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010070901 Diabetic dyslipidaemia Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- DJIMZCDISJKRRX-UHFFFAOYSA-N OC(=O)C(F)(F)F.NC(=O)C1CCCNC1 Chemical compound OC(=O)C(F)(F)F.NC(=O)C1CCCNC1 DJIMZCDISJKRRX-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000006639 cyclohexyl carbonyl group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- KFIGRESRYLYKKR-FHERZECASA-N methyl 6-[(3s)-3-[(4-hydroxycyclohexyl)carbamoyl]piperidin-1-yl]pyridine-3-carboxylate Chemical compound N1=CC(C(=O)OC)=CC=C1N1C[C@@H](C(=O)NC2CCC(O)CC2)CCC1 KFIGRESRYLYKKR-FHERZECASA-N 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- JRVXGJOZIQWGLG-UHFFFAOYSA-N n-cyclohexyl-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxamide Chemical compound [O-][N+](=O)C1=CC=CC=C1S(=O)(=O)N1CC(C(=O)NC2CCCCC2)CCC1 JRVXGJOZIQWGLG-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- QHSCXGMDNOKEGD-UHFFFAOYSA-N piperidine-1,3-dicarboxamide Chemical compound NC(=O)C1CCCN(C(N)=O)C1 QHSCXGMDNOKEGD-UHFFFAOYSA-N 0.000 claims 1
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 1
- PXVFTSOEZKVYJF-UVKLAMSESA-N tert-butyl 4-[6-[(3s)-3-[(4-hydroxycyclohexyl)carbamoyl]piperidin-1-yl]pyridin-3-yl]-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC(C=2C=NC(=CC=2)N2C[C@H](CCC2)C(=O)NC2CCC(O)CC2)=C1 PXVFTSOEZKVYJF-UVKLAMSESA-N 0.000 claims 1
- 125000004187 tetrahydropyran-2-yl group Chemical class [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58255704P | 2004-06-24 | 2004-06-24 | |
| US61457004P | 2004-09-30 | 2004-09-30 | |
| US68684005P | 2005-06-02 | 2005-06-02 | |
| PCT/US2005/022307 WO2006012226A2 (en) | 2004-06-24 | 2005-06-23 | N-substituted piperidines and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504275A JP2008504275A (ja) | 2008-02-14 |
| JP2008504275A5 true JP2008504275A5 (cg-RX-API-DMAC7.html) | 2008-08-14 |
Family
ID=35786661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518277A Pending JP2008504275A (ja) | 2004-06-24 | 2005-06-23 | Ｎ−置換ピペリジンおよびその医薬としての使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8071624B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1758580A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008504275A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005267289A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0512535A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2570637A1 (cg-RX-API-DMAC7.html) |
| CR (1) | CR8793A (cg-RX-API-DMAC7.html) |
| EA (1) | EA200700117A1 (cg-RX-API-DMAC7.html) |
| EC (1) | ECSP067114A (cg-RX-API-DMAC7.html) |
| IL (1) | IL179520A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06014574A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ551603A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006012226A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100222316A1 (en) * | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| EP1768954A4 (en) * | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| EA200700117A1 (ru) | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| WO2006012173A1 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| EP1758582A4 (en) * | 2004-06-24 | 2008-01-09 | Incyte Corp | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICAL PRODUCTS |
| EP1773773A4 (en) * | 2004-06-24 | 2009-07-29 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
| JP2008504276A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| WO2006020598A2 (en) * | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| GEP20125565B (en) * | 2004-11-10 | 2012-07-10 | Incyte Corp | Lactam compounds and their pharmaceutical use |
