JP2008501693A - 遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物 - Google Patents

遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物 Download PDF

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JP2008501693A
JP2008501693A JP2007515521A JP2007515521A JP2008501693A JP 2008501693 A JP2008501693 A JP 2008501693A JP 2007515521 A JP2007515521 A JP 2007515521A JP 2007515521 A JP2007515521 A JP 2007515521A JP 2008501693 A JP2008501693 A JP 2008501693A
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modified
composition
nucleoside
nucleosides
sugar
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JP2008501693A5 (https=
Inventor
バット、バルクリシェン
プラカッシュ、ターザ、ピー．
ダンデ、プラサッド
アラーソン、チャールズ
グリッフィー、リチャード
スウェイジ、エリック、イー．
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アイシス ファーマシューティカルズ、インク．
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Priority claimed from US10/859,825 external-priority patent/US20050053976A1/en
Priority claimed from PCT/US2004/017485 external-priority patent/WO2005120230A2/en
Priority claimed from PCT/US2004/017522 external-priority patent/WO2005121368A1/en
Priority claimed from US10/946,147 external-priority patent/US7875733B2/en
Application filed by アイシス ファーマシューティカルズ、インク． filed Critical アイシス ファーマシューティカルズ、インク．
Publication of JP2008501693A publication Critical patent/JP2008501693A/ja
Publication of JP2008501693A5 publication Critical patent/JP2008501693A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP2007515521A 2004-06-03 2005-06-02 遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物 Pending JP2008501693A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10/859,825 US20050053976A1 (en) 1996-06-06 2004-06-03 Chimeric oligomeric compounds and their use in gene modulation
PCT/US2004/017485 WO2005120230A2 (en) 2004-06-03 2004-06-03 POSITIONALLY MODIFIED siRNA CONSTRUCTS
PCT/US2004/017522 WO2005121368A1 (en) 2004-06-03 2004-06-03 Chimeric gapped oligomeric compositions
US58404504P 2004-06-29 2004-06-29
US60792704P 2004-09-07 2004-09-07
US10/946,147 US7875733B2 (en) 2003-09-18 2004-09-20 Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
PCT/US2005/019219 WO2005121371A2 (en) 2004-06-03 2005-06-02 Double strand compositions comprising differentially modified strands for use in gene modulation

Publications (2)

Publication Number Publication Date
JP2008501693A true JP2008501693A (ja) 2008-01-24
JP2008501693A5 JP2008501693A5 (https=) 2008-09-04

Family

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Application Number Title Priority Date Filing Date
JP2007515521A Pending JP2008501693A (ja) 2004-06-03 2005-06-02 遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物
JP2007515522A Pending JP2008501694A (ja) 2004-06-03 2005-06-02 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007515522A Pending JP2008501694A (ja) 2004-06-03 2005-06-02 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物

Country Status (6)

Country Link
US (16) US20080119427A1 (https=)
EP (3) EP1765415A4 (https=)
JP (2) JP2008501693A (https=)
AU (2) AU2005252662B2 (https=)
CA (2) CA2569419A1 (https=)
WO (3) WO2005121372A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008501694A (ja) * 2004-06-03 2008-01-24 アイシス ファーマシューティカルズ、インク． 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物
JP2012510816A (ja) * 2008-12-04 2012-05-17 オーピーケーオー・クルナ・エルエルシー Ｖｅｇｆに対する天然アンチセンス転写物の抑制による血管内皮増殖因子（ｖｅｇｆ）関連疾患の治療
JP2013514761A (ja) * 2009-12-09 2013-05-02 日東電工株式会社 Ｈｓｐ４７発現の調節

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