| US8110581B2 (en) | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| US20060122210A1 (en) * | 2004-11-18 | 2006-06-08 | Wenqing Yao | Inhibitors of 11-beta hydroxyl steroid dehydrogenase type I and methods of using the same |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| KR101302627B1 (ko) | 2005-01-05 | 2013-09-10 | 아비에 인코포레이티드 | 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제 |
| JP5078621B2 (ja) | 2005-01-05 | 2012-11-21 | アボット・ラボラトリーズ | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型酵素の阻害薬としてのアダマンチル誘導体 |
| BRPI0606437A (pt) * | 2005-01-06 | 2008-03-11 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, e, método de tratamento de um distúrbio de agregação de plaqueta |
| CN101133026B (zh) * | 2005-03-03 | 2011-07-06 | 霍夫曼-拉罗奇有限公司 | 作为治疗Ⅱ型糖尿病用的11β-羟基类固醇脱氢酶抑制剂的1-磺酰基-哌啶-3-羧酸酰胺衍生物 |
| JP5140577B2 (ja) * | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
| WO2006113261A2 (en) * | 2005-04-14 | 2006-10-26 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
| US7820699B2 (en) * | 2005-04-27 | 2010-10-26 | Hoffmann-La Roche Inc. | Cyclic amines |
| WO2007046867A2 (en) * | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their uses as therapeutic agents |
| RU2008101924A (ru) * | 2005-07-13 | 2009-08-20 | Астразенека Аб (Se) | Новые аналоги пиридина |
| EP1931652A2 (en) * | 2005-09-21 | 2008-06-18 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| BRPI0619446A2 (pt) | 2005-12-05 | 2011-10-04 | Incyte Corp | compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1 |
| US7998959B2 (en) * | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| TW200804341A (en) * | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| JP5099814B2 (ja) * | 2006-02-02 | 2012-12-19 | 田辺三菱製薬株式会社 | 含窒素複素二環式化合物 |
| JP2009526059A (ja) | 2006-02-07 | 2009-07-16 | ワイス | １１−ベータｈｓｄ１阻害剤 |
| TW200808807A (en) * | 2006-03-02 | 2008-02-16 | Incyte Corp | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| WO2007130898A1 (en) * | 2006-05-01 | 2007-11-15 | Incyte Corporation | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP2018378A2 (en) | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| TW200808695A (en) * | 2006-06-08 | 2008-02-16 | Amgen Inc | Benzamide derivatives and uses related thereto |
| TW200815426A (en) * | 2006-06-28 | 2008-04-01 | Astrazeneca Ab | New pyridine analogues II 333 |
| CA2655629A1 (en) * | 2006-07-04 | 2008-01-10 | Astrazeneca Ab | New pyridine analogues |
| JP2009542641A (ja) * | 2006-07-04 | 2009-12-03 | アストラゼネカ アクチボラグ | 新規ピリジン類縁体 |
| TW200811133A (en) * | 2006-07-04 | 2008-03-01 | Astrazeneca Ab | New pyridine analogues III 334 |
| CN101511792A (zh) * | 2006-07-04 | 2009-08-19 | 阿斯利康(瑞典)有限公司 | 新的吡啶类似物 |
| EP1918285A1 (en) * | 2006-11-03 | 2008-05-07 | Merck Sante | Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors |
| TW200833333A (en) * | 2007-01-12 | 2008-08-16 | Astrazeneca Ab | New pyridine analogues |
| BRPI0806529A2 (pt) * | 2007-01-12 | 2014-04-22 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, e, método de tratamento de um distúrbio de agregação de plaqueta |
| WO2008085119A1 (en) * | 2007-01-12 | 2008-07-17 | Astrazeneca Ab | New pyridine analogues viii 518 |
| WO2008145681A2 (en) * | 2007-05-31 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| PE20081892A1 (es) * | 2007-07-13 | 2009-02-21 | Astrazeneca Ab | Nuevos analogos de amino-piridina como agentes antitromboticos |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| DE102008010221A1 (de) | 2008-02-20 | 2009-08-27 | Bayer Healthcare Ag | Heteroaryl-substituierte Piperidine |
| JP5450435B2 (ja) * | 2007-11-30 | 2014-03-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ヘテロアリールで置換されたピペリジン類 |
| DE102007057718A1 (de) | 2007-11-30 | 2009-07-30 | Bayer Healthcare Ag | Heteroaryl-substituierte Piperidine |
| TW200944526A (en) | 2008-04-22 | 2009-11-01 | Vitae Pharmaceuticals Inc | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| WO2009147188A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| ATE552255T1 (de) | 2008-06-05 | 2012-04-15 | Glaxo Group Ltd | 4-aminoindazole |
| JP5502076B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規化合物 |
| US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
| PL3228320T3 (pl) * | 2008-10-17 | 2020-06-01 | Sanofi-Aventis Deutschland Gmbh | Kombinacja insuliny i agonisty GLP-1 |
| MX2011005150A (es) | 2008-12-19 | 2011-05-30 | Boehringer Ingelheim Int | Pirimidin-4-carboxamidas ciclicas como antagonistas del receptor ccr2 para el tratamiento de inflamacion, asma y epoc. |
| TWI465434B (zh) | 2008-12-22 | 2014-12-21 | Chemocentryx Inc | Ｃ５ａＲ拮抗劑 |
| JP5656880B2 (ja) | 2009-03-09 | 2015-01-21 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Ｐｉ３キナーゼの阻害剤としての４−オキサジアゾール−２−イル−インダゾール |
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| JO3025B1 (ar) | 2009-04-30 | 2016-09-05 | Glaxo Group Ltd | الأندازولات المستبدلة بالأوكسازول كمثبطات كيناز pi3 |
| DE102009022896A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022895A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022897A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| CA3011480C (en) | 2009-11-13 | 2021-11-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| SI2498801T1 (en) | 2009-11-13 | 2018-06-29 | Sanofi-Aventis Deutschland Gmbh | A pharmaceutical composition containing desPro36Exendin-4 (1-39) -Lys6-NH2 and methionine |
| PH12012501215A1 (en) | 2009-12-17 | 2015-11-13 | Centrexion Therapeutics Corp | New ccr2 receptor antagonists and uses thereof |
| US8877745B2 (en) | 2010-05-12 | 2014-11-04 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (en) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| HUE033644T2 (en) | 2010-06-24 | 2017-12-28 | Chemocentryx Inc | C5AR antagonists |
| EP2611458B1 (en) | 2010-08-30 | 2016-09-21 | Sanofi-Aventis Deutschland GmbH | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| WO2012051090A1 (en) * | 2010-10-11 | 2012-04-19 | Axikin Pharmaceuticals, Inc. | Salts of arylsulfonamide ccr3 antagonists |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| EP2750699B1 (en) | 2011-08-29 | 2015-07-22 | Sanofi-Aventis Deutschland GmbH | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| JP2016505001A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| HUE040323T2 (hu) | 2012-12-21 | 2019-02-28 | Epizyme Inc | PRMT5-inhibitorok és alkalmazásaik |
| EP2935243B1 (en) | 2012-12-21 | 2018-03-14 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9399194B2 (en) * | 2014-07-16 | 2016-07-26 | Battelle Energy Alliance, Llc | Methods for treating a liquid using draw solutions |
| JP2017530940A (ja) | 2014-08-04 | 2017-10-19 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| RU2712233C2 (ru) | 2014-09-29 | 2020-01-27 | Кемосентрикс, Инк. | СПОСОБЫ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ В ПОЛУЧЕНИИ C5aR АНТАГОНИСТОВ |
| PE20171622A1 (es) | 2014-12-12 | 2017-11-02 | Sanofi Aventis Deutschland | Formulacion de relacion fija de insulina glargina/lixisenatida |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| MX2022006069A (es) | 2016-01-14 | 2023-01-12 | Chemocentryx Inc | Metodo para tratar glomerulopatia c3. |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| KR20230109185A (ko) | 2016-06-07 | 2023-07-19 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| PT3601239T (pt) | 2017-03-23 | 2024-10-24 | Jacobio Pharmaceuticals Co Ltd | Novos derivados heterocíclicos úteis como inibidores de shp2 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL262366A (cg-RX-API-DMAC7.html) | 1960-03-14 | |||
| US3201466A (en) | 1963-03-08 | 1965-08-17 | Gulf Oil Corp | Substituted cyclopropanecarboxanilide herbicides |
| US3849403A (en) | 1968-04-29 | 1974-11-19 | American Home Prod | 2,3,4,5-tetrahydro-1,1,5,5-tetrasubstituted-1h-3-benzazepines |
| FR1600908A (en) | 1968-11-14 | 1970-08-03 | Hypocholesterolaemic and anorexigenic - phenoxy alkanoylaralkylamines | |
| DE2114420A1 (de) | 1971-03-25 | 1972-10-05 | Merck Patent Gmbh, 6100 Darmstadt | Substituierte Phenylalkanol-Derivate und Verfahren zu ihrer Herstellung |
| US3923350A (en) | 1974-03-11 | 1975-12-02 | Commercial Metals Company | Precision bearing assembly |
| ES427013A1 (es) | 1974-06-05 | 1976-07-16 | Alter Sa | Un procedimiento de preparacion de ciertas amidas del aci- do 2 - (p - clorofenoxi) - 2 - metilpropionico. |
| GB1460389A (en) | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
| US3933829A (en) | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
| TR18917A (tr) | 1974-10-31 | 1977-12-09 | Ciba Geigy Ag | 1-(bis-triflormetilfenil)-2-oksopirolidin-4-karbonik asitleri ve bunlarin tuerevleri |
| US3933350A (en) * | 1974-12-09 | 1976-01-20 | Mignano Frank J | Paper insert feeder |
| FR2312247A1 (fr) | 1975-05-30 | 1976-12-24 | Parcor | Derives de la thieno-pyridine, leur procede de preparation et leurs applications |
| US4145435A (en) | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| JPS57156450A (en) | 1981-03-24 | 1982-09-27 | Ihara Chem Ind Co Ltd | 1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid derivative, its preparation, and aquatic life repellent containing said compound as active component |
| US4439606A (en) | 1982-05-06 | 1984-03-27 | American Cyanamid Company | Antiatherosclerotic 1-piperazinecarbonyl compounds |
| CA1325217C (en) | 1983-11-07 | 1993-12-14 | John T. Lai | 3,5-dialkyl-4-hydroxyphenyl-substituted derivatives |
| JPS60149562A (ja) | 1984-01-13 | 1985-08-07 | Kyorin Pharmaceut Co Ltd | 新規なピペリジン誘導体およびその製法 |
| US4701459A (en) * | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
| FI874212A7 (fi) * | 1986-09-29 | 1988-03-30 | Bristol Myers Squibb Co | 5-arylideeni- ja 5-alkylideenisubstituoitujen hydantoiinien valmistusmenetelmä |
| EP0273659A1 (en) | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
| DE3911670A1 (de) | 1989-04-10 | 1990-10-11 | Schaeffler Waelzlager Kg | Radial-waelzlager |
| DE3920616A1 (de) | 1989-06-23 | 1991-01-03 | Boehringer Mannheim Gmbh | Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate |
| US5206240A (en) | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
| US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| FR2672213B1 (fr) | 1991-02-05 | 1995-03-10 | Sanofi Sa | Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres. |
| JPH04275271A (ja) | 1991-03-04 | 1992-09-30 | Lederle Japan Ltd | インドメタシン誘導体 |
| JPH04334357A (ja) * | 1991-05-02 | 1992-11-20 | Fujirebio Inc | 酵素阻害作用を有するアシル誘導体 |
| FR2678272B1 (fr) | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2705343B1 (fr) | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| DE9403308U1 (de) | 1994-02-28 | 1994-04-28 | INA Wälzlager Schaeffler KG, 91074 Herzogenaurach | Ausgleichsgetriebe für ein Kraftfahrzeug |
| FR2724656B1 (fr) | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| NZ293605A (en) | 1994-09-27 | 1998-07-28 | Janssen Pharmaceutica Nv | N-substituted piperidinyl bicyclic benzoate derivatives, 3-alkoxy-4-hydroxy-piperidine intermediates, and pharmaceutical compositions |
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5693567A (en) | 1995-06-07 | 1997-12-02 | Xerox Corporation | Separately etching insulating layer for contacts within array and for peripheral pads |
| FR2736053B1 (fr) | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| GB9517622D0 (en) | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
| EP0854869B1 (en) | 1995-09-29 | 2004-08-25 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| GB9604311D0 (en) * | 1996-02-29 | 1996-05-01 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase |
| GB9600235D0 (en) | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
| DE69733565T2 (de) | 1996-05-01 | 2006-05-11 | Ortho-Mcneil Pharmaceutical, Inc. | Carboxamiderivate von pyrrolidin, piperidin und hexahydropiperizin für behandlung von thrombosen |
| NZ334389A (en) | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
| HUP0000191A2 (hu) * | 1996-09-13 | 2001-04-28 | Schering Corp. | Farnezil-protein-transzferáz inhibitorként alkalmazható új triciklusos piperidinil-vegyületek |
| ZA979781B (en) | 1996-11-14 | 1998-06-08 | Akzo Nobel Nv | Piperidine derivatives. |
| GB2327609A (en) * | 1997-07-23 | 1999-02-03 | Merck & Co Inc | A method for eliciting an avß5 or dual avß3/avß5 antagonizing effect |
| DK1063230T3 (da) | 1998-02-27 | 2003-07-14 | Sankyo Co | Cykliske aminoforbindelser |
| US6087368A (en) | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| WO2000001702A1 (en) | 1998-07-02 | 2000-01-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| JP2002527477A (ja) | 1998-10-16 | 2002-08-27 | サントリー株式会社 | 神経細胞保護作用物質としてのアミノフェノキシ酢酸誘導体 |
| EP1165545A1 (en) | 1999-03-26 | 2002-01-02 | AstraZeneca AB | Novel compounds |
| CA2366264A1 (en) | 1999-04-02 | 2000-10-12 | Bristol-Myers Squibb Company | Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase |
| ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| PT1202994E (pt) | 1999-07-21 | 2004-08-31 | Astrazeneca Ab | Novos compostos |
| JP4275271B2 (ja) | 1999-11-15 | 2009-06-10 | 寺崎電気産業株式会社 | 計測表示装置 |
| RU2265021C2 (ru) | 1999-12-03 | 2005-11-27 | Оно Фармасьютикал Ко., Лтд. | Производные триазаспиро[5,5]ундекана (варианты), фармацевтическая композиция и способ регулирования хемокина/рецептора хемокина |
| KR100613176B1 (ko) | 1999-12-03 | 2006-08-17 | 오노 야꾸힝 고교 가부시키가이샤 | 트리아자스피로[5.5]운데칸 유도체 및 이들을유효성분으로 하는 약제 |
| IL152424A0 (en) | 2000-04-26 | 2003-05-29 | Warner Lambert Co | Cyclohexylamine derivative as subtype selective nmda receptor antagonist |
| US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
| AUPR079700A0 (en) * | 2000-10-17 | 2000-11-09 | Alchemia Pty Ltd | Combinatorial libraries of monosaccharides |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| US6547958B1 (en) | 2001-07-13 | 2003-04-15 | Chevron U.S.A. Inc. | Hydrocarbon conversion using zeolite SSZ-59 |
| EA200400708A1 (ru) | 2001-11-22 | 2004-10-28 | Биовитрум Аб | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 |
| US6818772B2 (en) * | 2002-02-22 | 2004-11-16 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| EP1478437B1 (en) * | 2002-02-27 | 2005-08-31 | Pfizer Products Inc. | Acc inhibitors |
| GB0213715D0 (en) | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| WO2004000789A1 (en) | 2002-06-19 | 2003-12-31 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| ATE384066T1 (de) | 2002-08-21 | 2008-02-15 | Astrazeneca Ab | Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren |
| WO2004022554A1 (en) | 2002-09-07 | 2004-03-18 | Celltech R & D Limited | Quinazolinone derivatives |
| US20040072802A1 (en) | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| MXPA05003867A (es) | 2002-10-09 | 2005-11-23 | Schering Corp | Tiadiazoldioxidos y tiadiazoloxidos como ligandos de receptor cxc-y cc-quimiocina. |
| MXPA05003632A (es) | 2002-10-11 | 2005-06-03 | Astrazeneca Ab | Derivados de piperidina 1, 4-disustituidos y su uso como inhibidores de 11-beta-hidroesteroide deshidrogenasa humana de tipo 1 (11betahsd1). |
| AU2002354054A1 (en) | 2002-10-18 | 2004-05-04 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
| WO2004058727A1 (en) | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
| ES2393996T3 (es) | 2002-12-25 | 2013-01-04 | Daiichi Sankyo Company, Limited | Derivados de diaminociclohexano antitrombóticos |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| EP1599447A1 (en) | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
| US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
| US20040188324A1 (en) | 2003-03-26 | 2004-09-30 | Saleh Elomari | Hydrocarbon conversion using molecular sieve SSZ-65 |
| ATE482747T1 (de) | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
| TW200509910A (en) | 2003-05-02 | 2005-03-16 | Elan Pharm Inc | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists |
| PT1638963E (pt) | 2003-05-20 | 2009-11-18 | Novartis Ag | Heterociclos de azoto n-acilado como ligandos de receptores activados pelo proliferador peroxissomal |
| SE0302755D0 (sv) | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel compounds |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US20070275990A1 (en) | 2003-11-13 | 2007-11-29 | Ono Pharmaceutical Co., Ltd. | Heterocyclic Spiro Compound |
| EP1696915A1 (en) | 2003-12-19 | 2006-09-06 | Pfizer, Inc. | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity |
| SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
| JP4851943B2 (ja) | 2003-12-22 | 2012-01-11 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドおよびｃｃ−ケモカインレセプターリガンドとしてのイソチアゾールジオキシド |
| EP1729755A1 (en) | 2004-01-21 | 2006-12-13 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using aspartyl-protease inihibitors |
| JP2007536369A (ja) | 2004-05-06 | 2007-12-13 | ファイザー・インク | プロリン及びモルホリン誘導体の新規化合物 |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| EP1773773A4 (en) | 2004-06-24 | 2009-07-29 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
| WO2006012173A1 (en) | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| EP1758582A4 (en) | 2004-06-24 | 2008-01-09 | Incyte Corp | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICAL PRODUCTS |
| JP2008504276A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| EP1768954A4 (en) | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| EA200700117A1 (ru) | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| WO2006020598A2 (en) | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| CA2584730A1 (en) | 2004-10-22 | 2006-05-04 | Cargill, Incorporated | Process for the production of maltodextrins and maltodextrins |
| GEP20125565B (en) | 2004-11-10 | 2012-07-10 | Incyte Corp | Lactam compounds and their pharmaceutical use |
| ATE538124T1 (de) | 2004-11-12 | 2012-01-15 | Bristol Myers Squibb Co | Imidazokondensierte tricyclische verbindungen auf thiazoloä4,5-büpyridin-basis und pharmazeutische zusammensetzungen damit |
| US20060122210A1 (en) | 2004-11-18 | 2006-06-08 | Wenqing Yao | Inhibitors of 11-beta hydroxyl steroid dehydrogenase type I and methods of using the same |
| KR101302627B1 (ko) | 2005-01-05 | 2013-09-10 | 아비에 인코포레이티드 | 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제 |
| CN101133026B (zh) | 2005-03-03 | 2011-07-06 | 霍夫曼-拉罗奇有限公司 | 作为治疗Ⅱ型糖尿病用的11β-羟基类固醇脱氢酶抑制剂的1-磺酰基-哌啶-3-羧酸酰胺衍生物 |
| EP1931652A2 (en) | 2005-09-21 | 2008-06-18 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| BRPI0619446A2 (pt) | 2005-12-05 | 2011-10-04 | Incyte Corp | compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1 |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| TW200804341A (en) | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| JP2007219880A (ja) * | 2006-02-17 | 2007-08-30 | Fujitsu Ltd | 評判情報処理プログラム、方法及び装置 |
| TW200808807A (en) | 2006-03-02 | 2008-02-16 | Incyte Corp | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2007103719A2 (en) | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| WO2007130898A1 (en) | 2006-05-01 | 2007-11-15 | Incyte Corporation | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 |
| EP2018378A2 (en) | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2005
- 2005-06-23 EA EA200700117A patent/EA200700117A1/ru unknown
- 2005-06-23 WO PCT/US2005/022307 patent/WO2006012226A2/en not_active Ceased
- 2005-06-23 BR BRPI0512535-9A patent/BRPI0512535A/pt not_active IP Right Cessation
- 2005-06-23 JP JP2007518277A patent/JP2008504275A/ja active Pending
- 2005-06-23 NZ NZ551603A patent/NZ551603A/en not_active IP Right Cessation
- 2005-06-23 CA CA002570637A patent/CA2570637A1/en not_active Abandoned
- 2005-06-23 US US11/159,448 patent/US8071624B2/en active Active
- 2005-06-23 EP EP05763380A patent/EP1758580A4/en not_active Withdrawn
- 2005-06-23 MX MXPA06014574A patent/MXPA06014574A/es not_active Application Discontinuation
- 2005-06-23 AU AU2005267289A patent/AU2005267289A1/en not_active Abandoned
-
2006
- 2006-11-23 IL IL179520A patent/IL179520A0/en unknown
- 2006-12-06 CR CR8793A patent/CR8793A/es unknown
- 2006-12-26 EC EC2006007114A patent/ECSP067114A/es unknown
-
2011
- 2011-10-24 US US13/279,700 patent/US8288417B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008504275A5 (cg-RX-API-DMAC7.html) | ||
| JP2008509910A5 (cg-RX-API-DMAC7.html) | ||
| ES2569327T3 (es) | Promotores de la apoptosis que contienen N-acilsulfonamida | |
| RU2566827C2 (ru) | Пиколинамидные и пиримидин-4-карбоксамидные соединения, способ их получения и фармацевтическая композиция, включающая их | |
| JP2010514788A5 (cg-RX-API-DMAC7.html) | ||
| AU2004305079B2 (en) | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | |
| JP2007519754A5 (cg-RX-API-DMAC7.html) | ||
| RU2416608C2 (ru) | Ароматическое соединение | |
| RU2011127402A (ru) | Селективные к bcl-2 агенты, вызывающие апоптоз, для лечения рака и иммунных заболеваний | |
| CA2473892A1 (en) | Novel quinoline derivatives | |
| JP2008504276A5 (cg-RX-API-DMAC7.html) | ||
| JP2013519733A5 (cg-RX-API-DMAC7.html) | ||
| HRP20131048T1 (hr) | Cikliäśki derivati kao modulatori aktivnosti receptora kemokina | |
| CA2575561A1 (en) | Amido compounds and their use as pharmaceuticals | |
| US20060178399A1 (en) | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient | |
| HRP20130220T1 (hr) | Modulatori indolamin 2,3-dioksigenaze i postupci upotrebe istih | |
| JP2008504274A5 (cg-RX-API-DMAC7.html) | ||
| JP2008542279A5 (cg-RX-API-DMAC7.html) | ||
| CA2541509C (en) | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | |
| RU2007141346A (ru) | Диарилсульфонсульфонамиды и их применение | |
| JP2013507449A5 (cg-RX-API-DMAC7.html) | ||
| JP2013513605A5 (cg-RX-API-DMAC7.html) | ||
| RU2011149360A (ru) | Замещенные фенилмочевины и фениламиды в качестве лигандов ваниллоидных рецепторов | |
| TR201807973T4 (tr) | Janus kinaz inhibitörleri olarak siyanometilpirazol karboksamidler. | |
| RU2008116313A (ru) | Диарилминсодержащие соединения, композиции и их примеение в качестве модуляторов рецепторов с-кit |